Q2XQV4 (ALDH2_PIG) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 54.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Aldehyde dehydrogenase, mitochondrial EC=1.2.1.3 Alternative name(s): ALDH class 2 ALDH-E2 | ||
| Gene names |
| ||
| Organism | Sus scrofa (Pig) [Reference proteome] | ||
| Taxonomic identifier | 9823 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus![]() |
Protein attributes
| Sequence length | 521 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Is capable of converting retinaldehyde to retinoic acid By similarity. |
| Catalytic activity | An aldehyde + NAD+ + H2O = a carboxylate + NADH. |
| Pathway | Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Mitochondrion matrix By similarity. |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| PTM | Acetylation |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | ethanol catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway |
| Cellular_component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 21 | 21 | Mitochondrion By similarity | ||||||
| Chain | 22 – 521 | 500 | Aldehyde dehydrogenase, mitochondrial | PRO_0000312492 | |||||
Regions | |||||||||
| Nucleotide binding | 266 – 271 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 289 | 1 | Proton acceptor By similarity | ||||||
| Active site | 323 | 1 | Nucleophile By similarity | ||||||
| Site | 190 | 1 | Transition state stabilizer By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 372 | 1 | N6-acetyllysine By similarity | ||||||
Sequences
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References
| [1] | Ji Y., Bennett B.M. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | DQ266356 mRNA. Translation: ABB70228.1. |
| RefSeq | NP_001038076.1. NM_001044611.2. |
| UniGene | Ssc.11147. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2D4E based on UniProtKB Q5SJP9. |
| ProteinModelPortal | Q2XQV4. |
| SMR | Q2XQV4. Positions 29-521. |
| ModBase | Search... |
Proteomic databases | |
| PaxDb | Q2XQV4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSSSCT00000010839; ENSSSCP00000010556; ENSSSCG00000009889. |
| GeneID | 733685. |
| KEGG | ssc:733685. |
Organism-specific databases | |
| CTD | 217. |
Phylogenomic databases | |
| eggNOG | COG1012. |
| GeneTree | ENSGT00550000074289. |
| HOGENOM | HOG000271505. |
| HOVERGEN | HBG000097. |
| KO | K00128. |
| OMA | MAKADDY. |
| OrthoDB | EOG41ZF9P. |
Enzyme and pathway databases | |
| UniPathway | UPA00780; UER00768. |
Gene expression databases | |
| ArrayExpress | Q2XQV4. |
Family and domain databases | |
| Gene3D | 3.40.309.10. 1 hit. 3.40.605.10. 1 hit. |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view] |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| SUPFAM | SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ALDH2_PIG | ||||||||
| Accession | Primary (citable) accession number: Q2XQV4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
