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Protein

Carcinoembryonic antigen-related cell adhesion molecule 16

Gene

CEACAM16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane.2 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

GO - Biological processi

  • sensory perception of sound Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 16
Alternative name(s):
Carcinoembryonic antigen-like 2
Gene namesi
Name:CEACAM16
Synonyms:CEAL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:31948. CEACAM16.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • stereocilium tip Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal dominant, 4B (DFNA4B)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:614614
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401T → P in DFNA4B. 1 Publication
Corresponds to variant rs387907149 [ dbSNP | Ensembl ].
VAR_067769
Natural varianti169 – 1691G → R in DFNA4B; impairs homooligomerization of the protein; decreases secretion of the protein. 1 Publication
VAR_072720

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

MalaCardsiCEACAM16.
MIMi614614. phenotype.
Orphaneti90635. Autosomal dominant non-syndromic sensorineural deafness type DFNA.
PharmGKBiPA142672131.

Polymorphism and mutation databases

BioMutaiCEACAM16.
DMDMi391358127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 425405Carcinoembryonic antigen-related cell adhesion molecule 16PRO_0000297564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi153 ↔ 201PROSITE-ProRule annotation
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence analysis
Disulfide bondi252 ↔ 293PROSITE-ProRule annotation
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ2WEN9.
PRIDEiQ2WEN9.

PTM databases

iPTMnetiQ2WEN9.

Expressioni

Gene expression databases

CleanExiHS_CEACAM16.

Organism-specific databases

HPAiHPA045075.

Interactioni

Subunit structurei

Homooligomer; can for homodimers and homotetramers (PubMed:21368133, PubMed:25589040). Interacts with TECTA (PubMed:21368133).2 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

STRINGi9606.ENSP00000385576.

Structurei

3D structure databases

ProteinModelPortaliQ2WEN9.
SMRiQ2WEN9. Positions 20-312, 324-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 21886Ig-like C2-type 1Add
BLAST
Domaini223 – 30987Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000004760.
HOVERGENiHBG101176.
InParanoidiQ2WEN9.
KOiK06499.
OMAiRWFFNGD.
OrthoDBiEOG74BJS7.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2WEN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTGYSWLL LSATFLNVGA EISITLEPAQ PSEGDNVTLV VHGLSGELLA
60 70 80 90 100
YSWYAGPTLS VSYLVASYIV STGDETPGPA HTGREAVRPD GSLDIQGILP
110 120 130 140 150
RHSGTYILQT FNRQLQTEVG YGHVQVHEIL AQPTVLANST ALVERRDTLR
160 170 180 190 200
LMCSSPSPTA EVRWFFNGGA LPVALRLGLS PDGRVLARHG IRREEAGAYQ
210 220 230 240 250
CEVWNPVSVS RSEPINLTVY FGPERVAILQ DSTTRTGCTI KVDFNTSLTL
260 270 280 290 300
WCVSRSCPEP EYVWTFNGQA LKNGQDHLNI SSMTAAQEGT YTCIAKNTKT
310 320 330 340 350
LLSGSASVVV KLSAAAVATM IVPVPTKPTE GQDVTLTVQG YPKDLLVYAW
360 370 380 390 400
YRGPASEPNR LLSQLPSGTW IAGPAHTGRE VGFPNCSLLV QKLNLTDTGR
410 420
YTLKTVTVQG KTETLEVELQ VAPLG
Length:425
Mass (Da):45,873
Last modified:June 13, 2012 - v2
Checksum:i9187F1CFE1C6B959
GO

Sequence cautioni

The sequence AAQ05841.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401T → P in DFNA4B. 1 Publication
Corresponds to variant rs387907149 [ dbSNP | Ensembl ].
VAR_067769
Natural varianti169 – 1691G → R in DFNA4B; impairs homooligomerization of the protein; decreases secretion of the protein. 1 Publication
VAR_072720

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479646 Genomic DNA. Translation: AAQ05841.1. Sequence problems.
EU021223 mRNA. Translation: ABS52739.1.
AC092066 Genomic DNA. No translation available.
BC144608 mRNA. No translation available.
CCDSiCCDS54278.1.
RefSeqiNP_001034302.2. NM_001039213.3.
UniGeneiHs.456381.

Genome annotation databases

EnsembliENST00000405314; ENSP00000385576; ENSG00000213892.
ENST00000587331; ENSP00000466561; ENSG00000213892.
GeneIDi388551.
KEGGihsa:388551.
UCSCiuc060zsz.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479646 Genomic DNA. Translation: AAQ05841.1. Sequence problems.
EU021223 mRNA. Translation: ABS52739.1.
AC092066 Genomic DNA. No translation available.
BC144608 mRNA. No translation available.
CCDSiCCDS54278.1.
RefSeqiNP_001034302.2. NM_001039213.3.
UniGeneiHs.456381.

3D structure databases

ProteinModelPortaliQ2WEN9.
SMRiQ2WEN9. Positions 20-312, 324-406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000385576.

PTM databases

iPTMnetiQ2WEN9.

Polymorphism and mutation databases

BioMutaiCEACAM16.
DMDMi391358127.

Proteomic databases

PaxDbiQ2WEN9.
PRIDEiQ2WEN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405314; ENSP00000385576; ENSG00000213892.
ENST00000587331; ENSP00000466561; ENSG00000213892.
GeneIDi388551.
KEGGihsa:388551.
UCSCiuc060zsz.1. human.

Organism-specific databases

CTDi388551.
GeneCardsiCEACAM16.
HGNCiHGNC:31948. CEACAM16.
HPAiHPA045075.
MalaCardsiCEACAM16.
MIMi614591. gene.
614614. phenotype.
neXtProtiNX_Q2WEN9.
Orphaneti90635. Autosomal dominant non-syndromic sensorineural deafness type DFNA.
PharmGKBiPA142672131.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000004760.
HOVERGENiHBG101176.
InParanoidiQ2WEN9.
KOiK06499.
OMAiRWFFNGD.
OrthoDBiEOG74BJS7.

Miscellaneous databases

GenomeRNAii388551.
PROiQ2WEN9.
SOURCEiSearch...

Gene expression databases

CleanExiHS_CEACAM16.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization, cloning, physical mapping, and expression analysis of a novel gene, CEAL2, encoding a carcinoembryonic antigen-like protein which is differentially expressed in different malignancies."
    Scorilas A.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of new carcinoembryonic antigen (CEA) family members."
    Krupar R.F.A., Sunami K., Zimmermann W., Kammerer R.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4)."
    Zheng J., Miller K.K., Yang T., Hildebrand M.S., Shearer A.E., DeLuca A.P., Scheetz T.E., Drummond J., Scherer S.E., Legan P.K., Goodyear R.J., Richardson G.P., Cheatham M.A., Smith R.J., Dallos P.
    Proc. Natl. Acad. Sci. U.S.A. 108:4218-4223(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN DFNA4B, VARIANT DFNA4B PRO-140, FUNCTION, SUBUNIT, INTERACTION WITH TECTA.
  6. "Exome sequencing identifies a novel CEACAM16 mutation associated with autosomal dominant nonsyndromic hearing loss DFNA4B in a Chinese family."
    Wang H., Wang X., He C., Li H., Qing J., Grati M., Hu Z., Li J., Hu Y., Xia K., Mei L., Wang X., Yu J., Chen H., Jiang L., Liu Y., Men M., Zhang H.
    , Guan L., Xiao J., Zhang J., Liu X., Feng Y.
    J. Hum. Genet. 60:119-126(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF VARIANT DFNA4B ARG-169, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.

Entry informationi

Entry nameiCEA16_HUMAN
AccessioniPrimary (citable) accession number: Q2WEN9
Secondary accession number(s): A7LI12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 13, 2012
Last modified: July 6, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.