Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2VWQ2

- NELL1_MOUSE

UniProt

Q2VWQ2 - NELL1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein kinase C-binding protein NELL1

Gene

Nell1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. negative regulation of cyclin catabolic process Source: UniProtKB
  3. negative regulation of osteoblast proliferation Source: UniProtKB
  4. positive regulation of bone mineralization Source: UniProtKB
  5. positive regulation of osteoblast differentiation Source: UniProtKB
  6. regulation of gene expression Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL1
Alternative name(s):
NEL-like protein 1
Gene namesi
Name:Nell1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2443902. Nell1.

Subcellular locationi

Cytoplasm By similarity. Nucleus envelope By similarity. Secreted By similarity
Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular region Source: UniProtKB-KW
  3. nuclear envelope Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 810789Protein kinase C-binding protein NELL1PRO_0000322642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi395 ↔ 407By similarity
Disulfide bondi401 ↔ 416By similarity
Disulfide bondi418 ↔ 432By similarity
Disulfide bondi438 ↔ 451By similarity
Disulfide bondi445 ↔ 460By similarity
Disulfide bondi462 ↔ 474By similarity
Disulfide bondi480 ↔ 493By similarity
Disulfide bondi487 ↔ 502By similarity
Disulfide bondi504 ↔ 515By similarity
Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi519 ↔ 529By similarity
Disulfide bondi523 ↔ 535By similarity
Disulfide bondi537 ↔ 546By similarity
Disulfide bondi553 ↔ 566By similarity
Disulfide bondi560 ↔ 575By similarity
Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi577 ↔ 594By similarity
Disulfide bondi600 ↔ 613By similarity
Disulfide bondi607 ↔ 622By similarity
Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi624 ↔ 630By similarity
Glycosylationi708 – 7081N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ2VWQ2.

Expressioni

Gene expression databases

BgeeiQ2VWQ2.
CleanExiMM_NELL1.
ExpressionAtlasiQ2VWQ2. baseline and differential.
GenevestigatoriQ2VWQ2.

Interactioni

Subunit structurei

Homotrimer. Binds to PKC beta-1. Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080550.

Structurei

3D structure databases

ProteinModelPortaliQ2VWQ2.
SMRiQ2VWQ2. Positions 296-627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 227171Laminin G-likePROSITE-ProRule annotationAdd
BLAST
Domaini271 – 33262VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini434 – 47542EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini476 – 51641EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini517 – 54731EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini549 – 58739EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini596 – 63136EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini632 – 68756VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini692 – 75059VWFC 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation
Contains 3 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG253557.
GeneTreeiENSGT00770000120551.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiQ2VWQ2.
OMAiGSHCEKD.
OrthoDBiEOG71VSRX.
PhylomeDBiQ2VWQ2.
TreeFamiTF323325.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2VWQ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPMDVILVLW FCVCTARTVL GFGMDPDLQM DIITELDLVN TTLGVTQVAG
60 70 80 90 100
LHNASKAFLF QDVQREIHSA PHVSEKLIQL FRNKSEFTFL ATVQQKPSTS
110 120 130 140 150
GVILSIRELE HSYFELESSG PREEIRYHYI HGGKPRTEAL PYRMADGQWH
160 170 180 190 200
KVALSVSASH LLLHVDCNRI YERVIDPPET NLPPGSNLWL GQRNQKHGFF
210 220 230 240 250
KGIIQDGKII FMPNGFITQC PNLNRTCPTC SDFLSLVQGI MDLQELLAKM
260 270 280 290 300
TAKLNYAETR LGQLENCHCE KTCQVSGLLY RDQDSWVDGD NCRNCTCKSG
310 320 330 340 350
AVECRRMSCP PLNCSPDSLP VHISGQCCKV CRPKCIYGGK VLAEGQRILT
360 370 380 390 400
KTCRECRGGV LVKITEACPP LNCSEKDHIL PENQCCRVCR GHNFCAEAPK
410 420 430 440 450
CGENSECKNW NTKATCECKN GYISVQGNSA YCEDIDECAA KMHYCHANTV
460 470 480 490 500
CVNLPGLYRC DCIPGYIRVD DFSCTEHDDC GSGQHNCDKN AICTNTVQGH
510 520 530 540 550
SCTCQPGYVG NGTVCKAFCE EGCRYGGTCV APNKCVCPSG FTGSHCEKDI
560 570 580 590 600
DECAEGFVEC HNHSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC
610 620 630 640 650
ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWILR
660 670 680 690 700
EDRCSVCSCK DGKIFCRRTA CDCQNPNVDL FCCPECDTRV TSQCLDQSGQ
710 720 730 740 750
KLYRSGDNWT HSCQQCRCLE GEADCWPLAC PSLSCEYTAI FEGECCPRCV
760 770 780 790 800
SDPCLADNIA YDIRKTCLDS SGISRLSGAV WTMAGSPCTT CQCKNGRVCC
810
SVDLVCLENN
Length:810
Mass (Da):89,415
Last modified:January 10, 2006 - v1
Checksum:i3AD132E97FB83590
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY622226 mRNA. Translation: AAV41488.1.
CCDSiCCDS21309.1.
RefSeqiNP_001032995.1. NM_001037906.2.
UniGeneiMm.383528.

Genome annotation databases

EnsembliENSMUST00000081872; ENSMUSP00000080550; ENSMUSG00000055409.
GeneIDi338352.
KEGGimmu:338352.
UCSCiuc009hbx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY622226 mRNA. Translation: AAV41488.1 .
CCDSi CCDS21309.1.
RefSeqi NP_001032995.1. NM_001037906.2.
UniGenei Mm.383528.

3D structure databases

ProteinModelPortali Q2VWQ2.
SMRi Q2VWQ2. Positions 296-627.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000080550.

Proteomic databases

PRIDEi Q2VWQ2.

Protocols and materials databases

DNASUi 338352.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081872 ; ENSMUSP00000080550 ; ENSMUSG00000055409 .
GeneIDi 338352.
KEGGi mmu:338352.
UCSCi uc009hbx.1. mouse.

Organism-specific databases

CTDi 4745.
MGIi MGI:2443902. Nell1.

Phylogenomic databases

eggNOGi NOG253557.
GeneTreei ENSGT00770000120551.
HOGENOMi HOG000217920.
HOVERGENi HBG004805.
InParanoidi Q2VWQ2.
OMAi GSHCEKD.
OrthoDBi EOG71VSRX.
PhylomeDBi Q2VWQ2.
TreeFami TF323325.

Miscellaneous databases

NextBioi 400121.
PROi Q2VWQ2.
SOURCEi Search...

Gene expression databases

Bgeei Q2VWQ2.
CleanExi MM_NELL1.
ExpressionAtlasi Q2VWQ2. baseline and differential.
Genevestigatori Q2VWQ2.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 4 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects."
    Desai J., Shannon M.E., Johnson M.D., Ruff D.W., Hughes L.A., Kerley M.K., Carpenter D.A., Johnson D.K., Rinchik E.M., Culiat C.T.
    Hum. Mol. Genet. 15:1329-1341(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: BJR.
    Tissue: Head.

Entry informationi

Entry nameiNELL1_MOUSE
AccessioniPrimary (citable) accession number: Q2VWQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 10, 2006
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3