Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LETM1 domain-containing protein LETM2, mitochondrial

Gene

LETM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
LETM1 domain-containing protein LETM2, mitochondrial
Alternative name(s):
LETM1 and EF-hand domain-containing protein 2
Leucine zipper-EF-hand-containing transmembrane protein 1-like
Gene namesi
Name:LETM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:14648. LETM2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 177152Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST
Topological domaini199 – 491293Mitochondrial matrixSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887111.

Polymorphism and mutation databases

DMDMi160013759.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionSequence analysisAdd
BLAST
Chaini26 – 491466LETM1 domain-containing protein LETM2, mitochondrialPRO_0000307137Add
BLAST

Proteomic databases

MaxQBiQ2VYF4.
PaxDbiQ2VYF4.
PeptideAtlasiQ2VYF4.
PRIDEiQ2VYF4.

PTM databases

iPTMnetiQ2VYF4.
PhosphoSiteiQ2VYF4.

Expressioni

Gene expression databases

BgeeiENSG00000165046.
CleanExiHS_LETM2.
ExpressionAtlasiQ2VYF4. baseline and differential.
GenevisibleiQ2VYF4. HS.

Organism-specific databases

HPAiHPA025032.
HPA053676.

Interactioni

Protein-protein interaction databases

BioGridi126495. 2 interactions.
IntActiQ2VYF4. 1 interaction.
STRINGi9606.ENSP00000428765.

Structurei

3D structure databases

ProteinModelPortaliQ2VYF4.
SMRiQ2VYF4. Positions 221-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini221 – 438218Letm1 RBDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili208 – 23528Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi382 – 3854Poly-Leu

Sequence similaritiesi

Contains 1 Letm1 RBD (ribosome-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1043. Eukaryota.
ENOG410XRSP. LUCA.
GeneTreeiENSGT00390000011225.
HOGENOMiHOG000113315.
HOVERGENiHBG108085.
InParanoidiQ2VYF4.
OMAiLRTCVDF.
OrthoDBiEOG091G034T.
PhylomeDBiQ2VYF4.
TreeFamiTF316321.

Family and domain databases

InterProiIPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
PROSITEiPS51758. LETM1_RBD. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2VYF4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFYSYNSVL AIARTRFPSH FVHPTCSSYS PSCAFLHLPD SHLNKTCMKN
60 70 80 90 100
YESKKYSDPS QPGNTVLHPG TRLIQKLHTS TCWLQEVPGK PQLEQATKHP
110 120 130 140 150
QVTSPQATKE TGMEIKEGKQ SYRQKIMDEL KYYYNGFYLL WIDAKVAARM
160 170 180 190 200
VWRLLHGQVL TRRERRRLLR TCVDFFRLVP FMVFLIVPFM EFLLPVFLKL
210 220 230 240 250
FPEMLPSTFE SESKKEEKQK KKMAVKLELA KFLQETMTEM ARRNRAKMGD
260 270 280 290 300
ASTQLSSYVK QVQTGHKPST KEIVRFSKLF EDQLALEHLD RPQLVALCKL
310 320 330 340 350
LELQTFGTNN LLRFQLLMKL KSIKADDEII AKEGVTALSV SELQAACRAR
360 370 380 390 400
GMRSLGLTEE QLRQQLTEWQ DLHLKENVPP SLLLLSRTFY LIDVKPKPIE
410 420 430 440 450
IPLSGEAPKT DILVELPTFT ESKENMVDLA PQLKGTKDED FIQPPPVTSS
460 470 480 490
PITPSTPISL PKGPITSSEE PTLQAKSQMT AQNSKASSKG A
Length:491
Mass (Da):55,921
Last modified:October 23, 2007 - v2
Checksum:iF7515E57C73237D1
GO
Isoform 2 (identifier: Q2VYF4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Show »
Length:444
Mass (Da):50,633
Checksum:i26CEFB04A32D4A42
GO
Isoform 3 (identifier: Q2VYF4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     168-215: Missing.

Show »
Length:396
Mass (Da):44,907
Checksum:i0E9D387A21BC5E28
GO
Isoform 4 (identifier: Q2VYF4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-214: Missing.
     215-215: K → M

Show »
Length:277
Mass (Da):30,909
Checksum:i192EC66CF62CF816
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti448 – 4481T → A in AAO49715 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 214214Missing in isoform 4. 1 PublicationVSP_028588Add
BLAST
Alternative sequencei1 – 4747Missing in isoform 2 and isoform 3. 2 PublicationsVSP_028589Add
BLAST
Alternative sequencei168 – 21548Missing in isoform 3. 1 PublicationVSP_028590Add
BLAST
Alternative sequencei215 – 2151K → M in isoform 4. 1 PublicationVSP_028591

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY173945 mRNA. Translation: AAO49715.1.
AK058138 mRNA. Translation: BAB71680.1.
AC087623 Genomic DNA. No translation available.
BC029541 mRNA. Translation: AAH29541.2.
CCDSiCCDS56534.1. [Q2VYF4-2]
CCDS6106.1. [Q2VYF4-3]
CCDS69466.1. [Q2VYF4-1]
RefSeqiNP_001186588.1. NM_001199659.2. [Q2VYF4-2]
NP_001273748.1. NM_001286819.1. [Q2VYF4-1]
NP_653253.1. NM_144652.3. [Q2VYF4-3]
XP_011542708.1. XM_011544406.1. [Q2VYF4-2]
XP_011542709.1. XM_011544407.1. [Q2VYF4-2]
XP_011542712.1. XM_011544410.2. [Q2VYF4-4]
UniGeneiHs.696457.
Hs.734005.

Genome annotation databases

EnsembliENST00000297720; ENSP00000297720; ENSG00000165046. [Q2VYF4-3]
ENST00000379957; ENSP00000369291; ENSG00000165046. [Q2VYF4-1]
ENST00000523983; ENSP00000428765; ENSG00000165046. [Q2VYF4-2]
ENST00000527710; ENSP00000434867; ENSG00000165046. [Q2VYF4-4]
GeneIDi137994.
KEGGihsa:137994.
UCSCiuc003xll.4. human. [Q2VYF4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY173945 mRNA. Translation: AAO49715.1.
AK058138 mRNA. Translation: BAB71680.1.
AC087623 Genomic DNA. No translation available.
BC029541 mRNA. Translation: AAH29541.2.
CCDSiCCDS56534.1. [Q2VYF4-2]
CCDS6106.1. [Q2VYF4-3]
CCDS69466.1. [Q2VYF4-1]
RefSeqiNP_001186588.1. NM_001199659.2. [Q2VYF4-2]
NP_001273748.1. NM_001286819.1. [Q2VYF4-1]
NP_653253.1. NM_144652.3. [Q2VYF4-3]
XP_011542708.1. XM_011544406.1. [Q2VYF4-2]
XP_011542709.1. XM_011544407.1. [Q2VYF4-2]
XP_011542712.1. XM_011544410.2. [Q2VYF4-4]
UniGeneiHs.696457.
Hs.734005.

3D structure databases

ProteinModelPortaliQ2VYF4.
SMRiQ2VYF4. Positions 221-389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126495. 2 interactions.
IntActiQ2VYF4. 1 interaction.
STRINGi9606.ENSP00000428765.

PTM databases

iPTMnetiQ2VYF4.
PhosphoSiteiQ2VYF4.

Polymorphism and mutation databases

DMDMi160013759.

Proteomic databases

MaxQBiQ2VYF4.
PaxDbiQ2VYF4.
PeptideAtlasiQ2VYF4.
PRIDEiQ2VYF4.

Protocols and materials databases

DNASUi137994.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297720; ENSP00000297720; ENSG00000165046. [Q2VYF4-3]
ENST00000379957; ENSP00000369291; ENSG00000165046. [Q2VYF4-1]
ENST00000523983; ENSP00000428765; ENSG00000165046. [Q2VYF4-2]
ENST00000527710; ENSP00000434867; ENSG00000165046. [Q2VYF4-4]
GeneIDi137994.
KEGGihsa:137994.
UCSCiuc003xll.4. human. [Q2VYF4-1]

Organism-specific databases

CTDi137994.
GeneCardsiLETM2.
HGNCiHGNC:14648. LETM2.
HPAiHPA025032.
HPA053676.
neXtProtiNX_Q2VYF4.
PharmGKBiPA134887111.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1043. Eukaryota.
ENOG410XRSP. LUCA.
GeneTreeiENSGT00390000011225.
HOGENOMiHOG000113315.
HOVERGENiHBG108085.
InParanoidiQ2VYF4.
OMAiLRTCVDF.
OrthoDBiEOG091G034T.
PhylomeDBiQ2VYF4.
TreeFamiTF316321.

Miscellaneous databases

ChiTaRSiLETM2. human.
GenomeRNAii137994.
PROiQ2VYF4.

Gene expression databases

BgeeiENSG00000165046.
CleanExiHS_LETM2.
ExpressionAtlasiQ2VYF4. baseline and differential.
GenevisibleiQ2VYF4. HS.

Family and domain databases

InterProiIPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
PROSITEiPS51758. LETM1_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLETM2_HUMAN
AccessioniPrimary (citable) accession number: Q2VYF4
Secondary accession number(s): A6NMG3, Q8NCR2, Q96LL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: September 7, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, it does not contain any EF-hand domains.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.