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Q2VWQ2

- NELL1_MOUSE

UniProt

Q2VWQ2 - NELL1_MOUSE

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Protein

Protein kinase C-binding protein NELL1

Gene
Nell1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. negative regulation of cyclin catabolic process Source: UniProtKB
  3. negative regulation of osteoblast proliferation Source: UniProtKB
  4. positive regulation of bone mineralization Source: UniProtKB
  5. positive regulation of osteoblast differentiation Source: UniProtKB
  6. regulation of gene expression Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL1
Alternative name(s):
NEL-like protein 1
Gene namesi
Name:Nell1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2443902. Nell1.

Subcellular locationi

Cytoplasm By similarity. Nucleus envelope By similarity. Secreted By similarity
Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular region Source: UniProtKB-SubCell
  3. nuclear envelope Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 810789Protein kinase C-binding protein NELL1PRO_0000322642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi224 – 2241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi294 – 2941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi372 – 3721N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi395 ↔ 407 By similarity
Disulfide bondi401 ↔ 416 By similarity
Disulfide bondi418 ↔ 432 By similarity
Disulfide bondi438 ↔ 451 By similarity
Disulfide bondi445 ↔ 460 By similarity
Disulfide bondi462 ↔ 474 By similarity
Disulfide bondi480 ↔ 493 By similarity
Disulfide bondi487 ↔ 502 By similarity
Disulfide bondi504 ↔ 515 By similarity
Glycosylationi511 – 5111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi519 ↔ 529 By similarity
Disulfide bondi523 ↔ 535 By similarity
Disulfide bondi537 ↔ 546 By similarity
Disulfide bondi553 ↔ 566 By similarity
Disulfide bondi560 ↔ 575 By similarity
Glycosylationi562 – 5621N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi577 ↔ 594 By similarity
Disulfide bondi600 ↔ 613 By similarity
Disulfide bondi607 ↔ 622 By similarity
Glycosylationi609 – 6091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi624 ↔ 630 By similarity
Glycosylationi708 – 7081N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ2VWQ2.

Expressioni

Gene expression databases

BgeeiQ2VWQ2.
CleanExiMM_NELL1.
GenevestigatoriQ2VWQ2.

Interactioni

Subunit structurei

Homotrimer. Binds to PKC beta-1. Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080550.

Structurei

3D structure databases

ProteinModelPortaliQ2VWQ2.
SMRiQ2VWQ2. Positions 296-627.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 227171Laminin G-likeAdd
BLAST
Domaini271 – 33262VWFC 1Add
BLAST
Domaini434 – 47542EGF-like 1; calcium-binding Reviewed predictionAdd
BLAST
Domaini476 – 51641EGF-like 2; calcium-binding Reviewed predictionAdd
BLAST
Domaini517 – 54731EGF-like 3Add
BLAST
Domaini549 – 58739EGF-like 4; calcium-binding Reviewed predictionAdd
BLAST
Domaini596 – 63136EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST
Domaini632 – 68756VWFC 2Add
BLAST
Domaini692 – 75059VWFC 3Add
BLAST

Sequence similaritiesi

Contains 5 EGF-like domains.
Contains 3 VWFC domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG253557.
GeneTreeiENSGT00750000117321.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiQ2VWQ2.
OMAiGSHCEKD.
OrthoDBiEOG71VSRX.
PhylomeDBiQ2VWQ2.
TreeFamiTF323325.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2VWQ2-1 [UniParc]FASTAAdd to Basket

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MPMDVILVLW FCVCTARTVL GFGMDPDLQM DIITELDLVN TTLGVTQVAG    50
LHNASKAFLF QDVQREIHSA PHVSEKLIQL FRNKSEFTFL ATVQQKPSTS 100
GVILSIRELE HSYFELESSG PREEIRYHYI HGGKPRTEAL PYRMADGQWH 150
KVALSVSASH LLLHVDCNRI YERVIDPPET NLPPGSNLWL GQRNQKHGFF 200
KGIIQDGKII FMPNGFITQC PNLNRTCPTC SDFLSLVQGI MDLQELLAKM 250
TAKLNYAETR LGQLENCHCE KTCQVSGLLY RDQDSWVDGD NCRNCTCKSG 300
AVECRRMSCP PLNCSPDSLP VHISGQCCKV CRPKCIYGGK VLAEGQRILT 350
KTCRECRGGV LVKITEACPP LNCSEKDHIL PENQCCRVCR GHNFCAEAPK 400
CGENSECKNW NTKATCECKN GYISVQGNSA YCEDIDECAA KMHYCHANTV 450
CVNLPGLYRC DCIPGYIRVD DFSCTEHDDC GSGQHNCDKN AICTNTVQGH 500
SCTCQPGYVG NGTVCKAFCE EGCRYGGTCV APNKCVCPSG FTGSHCEKDI 550
DECAEGFVEC HNHSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC 600
ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWILR 650
EDRCSVCSCK DGKIFCRRTA CDCQNPNVDL FCCPECDTRV TSQCLDQSGQ 700
KLYRSGDNWT HSCQQCRCLE GEADCWPLAC PSLSCEYTAI FEGECCPRCV 750
SDPCLADNIA YDIRKTCLDS SGISRLSGAV WTMAGSPCTT CQCKNGRVCC 800
SVDLVCLENN 810
Length:810
Mass (Da):89,415
Last modified:January 10, 2006 - v1
Checksum:i3AD132E97FB83590
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY622226 mRNA. Translation: AAV41488.1.
CCDSiCCDS21309.1.
RefSeqiNP_001032995.1. NM_001037906.2.
UniGeneiMm.383528.

Genome annotation databases

EnsembliENSMUST00000081872; ENSMUSP00000080550; ENSMUSG00000055409.
GeneIDi338352.
KEGGimmu:338352.
UCSCiuc009hbx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY622226 mRNA. Translation: AAV41488.1 .
CCDSi CCDS21309.1.
RefSeqi NP_001032995.1. NM_001037906.2.
UniGenei Mm.383528.

3D structure databases

ProteinModelPortali Q2VWQ2.
SMRi Q2VWQ2. Positions 296-627.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000080550.

Proteomic databases

PRIDEi Q2VWQ2.

Protocols and materials databases

DNASUi 338352.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081872 ; ENSMUSP00000080550 ; ENSMUSG00000055409 .
GeneIDi 338352.
KEGGi mmu:338352.
UCSCi uc009hbx.1. mouse.

Organism-specific databases

CTDi 4745.
MGIi MGI:2443902. Nell1.

Phylogenomic databases

eggNOGi NOG253557.
GeneTreei ENSGT00750000117321.
HOGENOMi HOG000217920.
HOVERGENi HBG004805.
InParanoidi Q2VWQ2.
OMAi GSHCEKD.
OrthoDBi EOG71VSRX.
PhylomeDBi Q2VWQ2.
TreeFami TF323325.

Miscellaneous databases

ChiTaRSi NELL1. mouse.
NextBioi 400121.
PROi Q2VWQ2.
SOURCEi Search...

Gene expression databases

Bgeei Q2VWQ2.
CleanExi MM_NELL1.
Genevestigatori Q2VWQ2.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 4 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects."
    Desai J., Shannon M.E., Johnson M.D., Ruff D.W., Hughes L.A., Kerley M.K., Carpenter D.A., Johnson D.K., Rinchik E.M., Culiat C.T.
    Hum. Mol. Genet. 15:1329-1341(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: BJR.
    Tissue: Head.

Entry informationi

Entry nameiNELL1_MOUSE
AccessioniPrimary (citable) accession number: Q2VWQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 10, 2006
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi