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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciNMUL323848:G1GTI-2376-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Nmul_A2286
OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Taxonomic identifieri323848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
Proteomesi
  • UP000002718 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalUniRule annotationAdd BLAST21
Transmembranei43 – 63HelicalUniRule annotationAdd BLAST21
Transmembranei83 – 103HelicalUniRule annotationAdd BLAST21
Transmembranei109 – 129HelicalUniRule annotationAdd BLAST21
Transmembranei184 – 204HelicalUniRule annotationAdd BLAST21
Transmembranei218 – 238HelicalUniRule annotationAdd BLAST21
Transmembranei248 – 268HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002502471 – 273Undecaprenyl-diphosphataseAdd BLAST273

Interactioni

Protein-protein interaction databases

STRINGi323848.Nmul_A2286

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OMAiPDARMGW
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2Y6P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWFLLLKGL ILGIVEGLTE FLPISSTGHL ILVSDLLNFN DEKGKVFTIV
60 70 80 90 100
IQLGAILAVC WEYRVKLRHV VTDIGSRQDA NRFVLNLLIA FLPAAILGLL
110 120 130 140 150
FIKTIKQYLF HPVPVALAFI VGGLLILWAE RRPHVVDVER VEDMDWKHAL
160 170 180 190 200
KVGLAQCLAL IPGTSRSGAT IIGGLFFGLS RKAATEFSFF LAIPVMFAAT
210 220 230 240 250
FYDLYKNRDI LHLDDASVFA IGFVASFISA LLAVRGLLRF VSQHDFSVFA
260 270
WYRIGFGIIV LITAYSGMVQ WSG
Length:273
Mass (Da):30,347
Last modified:December 20, 2005 - v1
Checksum:i8569162372D747DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA Translation: ABB75578.1
RefSeqiWP_011381584.1, NZ_FNVK01000006.1

Genome annotation databases

EnsemblBacteriaiABB75578; ABB75578; Nmul_A2286
KEGGinmu:Nmul_A2286

Similar proteinsi

Entry informationi

Entry nameiUPPP_NITMU
AccessioniPrimary (citable) accession number: Q2Y6P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: December 20, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health