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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei628ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAG342108:G1G2B-29-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:amb0027
OrganismiMagnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Taxonomic identifieri342108 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeMagnetospirillum
Proteomesi
  • UP000007058 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347691 – 862Leucine--tRNA ligaseAdd BLAST862

Proteomic databases

PRIDEiQ2WBE4

Interactioni

Protein-protein interaction databases

STRINGi342108.amb0027

Structurei

3D structure databases

ProteinModelPortaliQ2WBE4
SMRiQ2WBE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi49 – 59"HIGH" regionAdd BLAST11
Motifi625 – 629"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q2WBE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPDGISGD RYNVKETEAR WQQAWEAKRC FEAEIAPGKP KYYVLEMFPY
60 70 80 90 100
PSGRIHMGHV RNYTLGDVVA RYKRAKGFNV LHPMGWDAFG LPAENAAIQN
110 120 130 140 150
NVHPAKWTRE NIAAMREQLK SMGLSYDWRR EVATCEPEYY RHEQKMFLDF
160 170 180 190 200
LKAGLVYRKE SWVNWDPVEN TVLANEQVID GRGWRSGALV EKRLLSQWFL
210 220 230 240 250
KITAYAQDLL DSLATLERWP ERVRLMQENW IGRSEGARLM FDLDGRSDRL
260 270 280 290 300
EIFTTRPDTL FGAKFVAIAA NHPLAAELAA GNPALAEFVA ECNRMGTSEA
310 320 330 340 350
AIETAEKKGF DTGLRAVHPF DSTWTLPIYV ANFVLMDYGS GAIFGCPAHD
360 370 380 390 400
QRDLDFANKY GLGWTQVVEP ASDGQAVLAA IAKGEAYTGD GVAVNSQFLD
410 420 430 440 450
GLAVDEAKAE AIRRIEEMGR GERTINYRLR DWGVSRQRYW GCPIPVIHCE
460 470 480 490 500
ACGTVPVPAE QLPVVLPEDV SFDKPGNPLD HHPTWKHVDC PCCGKPARRE
510 520 530 540 550
TDTFDTFFES SWYFARYTSP DRTDVAFDRV AADYWMSVDQ YIGGIEHAVL
560 570 580 590 600
HLLYSRFFTR ALKDCGYLNV KEPFAGLLTQ GMICHETYKS EDGAWLFPTE
610 620 630 640 650
VVPGADGKLV HAETGAPVTG GRSEKMSKSK KNVVDPAGII DGYGADTARL
660 670 680 690 700
FMLSDSPPER DLDWTEAGID GAWRYVNRLW RMVATAELPP AGAPMPELSP
710 720 730 740 750
EAAKIRRLLH KTIAQVGEDL ERFHFNKAVA RIREMTNGLG ELPAGDSGAA
760 770 780 790 800
WVLREGLEAT ARLIGPMMPH LAEEMWLALG GSGLLAEAAW PEADPALLVE
810 820 830 840 850
DSVTVAVQVN GKLRATIELP KDVDAALAEQ TALAQPQVIS AMSGKPARKV
860
VVVPNRIVNV VV
Length:862
Mass (Da):95,889
Last modified:January 10, 2006 - v1
Checksum:i06D761D800A3D176
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007255 Genomic DNA Translation: BAE48831.1
RefSeqiWP_011382475.1, NC_007626.1

Genome annotation databases

EnsemblBacteriaiBAE48831; BAE48831; amb0027
KEGGimag:amb0027

Similar proteinsi

Entry informationi

Entry nameiSYL_MAGSA
AccessioniPrimary (citable) accession number: Q2WBE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 10, 2006
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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