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Q2WB09

- NADK_MAGSA

UniProt

Q2WB09 - NADK_MAGSA

Protein

NAD kinase

Gene

nadK

Organism
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441Proton acceptorUniRule annotation
    Binding sitei144 – 1441NADUniRule annotation
    Binding sitei152 – 1521NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 452NADUniRule annotation
    Nucleotide bindingi114 – 1152NADUniRule annotation
    Nucleotide bindingi155 – 1606NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAG342108:GJNU-163-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:amb0162
    OrganismiMagnetospirillum magneticum (strain AMB-1 / ATCC 700264)
    Taxonomic identifieri342108 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeMagnetospirillum
    ProteomesiUP000007058: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255NAD kinasePRO_1000005421Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi342108.amb0162.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2WB09.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000139847.
    KOiK00858.
    OMAiHESTVSI.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2WB09-1 [UniParc]FASTAAdd to Basket

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    MIFSSIAFVA AETEAAKAAL ARLEQRYPHV DPGEADVIIA LGGDGFMLET    50
    LHRFVDRRVP IYGMNRGSVG FLMNVYREHG LIERLSKAEE VILHPLRMKA 100
    RTASGEEVEA LAINEVSLLR ETRQAAKLRI RIDGKIRMDE LICDGILLST 150
    PAGSTAYNLS AHGPIIPLGA GIAALTPISA FRPRRWRGAL LPHTAKVVFE 200
    ILEAGKRPVS AVADYTEARD VVEVEVREDR TCDLVMLFDP EHNLEERIIT 250
    EQFLP 255
    Length:255
    Mass (Da):28,276
    Last modified:January 10, 2006 - v1
    Checksum:iDE6755BA07D410BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007255 Genomic DNA. Translation: BAE48966.1.
    RefSeqiWP_011382609.1. NC_007626.1.
    YP_419525.1. NC_007626.1.

    Genome annotation databases

    EnsemblBacteriaiBAE48966; BAE48966; amb0162.
    GeneIDi3805924.
    KEGGimag:amb0162.
    PATRICi22434586. VBIMagMag129836_0164.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007255 Genomic DNA. Translation: BAE48966.1 .
    RefSeqi WP_011382609.1. NC_007626.1.
    YP_419525.1. NC_007626.1.

    3D structure databases

    ProteinModelPortali Q2WB09.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342108.amb0162.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE48966 ; BAE48966 ; amb0162 .
    GeneIDi 3805924.
    KEGGi mag:amb0162.
    PATRICi 22434586. VBIMagMag129836_0164.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000139847.
    KOi K00858.
    OMAi HESTVSI.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci MMAG342108:GJNU-163-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the facultative anaerobic magnetotactic bacterium Magnetospirillum sp. strain AMB-1."
      Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H.
      DNA Res. 12:157-166(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AMB-1 / ATCC 700264.

    Entry informationi

    Entry nameiNADK_MAGSA
    AccessioniPrimary (citable) accession number: Q2WB09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3