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Protein

Protein ripply2

Gene

Ripply2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites.2 Publications

GO - Biological processi

  • axis specification Source: MGI
  • bone morphogenesis Source: MGI
  • determination of left/right symmetry Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • Notch signaling pathway Source: MGI
  • ossification Source: MGI
  • post-anal tail morphogenesis Source: MGI
  • regulation of gene expression Source: MGI
  • somite rostral/caudal axis specification Source: UniProtKB
  • somitogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ripply2
Gene namesi
Name:Ripply2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2685968. Ripply2.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Protein ripply2PRO_0000307760Add
BLAST

Proteomic databases

PaxDbiQ2WG76.
PRIDEiQ2WG76.

Expressioni

Tissue specificityi

Expressed in the embryonic anterior presomitic mesoderm. First expressed in S-I at E8.5, where expression is maintained until E13.5, with an additional stripe of expression sometimes seen in the rostral part of S0 and S-I.2 Publications

Inductioni

By MESP2, and acts in a negative feedback loop with MESP2, functioning negatively toward MESP2 to regulate NOTCH signaling in the anterior presomitic mesoderm.1 Publication

Gene expression databases

BgeeiENSMUSG00000047897.
CleanExiMM_RIPPLY2.
ExpressionAtlasiQ2WG76. baseline and differential.
GenevisibleiQ2WG76. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055369.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 10936Ripply homology domainSequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi34 – 374WRPW motifSequence analysis

Domaini

The ripply homology domain is required for transcriptional repression.By similarity
The WRPW motif is required for binding to tle/groucho proteins.By similarity

Sequence similaritiesi

Belongs to the ripply family.Curated

Phylogenomic databases

eggNOGiENOG410J290. Eukaryota.
ENOG4112884. LUCA.
GeneTreeiENSGT00390000008909.
HOGENOMiHOG000063681.
HOVERGENiHBG095612.
InParanoidiQ2WG76.
OMAiMPDGPGM.
PhylomeDBiQ2WG76.
TreeFamiTF336045.

Family and domain databases

InterProiIPR028127. Ripply_fam.
[Graphical view]
PANTHERiPTHR16770. PTHR16770. 1 hit.
PfamiPF14998. Ripply. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2WG76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTTESAESA HNPARPPSRS RCPPSAQPGS EGFWRPWVRT PGEKEKRTGP
60 70 80 90 100
RAAEALPSGP GMAEASGKLL QYQHPVRLFW PKSKCYDYLY QEAETLLKNF
110 120
PIQATISFYE DSDSEDEIEG LACENQSN
Length:128
Mass (Da):14,305
Last modified:January 10, 2006 - v1
Checksum:i4B9FFB58B5499506
GO

Sequence cautioni

The sequence BAC38162 differs from that shown.Intron retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB212223 mRNA. Translation: BAE53720.1.
AK081203 mRNA. Translation: BAC38162.1. Sequence problems.
CCDSiCCDS40715.1.
RefSeqiNP_001032996.1. NM_001037907.1.
UniGeneiMm.92244.

Genome annotation databases

EnsembliENSMUST00000058846; ENSMUSP00000055369; ENSMUSG00000047897.
GeneIDi382089.
KEGGimmu:382089.
UCSCiuc009qya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB212223 mRNA. Translation: BAE53720.1.
AK081203 mRNA. Translation: BAC38162.1. Sequence problems.
CCDSiCCDS40715.1.
RefSeqiNP_001032996.1. NM_001037907.1.
UniGeneiMm.92244.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055369.

Proteomic databases

PaxDbiQ2WG76.
PRIDEiQ2WG76.

Protocols and materials databases

DNASUi382089.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058846; ENSMUSP00000055369; ENSMUSG00000047897.
GeneIDi382089.
KEGGimmu:382089.
UCSCiuc009qya.1. mouse.

Organism-specific databases

CTDi134701.
MGIiMGI:2685968. Ripply2.

Phylogenomic databases

eggNOGiENOG410J290. Eukaryota.
ENOG4112884. LUCA.
GeneTreeiENSGT00390000008909.
HOGENOMiHOG000063681.
HOVERGENiHBG095612.
InParanoidiQ2WG76.
OMAiMPDGPGM.
PhylomeDBiQ2WG76.
TreeFamiTF336045.

Miscellaneous databases

PROiQ2WG76.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047897.
CleanExiMM_RIPPLY2.
ExpressionAtlasiQ2WG76. baseline and differential.
GenevisibleiQ2WG76. MM.

Family and domain databases

InterProiIPR028127. Ripply_fam.
[Graphical view]
PANTHERiPTHR16770. PTHR16770. 1 hit.
PfamiPF14998. Ripply. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIPP2_MOUSE
AccessioniPrimary (citable) accession number: Q2WG76
Secondary accession number(s): Q8BNN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 10, 2006
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.