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Protein

Protein kinase C-binding protein NELL1

Gene

Nell1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL1
Alternative name(s):
NEL-like protein 1
Gene namesi
Name:Nell1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2443902. Nell1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus envelope By similarity
  • Secreted By similarity

  • Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000032264222 – 810Protein kinase C-binding protein NELL1Add BLAST789

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Glycosylationi224N-linked (GlcNAc...)Sequence analysis1
Glycosylationi294N-linked (GlcNAc...)Sequence analysis1
Glycosylationi372N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi395 ↔ 407By similarity
Disulfide bondi401 ↔ 416By similarity
Disulfide bondi418 ↔ 432By similarity
Disulfide bondi438 ↔ 451By similarity
Disulfide bondi445 ↔ 460By similarity
Disulfide bondi462 ↔ 474By similarity
Disulfide bondi480 ↔ 493By similarity
Disulfide bondi487 ↔ 502By similarity
Disulfide bondi504 ↔ 515By similarity
Glycosylationi511N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi519 ↔ 529By similarity
Disulfide bondi523 ↔ 535By similarity
Disulfide bondi537 ↔ 546By similarity
Disulfide bondi553 ↔ 566By similarity
Disulfide bondi560 ↔ 575By similarity
Glycosylationi562N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi577 ↔ 594By similarity
Disulfide bondi600 ↔ 613By similarity
Disulfide bondi607 ↔ 622By similarity
Glycosylationi609N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi624 ↔ 630By similarity
Glycosylationi708N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ2VWQ2.
PRIDEiQ2VWQ2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055409.
CleanExiMM_NELL1.
ExpressionAtlasiQ2VWQ2. baseline and differential.
GenevisibleiQ2VWQ2. MM.

Interactioni

Subunit structurei

Homotrimer. Binds to PKC beta-1. Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080550.

Structurei

3D structure databases

ProteinModelPortaliQ2VWQ2.
SMRiQ2VWQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 227Laminin G-likePROSITE-ProRule annotationAdd BLAST171
Domaini271 – 332VWFC 1PROSITE-ProRule annotationAdd BLAST62
Domaini434 – 475EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini476 – 516EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini517 – 547EGF-like 3PROSITE-ProRule annotationAdd BLAST31
Domaini549 – 587EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini596 – 631EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini632 – 687VWFC 2PROSITE-ProRule annotationAdd BLAST56
Domaini692 – 750VWFC 3PROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Contains 5 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation
Contains 3 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KD9R. Eukaryota.
ENOG410XSZA. LUCA.
GeneTreeiENSGT00810000125439.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiQ2VWQ2.
OMAiGCRYGGT.
OrthoDBiEOG091G01DI.
PhylomeDBiQ2VWQ2.
TreeFamiTF323325.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2VWQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMDVILVLW FCVCTARTVL GFGMDPDLQM DIITELDLVN TTLGVTQVAG
60 70 80 90 100
LHNASKAFLF QDVQREIHSA PHVSEKLIQL FRNKSEFTFL ATVQQKPSTS
110 120 130 140 150
GVILSIRELE HSYFELESSG PREEIRYHYI HGGKPRTEAL PYRMADGQWH
160 170 180 190 200
KVALSVSASH LLLHVDCNRI YERVIDPPET NLPPGSNLWL GQRNQKHGFF
210 220 230 240 250
KGIIQDGKII FMPNGFITQC PNLNRTCPTC SDFLSLVQGI MDLQELLAKM
260 270 280 290 300
TAKLNYAETR LGQLENCHCE KTCQVSGLLY RDQDSWVDGD NCRNCTCKSG
310 320 330 340 350
AVECRRMSCP PLNCSPDSLP VHISGQCCKV CRPKCIYGGK VLAEGQRILT
360 370 380 390 400
KTCRECRGGV LVKITEACPP LNCSEKDHIL PENQCCRVCR GHNFCAEAPK
410 420 430 440 450
CGENSECKNW NTKATCECKN GYISVQGNSA YCEDIDECAA KMHYCHANTV
460 470 480 490 500
CVNLPGLYRC DCIPGYIRVD DFSCTEHDDC GSGQHNCDKN AICTNTVQGH
510 520 530 540 550
SCTCQPGYVG NGTVCKAFCE EGCRYGGTCV APNKCVCPSG FTGSHCEKDI
560 570 580 590 600
DECAEGFVEC HNHSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC
610 620 630 640 650
ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWILR
660 670 680 690 700
EDRCSVCSCK DGKIFCRRTA CDCQNPNVDL FCCPECDTRV TSQCLDQSGQ
710 720 730 740 750
KLYRSGDNWT HSCQQCRCLE GEADCWPLAC PSLSCEYTAI FEGECCPRCV
760 770 780 790 800
SDPCLADNIA YDIRKTCLDS SGISRLSGAV WTMAGSPCTT CQCKNGRVCC
810
SVDLVCLENN
Length:810
Mass (Da):89,415
Last modified:January 10, 2006 - v1
Checksum:i3AD132E97FB83590
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY622226 mRNA. Translation: AAV41488.1.
CCDSiCCDS21309.1.
RefSeqiNP_001032995.1. NM_001037906.2.
UniGeneiMm.383528.

Genome annotation databases

EnsembliENSMUST00000081872; ENSMUSP00000080550; ENSMUSG00000055409.
GeneIDi338352.
KEGGimmu:338352.
UCSCiuc009hbx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY622226 mRNA. Translation: AAV41488.1.
CCDSiCCDS21309.1.
RefSeqiNP_001032995.1. NM_001037906.2.
UniGeneiMm.383528.

3D structure databases

ProteinModelPortaliQ2VWQ2.
SMRiQ2VWQ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080550.

Proteomic databases

PaxDbiQ2VWQ2.
PRIDEiQ2VWQ2.

Protocols and materials databases

DNASUi338352.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081872; ENSMUSP00000080550; ENSMUSG00000055409.
GeneIDi338352.
KEGGimmu:338352.
UCSCiuc009hbx.1. mouse.

Organism-specific databases

CTDi4745.
MGIiMGI:2443902. Nell1.

Phylogenomic databases

eggNOGiENOG410KD9R. Eukaryota.
ENOG410XSZA. LUCA.
GeneTreeiENSGT00810000125439.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiQ2VWQ2.
OMAiGCRYGGT.
OrthoDBiEOG091G01DI.
PhylomeDBiQ2VWQ2.
TreeFamiTF323325.

Miscellaneous databases

PROiQ2VWQ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055409.
CleanExiMM_NELL1.
ExpressionAtlasiQ2VWQ2. baseline and differential.
GenevisibleiQ2VWQ2. MM.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNELL1_MOUSE
AccessioniPrimary (citable) accession number: Q2VWQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 10, 2006
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.