Reviewed, UniProtKB/Swiss-Prot Q2Y6Y6 (HIS82_NITMU)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 2
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 2

Gene names

Name:	hisC2
Ordered Locus Names:	Nmul_A2193

Organism

Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849) [Complete proteome] [HAMAP]

Taxonomic identifier

323848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Nitrosomonadaceae › Nitrosospira

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Histidinol-phosphate aminotransferase 2 HAMAP MF_01023		PRO_0000230218
Amino acid modifications
	Modified residue	228	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2Y6Y6-1 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: D275AAC1F7F41A02	FASTA	392	42,071
	10 20 30 40 50 60 MNICDLAPAY IRAISPYQPG KPISELAREM GMDEQSIIKL ASNENPLGTS PMALNAMSKA 70 80 90 100 110 120 LDEVSLYPDG SGFELKAALS ERYGVTSDQI VLGNGSNDVL ELAARVFLKP GASTVYSQHA 130 140 150 160 170 180 FAVYPLVTKA VGGIGISVPA RNYGHDLDAM LDAVAPETRV VFIANPNNPT GTLLPADDVL 190 200 210 220 230 240 RFLERVSPDV LVVLDEAYNE YLPPALKGDS IAWLKQFPNL LITRTFSKAY GMAGVRVGFG 250 260 270 280 290 300 LGHPDVAGLM NRVRQPFNVN NIGLAGAVAA LQDEEFVKRS YALNQAGMLQ IVTGLRQMGI 310 320 330 340 350 360 EYIPSYGNFL SFRVPGNVKA INESLLKQGV IVRPISIYEM PEHLRVTVGL ESENEKFLKS 370 380 390 LAIALETTEG AAADTIPEMA VSFPKVASGG TA

References

[1]

"Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000103 Genomic DNA. Translation: ABB75485.1.
RefSeq	YP_412877.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2Y6Y6.
Genome annotation databases
GeneID	3786218.
GenomeReviews	Gene locus Nmul_A2193 in contig CP000103_GR.
KEGG	nmu:Nmul_A2193.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2Y6Y6.
OMA	PLGMPKS.
Enzyme and pathway databases
BioCyc	NMUL323848:NMUL_A2193-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS82_NITMU

Accession

Primary (citable) accession number: Q2Y6Y6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	December 20, 2005
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)