Q2VYV5 (MUTL_MAGSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein MutL

Gene names

Name:	mutL
Ordered Locus Names:	amb4416

Organism

Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) [Complete proteome] [HAMAP]

Taxonomic identifier

342108 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Magnetospirillum › Magnetospirillum magneticum

Protein attributes

Sequence length	607 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP-Rule MF_00149
Sequence similarities	Belongs to the DNA mismatch repair MutL/HexB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	mismatch repair Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 607	607	DNA mismatch repair protein MutL HAMAP-Rule MF_00149		PRO_1000010040

Sequences

	Sequence		Length	Mass (Da)
	Q2VYV5 [UniParc]. Last modified January 10, 2006. Version 1. Checksum: A05C3C4F3F6E63D5	FASTA	607	63,967
	10 20 30 40 50 60 MSIRLLPPTL VNQIAAGEVV ERPASAVKEL VENAIDAGAS RIDVVLAEGG QSLIAVSDDG 70 80 90 100 110 120 CGMSPDEMML AVERHATSKL PDDDLVRIRF LGFRGEALPS IGSVARLTLT SRPRGADSAW 130 140 150 160 170 180 SLSVEGGAKG RPVPAAHPQG TRIEVRDLFY ATPARLKFLK AARTELTHAA DVIERLGMAH 190 200 210 220 230 240 PDIAFSLSDG GRKVLDLAAK RGEPGAALLS RIAQVVGREF EPNALALDAE RDGVRLTGWA 250 260 270 280 290 300 GLPTYNRATS AAQYLFVNGR PVKDRLVIGA VRGAYQDVLA RDRHPVVALF LELDPDQVDV 310 320 330 340 350 360 NVHPAKAEVR FRDSGLVRGL IVGAIRHALA GAGHRASSTL TGVALGALGG GGGNSPPPSF 370 380 390 400 410 420 AHYPPPRPSL PLIRAGIGAQ APLGLAEQGL GLHLPPAAPV APPEAREGPG EASVDYPLGA 430 440 450 460 470 480 AKAQLHDTYI VAETADGLVI VDQHAAHERL VFERLKLGLT EGQVARQGLL LPEVVDLGDA 490 500 510 520 530 540 GAARVTERAG DLARLGLVID SFGPGAVVVR EVPALLGDDD VQGLVRDLAD ELAEWGASTV 550 560 570 580 590 600 LEERLLHICA TMACHGSVRA GRRLSVPEMN ALLRRMEATP LSGQCNHGRP THVSLSLNDI EKLFGRR

References

[1]

"Complete genome sequence of the facultative anaerobic magnetotactic bacterium Magnetospirillum sp. strain AMB-1." Matsunaga T., Okamura Y., Fukuda Y., Wahyudi A.T., Murase Y., Takeyama H. DNA Res. 12:157-166(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AMB-1 / ATCC 700264.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP007255 Genomic DNA. Translation: BAE53220.1.
RefSeq	YP_423779.1. NC_007626.1.
3D structure databases
ProteinModelPortal	Q2VYV5.
ModBase	Search...
Protein-protein interaction databases
STRING	342108.amb4416.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAE53220; BAE53220; amb4416.
GeneID	3802851.
KEGG	mag:amb4416.
PATRIC	22443176. VBIMagMag129836_4403.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0323.
HOGENOM	HOG000256550.
KO	K03572.
OMA	ATMACHA.
ProtClustDB	PRK00095.
Enzyme and pathway databases
BioCyc	MMAG342108:GJNU-4469-MONOMER.
Family and domain databases
Gene3D	3.30.230.10. 1 hit. 3.30.565.10. 1 hit.
HAMAP	MF_00149. DNA_mis_repair.
InterPro	IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR003594. HATPase_ATP-bd. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
PANTHER	PTHR10073. PTHR10073. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00585. mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTL_MAGSA

Accession

Primary (citable) accession number: Q2VYV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program