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Q2WBE4

- SYL_MAGSA

UniProt

Q2WBE4 - SYL_MAGSA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei628 – 6281ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAG342108:GJNU-28-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:amb0027
OrganismiMagnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Taxonomic identifieri342108 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeMagnetospirillum
ProteomesiUP000007058: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Leucine--tRNA ligasePRO_0000334769Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342108.amb0027.

Structurei

3D structure databases

ProteinModelPortaliQ2WBE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 5911"HIGH" regionAdd
BLAST
Motifi625 – 6295"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2WBE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRPDGISGD RYNVKETEAR WQQAWEAKRC FEAEIAPGKP KYYVLEMFPY
60 70 80 90 100
PSGRIHMGHV RNYTLGDVVA RYKRAKGFNV LHPMGWDAFG LPAENAAIQN
110 120 130 140 150
NVHPAKWTRE NIAAMREQLK SMGLSYDWRR EVATCEPEYY RHEQKMFLDF
160 170 180 190 200
LKAGLVYRKE SWVNWDPVEN TVLANEQVID GRGWRSGALV EKRLLSQWFL
210 220 230 240 250
KITAYAQDLL DSLATLERWP ERVRLMQENW IGRSEGARLM FDLDGRSDRL
260 270 280 290 300
EIFTTRPDTL FGAKFVAIAA NHPLAAELAA GNPALAEFVA ECNRMGTSEA
310 320 330 340 350
AIETAEKKGF DTGLRAVHPF DSTWTLPIYV ANFVLMDYGS GAIFGCPAHD
360 370 380 390 400
QRDLDFANKY GLGWTQVVEP ASDGQAVLAA IAKGEAYTGD GVAVNSQFLD
410 420 430 440 450
GLAVDEAKAE AIRRIEEMGR GERTINYRLR DWGVSRQRYW GCPIPVIHCE
460 470 480 490 500
ACGTVPVPAE QLPVVLPEDV SFDKPGNPLD HHPTWKHVDC PCCGKPARRE
510 520 530 540 550
TDTFDTFFES SWYFARYTSP DRTDVAFDRV AADYWMSVDQ YIGGIEHAVL
560 570 580 590 600
HLLYSRFFTR ALKDCGYLNV KEPFAGLLTQ GMICHETYKS EDGAWLFPTE
610 620 630 640 650
VVPGADGKLV HAETGAPVTG GRSEKMSKSK KNVVDPAGII DGYGADTARL
660 670 680 690 700
FMLSDSPPER DLDWTEAGID GAWRYVNRLW RMVATAELPP AGAPMPELSP
710 720 730 740 750
EAAKIRRLLH KTIAQVGEDL ERFHFNKAVA RIREMTNGLG ELPAGDSGAA
760 770 780 790 800
WVLREGLEAT ARLIGPMMPH LAEEMWLALG GSGLLAEAAW PEADPALLVE
810 820 830 840 850
DSVTVAVQVN GKLRATIELP KDVDAALAEQ TALAQPQVIS AMSGKPARKV
860
VVVPNRIVNV VV
Length:862
Mass (Da):95,889
Last modified:January 10, 2006 - v1
Checksum:i06D761D800A3D176
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007255 Genomic DNA. Translation: BAE48831.1.
RefSeqiYP_419390.1. NC_007626.1.

Genome annotation databases

EnsemblBacteriaiBAE48831; BAE48831; amb0027.
GeneIDi3806649.
KEGGimag:amb0027.
PATRICi22434316. VBIMagMag129836_0029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007255 Genomic DNA. Translation: BAE48831.1 .
RefSeqi YP_419390.1. NC_007626.1.

3D structure databases

ProteinModelPortali Q2WBE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342108.amb0027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE48831 ; BAE48831 ; amb0027 .
GeneIDi 3806649.
KEGGi mag:amb0027.
PATRICi 22434316. VBIMagMag129836_0029.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MMAG342108:GJNU-28-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the facultative anaerobic magnetotactic bacterium Magnetospirillum sp. strain AMB-1."
    Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H.
    DNA Res. 12:157-166(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AMB-1 / ATCC 700264.

Entry informationi

Entry nameiSYL_MAGSA
AccessioniPrimary (citable) accession number: Q2WBE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 10, 2006
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3