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Q2Y6J1

- CLPX_NITMU

UniProt

Q2Y6J1 - CLPX_NITMU

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Protein
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene
clpX, Nmul_A2339
Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri13 – 3826C4-typeUniRule annotation
Add
BLAST
Nucleotide bindingi122 – 1298ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. nucleoside-triphosphatase activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein folding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciNMUL323848:GKEC-2382-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene namesi
Name:clpX
Ordered Locus Names:Nmul_A2339
OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
Taxonomic identifieri323848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
ProteomesiUP000002718: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
PRO_1000024599Add
BLAST

Proteomic databases

PRIDEiQ2Y6J1.

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes By similarity.

Protein-protein interaction databases

STRINGi323848.Nmul_A2339.

Structurei

3D structure databases

ProteinModelPortaliQ2Y6J1.
SMRiQ2Y6J1. Positions 9-50.

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1219.
HOGENOMiHOG000010093.
KOiK03544.
OMAiILLDIMY.
OrthoDBiEOG625JZK.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00175. ClpX.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamiPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00382. clpX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2Y6J1-1 [UniParc]FASTAAdd to Basket

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MSEKTGGEKL LYCSFCGKSQ HEVKKLIAGP SVFICDECIE LCNDIIREEI    50
QGVEAAKLAK SDLPVPHEIR QILDQYVIGQ EQAKKILSVA VYNHYKRLRT 100
LAKSADPDEI ELAKSNILLI GPTGSGKTLL AQTLARLLDV PFVMADATTL 150
TEAGYVGEDV ENIIQKLLQK CNYDAEKAQQ GIVYIDEIDK ISRKSDNPSI 200
TRDVSGEGVQ QALLKLIEGT VASVPPQGGR KHPNQEFVQV DTTNILFICG 250
GAFDGLEKII RARSEKGGIG FSASVRSQDN RKDFGAVLRG VEPEDLVKYG 300
LIPEFVGRLP VVATLEELDE AALIQILTEP RNALIKQYQK MFHMEGGIDL 350
EFREQALKAI ARKALVRKTG ARGLRSILEA ALLDTMFDLP SLENVAKVVI 400
DHTSVNGDIK PILIYSDKPK VAKSC 425
Length:425
Mass (Da):46,682
Last modified:December 20, 2005 - v1
Checksum:i35ADD6CCEA3B09D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000103 Genomic DNA. Translation: ABB75630.1.
RefSeqiYP_413022.1. NC_007614.1.

Genome annotation databases

EnsemblBacteriaiABB75630; ABB75630; Nmul_A2339.
GeneIDi3784742.
KEGGinmu:Nmul_A2339.
PATRICi22728334. VBINitMul110821_2718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000103 Genomic DNA. Translation: ABB75630.1 .
RefSeqi YP_413022.1. NC_007614.1.

3D structure databases

ProteinModelPortali Q2Y6J1.
SMRi Q2Y6J1. Positions 9-50.
ModBasei Search...

Protein-protein interaction databases

STRINGi 323848.Nmul_A2339.

Proteomic databases

PRIDEi Q2Y6J1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB75630 ; ABB75630 ; Nmul_A2339 .
GeneIDi 3784742.
KEGGi nmu:Nmul_A2339.
PATRICi 22728334. VBINitMul110821_2718.

Phylogenomic databases

eggNOGi COG1219.
HOGENOMi HOG000010093.
KOi K03544.
OMAi ILLDIMY.
OrthoDBi EOG625JZK.

Enzyme and pathway databases

BioCyci NMUL323848:GKEC-2382-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00175. ClpX.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view ]
Pfami PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00382. clpX. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25196 / NCIMB 11849.

Entry informationi

Entry nameiCLPX_NITMU
AccessioniPrimary (citable) accession number: Q2Y6J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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