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Q2Y6J1 (CLPX_NITMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene names
Name:clpX
Ordered Locus Names:Nmul_A2339
OrganismNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849) [Complete proteome] [HAMAP]
Taxonomic identifier323848 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175

Subunit structure

Heterodimer of ClpP and ClpX By similarity. HAMAP-Rule MF_00175

Sequence similarities

Belongs to the ClpX chaperone family.

Ontologies

Keywords
   DomainZinc-finger
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175
PRO_1000024599

Regions

Zinc finger13 – 3826C4-type HAMAP-Rule MF_00175
Nucleotide binding121 – 1288ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q2Y6J1 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 35ADD6CCEA3B09D5

FASTA42546,682
        10         20         30         40         50         60 
MSEKTGGEKL LYCSFCGKSQ HEVKKLIAGP SVFICDECIE LCNDIIREEI QGVEAAKLAK 

        70         80         90        100        110        120 
SDLPVPHEIR QILDQYVIGQ EQAKKILSVA VYNHYKRLRT LAKSADPDEI ELAKSNILLI 

       130        140        150        160        170        180 
GPTGSGKTLL AQTLARLLDV PFVMADATTL TEAGYVGEDV ENIIQKLLQK CNYDAEKAQQ 

       190        200        210        220        230        240 
GIVYIDEIDK ISRKSDNPSI TRDVSGEGVQ QALLKLIEGT VASVPPQGGR KHPNQEFVQV 

       250        260        270        280        290        300 
DTTNILFICG GAFDGLEKII RARSEKGGIG FSASVRSQDN RKDFGAVLRG VEPEDLVKYG 

       310        320        330        340        350        360 
LIPEFVGRLP VVATLEELDE AALIQILTEP RNALIKQYQK MFHMEGGIDL EFREQALKAI 

       370        380        390        400        410        420 
ARKALVRKTG ARGLRSILEA ALLDTMFDLP SLENVAKVVI DHTSVNGDIK PILIYSDKPK 


VAKSC 

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References

[1]"Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25196 / NCIMB 11849.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000103 Genomic DNA. Translation: ABB75630.1.
RefSeqYP_413022.1. NC_007614.1.

3D structure databases

ProteinModelPortalQ2Y6J1.
SMRQ2Y6J1. Positions 9-50.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING323848.Nmul_A2339.

Proteomic databases

PRIDEQ2Y6J1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB75630; ABB75630; Nmul_A2339.
GeneID3784742.
KEGGnmu:Nmul_A2339.
PATRIC22728334. VBINitMul110821_2718.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1219.
HOGENOMHOG000010093.
KOK03544.
OMALDTMFDL.
OrthoDBEOG625JZK.
ProtClustDBPRK05342.

Enzyme and pathway databases

BioCycNMUL323848:GKEC-2382-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00175. ClpX.
InterProIPR003593. AAA+_ATPase.
IPR013093. ATPase_AAA-2.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00382. clpX. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCLPX_NITMU
AccessionPrimary (citable) accession number: Q2Y6J1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families