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Q2XV99 (CP11A_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cholesterol side-chain cleavage enzyme, mitochondrial

EC=1.14.15.6
Alternative name(s):
CYPXIA1
Cholesterol desmolase
Cytochrome P450 11A1
Cytochrome P450(scc)
Gene names
Name:CYP11A1
Synonyms:CYP11A
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone By similarity.

Catalytic activity

Cholesterol + 6 reduced adrenodoxin + 3 O2 = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.

Cofactor

Heme group By similarity.

Pathway

Lipid metabolism; C21-steroid hormone metabolism.

Subunit structure

Interacts with FDX1/adrenodoxin By similarity.

Subcellular location

Mitochondrion membrane By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion By similarity
Chain40 – 521482Cholesterol side-chain cleavage enzyme, mitochondrial
PRO_0000045764

Sites

Metal binding4621Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2XV99 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 91B747E6AC00BA20

FASTA52160,242
        10         20         30         40         50         60 
MLAKGLPPRS VLVKGCQTFL SAPKERLGHL RVPTSEGAGI STRSPRPFNE IPSPGDNGWL 

        70         80         90        100        110        120 
NLYHFWRETG THKVHLHHVQ NFQKYDPIYR EKLGNVESVY VIDPEDVALL FKSEGPNPER 

       130        140        150        160        170        180 
FLIPPWVAYH QYYQRPIGVL LKKSAAWKKD RVALNQEVMA PETTKNFLPL LDAVSRDFVS 

       190        200        210        220        230        240 
VLHRRIKKAG SGNFSGDISD DLFRFAFESI TNVIFGERQG MLEEVVNPEG QRFIDAIYQM 

       250        260        270        280        290        300 
FHTSVHMLNL PPDLFRLFRT KTWKDHVAPR DVIFSKADMY TENFHWELRQ KGNVHHDYRG 

       310        320        330        340        350        360 
ILYRLLGDSK MSFEDIKANV TEMLAGGVDT TSMTLQWHLY EMARNLKVQD MLRAEVLAAR 

       370        380        390        400        410        420 
RQAQGDMATI LQLVPLLKAS IKETLRLHPI SVTLQRYLVN DLVLRGYMIP AKTLVQVAIY 

       430        440        450        460        470        480 
ALGREPTFFF DPENFDPTRW LSKDKNITYF RNLGFGWGVR QCLGRRIAEL EMTIFLINML 

       490        500        510        520 
ENFRVEIQHL SDVGTTFNLI LMPEKPISFT FWPFNQEATQ E 

« Hide

References

[1]Liu H., Larbie F., Luu-The V.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ228169 mRNA. Translation: ABB76810.1.
RefSeqNP_001271838.1. NM_001284909.1.
UniGeneMfa.5360.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102120640.
KEGGmcf:102120640.

Organism-specific databases

CTD100313513.

Phylogenomic databases

HOVERGENHBG051098.
KOK00498.

Enzyme and pathway databases

UniPathwayUPA00229.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP11A_MACFA
AccessionPrimary (citable) accession number: Q2XV99
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 20, 2005
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways