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Q2WBE4

- SYL_MAGSA

UniProt

Q2WBE4 - SYL_MAGSA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei628 – 6281ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAG342108:GJNU-28-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:amb0027
    OrganismiMagnetospirillum magneticum (strain AMB-1 / ATCC 700264)
    Taxonomic identifieri342108 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeMagnetospirillum
    ProteomesiUP000007058: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 862862Leucine--tRNA ligasePRO_0000334769Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi342108.amb0027.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2WBE4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi49 – 5911"HIGH" regionAdd
    BLAST
    Motifi625 – 6295"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2WBE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRPDGISGD RYNVKETEAR WQQAWEAKRC FEAEIAPGKP KYYVLEMFPY    50
    PSGRIHMGHV RNYTLGDVVA RYKRAKGFNV LHPMGWDAFG LPAENAAIQN 100
    NVHPAKWTRE NIAAMREQLK SMGLSYDWRR EVATCEPEYY RHEQKMFLDF 150
    LKAGLVYRKE SWVNWDPVEN TVLANEQVID GRGWRSGALV EKRLLSQWFL 200
    KITAYAQDLL DSLATLERWP ERVRLMQENW IGRSEGARLM FDLDGRSDRL 250
    EIFTTRPDTL FGAKFVAIAA NHPLAAELAA GNPALAEFVA ECNRMGTSEA 300
    AIETAEKKGF DTGLRAVHPF DSTWTLPIYV ANFVLMDYGS GAIFGCPAHD 350
    QRDLDFANKY GLGWTQVVEP ASDGQAVLAA IAKGEAYTGD GVAVNSQFLD 400
    GLAVDEAKAE AIRRIEEMGR GERTINYRLR DWGVSRQRYW GCPIPVIHCE 450
    ACGTVPVPAE QLPVVLPEDV SFDKPGNPLD HHPTWKHVDC PCCGKPARRE 500
    TDTFDTFFES SWYFARYTSP DRTDVAFDRV AADYWMSVDQ YIGGIEHAVL 550
    HLLYSRFFTR ALKDCGYLNV KEPFAGLLTQ GMICHETYKS EDGAWLFPTE 600
    VVPGADGKLV HAETGAPVTG GRSEKMSKSK KNVVDPAGII DGYGADTARL 650
    FMLSDSPPER DLDWTEAGID GAWRYVNRLW RMVATAELPP AGAPMPELSP 700
    EAAKIRRLLH KTIAQVGEDL ERFHFNKAVA RIREMTNGLG ELPAGDSGAA 750
    WVLREGLEAT ARLIGPMMPH LAEEMWLALG GSGLLAEAAW PEADPALLVE 800
    DSVTVAVQVN GKLRATIELP KDVDAALAEQ TALAQPQVIS AMSGKPARKV 850
    VVVPNRIVNV VV 862
    Length:862
    Mass (Da):95,889
    Last modified:January 10, 2006 - v1
    Checksum:i06D761D800A3D176
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007255 Genomic DNA. Translation: BAE48831.1.
    RefSeqiWP_011382475.1. NC_007626.1.
    YP_419390.1. NC_007626.1.

    Genome annotation databases

    EnsemblBacteriaiBAE48831; BAE48831; amb0027.
    GeneIDi3806649.
    KEGGimag:amb0027.
    PATRICi22434316. VBIMagMag129836_0029.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007255 Genomic DNA. Translation: BAE48831.1 .
    RefSeqi WP_011382475.1. NC_007626.1.
    YP_419390.1. NC_007626.1.

    3D structure databases

    ProteinModelPortali Q2WBE4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342108.amb0027.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE48831 ; BAE48831 ; amb0027 .
    GeneIDi 3806649.
    KEGGi mag:amb0027.
    PATRICi 22434316. VBIMagMag129836_0029.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MMAG342108:GJNU-28-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the facultative anaerobic magnetotactic bacterium Magnetospirillum sp. strain AMB-1."
      Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H.
      DNA Res. 12:157-166(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AMB-1 / ATCC 700264.

    Entry informationi

    Entry nameiSYL_MAGSA
    AccessioniPrimary (citable) accession number: Q2WBE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3