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Q2W724

- UPPP2_MAGSA

UniProt

Q2W724 - UPPP2_MAGSA

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Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMMAG342108:GJNU-1564-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 2UniRule annotation
Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
Gene namesi
Name:uppP2UniRule annotation
Ordered Locus Names:amb1547
OrganismiMagnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Taxonomic identifieri342108 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeMagnetospirillum
ProteomesiUP000007058: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Undecaprenyl-diphosphatase 2PRO_0000250243Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342108.amb1547.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST
Transmembranei38 – 5821HelicalUniRule annotationAdd
BLAST
Transmembranei75 – 9521HelicalUniRule annotationAdd
BLAST
Transmembranei103 – 12321HelicalUniRule annotationAdd
BLAST
Transmembranei138 – 15821HelicalUniRule annotationAdd
BLAST
Transmembranei178 – 19821HelicalUniRule annotationAdd
BLAST
Transmembranei212 – 23221HelicalUniRule annotationAdd
BLAST
Transmembranei240 – 26021HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2W724-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEALLLGVV EGLTEFLPIS STAHLMLIGD MLGFEGPPGK TYEIVVQLGA
60 70 80 90 100
ILAVCVVFRQ RLWGVATTIT QPRSFAFARN VMVAFLPAAV IGATLYKYIK
110 120 130 140 150
QMLESPLVAA IALVVGGVAI LVIERLVKRA RIHDIEDMSP ALALGVGFCQ
160 170 180 190 200
VLAMVPGVSR AGATIMGSML LGLDRRAAAE FSFFLAIPTM CGASAYSLYK
210 220 230 240 250
NWATLSFDGA GLIALGFVAA FLSALVVVKG FIGFVGRHGF APFAWYRIAF
260
GSLMAVLILM R
Length:261
Mass (Da):27,807
Last modified:January 10, 2006 - v1
Checksum:i0E7A3C1C5BA8ED35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007255 Genomic DNA. Translation: BAE50351.1.
RefSeqiWP_011383957.1. NC_007626.1.
YP_420910.1. NC_007626.1.

Genome annotation databases

EnsemblBacteriaiBAE50351; BAE50351; amb1547.
GeneIDi3806467.
KEGGimag:amb1547.
PATRICi22437359. VBIMagMag129836_1534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007255 Genomic DNA. Translation: BAE50351.1 .
RefSeqi WP_011383957.1. NC_007626.1.
YP_420910.1. NC_007626.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342108.amb1547.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE50351 ; BAE50351 ; amb1547 .
GeneIDi 3806467.
KEGGi mag:amb1547.
PATRICi 22437359. VBIMagMag129836_1534.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci MMAG342108:GJNU-1564-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the facultative anaerobic magnetotactic bacterium Magnetospirillum sp. strain AMB-1."
    Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H.
    DNA Res. 12:157-166(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AMB-1 / ATCC 700264.

Entry informationi

Entry nameiUPPP2_MAGSA
AccessioniPrimary (citable) accession number: Q2W724
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: January 10, 2006
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3