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Q2XNC8

- CP2D6_PANTR

UniProt

Q2XNC8 - CP2D6_PANTR

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Protein
Cytochrome P450 2D6
Gene
CYP2D6
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants By similarity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei301 – 3011Substrate By similarity
Metal bindingi443 – 4431Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2D6 (EC:1.14.14.1)
    Alternative name(s):
    CYPIID6
    Gene namesi
    Name:CYP2D6
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Cytochrome P450 2D6
    PRO_0000051733Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000042793.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2XNC8.
    SMRiQ2XNC8. Positions 34-497.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    KOiK17712.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2XNC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLEALVPLA VIVTIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD    50
    FQNTPYCFDQ LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD 100
    RPPVPITQIL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE 150
    QWVTEEAACL CAAFANHSGR PFRPNGLLDK AVSNVIASLT CGRRFEYDDP 200
    RFLRLLDLAQ EGLKEESGFL REVLNAIPVL LHIPALAGKV LRFQKAFLTQ 250
    LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA 300
    DLFSAGIVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ 350
    ARMPYTTAVI HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLFTNLS 400
    SVLKDKAVWE KPFRFHPEHF LDAQGHFVKP EAFLPFSAGR RACLGEPLAR 450
    MELFLFFTSL LQHFSFSVPT GQPRPSHHGV FAFLVTPSPY ELCAVPR 497
    Length:497
    Mass (Da):55,862
    Last modified:December 20, 2005 - v1
    Checksum:i389387F955E2F4F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ282164 Genomic DNA. Translation: ABB77911.1.
    RefSeqiNP_001035712.1. NM_001040622.1.
    UniGeneiPtr.6574.

    Genome annotation databases

    GeneIDi470228.
    KEGGiptr:470228.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ282164 Genomic DNA. Translation: ABB77911.1 .
    RefSeqi NP_001035712.1. NM_001040622.1.
    UniGenei Ptr.6574.

    3D structure databases

    ProteinModelPortali Q2XNC8.
    SMRi Q2XNC8. Positions 34-497.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000042793.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 470228.
    KEGGi ptr:470228.

    Organism-specific databases

    CTDi 1565.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    KOi K17712.

    Miscellaneous databases

    NextBioi 20847450.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CYP2D6 evolution and allele diversity among human races."
      Koch W.H., Nikoloff D.M., Lu W., Pan R.M., deLeon J., Wedlund P.J.
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCP2D6_PANTR
    AccessioniPrimary (citable) accession number: Q2XNC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: December 20, 2005
    Last modified: January 22, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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