Q2W724 (UPPP2_MAGSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 2
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2

Gene names

Name:	uppP2
Ordered Locus Names:	amb1547

Organism

Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) [Complete proteome] [HAMAP]

Taxonomic identifier

342108 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Magnetospirillum › Magnetospirillum magneticum

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006		PRO_0000250243
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	38 – 58	21	Helical; Potential
	Transmembrane	75 – 95	21	Helical; Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Transmembrane	138 – 158	21	Helical; Potential
	Transmembrane	178 – 198	21	Helical; Potential
	Transmembrane	212 – 232	21	Helical; Potential
	Transmembrane	240 – 260	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2W724 [UniParc]. Last modified January 10, 2006. Version 1. Checksum: 0E7A3C1C5BA8ED35	FASTA	261	27,807
	10 20 30 40 50 60 MLEALLLGVV EGLTEFLPIS STAHLMLIGD MLGFEGPPGK TYEIVVQLGA ILAVCVVFRQ 70 80 90 100 110 120 RLWGVATTIT QPRSFAFARN VMVAFLPAAV IGATLYKYIK QMLESPLVAA IALVVGGVAI 130 140 150 160 170 180 LVIERLVKRA RIHDIEDMSP ALALGVGFCQ VLAMVPGVSR AGATIMGSML LGLDRRAAAE 190 200 210 220 230 240 FSFFLAIPTM CGASAYSLYK NWATLSFDGA GLIALGFVAA FLSALVVVKG FIGFVGRHGF 250 260 APFAWYRIAF GSLMAVLILM R

References

[1]

"Complete genome sequence of the facultative anaerobic magnetotactic bacterium Magnetospirillum sp. strain AMB-1." Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H. DNA Res. 12:157-166(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AMB-1 / ATCC 700264.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP007255 Genomic DNA. Translation: BAE50351.1.
RefSeq	YP_420910.1. NC_007626.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	342108.amb1547.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAE50351; BAE50351; amb1547.
GeneID	3806467.
KEGG	mag:amb1547.
PATRIC	22437359. VBIMagMag129836_1534.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	RWLLRYI.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	MMAG342108:GJNU-1564-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_MAGSA

Accession

Primary (citable) accession number: Q2W724

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program