Q2WGN9 (GAB4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GRB2-associated-binding protein 4

Alternative name(s):
GRB2-associated binder 2-like
Short name=GAB2-like
GRB2-associated binder 4
GRB2-associated-binding protein 2-like
Growth factor receptor bound protein 2-associated protein 4

Gene names

Name:

GAB4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	574 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the GAB family. Contains 1 PH domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell migration Inferred from electronic annotation. Source: Compara integrin-mediated signaling pathway Inferred from electronic annotation. Source: Compara
Molecular_function	phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 574	574	GRB2-associated-binding protein 4		PRO_0000271192
Regions
	Domain	39 – 152	114	PH
Natural variations
	Natural variant	273	1	L → P. Corresponds to variant rs11703655 [ dbSNP | Ensembl ].		VAR_053098

Sequences

	Sequence		Length	Mass (Da)
	Q2WGN9 [UniParc]. Last modified January 10, 2006. Version 1. Checksum: F504C5CDF34C592C	FASTA	574	62,367
	10 20 30 40 50 60 MSLPSPSPSR ELCPPDPAFA PLSSWPGSGP AGGSTRSGHV LYSGWLRKSP PEKKLRLFAW 70 80 90 100 110 120 RKRWFILRRG QTSSDPDVLE YYKNDGSKKP LRTINLNLCE QLDVDVTLNF NKKEIQKGYM 130 140 150 160 170 180 FDIKTSERTF YLVAETREDM NEWVQSICQI CGFRQEESTG FLGNISSASH GLCSSPAEPS 190 200 210 220 230 240 CSHQHLPQEQ EPTSEPPVSH CVPPTWPIPA PPGCLRSHQH ASQRAEHARS ASFSQGSEAP 250 260 270 280 290 300 FIMRRNTAMQ NLAQHSGYSV DGVSGHIHGF HSLSKPSQHN AEFRGSTHRI PWSLASHGHT 310 320 330 340 350 360 RGSLTGSEAD NEASSGKYTQ HGGGNASRPA ESMHEGVCSF LPGRTLVGLS DSIASEGSCV 370 380 390 400 410 420 PMNPGSPTLP AVKQAGDDSQ GVCIPVGSCL VRFDLLGSPL TELSMHQDLS QGHEVQLPPV 430 440 450 460 470 480 NRSLKPNQKA NPTPPNLRNN RVINELSFKP PVTEPWSGTS HTFDSSSSQH PISTQSITNT 490 500 510 520 530 540 DSEDSGERYL FPNPASAFPV SGGTSSSAPP RSTGNIHYAA LDFQPSKPSI GSVTSGKKVD 550 560 570 YVQVDLEKTQ ALQKTMHEQM CLRQSSEPPR GAKL

References

[1]	"Identification and cDNA cloning of Grb2 associated binder 2 (GAB2)-like." Shimizu N., Minoshima S., Sasaki T., Hosono K. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB076978 mRNA. Translation: BAD06454.1.
IPI	IPI00413295.
RefSeq	NP_001032903.1. NM_001037814.1.
UniGene	Hs.434113.
3D structure databases
HSSP	HSSP built from PDB template 1ZM0 based on UniProtKB P08567.
ProteinModelPortal	Q2WGN9.
ModBase	Search...
PTM databases
PhosphoSite	Q2WGN9.
Polymorphism databases
DMDM	121947654.
Proteomic databases
PaxDb	Q2WGN9.
PRIDE	Q2WGN9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000400588; ENSP00000383431; ENSG00000215568.
GeneID	128954.
KEGG	hsa:128954.
UCSC	uc002zlw.3. human.
Organism-specific databases
CTD	128954.
GeneCards	GC22M017442.
HGNC	HGNC:18325. GAB4.
HPA	HPA044621.
neXtProt	NX_Q2WGN9.
PharmGKB	PA134933290.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG80382.
HOGENOM	HOG000236270.
HOVERGEN	HBG051685.
InParanoid	Q2WGN9.
OMA	SHGPCSS.
OrthoDB	EOG4N04DM.
Gene expression databases
Bgee	Q2WGN9.
CleanEx	HS_GAB4.
Genevestigator	Q2WGN9.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
Pfam	PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	128954.
NextBio	82519.

Entry information

Entry name

GAB4_HUMAN

Accession

Primary (citable) accession number: Q2WGN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.