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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNMUL323848:G1GTI-2716-MONOMER
UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Nmul_A2617
OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Taxonomic identifieri323848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
Proteomesi
  • UP000002718 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002583751 – 352Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST352

Interactioni

Protein-protein interaction databases

STRINGi323848.Nmul_A2617

Structurei

3D structure databases

ProteinModelPortaliQ2Y5R7
SMRiQ2Y5R7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
HOGENOMiHOG000229090
KOiK01933
OrthoDBiPOG091H0128

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

Q2Y5R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSKPHEEN LSPLSYRAAG VDIDAGERLV ENIRPYAKRT LRPEVLAGIG
60 70 80 90 100
GFGALFEISR KFNNPVLVAG TDGVGTKLKL AFESGRHDTV GIDLVAMSVN
110 120 130 140 150
DILVQGAEPL FFLDYFACGK LDVDTATLVV KGIAAGCEQA GCALIGGETA
160 170 180 190 200
EMPGMYPEGE YDLAGFAVGA VEKDRIITGT TIKAGDAVLG LASSGAHSNG
210 220 230 240 250
YSLIRKIIEK NNVDLSADFH GRALIDVIMA PTRIYVKPLL ELMRQVPVKG
260 270 280 290 300
MAHITGGGLL ENIPRILPEG VTAVLKKETW EMPPLFAWLQ REGNVADNEM
310 320 330 340 350
HRVFNCGIGM AVVVAPEYID AAAQLLQSKG EIAWRIGTIR EQRADEPRTI

LE
Length:352
Mass (Da):37,841
Last modified:October 31, 2006 - v2
Checksum:i9DDA3FC809C4DAFB
GO

Sequence cautioni

The sequence ABB75904 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA Translation: ABB75904.1 Different initiation.
RefSeqiWP_041352649.1, NZ_FNVK01000020.1

Genome annotation databases

EnsemblBacteriaiABB75904; ABB75904; Nmul_A2617
KEGGinmu:Nmul_A2617

Similar proteinsi

Entry informationi

Entry nameiPUR5_NITMU
AccessioniPrimary (citable) accession number: Q2Y5R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: May 23, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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