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Q2W4D7

- LPXB_MAGSA

UniProt

Q2W4D7 - LPXB_MAGSA

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMMAG342108:GJNU-2514-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:amb2484
OrganismiMagnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Taxonomic identifieri342108 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeMagnetospirillum
ProteomesiUP000007058: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Lipid-A-disaccharide synthasePRO_0000255196Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342108.amb2484.

Structurei

3D structure databases

ProteinModelPortaliQ2W4D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2W4D7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLIYLIAGEP SGDLLGGRLM AALKERLGEG VSFAGIGGES MRAEGLTSLF
60 70 80 90 100
PMTELSVMGL VEVLPRIPKI LRRVKQTISD IETKRPDALV TIDSWGFNGR
110 120 130 140 150
IQAGLKARGV PVPRIHYVAP MVWAWKSGRT KTLARVLDLL LTLLPNEPEW
160 170 180 190 200
FEKEGLKTLH VGHPVIEGAA SRGDGAAFRV RHGFAPDRKL LCVLPGSRHS
210 220 230 240 250
ETAKLLAPFG ETIALLARRF PDLAVVVPTV ETVADEVSQA VKSWALPSMV
260 270 280 290 300
VRGPEKYDAF AACDAALAAS GTVALELAMA RLPAVITYKV SPVSAFIATR
310 320 330 340 350
FLGLSLKFVT LVNILVDEAV MPELLQDDCR PDKLAAAVEH LLTDEAARAL
360 370 380 390
QAAGARRALE KLGLGGESPG KRAADAVIDF IRQGKEQRNG
Length:390
Mass (Da):41,913
Last modified:January 10, 2006 - v1
Checksum:i6654FB66F2025349
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007255 Genomic DNA. Translation: BAE51288.1.
RefSeqiWP_011384865.1. NC_007626.1.
YP_421847.1. NC_007626.1.

Genome annotation databases

EnsemblBacteriaiBAE51288; BAE51288; amb2484.
GeneIDi3804689.
KEGGimag:amb2484.
PATRICi22439206. VBIMagMag129836_2442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007255 Genomic DNA. Translation: BAE51288.1 .
RefSeqi WP_011384865.1. NC_007626.1.
YP_421847.1. NC_007626.1.

3D structure databases

ProteinModelPortali Q2W4D7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342108.amb2484.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE51288 ; BAE51288 ; amb2484 .
GeneIDi 3804689.
KEGGi mag:amb2484.
PATRICi 22439206. VBIMagMag129836_2442.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci MMAG342108:GJNU-2514-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the facultative anaerobic magnetotactic bacterium Magnetospirillum sp. strain AMB-1."
    Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H.
    DNA Res. 12:157-166(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AMB-1 / ATCC 700264.

Entry informationi

Entry nameiLPXB_MAGSA
AccessioniPrimary (citable) accession number: Q2W4D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 10, 2006
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3