Q2Y5S2 (UBIC_NITMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable chorismate--pyruvate lyase
Short name=CL
Short name=CPL
EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	Nmul_A2612

Organism

Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849) [Complete proteome] [HAMAP]

Taxonomic identifier

323848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Nitrosomonadaceae › Nitrosospira

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	Probable chorismate--pyruvate lyase HAMAP MF_01632		PRO_0000255910
Sites
	Binding site	73	1	Substrate By similarity
	Binding site	111	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2Y5S2 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 12CDEBF4927540ED	FASTA	180	20,246
	10 20 30 40 50 60 MNAAQLSDWH PAPSSISPRA RGWLQNRGSL TQLIQRRCCS EFSVKPVFQS LATVCDDELA 70 80 90 100 110 120 VMNLRRDELA LVREVYLYCG ETPVVFAHSV VARKHLRGAW RSLIGLGNKS LGTVLFTNPV 130 140 150 160 170 180 VKRTPLRFKK LTAAHPLFSR ACRKLRVQPG NLWARRSLFT LHGQSILVTE VFLPSILELA

References

[1]

"Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25196 / NCIMB 11849.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000103 Genomic DNA. Translation: ABB75899.1.
RefSeq	YP_413291.1. NC_007614.1.
3D structure databases
ProteinModelPortal	Q2Y5S2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2Y5S2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3786241.
GenomeReviews	Gene locus Nmul_A2612 in contig CP000103_GR.
KEGG	nmu:Nmul_A2612.
PATRIC	22728970. VBINitMul110821_3033.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3161.
HOGENOM	HBG644467.
OMA	PVVFAHS.
ProtClustDB	CLSK585969.
Enzyme and pathway databases
BioCyc	NMUL323848:NMUL_A2612-MONOMER.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
KO	K03181.
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_NITMU

Accession

Primary (citable) accession number: Q2Y5S2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	December 20, 2005
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program