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Protein

Alanine racemase

Gene

amb2095

Organism
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway:iD-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (amb2095)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei77 – 771Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei175 – 1751SubstrateUniRule annotation
Active sitei297 – 2971Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei345 – 3451Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMMAG342108:GJNU-2119-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:amb2095Imported
OrganismiMagnetospirillum magneticum (strain AMB-1 / ATCC 700264)Imported
Taxonomic identifieri342108 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeMagnetospirillum
ProteomesiUP000007058 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi342108.amb2095.

Structurei

3D structure databases

ProteinModelPortaliQ2W5H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiPAGVCWR.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2W5H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGWASGNCA ATCAFAEQGL VFPSEERDGA LSPLPGRTMT DLARATALLT
60 70 80 90 100
IDVAAIVANW KRLSALVAPA EASAVVKADC YGLGMDRIAP ALFAAGCRSF
110 120 130 140 150
FVACVNEGIA LRRLLPGAMI HVLSGPMGGD EAEFAAHGLI PVLNSLSQMT
160 170 180 190 200
GWASFAKKGS GAPAVAIHID TGMSRLGLSE PELERLAAKP EILAAMRPIL
210 220 230 240 250
VMSHLACADD SDSPMNARQL TTLRRLASHL PALPQSIAAS SGIFLGRGFH
260 270 280 290 300
LGMVRPGAAL YGLNPMPGRP NPMSQVIKLE GKIVQVRDVD SPQTVGYGAT
310 320 330 340 350
HRVEGKRRLA IVAVGYADGW FRSLSNRGHG MIGGVKVPVV GRVSMDLTTF
360 370 380 390 400
DVTDVPVESA HPGGLIQLIG PGYGPDHLAA EADTIGYEVL TALGRRHLRR

WIGTEGAAS
Length:409
Mass (Da):42,845
Last modified:January 10, 2006 - v1
Checksum:i6BBC9920F79A4B5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007255 Genomic DNA. Translation: BAE50899.1.

Genome annotation databases

EnsemblBacteriaiBAE50899; BAE50899; amb2095.
KEGGimag:amb2095.
PATRICi22438422. VBIMagMag129836_2057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007255 Genomic DNA. Translation: BAE50899.1.

3D structure databases

ProteinModelPortaliQ2W5H6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi342108.amb2095.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE50899; BAE50899; amb2095.
KEGGimag:amb2095.
PATRICi22438422. VBIMagMag129836_2057.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiPAGVCWR.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciMMAG342108:GJNU-2119-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the facultative anaerobic magnetotactic bacterium Magnetospirillum sp. strain AMB-1."
    Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H.
    DNA Res. 12:157-166(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AMB-1 / ATCC 700264Imported.

Entry informationi

Entry nameiQ2W5H6_MAGSA
AccessioniPrimary (citable) accession number: Q2W5H6
Entry historyi
Integrated into UniProtKB/TrEMBL: January 10, 2006
Last sequence update: January 10, 2006
Last modified: July 22, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.