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Q2WBE4

- SYL_MAGSA

UniProt

Q2WBE4 - SYL_MAGSA

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Protein
Leucine--tRNA ligase
Gene
leuS, amb0027
Organism
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei628 – 6281ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAG342108:GJNU-28-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:amb0027
OrganismiMagnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Taxonomic identifieri342108 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeMagnetospirillum
ProteomesiUP000007058: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Leucine--tRNA ligaseUniRule annotation
PRO_0000334769Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342108.amb0027.

Structurei

3D structure databases

ProteinModelPortaliQ2WBE4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 5911"HIGH" regionUniRule annotation
Add
BLAST
Motifi625 – 6295"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2WBE4-1 [UniParc]FASTAAdd to Basket

« Hide

MSRPDGISGD RYNVKETEAR WQQAWEAKRC FEAEIAPGKP KYYVLEMFPY    50
PSGRIHMGHV RNYTLGDVVA RYKRAKGFNV LHPMGWDAFG LPAENAAIQN 100
NVHPAKWTRE NIAAMREQLK SMGLSYDWRR EVATCEPEYY RHEQKMFLDF 150
LKAGLVYRKE SWVNWDPVEN TVLANEQVID GRGWRSGALV EKRLLSQWFL 200
KITAYAQDLL DSLATLERWP ERVRLMQENW IGRSEGARLM FDLDGRSDRL 250
EIFTTRPDTL FGAKFVAIAA NHPLAAELAA GNPALAEFVA ECNRMGTSEA 300
AIETAEKKGF DTGLRAVHPF DSTWTLPIYV ANFVLMDYGS GAIFGCPAHD 350
QRDLDFANKY GLGWTQVVEP ASDGQAVLAA IAKGEAYTGD GVAVNSQFLD 400
GLAVDEAKAE AIRRIEEMGR GERTINYRLR DWGVSRQRYW GCPIPVIHCE 450
ACGTVPVPAE QLPVVLPEDV SFDKPGNPLD HHPTWKHVDC PCCGKPARRE 500
TDTFDTFFES SWYFARYTSP DRTDVAFDRV AADYWMSVDQ YIGGIEHAVL 550
HLLYSRFFTR ALKDCGYLNV KEPFAGLLTQ GMICHETYKS EDGAWLFPTE 600
VVPGADGKLV HAETGAPVTG GRSEKMSKSK KNVVDPAGII DGYGADTARL 650
FMLSDSPPER DLDWTEAGID GAWRYVNRLW RMVATAELPP AGAPMPELSP 700
EAAKIRRLLH KTIAQVGEDL ERFHFNKAVA RIREMTNGLG ELPAGDSGAA 750
WVLREGLEAT ARLIGPMMPH LAEEMWLALG GSGLLAEAAW PEADPALLVE 800
DSVTVAVQVN GKLRATIELP KDVDAALAEQ TALAQPQVIS AMSGKPARKV 850
VVVPNRIVNV VV 862
Length:862
Mass (Da):95,889
Last modified:January 10, 2006 - v1
Checksum:i06D761D800A3D176
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007255 Genomic DNA. Translation: BAE48831.1.
RefSeqiWP_011382475.1. NC_007626.1.
YP_419390.1. NC_007626.1.

Genome annotation databases

EnsemblBacteriaiBAE48831; BAE48831; amb0027.
GeneIDi3806649.
KEGGimag:amb0027.
PATRICi22434316. VBIMagMag129836_0029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007255 Genomic DNA. Translation: BAE48831.1 .
RefSeqi WP_011382475.1. NC_007626.1.
YP_419390.1. NC_007626.1.

3D structure databases

ProteinModelPortali Q2WBE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342108.amb0027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE48831 ; BAE48831 ; amb0027 .
GeneIDi 3806649.
KEGGi mag:amb0027.
PATRICi 22434316. VBIMagMag129836_0029.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MMAG342108:GJNU-28-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the facultative anaerobic magnetotactic bacterium Magnetospirillum sp. strain AMB-1."
    Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H.
    DNA Res. 12:157-166(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AMB-1 / ATCC 700264.

Entry informationi

Entry nameiSYL_MAGSA
AccessioniPrimary (citable) accession number: Q2WBE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 10, 2006
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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