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Protein

Transient receptor potential cation channel subfamily M member 1

Gene

Trpm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 1
Alternative name(s):
Melastatin-1
Gene namesi
Name:Trpm1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1597140. Trpm1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 790790ExtracellularSequence analysisAdd
BLAST
Transmembranei791 – 81121HelicalSequence analysisAdd
BLAST
Topological domaini812 – 87564CytoplasmicSequence analysisAdd
BLAST
Transmembranei876 – 89621HelicalSequence analysisAdd
BLAST
Topological domaini897 – 8971ExtracellularSequence analysis
Transmembranei898 – 91821HelicalSequence analysisAdd
BLAST
Topological domaini919 – 94224CytoplasmicSequence analysisAdd
BLAST
Transmembranei943 – 96321HelicalSequence analysisAdd
BLAST
Topological domaini964 – 97310ExtracellularSequence analysis
Transmembranei974 – 99421HelicalSequence analysisAdd
BLAST
Topological domaini995 – 100612CytoplasmicSequence analysisAdd
BLAST
Transmembranei1007 – 102721HelicalSequence analysisAdd
BLAST
Topological domaini1028 – 110578ExtracellularSequence analysisAdd
BLAST
Transmembranei1106 – 112621HelicalSequence analysisAdd
BLAST
Topological domaini1127 – 115630CytoplasmicSequence analysisAdd
BLAST
Transmembranei1157 – 117721HelicalSequence analysisAdd
BLAST
Topological domaini1178 – 1628451ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16281628Transient receptor potential cation channel subfamily M member 1PRO_0000328932Add
BLAST

Proteomic databases

PaxDbiQ2WEA5.
PRIDEiQ2WEA5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062990.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1230 – 125930Sequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
ENOG410XR5B. LUCA.
HOGENOMiHOG000230920.
HOVERGENiHBG055663.
InParanoidiQ2WEA5.
KOiK04976.
PhylomeDBiQ2WEA5.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029588. TRPM1.
IPR032415. TRPM_tetra.
[Graphical view]
PANTHERiPTHR13800:SF13. PTHR13800:SF13. 2 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF16519. TRPM_tetra. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q2WEA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSMRKMSSS FKRGSIKSST SGSQKGQKAW IEKTFCKREC IFVIPSTKDP
60 70 80 90 100
NRCCCGQLTN QHIPPLPSVT PSSTAEDTKQ GDAQSGKWSV SKHTQSYPTD
110 120 130 140 150
SYGILEFQGG GYSNKAMYIR VSYDTKPDSL LHLMVKDWQL ELPKLLISVH
160 170 180 190 200
GGLQSFEMQP KLKQVFGKGL IKAAMTTGAW IFTGGVSTGV VSHVGDALKD
210 220 230 240 250
HSSKSRGRLC AIGIAPWGMV ENKEDLVGKD VTRVYQTMSN PLSKLSVLNN
260 270 280 290 300
SHTHFILADN GTLGKYGAEV KLRRQLEKHI SLQKINTRLG QGVPVVGLVV
310 320 330 340 350
EGGPNVVSIV LEYLREDPPV PVVVCDGSGR ASDILSFAHK YCDEGGVINE
360 370 380 390 400
SLRDQLLVTI QKTFNYSKSQ SHQLFAIIME CMKKKELVTV FRMGSEGQQD
410 420 430 440 450
VEMAILTALL KGTNVSAPDQ LSLALAWNRV DIARSQIFVF GPHWPPLGSL
460 470 480 490 500
APPVDTKVAE KEKKPPTATT KGRGKGKGKK KGKVKEEVEE ETDPRKIELL
510 520 530 540 550
NWVNALEQAM LDALVLDRVD FVKLLIENGV NMQHFLTIPR LEELYNTRLG
560 570 580 590 600
PPNTLHLLVR DVKKSNLPPD YHISLIDIGL VLEYLMGGAY RCNYTRKSFR
610 620 630 640 650
TLYNNLFGPK RPKALKLLGM EDDEPPAKGK KKKKKKKEEE IDIDVDDPAV
660 670 680 690 700
SRFQYPFHEL MVWAVLMKRQ KMAVFLWQRG EECMAKALVA CKLYKAMAHE
710 720 730 740 750
SSESELVDDI SQDLDNNSKD FGQLAVELLD QSYKHDEQVA MKLLTYELKN
760 770 780 790 800
WSNSTCLKLA VAAKHRDFIA HTCSQMLLTD MWMGRLRMRK NPGLKVIMGI
810 820 830 840 850
LIPPTILFLE FRSYDDFSYQ TSKENEDGKE KEEENVDANA DAGSRKGDEE
860 870 880 890 900
NEHKKQRSIP IGTKICEFYN APIVKFWFYT ISYLGYLLLF NYVILVRMDG
910 920 930 940 950
WPSPQEWIVI SYIVSLALEK IREILMSEPG KLSQKIKVWL QEYWNITDLV
960 970 980 990 1000
AISMFMVGAI LRLQNQPYMG YGRVIYCVDI ILWYIRVLDI FGVNKYLGPY
1010 1020 1030 1040 1050
VMMIGKMMID MLYFVVIMLV VLMSFGVARQ AILHPEEKPS WKLARNIFYM
1060 1070 1080 1090 1100
PYWMIYGEVF ADQIDRKTRI HIYAMEINPP CGENLYDEEG KRLPPCIPGA
1110 1120 1130 1140 1150
WLTPALMACY LLVANILLVN LLIAVFNNTF FEVKSISNQV WKFQRYQLIM
1160 1170 1180 1190 1200
TFHDRPVLPP PMIILSHIYI IVMRLSGRCR KKREGDQEER DRGLKLFLSD
1210 1220 1230 1240 1250
EELKKLHEFE EQCVQEHFRE KEDEQQSSSD ERIRVTSERV ENMSMRLEEI
1260 1270 1280 1290 1300
NERENFMKAS LQTVDLRLSQ LEELSGRMVG ALENLAGIDR SDLIQARSRA
1310 1320 1330 1340 1350
SSECEATYLL RQSSINSADG YSMYRYHFNG EELLFEEPAL STSPGTVFRK
1360 1370 1380 1390 1400
KTCSFRVKEE DVKPHLDQPS SLHHTPGPSP PATPGRSRLA LDGPLSTELR
1410 1420 1430 1440 1450
PGLDPGISAG ELDPRADFKS AEVAPSLNTA NVASTQLTVE STVSHPLRES
1460 1470 1480 1490 1500
KLARYYPGDL NTYKTMKSRS FVYSEGRKLV RGLSNWGAEY SSIMDQTWNS
1510 1520 1530 1540 1550
AEWRCQVQRI TRSRSTDIPY IVSEAASQDE FEDEHRESLL APQISRSALT
1560 1570 1580 1590 1600
VSDRPEKENL LSVKPHQTLG FPCLRSRSLH GHPRSAKPSP SKLDRAGHAS
1610 1620
STSNLAVMSD APEGQNTQQE KGNPETEC
Length:1,628
Mass (Da):184,318
Last modified:January 10, 2006 - v1
Checksum:i2CFB057DF62CB102
GO
Isoform 21 Publication (identifier: Q2WEA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1066-1072: RKTRIHI → L

Show »
Length:1,622
Mass (Da):183,526
Checksum:iDD4594078C460875
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1066 – 10727RKTRIHI → L in isoform 2. 1 PublicationVSP_052740

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ867482 mRNA. Translation: CAI30141.1.
AJ867483 mRNA. Translation: CAI30142.1.
RefSeqiNP_001032822.1. NM_001037733.1. [Q2WEA5-2]
NP_001032823.1. NM_001037734.1. [Q2WEA5-1]
UniGeneiRn.211311.

Genome annotation databases

GeneIDi361586.
KEGGirno:361586.
UCSCiRGD:1597140. rat. [Q2WEA5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ867482 mRNA. Translation: CAI30141.1.
AJ867483 mRNA. Translation: CAI30142.1.
RefSeqiNP_001032822.1. NM_001037733.1. [Q2WEA5-2]
NP_001032823.1. NM_001037734.1. [Q2WEA5-1]
UniGeneiRn.211311.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062990.

Proteomic databases

PaxDbiQ2WEA5.
PRIDEiQ2WEA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361586.
KEGGirno:361586.
UCSCiRGD:1597140. rat. [Q2WEA5-1]

Organism-specific databases

CTDi4308.
RGDi1597140. Trpm1.

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
ENOG410XR5B. LUCA.
HOGENOMiHOG000230920.
HOVERGENiHBG055663.
InParanoidiQ2WEA5.
KOiK04976.
PhylomeDBiQ2WEA5.

Miscellaneous databases

NextBioi676824.
PROiQ2WEA5.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029588. TRPM1.
IPR032415. TRPM_tetra.
[Graphical view]
PANTHERiPTHR13800:SF13. PTHR13800:SF13. 2 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF16519. TRPM_tetra. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Transcriptional regulation and processing increase the functional variability of TRPM channels."
    Lis A., Wissenbach U., Philipp S.E.
    Naunyn Schmiedebergs Arch. Pharmacol. 371:315-324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
    Strain: Dark agoutiImported.
    Tissue: EyeImported.

Entry informationi

Entry nameiTRPM1_RAT
AccessioniPrimary (citable) accession number: Q2WEA5
Secondary accession number(s): Q2WEA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 10, 2006
Last modified: January 20, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.