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Protein

Carcinoembryonic antigen-related cell adhesion molecule 16

Gene

CEACAM16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane.2 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

GO - Biological processi

  • sensory perception of sound Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 16
Alternative name(s):
Carcinoembryonic antigen-like 2
Gene namesi
Name:CEACAM16
Synonyms:CEAL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000213892.10
HGNCiHGNC:31948 CEACAM16
MIMi614591 gene
neXtProtiNX_Q2WEN9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal dominant, 4B (DFNA4B)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:614614
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067769140T → P in DFNA4B. 1 PublicationCorresponds to variant dbSNP:rs387907149EnsemblClinVar.1
Natural variantiVAR_072720169G → R in DFNA4B; impairs homooligomerization of the protein; decreases secretion of the protein. 1 PublicationCorresponds to variant dbSNP:rs876661405EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNETi388551
MalaCardsiCEACAM16
MIMi614614 phenotype
OpenTargetsiENSG00000213892
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBiPA142672131

Polymorphism and mutation databases

BioMutaiCEACAM16
DMDMi391358127

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000029756421 – 425Carcinoembryonic antigen-related cell adhesion molecule 16Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 201PROSITE-ProRule annotation
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi252 ↔ 293PROSITE-ProRule annotation
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ2WEN9
PeptideAtlasiQ2WEN9
PRIDEiQ2WEN9

PTM databases

iPTMnetiQ2WEN9
PhosphoSitePlusiQ2WEN9

Expressioni

Gene expression databases

BgeeiENSG00000213892
CleanExiHS_CEACAM16

Organism-specific databases

HPAiHPA045075

Interactioni

Subunit structurei

Homooligomer; can for homodimers and homotetramers (PubMed:21368133, PubMed:25589040). Interacts with TECTA (PubMed:21368133).2 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

STRINGi9606.ENSP00000385576

Structurei

3D structure databases

ProteinModelPortaliQ2WEN9
SMRiQ2WEN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 218Ig-like C2-type 1Add BLAST86
Domaini223 – 309Ig-like C2-type 2Add BLAST87

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1 Eukaryota
ENOG410YR1P LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000004760
HOVERGENiHBG101176
InParanoidiQ2WEN9
KOiK06499
OMAiPAEVRWF
OrthoDBiEOG091G0AMM

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2WEN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTGYSWLL LSATFLNVGA EISITLEPAQ PSEGDNVTLV VHGLSGELLA
60 70 80 90 100
YSWYAGPTLS VSYLVASYIV STGDETPGPA HTGREAVRPD GSLDIQGILP
110 120 130 140 150
RHSGTYILQT FNRQLQTEVG YGHVQVHEIL AQPTVLANST ALVERRDTLR
160 170 180 190 200
LMCSSPSPTA EVRWFFNGGA LPVALRLGLS PDGRVLARHG IRREEAGAYQ
210 220 230 240 250
CEVWNPVSVS RSEPINLTVY FGPERVAILQ DSTTRTGCTI KVDFNTSLTL
260 270 280 290 300
WCVSRSCPEP EYVWTFNGQA LKNGQDHLNI SSMTAAQEGT YTCIAKNTKT
310 320 330 340 350
LLSGSASVVV KLSAAAVATM IVPVPTKPTE GQDVTLTVQG YPKDLLVYAW
360 370 380 390 400
YRGPASEPNR LLSQLPSGTW IAGPAHTGRE VGFPNCSLLV QKLNLTDTGR
410 420
YTLKTVTVQG KTETLEVELQ VAPLG
Length:425
Mass (Da):45,873
Last modified:June 13, 2012 - v2
Checksum:i9187F1CFE1C6B959
GO

Sequence cautioni

The sequence AAQ05841 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067769140T → P in DFNA4B. 1 PublicationCorresponds to variant dbSNP:rs387907149EnsemblClinVar.1
Natural variantiVAR_072720169G → R in DFNA4B; impairs homooligomerization of the protein; decreases secretion of the protein. 1 PublicationCorresponds to variant dbSNP:rs876661405EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479646 Genomic DNA Translation: AAQ05841.1 Sequence problems.
EU021223 mRNA Translation: ABS52739.1
AC092066 Genomic DNA No translation available.
BC144608 mRNA No translation available.
CCDSiCCDS54278.1
RefSeqiNP_001034302.2, NM_001039213.3
UniGeneiHs.456381

Genome annotation databases

EnsembliENST00000405314; ENSP00000385576; ENSG00000213892
ENST00000587331; ENSP00000466561; ENSG00000213892
GeneIDi388551
KEGGihsa:388551
UCSCiuc060zsz.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCEA16_HUMAN
AccessioniPrimary (citable) accession number: Q2WEN9
Secondary accession number(s): A7LI12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 13, 2012
Last modified: April 25, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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