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Q2W724

- UPPP2_MAGSA

UniProt

Q2W724 - UPPP2_MAGSA

Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciMMAG342108:GJNU-1564-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 2UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
    Gene namesi
    Name:uppP2UniRule annotation
    Ordered Locus Names:amb1547
    OrganismiMagnetospirillum magneticum (strain AMB-1 / ATCC 700264)
    Taxonomic identifieri342108 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeMagnetospirillum
    ProteomesiUP000007058: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Undecaprenyl-diphosphatase 2PRO_0000250243Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi342108.amb1547.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei38 – 5821HelicalUniRule annotationAdd
    BLAST
    Transmembranei75 – 9521HelicalUniRule annotationAdd
    BLAST
    Transmembranei103 – 12321HelicalUniRule annotationAdd
    BLAST
    Transmembranei138 – 15821HelicalUniRule annotationAdd
    BLAST
    Transmembranei178 – 19821HelicalUniRule annotationAdd
    BLAST
    Transmembranei212 – 23221HelicalUniRule annotationAdd
    BLAST
    Transmembranei240 – 26021HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2W724-1 [UniParc]FASTAAdd to Basket

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    MLEALLLGVV EGLTEFLPIS STAHLMLIGD MLGFEGPPGK TYEIVVQLGA    50
    ILAVCVVFRQ RLWGVATTIT QPRSFAFARN VMVAFLPAAV IGATLYKYIK 100
    QMLESPLVAA IALVVGGVAI LVIERLVKRA RIHDIEDMSP ALALGVGFCQ 150
    VLAMVPGVSR AGATIMGSML LGLDRRAAAE FSFFLAIPTM CGASAYSLYK 200
    NWATLSFDGA GLIALGFVAA FLSALVVVKG FIGFVGRHGF APFAWYRIAF 250
    GSLMAVLILM R 261
    Length:261
    Mass (Da):27,807
    Last modified:January 10, 2006 - v1
    Checksum:i0E7A3C1C5BA8ED35
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007255 Genomic DNA. Translation: BAE50351.1.
    RefSeqiYP_420910.1. NC_007626.1.

    Genome annotation databases

    EnsemblBacteriaiBAE50351; BAE50351; amb1547.
    GeneIDi3806467.
    KEGGimag:amb1547.
    PATRICi22437359. VBIMagMag129836_1534.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007255 Genomic DNA. Translation: BAE50351.1 .
    RefSeqi YP_420910.1. NC_007626.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342108.amb1547.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE50351 ; BAE50351 ; amb1547 .
    GeneIDi 3806467.
    KEGGi mag:amb1547.
    PATRICi 22437359. VBIMagMag129836_1534.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci MMAG342108:GJNU-1564-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the facultative anaerobic magnetotactic bacterium Magnetospirillum sp. strain AMB-1."
      Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H.
      DNA Res. 12:157-166(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AMB-1 / ATCC 700264.

    Entry informationi

    Entry nameiUPPP2_MAGSA
    AccessioniPrimary (citable) accession number: Q2W724
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3