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Protein

Long-chain-fatty-acid--CoA ligase ACSBG2

Gene

Acsbg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis (By similarity).By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei496 – 4961ATPBy similarity
Binding sitei511 – 5111ATPBy similarity
Binding sitei624 – 6241ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi227 – 2359ATPBy similarity
Nucleotide bindingi418 – 4236ATPBy similarity

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • fatty acid beta-oxidation Source: MGI
  • fatty acid metabolic process Source: MGI
  • long-chain fatty acid metabolic process Source: MGI
  • multicellular organismal development Source: UniProtKB-KW
  • spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ligase

Keywords - Biological processi

Differentiation, Fatty acid metabolism, Lipid metabolism, Spermatogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Bubblegum-related protein
Gene namesi
Name:Acsbg2
Synonyms:Bgr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3587728. Acsbg2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 667667Long-chain-fatty-acid--CoA ligase ACSBG2PRO_0000315813Add
BLAST

Proteomic databases

PRIDEiQ2XU92.

PTM databases

PhosphoSiteiQ2XU92.

Expressioni

Tissue specificityi

Testis- and brainstem-specific. Expressed in pubertal and adult testis. Enriched in germ cells and Sertoli cells while present at a lower level in Leydig cells. Present in testicular Sertoli cells and large motoneurons in the medulla oblongata and cervical spinal cord (at protein level).2 Publications

Gene expression databases

BgeeiQ2XU92.
CleanExiMM_ACSBG2.
GenevisibleiQ2XU92. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042352.

Structurei

3D structure databases

ProteinModelPortaliQ2XU92.
SMRiQ2XU92. Positions 38-633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ2XU92.
KOiK15013.
OMAiNITWTAG.
OrthoDBiEOG7B5WVB.
PhylomeDBiQ2XU92.
TreeFamiTF354286.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2XU92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQEKKAEDL ERGTDATSAV PRLWSTHCDG EVLLRLSKHG PGHETPMTIP
60 70 80 90 100
ELFQESAERF SAYPALASKN GKKWDTLTFS QYYEMCRKAA KSLIKLGLQR
110 120 130 140 150
FQCVGILGFN SVEWVVTALG TILAGGLCVG IYATNSAEAC QYVIQQANVS
160 170 180 190 200
ILIVENDQQL QKILLIPPDK METVKAIVQY KLPLMESMAN LYSWNDFMEL
210 220 230 240 250
GNDIPNIQLD RVILSQKANQ CAVILYTSGT TGTPKGVLLS HDNITWTAGA
260 270 280 290 300
MSQEMEINRV SGKQNTIVSY LPLSHIAAQL TDIWIPIKIG ALTFFAQPDA
310 320 330 340 350
LRGTLVYTLQ EVKPTLFMGV PRIWEKMQDT IKENVARSSR LRKKAFAWAK
360 370 380 390 400
MLGLKVNTKR MLGKRDIPMN YRMAKALVFA KVRTSLGLDN CHAFFSSASP
410 420 430 440 450
LSQDVSEFFL SLDIPIGEIY GMSECSGPHT VSNKSVYRVL SCGKVLSGCK
460 470 480 490 500
NMLYNQNKEG VGEVCMWGRH VFMGYLNKEE ATLEALDENG WLHSGDIGRL
510 520 530 540 550
DSHDFLYITG RIKEILITAG GENVSPIPIE TLVKEKIPII SHAMLVGDKA
560 570 580 590 600
KFLCMLLTLK CETDRKSGEP LNKLSVEAKS FCQMLGSQAT TVSDILKSRD
610 620 630 640 650
QVVYTAIQYG IDIVNQQAMS DSHRIRKWII LEKDFSIQGG ELGPTSKLKR
660
SVITQKYKAQ IDSMYLS
Length:667
Mass (Da):74,319
Last modified:December 20, 2005 - v1
Checksum:i70E1D0EC8AC4726F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ250679 mRNA. Translation: ABB54488.1.
CCDSiCCDS28916.1.
RefSeqiNP_001034203.1. NM_001039114.1.
UniGeneiMm.179421.

Genome annotation databases

EnsembliENSMUST00000043062; ENSMUSP00000042352; ENSMUSG00000024207.
GeneIDi328845.
KEGGimmu:328845.
UCSCiuc008ddi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ250679 mRNA. Translation: ABB54488.1.
CCDSiCCDS28916.1.
RefSeqiNP_001034203.1. NM_001039114.1.
UniGeneiMm.179421.

3D structure databases

ProteinModelPortaliQ2XU92.
SMRiQ2XU92. Positions 38-633.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042352.

PTM databases

PhosphoSiteiQ2XU92.

Proteomic databases

PRIDEiQ2XU92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043062; ENSMUSP00000042352; ENSMUSG00000024207.
GeneIDi328845.
KEGGimmu:328845.
UCSCiuc008ddi.1. mouse.

Organism-specific databases

CTDi81616.
MGIiMGI:3587728. Acsbg2.

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ2XU92.
KOiK15013.
OMAiNITWTAG.
OrthoDBiEOG7B5WVB.
PhylomeDBiQ2XU92.
TreeFamiTF354286.

Miscellaneous databases

NextBioi398481.
PROiQ2XU92.
SOURCEiSearch...

Gene expression databases

BgeeiQ2XU92.
CleanExiMM_ACSBG2.
GenevisibleiQ2XU92. MM.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The second member of the human and murine 'bubblegum' family is a testis-and brainstem-specific acyl-CoA synthetase."
    Pei Z., Jia Z., Watkins P.A.
    J. Biol. Chem. 281:6632-6641(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: 129/SvEv.
  2. "A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis."
    Fraisl P., Tanaka H., Forss-Petter S., Lassmann H., Nishimune Y., Berger J.
    Arch. Biochem. Biophys. 451:23-33(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiACBG2_MOUSE
AccessioniPrimary (citable) accession number: Q2XU92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: July 22, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.