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Q2XU92

- ACBG2_MOUSE

UniProt

Q2XU92 - ACBG2_MOUSE

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Protein
Long-chain-fatty-acid--CoA ligase ACSBG2
Gene
Acsbg2, Bgr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis By similarity.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei496 – 4961ATP By similarity
Binding sitei511 – 5111ATP By similarity
Binding sitei624 – 6241ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi227 – 2359ATP By similarity
Nucleotide bindingi418 – 4236ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acyl-CoA hydrolase activity Source: Ensembl
  3. long-chain fatty acid-CoA ligase activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. fatty acid beta-oxidation Source: MGI
  3. fatty acid metabolic process Source: MGI
  4. multicellular organismal development Source: UniProtKB-KW
  5. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ligase

Keywords - Biological processi

Differentiation, Fatty acid metabolism, Lipid metabolism, Spermatogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Bubblegum-related protein
Gene namesi
Name:Acsbg2
Synonyms:Bgr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:3587728. Acsbg2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. membrane Source: UniProtKB-SubCell
  4. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 667667Long-chain-fatty-acid--CoA ligase ACSBG2
PRO_0000315813Add
BLAST

Proteomic databases

PRIDEiQ2XU92.

PTM databases

PhosphoSiteiQ2XU92.

Expressioni

Tissue specificityi

Testis- and brainstem-specific. Expressed in pubertal and adult testis. Enriched in germ cells and Sertoli cells while present at a lower level in Leydig cells. Present in testicular Sertoli cells and large motoneurons in the medulla oblongata and cervical spinal cord (at protein level).2 Publications

Gene expression databases

BgeeiQ2XU92.
CleanExiMM_ACSBG2.
GenevestigatoriQ2XU92.

Structurei

3D structure databases

ProteinModelPortaliQ2XU92.
SMRiQ2XU92. Positions 38-633.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ2XU92.
KOiK15013.
OMAiQMYTKKK.
OrthoDBiEOG7B5WVB.
PhylomeDBiQ2XU92.
TreeFamiTF354286.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2XU92-1 [UniParc]FASTAAdd to Basket

« Hide

MTQEKKAEDL ERGTDATSAV PRLWSTHCDG EVLLRLSKHG PGHETPMTIP    50
ELFQESAERF SAYPALASKN GKKWDTLTFS QYYEMCRKAA KSLIKLGLQR 100
FQCVGILGFN SVEWVVTALG TILAGGLCVG IYATNSAEAC QYVIQQANVS 150
ILIVENDQQL QKILLIPPDK METVKAIVQY KLPLMESMAN LYSWNDFMEL 200
GNDIPNIQLD RVILSQKANQ CAVILYTSGT TGTPKGVLLS HDNITWTAGA 250
MSQEMEINRV SGKQNTIVSY LPLSHIAAQL TDIWIPIKIG ALTFFAQPDA 300
LRGTLVYTLQ EVKPTLFMGV PRIWEKMQDT IKENVARSSR LRKKAFAWAK 350
MLGLKVNTKR MLGKRDIPMN YRMAKALVFA KVRTSLGLDN CHAFFSSASP 400
LSQDVSEFFL SLDIPIGEIY GMSECSGPHT VSNKSVYRVL SCGKVLSGCK 450
NMLYNQNKEG VGEVCMWGRH VFMGYLNKEE ATLEALDENG WLHSGDIGRL 500
DSHDFLYITG RIKEILITAG GENVSPIPIE TLVKEKIPII SHAMLVGDKA 550
KFLCMLLTLK CETDRKSGEP LNKLSVEAKS FCQMLGSQAT TVSDILKSRD 600
QVVYTAIQYG IDIVNQQAMS DSHRIRKWII LEKDFSIQGG ELGPTSKLKR 650
SVITQKYKAQ IDSMYLS 667
Length:667
Mass (Da):74,319
Last modified:December 20, 2005 - v1
Checksum:i70E1D0EC8AC4726F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ250679 mRNA. Translation: ABB54488.1.
CCDSiCCDS28916.1.
RefSeqiNP_001034203.1. NM_001039114.1.
UniGeneiMm.179421.

Genome annotation databases

EnsembliENSMUST00000043062; ENSMUSP00000042352; ENSMUSG00000024207.
GeneIDi328845.
KEGGimmu:328845.
UCSCiuc008ddi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ250679 mRNA. Translation: ABB54488.1 .
CCDSi CCDS28916.1.
RefSeqi NP_001034203.1. NM_001039114.1.
UniGenei Mm.179421.

3D structure databases

ProteinModelPortali Q2XU92.
SMRi Q2XU92. Positions 38-633.
ModBasei Search...

PTM databases

PhosphoSitei Q2XU92.

Proteomic databases

PRIDEi Q2XU92.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043062 ; ENSMUSP00000042352 ; ENSMUSG00000024207 .
GeneIDi 328845.
KEGGi mmu:328845.
UCSCi uc008ddi.1. mouse.

Organism-specific databases

CTDi 81616.
MGIi MGI:3587728. Acsbg2.

Phylogenomic databases

eggNOGi COG1022.
GeneTreei ENSGT00690000101725.
HOGENOMi HOG000230004.
HOVERGENi HBG054660.
InParanoidi Q2XU92.
KOi K15013.
OMAi QMYTKKK.
OrthoDBi EOG7B5WVB.
PhylomeDBi Q2XU92.
TreeFami TF354286.

Miscellaneous databases

NextBioi 398481.
PROi Q2XU92.
SOURCEi Search...

Gene expression databases

Bgeei Q2XU92.
CleanExi MM_ACSBG2.
Genevestigatori Q2XU92.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The second member of the human and murine 'bubblegum' family is a testis-and brainstem-specific acyl-CoA synthetase."
    Pei Z., Jia Z., Watkins P.A.
    J. Biol. Chem. 281:6632-6641(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: 129/SvEv.
  2. "A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis."
    Fraisl P., Tanaka H., Forss-Petter S., Lassmann H., Nishimune Y., Berger J.
    Arch. Biochem. Biophys. 451:23-33(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiACBG2_MOUSE
AccessioniPrimary (citable) accession number: Q2XU92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi