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Q2VWQ2

- NELL1_MOUSE

UniProt

Q2VWQ2 - NELL1_MOUSE

Protein

Protein kinase C-binding protein NELL1

Gene

Nell1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. negative regulation of cyclin catabolic process Source: UniProtKB
    3. negative regulation of osteoblast proliferation Source: UniProtKB
    4. positive regulation of bone mineralization Source: UniProtKB
    5. positive regulation of osteoblast differentiation Source: UniProtKB
    6. regulation of gene expression Source: UniProtKB

    Keywords - Biological processi

    Differentiation

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C-binding protein NELL1
    Alternative name(s):
    NEL-like protein 1
    Gene namesi
    Name:Nell1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2443902. Nell1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus envelope By similarity. Secreted By similarity
    Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular region Source: UniProtKB-SubCell
    3. nuclear envelope Source: UniProtKB
    4. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 810789Protein kinase C-binding protein NELL1PRO_0000322642Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi395 ↔ 407By similarity
    Disulfide bondi401 ↔ 416By similarity
    Disulfide bondi418 ↔ 432By similarity
    Disulfide bondi438 ↔ 451By similarity
    Disulfide bondi445 ↔ 460By similarity
    Disulfide bondi462 ↔ 474By similarity
    Disulfide bondi480 ↔ 493By similarity
    Disulfide bondi487 ↔ 502By similarity
    Disulfide bondi504 ↔ 515By similarity
    Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi519 ↔ 529By similarity
    Disulfide bondi523 ↔ 535By similarity
    Disulfide bondi537 ↔ 546By similarity
    Disulfide bondi553 ↔ 566By similarity
    Disulfide bondi560 ↔ 575By similarity
    Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi577 ↔ 594By similarity
    Disulfide bondi600 ↔ 613By similarity
    Disulfide bondi607 ↔ 622By similarity
    Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi624 ↔ 630By similarity
    Glycosylationi708 – 7081N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ2VWQ2.

    Expressioni

    Gene expression databases

    BgeeiQ2VWQ2.
    CleanExiMM_NELL1.
    GenevestigatoriQ2VWQ2.

    Interactioni

    Subunit structurei

    Homotrimer. Binds to PKC beta-1. Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000080550.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2VWQ2.
    SMRiQ2VWQ2. Positions 296-627.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini57 – 227171Laminin G-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini271 – 33262VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini434 – 47542EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini476 – 51641EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini517 – 54731EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini549 – 58739EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini596 – 63136EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini632 – 68756VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini692 – 75059VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 5 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.PROSITE-ProRule annotation
    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG253557.
    GeneTreeiENSGT00750000117321.
    HOGENOMiHOG000217920.
    HOVERGENiHBG004805.
    InParanoidiQ2VWQ2.
    OMAiGSHCEKD.
    OrthoDBiEOG71VSRX.
    PhylomeDBiQ2VWQ2.
    TreeFamiTF323325.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 3 hits.
    PF12661. hEGF. 1 hit.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 3 hits.
    SM00179. EGF_CA. 2 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 4 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 5 hits.
    PS01187. EGF_CA. 3 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2VWQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPMDVILVLW FCVCTARTVL GFGMDPDLQM DIITELDLVN TTLGVTQVAG    50
    LHNASKAFLF QDVQREIHSA PHVSEKLIQL FRNKSEFTFL ATVQQKPSTS 100
    GVILSIRELE HSYFELESSG PREEIRYHYI HGGKPRTEAL PYRMADGQWH 150
    KVALSVSASH LLLHVDCNRI YERVIDPPET NLPPGSNLWL GQRNQKHGFF 200
    KGIIQDGKII FMPNGFITQC PNLNRTCPTC SDFLSLVQGI MDLQELLAKM 250
    TAKLNYAETR LGQLENCHCE KTCQVSGLLY RDQDSWVDGD NCRNCTCKSG 300
    AVECRRMSCP PLNCSPDSLP VHISGQCCKV CRPKCIYGGK VLAEGQRILT 350
    KTCRECRGGV LVKITEACPP LNCSEKDHIL PENQCCRVCR GHNFCAEAPK 400
    CGENSECKNW NTKATCECKN GYISVQGNSA YCEDIDECAA KMHYCHANTV 450
    CVNLPGLYRC DCIPGYIRVD DFSCTEHDDC GSGQHNCDKN AICTNTVQGH 500
    SCTCQPGYVG NGTVCKAFCE EGCRYGGTCV APNKCVCPSG FTGSHCEKDI 550
    DECAEGFVEC HNHSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC 600
    ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWILR 650
    EDRCSVCSCK DGKIFCRRTA CDCQNPNVDL FCCPECDTRV TSQCLDQSGQ 700
    KLYRSGDNWT HSCQQCRCLE GEADCWPLAC PSLSCEYTAI FEGECCPRCV 750
    SDPCLADNIA YDIRKTCLDS SGISRLSGAV WTMAGSPCTT CQCKNGRVCC 800
    SVDLVCLENN 810
    Length:810
    Mass (Da):89,415
    Last modified:January 10, 2006 - v1
    Checksum:i3AD132E97FB83590
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY622226 mRNA. Translation: AAV41488.1.
    CCDSiCCDS21309.1.
    RefSeqiNP_001032995.1. NM_001037906.2.
    UniGeneiMm.383528.

    Genome annotation databases

    EnsembliENSMUST00000081872; ENSMUSP00000080550; ENSMUSG00000055409.
    GeneIDi338352.
    KEGGimmu:338352.
    UCSCiuc009hbx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY622226 mRNA. Translation: AAV41488.1 .
    CCDSi CCDS21309.1.
    RefSeqi NP_001032995.1. NM_001037906.2.
    UniGenei Mm.383528.

    3D structure databases

    ProteinModelPortali Q2VWQ2.
    SMRi Q2VWQ2. Positions 296-627.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000080550.

    Proteomic databases

    PRIDEi Q2VWQ2.

    Protocols and materials databases

    DNASUi 338352.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081872 ; ENSMUSP00000080550 ; ENSMUSG00000055409 .
    GeneIDi 338352.
    KEGGi mmu:338352.
    UCSCi uc009hbx.1. mouse.

    Organism-specific databases

    CTDi 4745.
    MGIi MGI:2443902. Nell1.

    Phylogenomic databases

    eggNOGi NOG253557.
    GeneTreei ENSGT00750000117321.
    HOGENOMi HOG000217920.
    HOVERGENi HBG004805.
    InParanoidi Q2VWQ2.
    OMAi GSHCEKD.
    OrthoDBi EOG71VSRX.
    PhylomeDBi Q2VWQ2.
    TreeFami TF323325.

    Miscellaneous databases

    ChiTaRSi NELL1. mouse.
    NextBioi 400121.
    PROi Q2VWQ2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q2VWQ2.
    CleanExi MM_NELL1.
    Genevestigatori Q2VWQ2.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 3 hits.
    PF12661. hEGF. 1 hit.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 3 hits.
    SM00179. EGF_CA. 2 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 5 hits.
    PS01187. EGF_CA. 3 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects."
      Desai J., Shannon M.E., Johnson M.D., Ruff D.W., Hughes L.A., Kerley M.K., Carpenter D.A., Johnson D.K., Rinchik E.M., Culiat C.T.
      Hum. Mol. Genet. 15:1329-1341(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: BJR.
      Tissue: Head.

    Entry informationi

    Entry nameiNELL1_MOUSE
    AccessioniPrimary (citable) accession number: Q2VWQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3