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Protein

Zinc finger protein 284

Gene

ZNF284

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16925C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri175 – 19723C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 15; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 284
Gene namesi
Name:ZNF284
Synonyms:ZNF284L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13078. ZNF284.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37654.

Polymorphism and mutation databases

BioMutaiZNF284.
DMDMi121941972.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Zinc finger protein 284PRO_0000280403Add
BLAST

Proteomic databases

PaxDbiQ2VY69.
PRIDEiQ2VY69.

PTM databases

iPTMnetiQ2VY69.
PhosphoSiteiQ2VY69.

Expressioni

Tissue specificityi

Expressed in lung, liver, pancreas and thymus. Lower expression in heart, placenta, spleen, prostate, ovary, small intestine and colon. No expression seen in brain, skeletal muscle, kidney, testis and peripheral blood leukocyte.2 Publications

Gene expression databases

BgeeiQ2VY69.
CleanExiHS_ZNF284.
GenevisibleiQ2VY69. HS.

Interactioni

Protein-protein interaction databases

BioGridi131208. 2 interactions.
STRINGi9606.ENSP00000411032.

Structurei

3D structure databases

ProteinModelPortaliQ2VY69.
SMRiQ2VY69. Positions 7-49, 156-582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7871KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16925C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri175 – 19723C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 15; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ2VY69.
KOiK09228.
OMAiHTCNEYR.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ2VY69.
TreeFamiTF341885.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2VY69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMFKEAVTF KDVAVVFTEE ELGLLDVSQR KLYRDVMLEN FRNLLSVGHQ
60 70 80 90 100
LSHRDTFHFQ REEKFWIMET ATQREGNSGG KIQTELESVP ETGPHEEWSC
110 120 130 140 150
QQIWEQTASE LTRPQDSISS SQFSTQGDVP SQVDAGLSII HIGETPSEHG
160 170 180 190 200
KCKKFFSDVS ILDLHQQLHS GKISHTCNEY RKRFCYSSAL CLHQKVHMGE
210 220 230 240 250
KRYKCDVCSK AFSQNSQLQT HQRIHTGEKP FKCEQCGKSF SRRSGMYVHC
260 270 280 290 300
KLHTGEKPHI CEECGKAFIH NSQLREHQRI HTGEKPFKCY ICGKSFHSRS
310 320 330 340 350
NLNRHSMVHM QEKSFRCDTC SNSFGQRSAL NSHCMDHTKE KLYKCEECGR
360 370 380 390 400
SFTCRQDLCK HQMDHTGDKP YNCNVCGKGF RWSSCLSRHQ RVHNGETTFK
410 420 430 440 450
CDGCGKRFYM NSQGHSHQRA YREEELYKCQ KCGKGYISKF NLDLHQRVHT
460 470 480 490 500
GERPYNCKEC GKSFRWASGI LRHKRLHTGE KPFKCEECGK RFTENSKLRF
510 520 530 540 550
HQRIHTGEKP YKCEECGKGF RWASTHLTHQ RLHSREKLFQ CEDCGKSSEH
560 570 580 590
SSCLQDQQSD HSGEKTSKCE DCGKRYERRL NLDMILSLFL NDI
Length:593
Mass (Da):69,019
Last modified:January 10, 2006 - v1
Checksum:iAA147748E360DA84
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti546 – 5461K → E.
Corresponds to variant rs8113249 [ dbSNP | Ensembl ].
VAR_031135
Natural varianti577 – 5771E → K.
Corresponds to variant rs8113249 [ dbSNP | Ensembl ].
VAR_059909

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY458845 mRNA. Translation: AAS13443.1.
AY166789 mRNA. Translation: AAO45838.1.
CCDSiCCDS46099.1.
RefSeqiNP_001032902.1. NM_001037813.2.
XP_005258916.1. XM_005258859.2.
XP_006723250.1. XM_006723187.2.
XP_011525209.1. XM_011526907.1.
XP_011525210.1. XM_011526908.1.
UniGeneiHs.445395.
Hs.720813.

Genome annotation databases

EnsembliENST00000421176; ENSP00000411032; ENSG00000186026.
GeneIDi342909.
KEGGihsa:342909.
UCSCiuc002oyg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY458845 mRNA. Translation: AAS13443.1.
AY166789 mRNA. Translation: AAO45838.1.
CCDSiCCDS46099.1.
RefSeqiNP_001032902.1. NM_001037813.2.
XP_005258916.1. XM_005258859.2.
XP_006723250.1. XM_006723187.2.
XP_011525209.1. XM_011526907.1.
XP_011525210.1. XM_011526908.1.
UniGeneiHs.445395.
Hs.720813.

3D structure databases

ProteinModelPortaliQ2VY69.
SMRiQ2VY69. Positions 7-49, 156-582.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131208. 2 interactions.
STRINGi9606.ENSP00000411032.

PTM databases

iPTMnetiQ2VY69.
PhosphoSiteiQ2VY69.

Polymorphism and mutation databases

BioMutaiZNF284.
DMDMi121941972.

Proteomic databases

PaxDbiQ2VY69.
PRIDEiQ2VY69.

Protocols and materials databases

DNASUi342909.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421176; ENSP00000411032; ENSG00000186026.
GeneIDi342909.
KEGGihsa:342909.
UCSCiuc002oyg.2. human.

Organism-specific databases

CTDi342909.
GeneCardsiZNF284.
HGNCiHGNC:13078. ZNF284.
neXtProtiNX_Q2VY69.
PharmGKBiPA37654.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ2VY69.
KOiK09228.
OMAiHTCNEYR.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ2VY69.
TreeFamiTF341885.

Miscellaneous databases

GenomeRNAii342909.
PROiQ2VY69.

Gene expression databases

BgeeiQ2VY69.
CleanExiHS_ZNF284.
GenevisibleiQ2VY69. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L)."
    Yin G., Ji C., Zeng L., Wang Z., Wang J., Shen Z., Wu T., Gu S., Xie Y., Mao Y.
    Mol. Biol. Rep. 33:137-144(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
    Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
    Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-232, TISSUE SPECIFICITY.
    Tissue: Testis.

Entry informationi

Entry nameiZN284_HUMAN
AccessioniPrimary (citable) accession number: Q2VY69
Secondary accession number(s): Q86WM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: January 10, 2006
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.