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Q2VWQ2 (NELL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein kinase C-binding protein NELL1
Alternative name(s):
NEL-like protein 1
Gene names
Name:Nell1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length810 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. Ref.1

Subunit structure

Homotrimer. Binds to PKC beta-1. Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus envelope By similarity. Secreted By similarity. Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region By similarity.

Sequence similarities

Contains 5 EGF-like domains.

Contains 1 laminin G-like domain.

Contains 3 VWFC domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 810789Protein kinase C-binding protein NELL1
PRO_0000322642

Regions

Domain57 – 227171Laminin G-like
Domain271 – 33262VWFC 1
Domain434 – 47542EGF-like 1; calcium-binding Potential
Domain476 – 51641EGF-like 2; calcium-binding Potential
Domain517 – 54731EGF-like 3
Domain549 – 58739EGF-like 4; calcium-binding Potential
Domain596 – 63136EGF-like 5; calcium-binding Potential
Domain632 – 68756VWFC 2
Domain692 – 75059VWFC 3

Amino acid modifications

Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation2241N-linked (GlcNAc...) Potential
Glycosylation2941N-linked (GlcNAc...) Potential
Glycosylation3721N-linked (GlcNAc...) Potential
Glycosylation5111N-linked (GlcNAc...) Potential
Glycosylation5621N-linked (GlcNAc...) Potential
Glycosylation6091N-linked (GlcNAc...) Potential
Glycosylation7081N-linked (GlcNAc...) Potential
Disulfide bond395 ↔ 407 By similarity
Disulfide bond401 ↔ 416 By similarity
Disulfide bond418 ↔ 432 By similarity
Disulfide bond438 ↔ 451 By similarity
Disulfide bond445 ↔ 460 By similarity
Disulfide bond462 ↔ 474 By similarity
Disulfide bond480 ↔ 493 By similarity
Disulfide bond487 ↔ 502 By similarity
Disulfide bond504 ↔ 515 By similarity
Disulfide bond519 ↔ 529 By similarity
Disulfide bond523 ↔ 535 By similarity
Disulfide bond537 ↔ 546 By similarity
Disulfide bond553 ↔ 566 By similarity
Disulfide bond560 ↔ 575 By similarity
Disulfide bond577 ↔ 594 By similarity
Disulfide bond600 ↔ 613 By similarity
Disulfide bond607 ↔ 622 By similarity
Disulfide bond624 ↔ 630 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2VWQ2 [UniParc].

Last modified January 10, 2006. Version 1.
Checksum: 3AD132E97FB83590

FASTA81089,415
        10         20         30         40         50         60 
MPMDVILVLW FCVCTARTVL GFGMDPDLQM DIITELDLVN TTLGVTQVAG LHNASKAFLF 

        70         80         90        100        110        120 
QDVQREIHSA PHVSEKLIQL FRNKSEFTFL ATVQQKPSTS GVILSIRELE HSYFELESSG 

       130        140        150        160        170        180 
PREEIRYHYI HGGKPRTEAL PYRMADGQWH KVALSVSASH LLLHVDCNRI YERVIDPPET 

       190        200        210        220        230        240 
NLPPGSNLWL GQRNQKHGFF KGIIQDGKII FMPNGFITQC PNLNRTCPTC SDFLSLVQGI 

       250        260        270        280        290        300 
MDLQELLAKM TAKLNYAETR LGQLENCHCE KTCQVSGLLY RDQDSWVDGD NCRNCTCKSG 

       310        320        330        340        350        360 
AVECRRMSCP PLNCSPDSLP VHISGQCCKV CRPKCIYGGK VLAEGQRILT KTCRECRGGV 

       370        380        390        400        410        420 
LVKITEACPP LNCSEKDHIL PENQCCRVCR GHNFCAEAPK CGENSECKNW NTKATCECKN 

       430        440        450        460        470        480 
GYISVQGNSA YCEDIDECAA KMHYCHANTV CVNLPGLYRC DCIPGYIRVD DFSCTEHDDC 

       490        500        510        520        530        540 
GSGQHNCDKN AICTNTVQGH SCTCQPGYVG NGTVCKAFCE EGCRYGGTCV APNKCVCPSG 

       550        560        570        580        590        600 
FTGSHCEKDI DECAEGFVEC HNHSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC 

       610        620        630        640        650        660 
ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWILR EDRCSVCSCK 

       670        680        690        700        710        720 
DGKIFCRRTA CDCQNPNVDL FCCPECDTRV TSQCLDQSGQ KLYRSGDNWT HSCQQCRCLE 

       730        740        750        760        770        780 
GEADCWPLAC PSLSCEYTAI FEGECCPRCV SDPCLADNIA YDIRKTCLDS SGISRLSGAV 

       790        800        810 
WTMAGSPCTT CQCKNGRVCC SVDLVCLENN 

« Hide

References

[1]"Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects."
Desai J., Shannon M.E., Johnson M.D., Ruff D.W., Hughes L.A., Kerley M.K., Carpenter D.A., Johnson D.K., Rinchik E.M., Culiat C.T.
Hum. Mol. Genet. 15:1329-1341(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: BJR.
Tissue: Head.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY622226 mRNA. Translation: AAV41488.1.
RefSeqNP_001032995.1. NM_001037906.2.
UniGeneMm.383528.

3D structure databases

ProteinModelPortalQ2VWQ2.
SMRQ2VWQ2. Positions 29-214, 269-629, 701-752.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000080550.

Proteomic databases

PRIDEQ2VWQ2.

Protocols and materials databases

DNASU338352.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000081872; ENSMUSP00000080550; ENSMUSG00000055409.
GeneID338352.
KEGGmmu:338352.
UCSCuc009hbx.1. mouse.

Organism-specific databases

CTD4745.
MGIMGI:2443902. Nell1.

Phylogenomic databases

eggNOGNOG253557.
GeneTreeENSGT00750000117321.
HOGENOMHOG000217920.
HOVERGENHBG004805.
InParanoidQ2VWQ2.
OMAGSHCEKD.
OrthoDBEOG71VSRX.
PhylomeDBQ2VWQ2.
TreeFamTF323325.

Gene expression databases

BgeeQ2VWQ2.
CleanExMM_NELL1.
GenevestigatorQ2VWQ2.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamPF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 4 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNELL1. mouse.
NextBio400121.
PROQ2VWQ2.
SOURCESearch...

Entry information

Entry nameNELL1_MOUSE
AccessionPrimary (citable) accession number: Q2VWQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 10, 2006
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot