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Protein

Zinc finger protein 284

Gene

ZNF284

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 169C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri175 – 197C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 284
Gene namesi
Name:ZNF284
Synonyms:ZNF284L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000186026.6.
HGNCiHGNC:13078. ZNF284.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186026.
PharmGKBiPA37654.

Polymorphism and mutation databases

BioMutaiZNF284.
DMDMi121941972.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804031 – 593Zinc finger protein 284Add BLAST593

Proteomic databases

PaxDbiQ2VY69.
PeptideAtlasiQ2VY69.
PRIDEiQ2VY69.

PTM databases

iPTMnetiQ2VY69.
PhosphoSitePlusiQ2VY69.

Expressioni

Tissue specificityi

Expressed in lung, liver, pancreas and thymus. Lower expression in heart, placenta, spleen, prostate, ovary, small intestine and colon. No expression seen in brain, skeletal muscle, kidney, testis and peripheral blood leukocyte.2 Publications

Gene expression databases

BgeeiENSG00000186026.
CleanExiHS_ZNF284.
GenevisibleiQ2VY69. HS.

Interactioni

Protein-protein interaction databases

BioGridi131208. 2 interactors.
STRINGi9606.ENSP00000411032.

Structurei

3D structure databases

ProteinModelPortaliQ2VY69.
SMRiQ2VY69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 169C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri175 – 197C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00870000136402.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ2VY69.
KOiK09228.
OMAiHTCNEYR.
OrthoDBiEOG091G02KC.
PhylomeDBiQ2VY69.
TreeFamiTF341885.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.

Sequencei

Sequence statusi: Complete.

Q2VY69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMFKEAVTF KDVAVVFTEE ELGLLDVSQR KLYRDVMLEN FRNLLSVGHQ
60 70 80 90 100
LSHRDTFHFQ REEKFWIMET ATQREGNSGG KIQTELESVP ETGPHEEWSC
110 120 130 140 150
QQIWEQTASE LTRPQDSISS SQFSTQGDVP SQVDAGLSII HIGETPSEHG
160 170 180 190 200
KCKKFFSDVS ILDLHQQLHS GKISHTCNEY RKRFCYSSAL CLHQKVHMGE
210 220 230 240 250
KRYKCDVCSK AFSQNSQLQT HQRIHTGEKP FKCEQCGKSF SRRSGMYVHC
260 270 280 290 300
KLHTGEKPHI CEECGKAFIH NSQLREHQRI HTGEKPFKCY ICGKSFHSRS
310 320 330 340 350
NLNRHSMVHM QEKSFRCDTC SNSFGQRSAL NSHCMDHTKE KLYKCEECGR
360 370 380 390 400
SFTCRQDLCK HQMDHTGDKP YNCNVCGKGF RWSSCLSRHQ RVHNGETTFK
410 420 430 440 450
CDGCGKRFYM NSQGHSHQRA YREEELYKCQ KCGKGYISKF NLDLHQRVHT
460 470 480 490 500
GERPYNCKEC GKSFRWASGI LRHKRLHTGE KPFKCEECGK RFTENSKLRF
510 520 530 540 550
HQRIHTGEKP YKCEECGKGF RWASTHLTHQ RLHSREKLFQ CEDCGKSSEH
560 570 580 590
SSCLQDQQSD HSGEKTSKCE DCGKRYERRL NLDMILSLFL NDI
Length:593
Mass (Da):69,019
Last modified:January 10, 2006 - v1
Checksum:iAA147748E360DA84
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031135546K → E. Corresponds to variant dbSNP:rs8113249Ensembl.1
Natural variantiVAR_059909577E → K. Corresponds to variant dbSNP:rs8113249Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY458845 mRNA. Translation: AAS13443.1.
AY166789 mRNA. Translation: AAO45838.1.
CCDSiCCDS46099.1.
RefSeqiNP_001032902.1. NM_001037813.3.
XP_011525209.1. XM_011526907.2.
XP_011525210.1. XM_011526908.2.
UniGeneiHs.445395.
Hs.720813.

Genome annotation databases

EnsembliENST00000421176; ENSP00000411032; ENSG00000186026.
GeneIDi342909.
KEGGihsa:342909.
UCSCiuc002oyg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN284_HUMAN
AccessioniPrimary (citable) accession number: Q2VY69
Secondary accession number(s): Q86WM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: January 10, 2006
Last modified: September 27, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families