Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2XU92

- ACBG2_MOUSE

UniProt

Q2XU92 - ACBG2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Long-chain-fatty-acid--CoA ligase ACSBG2

Gene

Acsbg2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis (By similarity).By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei496 – 4961ATPBy similarity
Binding sitei511 – 5111ATPBy similarity
Binding sitei624 – 6241ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi227 – 2359ATPBy similarity
Nucleotide bindingi418 – 4236ATPBy similarity

GO - Molecular functioni

  1. acyl-CoA hydrolase activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. long-chain fatty acid-CoA ligase activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. fatty acid beta-oxidation Source: MGI
  3. fatty acid metabolic process Source: MGI
  4. long-chain fatty acid metabolic process Source: GOC
  5. multicellular organismal development Source: UniProtKB-KW
  6. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ligase

Keywords - Biological processi

Differentiation, Fatty acid metabolism, Lipid metabolism, Spermatogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Bubblegum-related protein
Gene namesi
Name:Acsbg2
Synonyms:Bgr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:3587728. Acsbg2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. membrane Source: UniProtKB-KW
  4. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 667667Long-chain-fatty-acid--CoA ligase ACSBG2PRO_0000315813Add
BLAST

Proteomic databases

PRIDEiQ2XU92.

PTM databases

PhosphoSiteiQ2XU92.

Expressioni

Tissue specificityi

Testis- and brainstem-specific. Expressed in pubertal and adult testis. Enriched in germ cells and Sertoli cells while present at a lower level in Leydig cells. Present in testicular Sertoli cells and large motoneurons in the medulla oblongata and cervical spinal cord (at protein level).2 Publications

Gene expression databases

BgeeiQ2XU92.
CleanExiMM_ACSBG2.
GenevestigatoriQ2XU92.

Structurei

3D structure databases

ProteinModelPortaliQ2XU92.
SMRiQ2XU92. Positions 38-633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ2XU92.
KOiK15013.
OMAiQMYTKKK.
OrthoDBiEOG7B5WVB.
PhylomeDBiQ2XU92.
TreeFamiTF354286.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2XU92-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQEKKAEDL ERGTDATSAV PRLWSTHCDG EVLLRLSKHG PGHETPMTIP
60 70 80 90 100
ELFQESAERF SAYPALASKN GKKWDTLTFS QYYEMCRKAA KSLIKLGLQR
110 120 130 140 150
FQCVGILGFN SVEWVVTALG TILAGGLCVG IYATNSAEAC QYVIQQANVS
160 170 180 190 200
ILIVENDQQL QKILLIPPDK METVKAIVQY KLPLMESMAN LYSWNDFMEL
210 220 230 240 250
GNDIPNIQLD RVILSQKANQ CAVILYTSGT TGTPKGVLLS HDNITWTAGA
260 270 280 290 300
MSQEMEINRV SGKQNTIVSY LPLSHIAAQL TDIWIPIKIG ALTFFAQPDA
310 320 330 340 350
LRGTLVYTLQ EVKPTLFMGV PRIWEKMQDT IKENVARSSR LRKKAFAWAK
360 370 380 390 400
MLGLKVNTKR MLGKRDIPMN YRMAKALVFA KVRTSLGLDN CHAFFSSASP
410 420 430 440 450
LSQDVSEFFL SLDIPIGEIY GMSECSGPHT VSNKSVYRVL SCGKVLSGCK
460 470 480 490 500
NMLYNQNKEG VGEVCMWGRH VFMGYLNKEE ATLEALDENG WLHSGDIGRL
510 520 530 540 550
DSHDFLYITG RIKEILITAG GENVSPIPIE TLVKEKIPII SHAMLVGDKA
560 570 580 590 600
KFLCMLLTLK CETDRKSGEP LNKLSVEAKS FCQMLGSQAT TVSDILKSRD
610 620 630 640 650
QVVYTAIQYG IDIVNQQAMS DSHRIRKWII LEKDFSIQGG ELGPTSKLKR
660
SVITQKYKAQ IDSMYLS
Length:667
Mass (Da):74,319
Last modified:December 20, 2005 - v1
Checksum:i70E1D0EC8AC4726F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ250679 mRNA. Translation: ABB54488.1.
CCDSiCCDS28916.1.
RefSeqiNP_001034203.1. NM_001039114.1.
UniGeneiMm.179421.

Genome annotation databases

EnsembliENSMUST00000043062; ENSMUSP00000042352; ENSMUSG00000024207.
GeneIDi328845.
KEGGimmu:328845.
UCSCiuc008ddi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ250679 mRNA. Translation: ABB54488.1 .
CCDSi CCDS28916.1.
RefSeqi NP_001034203.1. NM_001039114.1.
UniGenei Mm.179421.

3D structure databases

ProteinModelPortali Q2XU92.
SMRi Q2XU92. Positions 38-633.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q2XU92.

Proteomic databases

PRIDEi Q2XU92.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043062 ; ENSMUSP00000042352 ; ENSMUSG00000024207 .
GeneIDi 328845.
KEGGi mmu:328845.
UCSCi uc008ddi.1. mouse.

Organism-specific databases

CTDi 81616.
MGIi MGI:3587728. Acsbg2.

Phylogenomic databases

eggNOGi COG1022.
GeneTreei ENSGT00690000101725.
HOGENOMi HOG000230004.
HOVERGENi HBG054660.
InParanoidi Q2XU92.
KOi K15013.
OMAi QMYTKKK.
OrthoDBi EOG7B5WVB.
PhylomeDBi Q2XU92.
TreeFami TF354286.

Miscellaneous databases

NextBioi 398481.
PROi Q2XU92.
SOURCEi Search...

Gene expression databases

Bgeei Q2XU92.
CleanExi MM_ACSBG2.
Genevestigatori Q2XU92.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The second member of the human and murine 'bubblegum' family is a testis-and brainstem-specific acyl-CoA synthetase."
    Pei Z., Jia Z., Watkins P.A.
    J. Biol. Chem. 281:6632-6641(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: 129/SvEv.
  2. "A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis."
    Fraisl P., Tanaka H., Forss-Petter S., Lassmann H., Nishimune Y., Berger J.
    Arch. Biochem. Biophys. 451:23-33(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiACBG2_MOUSE
AccessioniPrimary (citable) accession number: Q2XU92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3