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Q2XQV4

- ALDH2_PIG

UniProt

Q2XQV4 - ALDH2_PIG

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Protein

Aldehyde dehydrogenase, mitochondrial

Gene

ALDH2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Is capable of converting retinaldehyde to retinoic acid.By similarity

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei190 – 1901Transition state stabilizerBy similarity
Active sitei289 – 2891Proton acceptorPROSITE-ProRule annotation
Active sitei323 – 3231NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi266 – 2716NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_204172. Ethanol oxidation.
REACT_235842. Metabolism of serotonin.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, mitochondrial (EC:1.2.1.3)
Alternative name(s):
ALDH class 2
ALDH-E2
Gene namesi
Name:ALDH2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 14

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121MitochondrionBy similarityAdd
BLAST
Chaini22 – 521500Aldehyde dehydrogenase, mitochondrialPRO_0000312492Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561N6-acetyllysineBy similarity
Modified residuei77 – 771N6-acetyllysineBy similarity
Modified residuei163 – 1631N6-acetyllysineBy similarity
Modified residuei372 – 3721N6-acetyllysineBy similarity
Modified residuei379 – 3791N6-acetyllysineBy similarity
Modified residuei387 – 3871N6-acetyllysineBy similarity
Modified residuei430 – 4301N6-acetyllysineBy similarity
Modified residuei432 – 4321N6-acetyllysineBy similarity
Modified residuei445 – 4451N6-acetyllysineBy similarity
Modified residuei455 – 4551N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2XQV4.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2XQV4.
SMRiQ2XQV4. Positions 29-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ2XQV4.
KOiK00128.
OMAiYINTGKQ.
OrthoDBiEOG7PS1F7.
TreeFamiTF300455.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2XQV4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRPAALAAA RLVLRQGRRL LSAAPTQAVP APNQQPEIFY NQIFINNEWH
60 70 80 90 100
DAISKKTFPT VNPSTGDVIC HVAEGDKEDV DRAVEAARAA FQLGSPWRRL
110 120 130 140 150
DASDRGRLLN RLADLIERDR TYLAALETLD NGKPYVISYL VDLDMVLKCL
160 170 180 190 200
RYYAGWADKY HGKTLPIDGD YFSYTRHEPV GVCGQIIPWN FPLLMQAWKL
210 220 230 240 250
GPALATGNVV VMKVSEQTPL TALYVANLIK EAGFPPGVVN IVPGYGPTAG
260 270 280 290 300
AAIASHEDVD KVAFTGSTEV GHLIQVAAGK SNLKRVTLEL GGKSPNIIMS
310 320 330 340 350
DADMDWAVEQ AHFALFFNQG QCCCAGSRTF VQEDIYAEFV ERSVARARSR
360 370 380 390 400
VVGNPFDSRT EQGPQIDETQ FKKILGYIKS GKEEGAKLLC GGGAAADRGY
410 420 430 440 450
FIQPTVFGDV QDGMTIAKEE IFGPVMQILK FKTIEEVIGR ANNSKYGLAA
460 470 480 490 500
AVFTKDLDKA NYLSQALQAG TVWVNCYDVF GAQSPFGGYK LSGSGRELGE
510 520
YGLQAYTEVK TVTVKVPQKN S
Length:521
Mass (Da):56,921
Last modified:December 20, 2005 - v1
Checksum:i12913E10ECD560A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ266356 mRNA. Translation: ABB70228.1.
RefSeqiNP_001038076.1. NM_001044611.2.
UniGeneiSsc.11147.

Genome annotation databases

EnsembliENSSSCT00000010839; ENSSSCP00000010556; ENSSSCG00000009889.
GeneIDi733685.
KEGGissc:733685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ266356 mRNA. Translation: ABB70228.1 .
RefSeqi NP_001038076.1. NM_001044611.2.
UniGenei Ssc.11147.

3D structure databases

ProteinModelPortali Q2XQV4.
SMRi Q2XQV4. Positions 29-521.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q2XQV4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000010839 ; ENSSSCP00000010556 ; ENSSSCG00000009889 .
GeneIDi 733685.
KEGGi ssc:733685.

Organism-specific databases

CTDi 217.

Phylogenomic databases

eggNOGi COG1012.
GeneTreei ENSGT00760000118999.
HOGENOMi HOG000271505.
HOVERGENi HBG000097.
InParanoidi Q2XQV4.
KOi K00128.
OMAi YINTGKQ.
OrthoDBi EOG7PS1F7.
TreeFami TF300455.

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .
Reactomei REACT_204172. Ethanol oxidation.
REACT_235842. Metabolism of serotonin.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Ji Y., Bennett B.M.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiALDH2_PIG
AccessioniPrimary (citable) accession number: Q2XQV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 20, 2005
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3