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Q2XNC8

- CP2D6_PANTR

UniProt

Q2XNC8 - CP2D6_PANTR

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Protein

Cytochrome P450 2D6

Gene

CYP2D6

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants (By similarity).By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei301 – 3011SubstrateBy similarity
Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D6 (EC:1.14.14.1)
Alternative name(s):
CYPIID6
Gene namesi
Name:CYP2D6
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Cytochrome P450 2D6PRO_0000051733Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000042793.

Structurei

3D structure databases

ProteinModelPortaliQ2XNC8.
SMRiQ2XNC8. Positions 34-497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ2XNC8.
KOiK17712.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2XNC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLEALVPLA VIVTIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD
60 70 80 90 100
FQNTPYCFDQ LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD
110 120 130 140 150
RPPVPITQIL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE
160 170 180 190 200
QWVTEEAACL CAAFANHSGR PFRPNGLLDK AVSNVIASLT CGRRFEYDDP
210 220 230 240 250
RFLRLLDLAQ EGLKEESGFL REVLNAIPVL LHIPALAGKV LRFQKAFLTQ
260 270 280 290 300
LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA
310 320 330 340 350
DLFSAGIVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ
360 370 380 390 400
ARMPYTTAVI HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLFTNLS
410 420 430 440 450
SVLKDKAVWE KPFRFHPEHF LDAQGHFVKP EAFLPFSAGR RACLGEPLAR
460 470 480 490
MELFLFFTSL LQHFSFSVPT GQPRPSHHGV FAFLVTPSPY ELCAVPR
Length:497
Mass (Da):55,862
Last modified:December 20, 2005 - v1
Checksum:i389387F955E2F4F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ282164 Genomic DNA. Translation: ABB77911.1.
RefSeqiNP_001035712.1. NM_001040622.1.
UniGeneiPtr.6574.

Genome annotation databases

GeneIDi470228.
KEGGiptr:470228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ282164 Genomic DNA. Translation: ABB77911.1 .
RefSeqi NP_001035712.1. NM_001040622.1.
UniGenei Ptr.6574.

3D structure databases

ProteinModelPortali Q2XNC8.
SMRi Q2XNC8. Positions 34-497.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000042793.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 470228.
KEGGi ptr:470228.

Organism-specific databases

CTDi 1565.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi Q2XNC8.
KOi K17712.

Miscellaneous databases

NextBioi 20847450.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "CYP2D6 evolution and allele diversity among human races."
    Koch W.H., Nikoloff D.M., Lu W., Pan R.M., deLeon J., Wedlund P.J.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCP2D6_PANTR
AccessioniPrimary (citable) accession number: Q2XNC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3