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Q2XQV4

- ALDH2_PIG

UniProt

Q2XQV4 - ALDH2_PIG

Protein

Aldehyde dehydrogenase, mitochondrial

Gene

ALDH2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Is capable of converting retinaldehyde to retinoic acid.By similarity

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei190 – 1901Transition state stabilizerBy similarity
    Active sitei289 – 2891Proton acceptorPROSITE-ProRule annotation
    Active sitei323 – 3231NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi266 – 2716NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    ReactomeiREACT_204172. Ethanol oxidation.
    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase, mitochondrial (EC:1.2.1.3)
    Alternative name(s):
    ALDH class 2
    ALDH-E2
    Gene namesi
    Name:ALDH2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 14

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121MitochondrionBy similarityAdd
    BLAST
    Chaini22 – 521500Aldehyde dehydrogenase, mitochondrialPRO_0000312492Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei56 – 561N6-acetyllysineBy similarity
    Modified residuei77 – 771N6-acetyllysineBy similarity
    Modified residuei163 – 1631N6-acetyllysineBy similarity
    Modified residuei372 – 3721N6-acetyllysineBy similarity
    Modified residuei379 – 3791N6-acetyllysineBy similarity
    Modified residuei387 – 3871N6-acetyllysineBy similarity
    Modified residuei430 – 4301N6-acetyllysineBy similarity
    Modified residuei432 – 4321N6-acetyllysineBy similarity
    Modified residuei445 – 4451N6-acetyllysineBy similarity
    Modified residuei455 – 4551N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ2XQV4.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ2XQV4.
    SMRiQ2XQV4. Positions 29-521.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00550000074289.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    KOiK00128.
    OMAiYINTGKQ.
    OrthoDBiEOG7PS1F7.
    TreeFamiTF300455.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2XQV4-1 [UniParc]FASTAAdd to Basket

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    MLRPAALAAA RLVLRQGRRL LSAAPTQAVP APNQQPEIFY NQIFINNEWH    50
    DAISKKTFPT VNPSTGDVIC HVAEGDKEDV DRAVEAARAA FQLGSPWRRL 100
    DASDRGRLLN RLADLIERDR TYLAALETLD NGKPYVISYL VDLDMVLKCL 150
    RYYAGWADKY HGKTLPIDGD YFSYTRHEPV GVCGQIIPWN FPLLMQAWKL 200
    GPALATGNVV VMKVSEQTPL TALYVANLIK EAGFPPGVVN IVPGYGPTAG 250
    AAIASHEDVD KVAFTGSTEV GHLIQVAAGK SNLKRVTLEL GGKSPNIIMS 300
    DADMDWAVEQ AHFALFFNQG QCCCAGSRTF VQEDIYAEFV ERSVARARSR 350
    VVGNPFDSRT EQGPQIDETQ FKKILGYIKS GKEEGAKLLC GGGAAADRGY 400
    FIQPTVFGDV QDGMTIAKEE IFGPVMQILK FKTIEEVIGR ANNSKYGLAA 450
    AVFTKDLDKA NYLSQALQAG TVWVNCYDVF GAQSPFGGYK LSGSGRELGE 500
    YGLQAYTEVK TVTVKVPQKN S 521
    Length:521
    Mass (Da):56,921
    Last modified:December 20, 2005 - v1
    Checksum:i12913E10ECD560A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ266356 mRNA. Translation: ABB70228.1.
    RefSeqiNP_001038076.1. NM_001044611.2.
    UniGeneiSsc.11147.

    Genome annotation databases

    EnsembliENSSSCT00000010839; ENSSSCP00000010556; ENSSSCG00000009889.
    GeneIDi733685.
    KEGGissc:733685.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ266356 mRNA. Translation: ABB70228.1 .
    RefSeqi NP_001038076.1. NM_001044611.2.
    UniGenei Ssc.11147.

    3D structure databases

    ProteinModelPortali Q2XQV4.
    SMRi Q2XQV4. Positions 29-521.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q2XQV4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000010839 ; ENSSSCP00000010556 ; ENSSSCG00000009889 .
    GeneIDi 733685.
    KEGGi ssc:733685.

    Organism-specific databases

    CTDi 217.

    Phylogenomic databases

    eggNOGi COG1012.
    GeneTreei ENSGT00550000074289.
    HOGENOMi HOG000271505.
    HOVERGENi HBG000097.
    KOi K00128.
    OMAi YINTGKQ.
    OrthoDBi EOG7PS1F7.
    TreeFami TF300455.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .
    Reactomei REACT_204172. Ethanol oxidation.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ji Y., Bennett B.M.
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiALDH2_PIG
    AccessioniPrimary (citable) accession number: Q2XQV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3