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Q2XQV4

- ALDH2_PIG

UniProt

Q2XQV4 - ALDH2_PIG

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Protein
Aldehyde dehydrogenase, mitochondrial
Gene
ALDH2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Is capable of converting retinaldehyde to retinoic acid By similarity.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei190 – 1901Transition state stabilizer By similarity
Active sitei289 – 2891Proton acceptor By similarity
Active sitei323 – 3231Nucleophile By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi266 – 2716NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_204172. Ethanol oxidation.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, mitochondrial (EC:1.2.1.3)
Alternative name(s):
ALDH class 2
ALDH-E2
Gene namesi
Name:ALDH2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 14

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121Mitochondrion By similarity
Add
BLAST
Chaini22 – 521500Aldehyde dehydrogenase, mitochondrial
PRO_0000312492Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561N6-acetyllysine By similarity
Modified residuei77 – 771N6-acetyllysine By similarity
Modified residuei163 – 1631N6-acetyllysine By similarity
Modified residuei372 – 3721N6-acetyllysine By similarity
Modified residuei379 – 3791N6-acetyllysine By similarity
Modified residuei387 – 3871N6-acetyllysine By similarity
Modified residuei430 – 4301N6-acetyllysine By similarity
Modified residuei432 – 4321N6-acetyllysine By similarity
Modified residuei445 – 4451N6-acetyllysine By similarity
Modified residuei455 – 4551N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2XQV4.

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ2XQV4.
SMRiQ2XQV4. Positions 29-521.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00550000074289.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
KOiK00128.
OMAiYINTGKQ.
OrthoDBiEOG7PS1F7.
TreeFamiTF300455.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2XQV4-1 [UniParc]FASTAAdd to Basket

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MLRPAALAAA RLVLRQGRRL LSAAPTQAVP APNQQPEIFY NQIFINNEWH    50
DAISKKTFPT VNPSTGDVIC HVAEGDKEDV DRAVEAARAA FQLGSPWRRL 100
DASDRGRLLN RLADLIERDR TYLAALETLD NGKPYVISYL VDLDMVLKCL 150
RYYAGWADKY HGKTLPIDGD YFSYTRHEPV GVCGQIIPWN FPLLMQAWKL 200
GPALATGNVV VMKVSEQTPL TALYVANLIK EAGFPPGVVN IVPGYGPTAG 250
AAIASHEDVD KVAFTGSTEV GHLIQVAAGK SNLKRVTLEL GGKSPNIIMS 300
DADMDWAVEQ AHFALFFNQG QCCCAGSRTF VQEDIYAEFV ERSVARARSR 350
VVGNPFDSRT EQGPQIDETQ FKKILGYIKS GKEEGAKLLC GGGAAADRGY 400
FIQPTVFGDV QDGMTIAKEE IFGPVMQILK FKTIEEVIGR ANNSKYGLAA 450
AVFTKDLDKA NYLSQALQAG TVWVNCYDVF GAQSPFGGYK LSGSGRELGE 500
YGLQAYTEVK TVTVKVPQKN S 521
Length:521
Mass (Da):56,921
Last modified:December 20, 2005 - v1
Checksum:i12913E10ECD560A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ266356 mRNA. Translation: ABB70228.1.
RefSeqiNP_001038076.1. NM_001044611.2.
UniGeneiSsc.11147.

Genome annotation databases

EnsembliENSSSCT00000010839; ENSSSCP00000010556; ENSSSCG00000009889.
GeneIDi733685.
KEGGissc:733685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ266356 mRNA. Translation: ABB70228.1 .
RefSeqi NP_001038076.1. NM_001044611.2.
UniGenei Ssc.11147.

3D structure databases

ProteinModelPortali Q2XQV4.
SMRi Q2XQV4. Positions 29-521.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q2XQV4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000010839 ; ENSSSCP00000010556 ; ENSSSCG00000009889 .
GeneIDi 733685.
KEGGi ssc:733685.

Organism-specific databases

CTDi 217.

Phylogenomic databases

eggNOGi COG1012.
GeneTreei ENSGT00550000074289.
HOGENOMi HOG000271505.
HOVERGENi HBG000097.
KOi K00128.
OMAi YINTGKQ.
OrthoDBi EOG7PS1F7.
TreeFami TF300455.

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .
Reactomei REACT_204172. Ethanol oxidation.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Ji Y., Bennett B.M.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiALDH2_PIG
AccessioniPrimary (citable) accession number: Q2XQV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 20, 2005
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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