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Protein

Kelch-like protein 38

Gene

KLHL38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 38
Gene namesi
Name:KLHL38
Synonyms:C8orfK36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:34435. KLHL38.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393613.

Polymorphism and mutation databases

BioMutaiKLHL38.
DMDMi296439315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Kelch-like protein 38PRO_0000325809Add
BLAST

Proteomic databases

PaxDbiQ2WGJ6.
PRIDEiQ2WGJ6.

PTM databases

iPTMnetiQ2WGJ6.
PhosphoSiteiQ2WGJ6.

Expressioni

Gene expression databases

BgeeiQ2WGJ6.
CleanExiHS_KLHL38.

Organism-specific databases

HPAiHPA024770.
HPA027115.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BLZF1Q9H2G93EBI-6426443,EBI-2548012
HSP90AB1P082383EBI-6426443,EBI-352572
KRT31Q153233EBI-6426443,EBI-948001
KRT38O760153EBI-6426443,EBI-1047263
KRT40Q6A1623EBI-6426443,EBI-10171697
KRTAP10-7P604093EBI-6426443,EBI-10172290
KRTAP10-8P604103EBI-6426443,EBI-10171774
KRTAP10-9P604113EBI-6426443,EBI-10172052
KRTAP5-9P263713EBI-6426443,EBI-3958099
MAGEA6P433603EBI-6426443,EBI-1045155
MEOX2A4D1273EBI-6426443,EBI-10172134
NOTCH2NLQ7Z3S93EBI-6426443,EBI-945833
NUDCD3Q8IVD92EBI-6426443,EBI-744342
RGS20O760813EBI-6426443,EBI-1052678
RGS20O76081-63EBI-6426443,EBI-10178530
TADA2AO754783EBI-6426443,EBI-742268
TEKT5Q96M293EBI-6426443,EBI-10239812
TRAF1Q130773EBI-6426443,EBI-359224
TRIM42A1L4B63EBI-6426443,EBI-10172216
TRIM54Q9BYV23EBI-6426443,EBI-2130429
UBE3AQ05086-23EBI-6426443,EBI-10175863
USHBP1Q8N6Y03EBI-6426443,EBI-739895
ZNF341Q9BYN73EBI-6426443,EBI-9089622

Protein-protein interaction databases

BioGridi131043. 23 interactions.
IntActiQ2WGJ6. 35 interactions.
STRINGi9606.ENSP00000321475.

Structurei

3D structure databases

ProteinModelPortaliQ2WGJ6.
SMRiQ2WGJ6. Positions 4-258, 305-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 10168BTBPROSITE-ProRule annotationAdd
BLAST
Domaini136 – 237102BACKAdd
BLAST
Repeati285 – 33248Kelch 1Add
BLAST
Repeati334 – 38350Kelch 2Add
BLAST
Repeati384 – 43148Kelch 3Add
BLAST
Repeati433 – 47947Kelch 4Add
BLAST
Repeati480 – 52142Kelch 5Add
BLAST
Repeati523 – 57351Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
HOGENOMiHOG000082537.
HOVERGENiHBG095739.
InParanoidiQ2WGJ6.
KOiK13959.
OMAiEALMVWI.
OrthoDBiEOG7J17ZC.
PhylomeDBiQ2WGJ6.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030568. KLHL38.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF8. PTHR24412:SF8. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2WGJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEESLDGLL FKDHDFSSDL LRQLNSLRQS RILTDVSICA GAREIPCHRN
60 70 80 90 100
VLASSSPYFR AMFCSSFREK SEAKVQLKGI DPPTLDQIVS YVYTGEAHIA
110 120 130 140 150
TDNVLPVMEA ASMLQFPKLF EACSSYLQSQ LAPSNCLGMI RLSEILSCET
160 170 180 190 200
LKKKAREVAL TSFPEVAASA DLKELCALEL RDYLGDDGLC GEEEKVFEAL
210 220 230 240 250
MVWIKHDLQA RKRYMQELFK QVRLQYIHPA FFHHFIANDA LLQSSPACQI
260 270 280 290 300
ILETAKRQMF SLCGTTVPDC KLLLHVPPRN SYQDFLILLG GRKDSQQTTR
310 320 330 340 350
DVLLYSKQTG QWQSLAKLPT RLYKASAITL HRSIYVLGGM AVSSGRSLVS
360 370 380 390 400
HNVYIFSLKL NQWRLGEPML VARYSHRSTA HKNFIFSIGG IGEGQELMGS
410 420 430 440 450
MERYDSICNV WESMASMPVG VLHPAVAVKD QRLYLFGGED IMQNPVRLIQ
460 470 480 490 500
VYHISRNSWF KMETRMIKNV CAPAVVLGER IVIVGGYTRR ILAYDPQSNK
510 520 530 540 550
FVKCADMKDR RMHHGATVMG NKLYVTGGRR LTTDCNIEDS ASFDCYDPET
560 570 580
DTWTSQGQLP HKLFDHACLT LQCIPRTSGL P
Length:581
Mass (Da):65,541
Last modified:May 18, 2010 - v3
Checksum:iC6655BD039F4C757
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti98 – 981H → R in EAW92045 (Ref. 3) Curated
Sequence conflicti98 – 981H → R in AAI27887 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti310 – 3101G → S.
Corresponds to variant rs16898693 [ dbSNP | Ensembl ].
VAR_059437
Natural varianti334 – 3341I → V.2 Publications
Corresponds to variant rs11784192 [ dbSNP | Ensembl ].
VAR_060485
Natural varianti346 – 3461R → K.2 Publications
Corresponds to variant rs11780509 [ dbSNP | Ensembl ].
VAR_060486
Natural varianti352 – 3521N → Y.
Corresponds to variant rs11784175 [ dbSNP | Ensembl ].
VAR_059438
Natural varianti394 – 3941G → R.
Corresponds to variant rs16898691 [ dbSNP | Ensembl ].
VAR_059439
Natural varianti504 – 5041C → Y.
Corresponds to variant rs11779866 [ dbSNP | Ensembl ].
VAR_059440

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196636 mRNA. Translation: BAE53438.1.
AC135166 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW92045.1.
BC127886 mRNA. Translation: AAI27887.1.
CCDSiCCDS43766.1.
RefSeqiNP_001075144.2. NM_001081675.2.
XP_005250958.1. XM_005250901.3.
UniGeneiHs.450252.

Genome annotation databases

EnsembliENST00000325995; ENSP00000321475; ENSG00000175946.
GeneIDi340359.
KEGGihsa:340359.
UCSCiuc003yqs.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196636 mRNA. Translation: BAE53438.1.
AC135166 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW92045.1.
BC127886 mRNA. Translation: AAI27887.1.
CCDSiCCDS43766.1.
RefSeqiNP_001075144.2. NM_001081675.2.
XP_005250958.1. XM_005250901.3.
UniGeneiHs.450252.

3D structure databases

ProteinModelPortaliQ2WGJ6.
SMRiQ2WGJ6. Positions 4-258, 305-554.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131043. 23 interactions.
IntActiQ2WGJ6. 35 interactions.
STRINGi9606.ENSP00000321475.

PTM databases

iPTMnetiQ2WGJ6.
PhosphoSiteiQ2WGJ6.

Polymorphism and mutation databases

BioMutaiKLHL38.
DMDMi296439315.

Proteomic databases

PaxDbiQ2WGJ6.
PRIDEiQ2WGJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325995; ENSP00000321475; ENSG00000175946.
GeneIDi340359.
KEGGihsa:340359.
UCSCiuc003yqs.2. human.

Organism-specific databases

CTDi340359.
GeneCardsiKLHL38.
HGNCiHGNC:34435. KLHL38.
HPAiHPA024770.
HPA027115.
neXtProtiNX_Q2WGJ6.
PharmGKBiPA162393613.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
HOGENOMiHOG000082537.
HOVERGENiHBG095739.
InParanoidiQ2WGJ6.
KOiK13959.
OMAiEALMVWI.
OrthoDBiEOG7J17ZC.
PhylomeDBiQ2WGJ6.
TreeFamiTF329218.

Miscellaneous databases

GenomeRNAii340359.
NextBioi97835.
PROiQ2WGJ6.

Gene expression databases

BgeeiQ2WGJ6.
CleanExiHS_KLHL38.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030568. KLHL38.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF8. PTHR24412:SF8. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel gene on human chromosome 8."
    Shimizu N., Asakawa S., Shimizu A., Yamazaki S., Ishikawa S.K.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart and Skeletal muscle.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS VAL-334 AND LYS-346.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-334 AND LYS-346.

Entry informationi

Entry nameiKLH38_HUMAN
AccessioniPrimary (citable) accession number: Q2WGJ6
Secondary accession number(s): A0PK12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.