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Protein

Kelch-like protein 38

Gene

KLHL38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 38
Gene namesi
Name:KLHL38
Synonyms:C8orfK36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000175946.8
HGNCiHGNC:34435 KLHL38
neXtProtiNX_Q2WGJ6

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi340359
OpenTargetsiENSG00000175946
PharmGKBiPA162393613

Polymorphism and mutation databases

BioMutaiKLHL38
DMDMi296439315

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258091 – 581Kelch-like protein 38Add BLAST581

Proteomic databases

PaxDbiQ2WGJ6
PeptideAtlasiQ2WGJ6
PRIDEiQ2WGJ6

PTM databases

iPTMnetiQ2WGJ6
PhosphoSitePlusiQ2WGJ6

Expressioni

Gene expression databases

BgeeiENSG00000175946
CleanExiHS_KLHL38

Organism-specific databases

HPAiHPA024770
HPA027115

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi131043, 23 interactors
IntActiQ2WGJ6, 91 interactors
STRINGi9606.ENSP00000321475

Structurei

3D structure databases

ProteinModelPortaliQ2WGJ6
SMRiQ2WGJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 101BTBPROSITE-ProRule annotationAdd BLAST68
Domaini136 – 237BACKAdd BLAST102
Repeati285 – 332Kelch 1Add BLAST48
Repeati334 – 383Kelch 2Add BLAST50
Repeati384 – 431Kelch 3Add BLAST48
Repeati433 – 479Kelch 4Add BLAST47
Repeati480 – 521Kelch 5Add BLAST42
Repeati523 – 573Kelch 6Add BLAST51

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00910000143979
HOGENOMiHOG000082537
HOVERGENiHBG095739
InParanoidiQ2WGJ6
KOiK13959
OMAiGGEDIMQ
OrthoDBiEOG091G03OC
PhylomeDBiQ2WGJ6
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030568 KLHL38
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF8 PTHR24412:SF8, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 2 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q2WGJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEESLDGLL FKDHDFSSDL LRQLNSLRQS RILTDVSICA GAREIPCHRN
60 70 80 90 100
VLASSSPYFR AMFCSSFREK SEAKVQLKGI DPPTLDQIVS YVYTGEAHIA
110 120 130 140 150
TDNVLPVMEA ASMLQFPKLF EACSSYLQSQ LAPSNCLGMI RLSEILSCET
160 170 180 190 200
LKKKAREVAL TSFPEVAASA DLKELCALEL RDYLGDDGLC GEEEKVFEAL
210 220 230 240 250
MVWIKHDLQA RKRYMQELFK QVRLQYIHPA FFHHFIANDA LLQSSPACQI
260 270 280 290 300
ILETAKRQMF SLCGTTVPDC KLLLHVPPRN SYQDFLILLG GRKDSQQTTR
310 320 330 340 350
DVLLYSKQTG QWQSLAKLPT RLYKASAITL HRSIYVLGGM AVSSGRSLVS
360 370 380 390 400
HNVYIFSLKL NQWRLGEPML VARYSHRSTA HKNFIFSIGG IGEGQELMGS
410 420 430 440 450
MERYDSICNV WESMASMPVG VLHPAVAVKD QRLYLFGGED IMQNPVRLIQ
460 470 480 490 500
VYHISRNSWF KMETRMIKNV CAPAVVLGER IVIVGGYTRR ILAYDPQSNK
510 520 530 540 550
FVKCADMKDR RMHHGATVMG NKLYVTGGRR LTTDCNIEDS ASFDCYDPET
560 570 580
DTWTSQGQLP HKLFDHACLT LQCIPRTSGL P
Length:581
Mass (Da):65,541
Last modified:May 18, 2010 - v3
Checksum:iC6655BD039F4C757
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98H → R in EAW92045 (Ref. 3) Curated1
Sequence conflicti98H → R in AAI27887 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059437310G → S. Corresponds to variant dbSNP:rs16898693Ensembl.1
Natural variantiVAR_060485334I → V2 PublicationsCorresponds to variant dbSNP:rs11784192Ensembl.1
Natural variantiVAR_060486346R → K2 PublicationsCorresponds to variant dbSNP:rs11780509Ensembl.1
Natural variantiVAR_059438352N → Y. Corresponds to variant dbSNP:rs11784175Ensembl.1
Natural variantiVAR_059439394G → R. Corresponds to variant dbSNP:rs16898691Ensembl.1
Natural variantiVAR_059440504C → Y. Corresponds to variant dbSNP:rs11779866Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196636 mRNA Translation: BAE53438.1
AC135166 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92045.1
BC127886 mRNA Translation: AAI27887.1
CCDSiCCDS43766.1
RefSeqiNP_001075144.2, NM_001081675.2
XP_005250958.1, XM_005250901.4
UniGeneiHs.450252

Genome annotation databases

EnsembliENST00000325995; ENSP00000321475; ENSG00000175946
GeneIDi340359
KEGGihsa:340359
UCSCiuc003yqs.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKLH38_HUMAN
AccessioniPrimary (citable) accession number: Q2WGJ6
Secondary accession number(s): A0PK12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: February 28, 2018
This is version 107 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health