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Q2XU92

- ACBG2_MOUSE

UniProt

Q2XU92 - ACBG2_MOUSE

Protein

Long-chain-fatty-acid--CoA ligase ACSBG2

Gene

Acsbg2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis By similarity.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei496 – 4961ATPBy similarity
    Binding sitei511 – 5111ATPBy similarity
    Binding sitei624 – 6241ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi227 – 2359ATPBy similarity
    Nucleotide bindingi418 – 4236ATPBy similarity

    GO - Molecular functioni

    1. acyl-CoA hydrolase activity Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. long-chain fatty acid-CoA ligase activity Source: MGI

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. fatty acid beta-oxidation Source: MGI
    3. fatty acid metabolic process Source: MGI
    4. multicellular organismal development Source: UniProtKB-KW
    5. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Ligase

    Keywords - Biological processi

    Differentiation, Fatty acid metabolism, Lipid metabolism, Spermatogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
    Alternative name(s):
    Acyl-CoA synthetase bubblegum family member 2
    Bubblegum-related protein
    Gene namesi
    Name:Acsbg2
    Synonyms:Bgr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:3587728. Acsbg2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. membrane Source: UniProtKB-SubCell
    4. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 667667Long-chain-fatty-acid--CoA ligase ACSBG2PRO_0000315813Add
    BLAST

    Proteomic databases

    PRIDEiQ2XU92.

    PTM databases

    PhosphoSiteiQ2XU92.

    Expressioni

    Tissue specificityi

    Testis- and brainstem-specific. Expressed in pubertal and adult testis. Enriched in germ cells and Sertoli cells while present at a lower level in Leydig cells. Present in testicular Sertoli cells and large motoneurons in the medulla oblongata and cervical spinal cord (at protein level).2 Publications

    Gene expression databases

    BgeeiQ2XU92.
    CleanExiMM_ACSBG2.
    GenevestigatoriQ2XU92.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2XU92.
    SMRiQ2XU92. Positions 38-633.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1022.
    GeneTreeiENSGT00690000101725.
    HOGENOMiHOG000230004.
    HOVERGENiHBG054660.
    InParanoidiQ2XU92.
    KOiK15013.
    OMAiQMYTKKK.
    OrthoDBiEOG7B5WVB.
    PhylomeDBiQ2XU92.
    TreeFamiTF354286.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2XU92-1 [UniParc]FASTAAdd to Basket

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    MTQEKKAEDL ERGTDATSAV PRLWSTHCDG EVLLRLSKHG PGHETPMTIP    50
    ELFQESAERF SAYPALASKN GKKWDTLTFS QYYEMCRKAA KSLIKLGLQR 100
    FQCVGILGFN SVEWVVTALG TILAGGLCVG IYATNSAEAC QYVIQQANVS 150
    ILIVENDQQL QKILLIPPDK METVKAIVQY KLPLMESMAN LYSWNDFMEL 200
    GNDIPNIQLD RVILSQKANQ CAVILYTSGT TGTPKGVLLS HDNITWTAGA 250
    MSQEMEINRV SGKQNTIVSY LPLSHIAAQL TDIWIPIKIG ALTFFAQPDA 300
    LRGTLVYTLQ EVKPTLFMGV PRIWEKMQDT IKENVARSSR LRKKAFAWAK 350
    MLGLKVNTKR MLGKRDIPMN YRMAKALVFA KVRTSLGLDN CHAFFSSASP 400
    LSQDVSEFFL SLDIPIGEIY GMSECSGPHT VSNKSVYRVL SCGKVLSGCK 450
    NMLYNQNKEG VGEVCMWGRH VFMGYLNKEE ATLEALDENG WLHSGDIGRL 500
    DSHDFLYITG RIKEILITAG GENVSPIPIE TLVKEKIPII SHAMLVGDKA 550
    KFLCMLLTLK CETDRKSGEP LNKLSVEAKS FCQMLGSQAT TVSDILKSRD 600
    QVVYTAIQYG IDIVNQQAMS DSHRIRKWII LEKDFSIQGG ELGPTSKLKR 650
    SVITQKYKAQ IDSMYLS 667
    Length:667
    Mass (Da):74,319
    Last modified:December 20, 2005 - v1
    Checksum:i70E1D0EC8AC4726F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ250679 mRNA. Translation: ABB54488.1.
    CCDSiCCDS28916.1.
    RefSeqiNP_001034203.1. NM_001039114.1.
    UniGeneiMm.179421.

    Genome annotation databases

    EnsembliENSMUST00000043062; ENSMUSP00000042352; ENSMUSG00000024207.
    GeneIDi328845.
    KEGGimmu:328845.
    UCSCiuc008ddi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ250679 mRNA. Translation: ABB54488.1 .
    CCDSi CCDS28916.1.
    RefSeqi NP_001034203.1. NM_001039114.1.
    UniGenei Mm.179421.

    3D structure databases

    ProteinModelPortali Q2XU92.
    SMRi Q2XU92. Positions 38-633.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q2XU92.

    Proteomic databases

    PRIDEi Q2XU92.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043062 ; ENSMUSP00000042352 ; ENSMUSG00000024207 .
    GeneIDi 328845.
    KEGGi mmu:328845.
    UCSCi uc008ddi.1. mouse.

    Organism-specific databases

    CTDi 81616.
    MGIi MGI:3587728. Acsbg2.

    Phylogenomic databases

    eggNOGi COG1022.
    GeneTreei ENSGT00690000101725.
    HOGENOMi HOG000230004.
    HOVERGENi HBG054660.
    InParanoidi Q2XU92.
    KOi K15013.
    OMAi QMYTKKK.
    OrthoDBi EOG7B5WVB.
    PhylomeDBi Q2XU92.
    TreeFami TF354286.

    Miscellaneous databases

    NextBioi 398481.
    PROi Q2XU92.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q2XU92.
    CleanExi MM_ACSBG2.
    Genevestigatori Q2XU92.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The second member of the human and murine 'bubblegum' family is a testis-and brainstem-specific acyl-CoA synthetase."
      Pei Z., Jia Z., Watkins P.A.
      J. Biol. Chem. 281:6632-6641(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: 129/SvEv.
    2. "A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis."
      Fraisl P., Tanaka H., Forss-Petter S., Lassmann H., Nishimune Y., Berger J.
      Arch. Biochem. Biophys. 451:23-33(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiACBG2_MOUSE
    AccessioniPrimary (citable) accession number: Q2XU92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3