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Protein

Fer-1-like protein 6

Gene

FER1L6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fer-1-like protein 6
Gene namesi
Name:FER1L6
Synonyms:C8orfK23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000214814.6.
HGNCiHGNC:28065. FER1L6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 1824CytoplasmicSequence analysisAdd BLAST1824
Transmembranei1825 – 1845HelicalSequence analysisAdd BLAST21
Topological domaini1846 – 1857ExtracellularSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi654463.
OpenTargetsiENSG00000214814.
PharmGKBiPA162388227.

Polymorphism and mutation databases

BioMutaiFER1L6.
DMDMi262527544.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003236741 – 1857Fer-1-like protein 6Add BLAST1857

Proteomic databases

PaxDbiQ2WGJ9.
PeptideAtlasiQ2WGJ9.
PRIDEiQ2WGJ9.

PTM databases

iPTMnetiQ2WGJ9.
PhosphoSitePlusiQ2WGJ9.

Expressioni

Gene expression databases

BgeeiENSG00000214814.
CleanExiHS_FER1L6.

Organism-specific databases

HPAiHPA054117.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381982.

Structurei

3D structure databases

ProteinModelPortaliQ2WGJ9.
SMRiQ2WGJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 160C2 1PROSITE-ProRule annotationAdd BLAST91
Domaini230 – 345C2 2PROSITE-ProRule annotationAdd BLAST116
Domaini813 – 918C2 3PROSITE-ProRule annotationAdd BLAST106
Domaini1047 – 1081C2 4PROSITE-ProRule annotationAdd BLAST35
Domaini1343 – 1441C2 5PROSITE-ProRule annotationAdd BLAST99
Domaini1583 – 1712C2 6PROSITE-ProRule annotationAdd BLAST130

Sequence similaritiesi

Belongs to the ferlin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1326. Eukaryota.
ENOG410XPT2. LUCA.
GeneTreeiENSGT00550000074414.
HOGENOMiHOG000006770.
HOVERGENiHBG108221.
InParanoidiQ2WGJ9.
OMAiHHKLIGS.
OrthoDBiEOG091G0IG2.
PhylomeDBiQ2WGJ9.
TreeFamiTF316871.

Family and domain databases

Gene3Di2.60.40.150. 6 hits.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR030000. FER1L6.
IPR012968. FerIin_dom.
IPR012561. Ferlin_B-domain.
IPR032362. Ferlin_C.
PANTHERiPTHR12546:SF52. PTHR12546:SF52. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 6 hits.
PF08150. FerB. 1 hit.
PF08151. FerI. 1 hit.
PF16165. Ferlin_C. 1 hit.
SMARTiView protein in SMART
SM00239. C2. 5 hits.
SM01201. FerB. 1 hit.
SM01202. FerI. 1 hit.
SUPFAMiSSF49562. SSF49562. 6 hits.
PROSITEiView protein in PROSITE
PS50004. C2. 5 hits.

Sequencei

Sequence statusi: Complete.

Q2WGJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGLKVKKKR NKAEKGLILA NKAAKDSQGD TEALQEEPSH QEGPRGDLVH
60 70 80 90 100
DDASIFPVPS ASPKRRSKLL TKIHDGEVRS QNYQIAITIT EARQLVGENI
110 120 130 140 150
DPVVTIEIGD EKKQSTVKEG TNSPFYNEYF VFDFIGPQVH LFDKIIKISV
160 170 180 190 200
FHHKLIGSVL IGSFKVDLGT VYNQPGHQFC NKWALLTDPG DIRTGTKGYL
210 220 230 240 250
KCDISVMGKG DVLKTSPKTS DTEEPIEKNL LIPNGFPLER PWARFYVRLY
260 270 280 290 300
KAEGLPKMNS SIMANVTKAF VGDSKDLVDP FVEVSFAGQM GRTTVQKNCA
310 320 330 340 350
DPVWHEQVIF KEMFPPLCRR VKIQVWDEGS MNDVALATHF IDLKKISNEQ
360 370 380 390 400
DGDKGFLPTF GPAWINLYGS PRNHSLMDDY QEMNEGFGEG VSFRGRILVE
410 420 430 440 450
IAVEILSGRA QESKFSKALK ELKLPSKDKD SKSSKGKDKA DKTEDGKSQQ
460 470 480 490 500
ASNKTNSTEV EVESFDVPPE IVPEKNEEFL LFGAFFEATM IDRKIGDKPI
510 520 530 540 550
SFEVSIGNFG NLIDGGSHHG SKKSAESAEE DLLPLLHEGQ GDVAHDVPIP
560 570 580 590 600
MASTTHPEKP LVTEGNRNYN YLPFEAKKPC VYFISSWGDQ TFRLHWSNML
610 620 630 640 650
EKMADFLEES IEEVRELIKI SQEAPEEKMK TVLSDFISRS SAFISEAEKK
660 670 680 690 700
PKMLNQTTLD KKRLTLCWQE LEAMCKEAKG IIQQQKKKLS VDEMIHEAQN
710 720 730 740 750
FVEKIRFLVD EPQHTIPDVF IWMLSNNRRV AYARIASKDL LYSPVAGQMG
760 770 780 790 800
KHCGKIKTHF LKPPGKRPAG WSVQAKVDVY LWLGSIKHAS AILDNLPVGY
810 820 830 840 850
EAEMSSKGAG TNHPPSNLLY QEQHVFQLRA HMYQARGLIA ADSNGLSDPF
860 870 880 890 900
AKVTFLSHCQ TTKIISQTLS PTWNQMLLFN DLVLHGDVKE LAESPPLVVV
910 920 930 940 950
ELYDSDAVGK PEYLGATVAA PVVKLADQDY EPPRLCYHPI FCGNLSGGDL
960 970 980 990 1000
LAVFELLQVP PSGLQGLPPV EPPDITQIYP VPANIRPVLS KYRVEVLFWG
1010 1020 1030 1040 1050
VREMKKVQLL SVDRPQALIE CGGQGVKSCV IQSYKNNPNF SIQADAFEVE
1060 1070 1080 1090 1100
LPENELLHPP LSICVVDWRA FGRSTLVGTY TINYLKQFLC KLREPLAPIT
1110 1120 1130 1140 1150
QVDGTQPGHD ISDSLTATES SGAHSSSQDP PADHIYVDVE PPPTVVPDSA
1160 1170 1180 1190 1200
QAQPAILVDV PDSSPMLEPE HTPVAQEPPK DGKPKDPRKP SRRSTKRRKR
1210 1220 1230 1240 1250
TIADESAENV IDWWSKYYAS LKKAQKAKER NPKGKKGNTE AKPDEVVVDI
1260 1270 1280 1290 1300
EDGPKKKKDK MLKKKPKDDG IPNLAILQIY DGDLESEFNN FEDWVKTFEL
1310 1320 1330 1340 1350
FRGKSTEDDH GLDGDRVIGK FKGSFCIYKS PQDSSSEDSG QLRIQQGIPP
1360 1370 1380 1390 1400
NHPVTVLIRV YIVAAFNLSP ADPDGKSDPY IVIKLGKTEI KDRDKYIPKQ
1410 1420 1430 1440 1450
LNPVFGRSFE IQATFPKESL LSILIYDHDM IGTDDLIGET KIDLENRFYS
1460 1470 1480 1490 1500
KHRAICGLQS QYEIEGYNAW RDTSKPTEIL TKLCKDNKLD GPYFHPGKIQ
1510 1520 1530 1540 1550
IGNQVFSGKT IFTEEDTDET VESYEHLALK VLHSWEDIPE VGCRLVPEHI
1560 1570 1580 1590 1600
ETRPLYHKDK PGMEQGRLQM WVDMFPKDMP QPGPPVDISP RRPKGYELRV
1610 1620 1630 1640 1650
TIWNTEDVIL EDENIFTGQK SSDIYVKGWL KGLEDDKQET DVHYNSLTGE
1660 1670 1680 1690 1700
GNFNWRFLFP FQYLPAEKQM VITKRENIFS LEKMECKTPA VLVLQVWDFE
1710 1720 1730 1740 1750
RLSSDDFLGT LEMNLNSFPR AAKSAKACDL AKFENASEET KISIFQQKRV
1760 1770 1780 1790 1800
RGWWPFSKSK ELTGKVEAEF HLVTAEEAEK NPVGKARKEP EPLAKPNRPD
1810 1820 1830 1840 1850
TSFSWFMSPF KCLYYLIWKN YKKYIIIAFI LIILIIFLVL FIYTLPGAIS

RRIVVGS
Length:1,857
Mass (Da):209,308
Last modified:November 3, 2009 - v2
Checksum:i9A86F3E7E924B16B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti519H → Y in BAE53435 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0395581110D → E. Corresponds to variant dbSNP:rs7012186Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196633 mRNA. Translation: BAE53435.1.
AC090753 Genomic DNA. No translation available.
AC100871 Genomic DNA. No translation available.
CCDSiCCDS43767.1.
RefSeqiNP_001034201.2. NM_001039112.2.
XP_011515534.1. XM_011517232.2.
XP_011515535.1. XM_011517233.2.
UniGeneiHs.632058.

Genome annotation databases

EnsembliENST00000522917; ENSP00000428280; ENSG00000214814.
GeneIDi654463.
KEGGihsa:654463.
UCSCiuc003yqw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFR1L6_HUMAN
AccessioniPrimary (citable) accession number: Q2WGJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 3, 2009
Last modified: September 27, 2017
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families