Q2W4D7 (LPXB_MAGSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	amb2484

Organism

Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) [Complete proteome] [HAMAP]

Taxonomic identifier

342108 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Magnetospirillum › Magnetospirillum magneticum

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_0000255196

Sequences

	Sequence		Length	Mass (Da)
	Q2W4D7 [UniParc]. Last modified January 10, 2006. Version 1. Checksum: 6654FB66F2025349	FASTA	390	41,913
	10 20 30 40 50 60 MLIYLIAGEP SGDLLGGRLM AALKERLGEG VSFAGIGGES MRAEGLTSLF PMTELSVMGL 70 80 90 100 110 120 VEVLPRIPKI LRRVKQTISD IETKRPDALV TIDSWGFNGR IQAGLKARGV PVPRIHYVAP 130 140 150 160 170 180 MVWAWKSGRT KTLARVLDLL LTLLPNEPEW FEKEGLKTLH VGHPVIEGAA SRGDGAAFRV 190 200 210 220 230 240 RHGFAPDRKL LCVLPGSRHS ETAKLLAPFG ETIALLARRF PDLAVVVPTV ETVADEVSQA 250 260 270 280 290 300 VKSWALPSMV VRGPEKYDAF AACDAALAAS GTVALELAMA RLPAVITYKV SPVSAFIATR 310 320 330 340 350 360 FLGLSLKFVT LVNILVDEAV MPELLQDDCR PDKLAAAVEH LLTDEAARAL QAAGARRALE 370 380 390 KLGLGGESPG KRAADAVIDF IRQGKEQRNG

References

[1]

"Complete genome sequence of the facultative anaerobic magnetotactic bacterium Magnetospirillum sp. strain AMB-1." Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H. DNA Res. 12:157-166(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AMB-1 / ATCC 700264.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP007255 Genomic DNA. Translation: BAE51288.1.
RefSeq	YP_421847.1. NC_007626.1.
3D structure databases
ProteinModelPortal	Q2W4D7.
ModBase	Search...
Protein-protein interaction databases
STRING	342108.amb2484.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAE51288; BAE51288; amb2484.
GeneID	3804689.
KEGG	mag:amb2484.
PATRIC	22439206. VBIMagMag129836_2442.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HOG000018004.
KO	K00748.
OMA	PTVWAWR.
ProtClustDB	CLSK745081.
Enzyme and pathway databases
BioCyc	MMAG342108:GJNU-2514-MONOMER.
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB.
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_MAGSA

Accession

Primary (citable) accession number: Q2W4D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program