Q2XPP3 (Q2XPP3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Type II 3a-hydroxysteroid dehydrogenase variant EMBL ABB76132.1
Organism	Homo sapiens (Human) EMBL ABB76132.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Molecular_function	oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	55	1	Proton donor By similarity PIRSR PIRSR000097-1

Sequences

	Sequence		Length	Mass (Da)
	Q2XPP3 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 23D42E6CB3C48ACF	FASTA	323	36,768
	10 20 30 40 50 60 MDSKHQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ 70 80 90 100 110 120 VGLAVRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKKAQLDY VDLYLIHSPM 130 140 150 160 170 180 SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP 190 200 210 220 230 240 GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV 250 260 270 280 290 300 LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD 310 320 RNLHYFNSDS FASHPNYPYS DEY

References

[1]	"Overexpression of dihydrodiol dehydrogenase 2, AKR1C2, in bladder cancer patients from high-risk region of black foot disease in Taiwan." Chow K.-C. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Bladder cancer EMBL ABB76132.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ269985 mRNA. Translation: ABB76132.1.
IPI	IPI00291483.
UniGene	Hs.78183.
3D structure databases
ProteinModelPortal	Q2XPP3.
SMR	Q2XPP3. Positions 6-321.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2XPP3.
Proteomic databases
PRIDE	Q2XPP3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000020.
Gene expression databases
ArrayExpress	Q2XPP3.
Family and domain databases
Gene3D	3.20.20.100. 1 hit.
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_subgr. IPR023210. NADP_OxRdtase_dom. [Graphical view]
PANTHER	PTHR11732. PTHR11732. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PIRSF	PIRSF000097. AKR. 1 hit.
PRINTS	PR00069. ALDKETRDTASE.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2XPP3_HUMAN

Accession

Primary (citable) accession number: Q2XPP3

Entry history

Integrated into UniProtKB/TrEMBL:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	March 6, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.