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Q2Y863

- NAGZ_NITMU

UniProt

Q2Y863 - NAGZ_NITMU

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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641SubstrateUniRule annotation
Binding sitei72 – 721SubstrateUniRule annotation
Binding sitei138 – 1381SubstrateUniRule annotation
Sitei179 – 1791Important for catalytic activityUniRule annotation
Active sitei181 – 1811Proton donor/acceptorUniRule annotation
Active sitei252 – 2521NucleophileUniRule annotation

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. cell wall organization Source: UniProtKB-KW
  5. peptidoglycan biosynthetic process Source: UniProtKB-KW
  6. peptidoglycan turnover Source: UniProtKB-HAMAP
  7. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciNMUL323848:GKEC-1792-MONOMER.
UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:Nmul_A1761
OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
Taxonomic identifieri323848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
ProteomesiUP000002718: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Beta-hexosaminidasePRO_0000234919Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323848.Nmul_A1761.

Structurei

3D structure databases

ProteinModelPortaliQ2Y863.
SMRiQ2Y863. Positions 2-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 1692Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000248526.
KOiK01207.
OMAiLLNGFVW.
OrthoDBiEOG6BCT06.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ.
InterProiIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2Y863-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLGPVILDI EGTQLTANDK KKLRHPLVGG VILFTRNYSS LAQLMHLTAE
60 70 80 90 100
IHALRTPPLL VAVDHEGGRV QRFREDFTRL PPMRELGRIW DEHPAQARHL
110 120 130 140 150
AHEAGYVLAA ELRAAGVDFS FTPVLDMDYG QSSVIRDRAF HRDPQAIAEL
160 170 180 190 200
AHSLMSGLKS AGMAAVGKHF PGHGYIEADS HFEMPVDERT YAQIEMDDLI
210 220 230 240 250
PFRKMIGFGL TGMMPAHVIY PKVDALPAGF SEVWLKKVLR GELGFEGCIF
260 270 280 290 300
SDDLNMAGAA FAGNPVERAQ KALHAGCDMV LLCNNPEAAE MLLAELHWDL
310 320 330 340
PALGVIRLAR MRGRPNPDSL VKLHENPNFV SAVEKIAGIG VRSGELPLV
Length:349
Mass (Da):38,354
Last modified:December 20, 2005 - v1
Checksum:i23E9D42AAFCBA50C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA. Translation: ABB75058.1.
RefSeqiWP_011381078.1. NC_007614.1.
YP_412450.1. NC_007614.1.

Genome annotation databases

EnsemblBacteriaiABB75058; ABB75058; Nmul_A1761.
GeneIDi3783961.
KEGGinmu:Nmul_A1761.
PATRICi22726992. VBINitMul110821_2057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA. Translation: ABB75058.1 .
RefSeqi WP_011381078.1. NC_007614.1.
YP_412450.1. NC_007614.1.

3D structure databases

ProteinModelPortali Q2Y863.
SMRi Q2Y863. Positions 2-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323848.Nmul_A1761.

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB75058 ; ABB75058 ; Nmul_A1761 .
GeneIDi 3783961.
KEGGi nmu:Nmul_A1761.
PATRICi 22726992. VBINitMul110821_2057.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000248526.
KOi K01207.
OMAi LLNGFVW.
OrthoDBi EOG6BCT06.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci NMUL323848:GKEC-1792-MONOMER.

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
HAMAPi MF_00364. NagZ.
InterProi IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00933. Glyco_hydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25196 / NCIMB 11849.

Entry informationi

Entry nameiNAGZ_NITMU
AccessioniPrimary (citable) accession number: Q2Y863
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3