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Q2Y6J1

- CLPX_NITMU

UniProt

Q2Y6J1 - CLPX_NITMU

Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri13 – 3826C4-typeUniRule annotationAdd
    BLAST
    Nucleotide bindingi122 – 1298ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. nucleoside-triphosphatase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein folding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciNMUL323848:GKEC-2382-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
    Gene namesi
    Name:clpXUniRule annotation
    Ordered Locus Names:Nmul_A2339
    OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
    Taxonomic identifieri323848 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
    ProteomesiUP000002718: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425ATP-dependent Clp protease ATP-binding subunit ClpXPRO_1000024599Add
    BLAST

    Proteomic databases

    PRIDEiQ2Y6J1.

    Interactioni

    Subunit structurei

    Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    STRINGi323848.Nmul_A2339.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2Y6J1.
    SMRiQ2Y6J1. Positions 9-50.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ClpX chaperone family.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri13 – 3826C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1219.
    HOGENOMiHOG000010093.
    KOiK03544.
    OMAiILLDIMY.
    OrthoDBiEOG625JZK.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00175. ClpX.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view]
    PfamiPF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00382. clpX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2Y6J1-1 [UniParc]FASTAAdd to Basket

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    MSEKTGGEKL LYCSFCGKSQ HEVKKLIAGP SVFICDECIE LCNDIIREEI    50
    QGVEAAKLAK SDLPVPHEIR QILDQYVIGQ EQAKKILSVA VYNHYKRLRT 100
    LAKSADPDEI ELAKSNILLI GPTGSGKTLL AQTLARLLDV PFVMADATTL 150
    TEAGYVGEDV ENIIQKLLQK CNYDAEKAQQ GIVYIDEIDK ISRKSDNPSI 200
    TRDVSGEGVQ QALLKLIEGT VASVPPQGGR KHPNQEFVQV DTTNILFICG 250
    GAFDGLEKII RARSEKGGIG FSASVRSQDN RKDFGAVLRG VEPEDLVKYG 300
    LIPEFVGRLP VVATLEELDE AALIQILTEP RNALIKQYQK MFHMEGGIDL 350
    EFREQALKAI ARKALVRKTG ARGLRSILEA ALLDTMFDLP SLENVAKVVI 400
    DHTSVNGDIK PILIYSDKPK VAKSC 425
    Length:425
    Mass (Da):46,682
    Last modified:December 20, 2005 - v1
    Checksum:i35ADD6CCEA3B09D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000103 Genomic DNA. Translation: ABB75630.1.
    RefSeqiYP_413022.1. NC_007614.1.

    Genome annotation databases

    EnsemblBacteriaiABB75630; ABB75630; Nmul_A2339.
    GeneIDi3784742.
    KEGGinmu:Nmul_A2339.
    PATRICi22728334. VBINitMul110821_2718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000103 Genomic DNA. Translation: ABB75630.1 .
    RefSeqi YP_413022.1. NC_007614.1.

    3D structure databases

    ProteinModelPortali Q2Y6J1.
    SMRi Q2Y6J1. Positions 9-50.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323848.Nmul_A2339.

    Proteomic databases

    PRIDEi Q2Y6J1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB75630 ; ABB75630 ; Nmul_A2339 .
    GeneIDi 3784742.
    KEGGi nmu:Nmul_A2339.
    PATRICi 22728334. VBINitMul110821_2718.

    Phylogenomic databases

    eggNOGi COG1219.
    HOGENOMi HOG000010093.
    KOi K03544.
    OMAi ILLDIMY.
    OrthoDBi EOG625JZK.

    Enzyme and pathway databases

    BioCyci NMUL323848:GKEC-2382-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00175. ClpX.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view ]
    Pfami PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00382. clpX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25196 / NCIMB 11849.

    Entry informationi

    Entry nameiCLPX_NITMU
    AccessioniPrimary (citable) accession number: Q2Y6J1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3