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Q2XPP3

- Q2XPP3_HUMAN

UniProt

Q2XPP3 - Q2XPP3_HUMAN

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Protein
Submitted name:

Type II 3a-hydroxysteroid dehydrogenase variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551Proton donorUniRule annotation

GO - Molecular functioni

  1. oxidoreductase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Type II 3a-hydroxysteroid dehydrogenase variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PRIDEiQ2XPP3.

Structurei

3D structure databases

ProteinModelPortaliQ2XPP3.
SMRiQ2XPP3. Positions 6-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000020.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2XPP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSKHQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID
60 70 80 90 100
SAHLYNNEEQ VGLAVRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE
110 120 130 140 150
RSLKKAQLDY VDLYLIHSPM SLKPGEELSP TDENGKVIFD IVDLCTTWEA
160 170 180 190 200
MEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNRS
210 220 230 240 250
KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV LCALAKKHKR
260 270 280 290 300
TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD
310 320
RNLHYFNSDS FASHPNYPYS DEY
Length:323
Mass (Da):36,768
Last modified:December 20, 2005 - v1
Checksum:i23D42E6CB3C48ACF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ269985 mRNA. Translation: ABB76132.1.
UniGeneiHs.78183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ269985 mRNA. Translation: ABB76132.1 .
UniGenei Hs.78183.

3D structure databases

ProteinModelPortali Q2XPP3.
SMRi Q2XPP3. Positions 6-321.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q2XPP3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000020.

Family and domain databases

Gene3Di 3.20.20.100. 1 hit.
InterProi IPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view ]
PANTHERi PTHR11732. PTHR11732. 1 hit.
Pfami PF00248. Aldo_ket_red. 1 hit.
[Graphical view ]
PIRSFi PIRSF000097. AKR. 1 hit.
PRINTSi PR00069. ALDKETRDTASE.
SUPFAMi SSF51430. SSF51430. 1 hit.
PROSITEi PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Overexpression of dihydrodiol dehydrogenase 2, AKR1C2, in bladder cancer patients from high-risk region of black foot disease in Taiwan."
    Chow K.-C.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Bladder cancerImported.

Entry informationi

Entry nameiQ2XPP3_HUMAN
AccessioniPrimary (citable) accession number: Q2XPP3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 20, 2005
Last sequence update: December 20, 2005
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.