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Q2XU92 (ACBG2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2

EC=6.2.1.3
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Bubblegum-related protein
Gene names
Name:Acsbg2
Synonyms:Bgr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length667 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Subcellular location

Cytoplasm. Membrane; Peripheral membrane protein.

Tissue specificity

Testis- and brainstem-specific. Expressed in pubertal and adult testis. Enriched in germ cells and Sertoli cells while present at a lower level in Leydig cells. Present in testicular Sertoli cells and large motoneurons in the medulla oblongata and cervical spinal cord (at protein level). Ref.1 Ref.2

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 667667Long-chain-fatty-acid--CoA ligase ACSBG2
PRO_0000315813

Regions

Nucleotide binding227 – 2359ATP By similarity
Nucleotide binding418 – 4236ATP By similarity

Sites

Binding site4961ATP By similarity
Binding site5111ATP By similarity
Binding site6241ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2XU92 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 70E1D0EC8AC4726F

FASTA66774,319
        10         20         30         40         50         60 
MTQEKKAEDL ERGTDATSAV PRLWSTHCDG EVLLRLSKHG PGHETPMTIP ELFQESAERF 

        70         80         90        100        110        120 
SAYPALASKN GKKWDTLTFS QYYEMCRKAA KSLIKLGLQR FQCVGILGFN SVEWVVTALG 

       130        140        150        160        170        180 
TILAGGLCVG IYATNSAEAC QYVIQQANVS ILIVENDQQL QKILLIPPDK METVKAIVQY 

       190        200        210        220        230        240 
KLPLMESMAN LYSWNDFMEL GNDIPNIQLD RVILSQKANQ CAVILYTSGT TGTPKGVLLS 

       250        260        270        280        290        300 
HDNITWTAGA MSQEMEINRV SGKQNTIVSY LPLSHIAAQL TDIWIPIKIG ALTFFAQPDA 

       310        320        330        340        350        360 
LRGTLVYTLQ EVKPTLFMGV PRIWEKMQDT IKENVARSSR LRKKAFAWAK MLGLKVNTKR 

       370        380        390        400        410        420 
MLGKRDIPMN YRMAKALVFA KVRTSLGLDN CHAFFSSASP LSQDVSEFFL SLDIPIGEIY 

       430        440        450        460        470        480 
GMSECSGPHT VSNKSVYRVL SCGKVLSGCK NMLYNQNKEG VGEVCMWGRH VFMGYLNKEE 

       490        500        510        520        530        540 
ATLEALDENG WLHSGDIGRL DSHDFLYITG RIKEILITAG GENVSPIPIE TLVKEKIPII 

       550        560        570        580        590        600 
SHAMLVGDKA KFLCMLLTLK CETDRKSGEP LNKLSVEAKS FCQMLGSQAT TVSDILKSRD 

       610        620        630        640        650        660 
QVVYTAIQYG IDIVNQQAMS DSHRIRKWII LEKDFSIQGG ELGPTSKLKR SVITQKYKAQ 


IDSMYLS 

« Hide

References

[1]"The second member of the human and murine 'bubblegum' family is a testis-and brainstem-specific acyl-CoA synthetase."
Pei Z., Jia Z., Watkins P.A.
J. Biol. Chem. 281:6632-6641(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: 129/SvEv.
[2]"A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis."
Fraisl P., Tanaka H., Forss-Petter S., Lassmann H., Nishimune Y., Berger J.
Arch. Biochem. Biophys. 451:23-33(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ250679 mRNA. Translation: ABB54488.1.
CCDSCCDS28916.1.
RefSeqNP_001034203.1. NM_001039114.1.
UniGeneMm.179421.

3D structure databases

ProteinModelPortalQ2XU92.
SMRQ2XU92. Positions 38-633.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ2XU92.

Proteomic databases

PRIDEQ2XU92.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043062; ENSMUSP00000042352; ENSMUSG00000024207.
GeneID328845.
KEGGmmu:328845.
UCSCuc008ddi.1. mouse.

Organism-specific databases

CTD81616.
MGIMGI:3587728. Acsbg2.

Phylogenomic databases

eggNOGCOG1022.
GeneTreeENSGT00690000101725.
HOGENOMHOG000230004.
HOVERGENHBG054660.
InParanoidQ2XU92.
KOK15013.
OMAQMYTKKK.
OrthoDBEOG7B5WVB.
PhylomeDBQ2XU92.
TreeFamTF354286.

Gene expression databases

BgeeQ2XU92.
CleanExMM_ACSBG2.
GenevestigatorQ2XU92.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio398481.
PROQ2XU92.
SOURCESearch...

Entry information

Entry nameACBG2_MOUSE
AccessionPrimary (citable) accession number: Q2XU92
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot