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Q2Y7W4 (TRUB_NITMU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
tRNA pseudouridine synthase B
EC=5.4.99.25
Alternative name(s):
tRNA pseudouridine(55) synthase
Short name=Psi55 synthase
tRNA pseudouridylate synthase
tRNA-uridine isomerase
Gene names
Name:truB
Ordered Locus Names:Nmul_A1862
OrganismNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849) [Complete proteome] [HAMAP]
Taxonomic identifier323848 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Nitrosomonadaceae › Nitrosospira ›

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs By similarity. HAMAP-Rule MF_01080

Catalytic activity

tRNA uridine55 = tRNA pseudouridine55. HAMAP-Rule MF_01080

Sequence similarities

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.

Ontologies

Keywords
   Biological processtRNA processing
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA pseudouridine synthesis

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

pseudouridine synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313tRNA pseudouridine synthase B HAMAP-Rule MF_01080
PRO_0000229365

Sites

Active site461Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2Y7W4 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: A3FD1CF30B6604ED

FASTA31333,564
        10         20         30         40         50         60 
MSPGSKRHIS GVLLLDKASG LSSNQALQTA KRIFSAHKAG HTGTLDPMAT GLLPICFGEA 

        70         80         90        100        110        120 
TKFSSALLGA DKTYEAVLRL GYMSTTGDAE GEISIAAGME SQYVDLTREK IEAVRKSFIG 

       130        140        150        160        170        180 
VITQVPPMYS AIKHRGKPMY TFARAGVEIE RQPRAITIHD LSIEAYQGNE MRIRVTCGSG 

       190        200        210        220        230        240 
TYIRTLAEDL GHALGCGGAY LTALRRSALG GFDLPQAYTL TGLEAMPPSQ RDSCLLPADS 

       250        260        270        280        290        300 
LLRSLPPVVV DSAAALSLLQ GRAIPGTHPA GESLLPGRQV RLYDKAQRFL GLGEISTEGY 

       310 
ISPKRLIRFE QSL

« Hide

References

[1]"Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25196 / NCIMB 11849.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000103 Genomic DNA. Translation: ABB75157.1.
RefSeqYP_412549.1. NC_007614.1.

3D structure databases

ProteinModelPortalQ2Y7W4.
ModBaseSearch...

Protein-protein interaction databases

STRING323848.Nmul_A1862.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB75157; ABB75157; Nmul_A1862.
GeneID3786606.
KEGGnmu:Nmul_A1862.
PATRIC22727236. VBINitMul110821_2177.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0130.
HOGENOMHOG000231223.
KOK03177.
OMALGCGAYV.

Enzyme and pathway databases

BioCycNMUL323848:GKEC-1896-MONOMER.

Family and domain databases

Gene3D2.30.130.10. 1 hit.
HAMAPMF_01080. TruB_bact.
InterProIPR002501. PsdUridine_synth.
IPR020103. PsdUridine_synth_cat_dom.
IPR015947. PUA-like_domain.
IPR014780. tRNA_psdUridine_synth_TruB.
IPR015240. tRNA_sdUridine_synth_fam1_C.
[Graphical view]
PANTHERPTHR13767. PTHR13767. 1 hit.
PfamPF09157. TruB-C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMSSF55120. PsdUridine_synth_cat_dom. 1 hit.
SSF88697. PUA-like. 1 hit.
TIGRFAMsTIGR00431. TruB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRUB_NITMU
AccessionPrimary (citable) accession number: Q2Y7W4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 20, 2005
Last modified: May 29, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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