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Protein

Protogenin

Gene

PRTG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in anteroposterior axis elongation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protogenin
Alternative name(s):
Protein Shen-Dan
Gene namesi
Name:PRTGImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:26373. PRTG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 949914ExtracellularSequence analysisAdd
BLAST
Transmembranei950 – 97021HelicalSequence analysisAdd
BLAST
Topological domaini971 – 1150180CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671124.

Polymorphism and mutation databases

BioMutaiPRTG.
DMDMi121946850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence analysisAdd
BLAST
Chaini36 – 11501115ProtogeninSequence analysisPRO_0000317047Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 ↔ 113PROSITE-ProRule annotation
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Disulfide bondi156 ↔ 205PROSITE-ProRule annotation
Disulfide bondi256 ↔ 304PROSITE-ProRule annotation
Disulfide bondi348 ↔ 395PROSITE-ProRule annotation
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence analysis
Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ2VWP7.
PRIDEiQ2VWP7.

PTM databases

iPTMnetiQ2VWP7.
PhosphoSiteiQ2VWP7.

Expressioni

Gene expression databases

BgeeiQ2VWP7.
CleanExiHS_PRTG.
ExpressionAtlasiQ2VWP7. baseline and differential.
GenevisibleiQ2VWP7. HS.

Organism-specific databases

HPAiHPA032138.

Interactioni

Protein-protein interaction databases

BioGridi129634. 2 interactions.
STRINGi9606.ENSP00000373937.

Structurei

3D structure databases

ProteinModelPortaliQ2VWP7.
SMRiQ2VWP7. Positions 37-612, 617-912.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 13095Ig-like 1Sequence analysisAdd
BLAST
Domaini135 – 22288Ig-like 2Sequence analysisAdd
BLAST
Domaini235 – 32288Ig-like 3Sequence analysisAdd
BLAST
Domaini327 – 41185Ig-like 4Sequence analysisAdd
BLAST
Domaini421 – 51595Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini517 – 61397Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini618 – 717100Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini724 – 81794Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini822 – 91796Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Sequence analysis
Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 4 Ig-like (immunoglobulin-like) domains.Sequence analysis

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4221. Eukaryota.
ENOG410Z913. LUCA.
GeneTreeiENSGT00840000129688.
HOGENOMiHOG000113009.
HOVERGENiHBG101283.
InParanoidiQ2VWP7.
OMAiVWCFSEL.
OrthoDBiEOG776SP5.
PhylomeDBiQ2VWP7.
TreeFamiTF321506.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033011. Protogenin.
[Graphical view]
PANTHERiPTHR10489:SF661. PTHR10489:SF661. 1 hit.
PfamiPF00041. fn3. 5 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2VWP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPLRPLAR LRPPGMLLRA LLLLLLLSPL PGVWCFSELS FVKEPQDVTV
60 70 80 90 100
TRKDPVVLDC QAHGEVPIKV TWLKNGAKMS ENKRIEVLSN GSLYISEVEG
110 120 130 140 150
RRGEQSDEGF YQCLAMNKYG AILSQKAHLA LSTISAFEVQ PISTEVHEGG
160 170 180 190 200
VARFACKISS HPPAVITWEF NRTTLPMTMD RITALPTGVL QIYDVSQRDS
210 220 230 240 250
GNYRCIAATV AHRRKSMEAS LTVIPAKESK SFHTPTIIAG PQNITTSLHQ
260 270 280 290 300
TVVLECMATG NPKPIISWSR LDHKSIDVFN TRVLGNGNLM ISDVRLQHAG
310 320 330 340 350
VYVCRATTPG TRNFTVAMAT LTVLAPPSFV EWPESLTRPR AGTARFVCQA
360 370 380 390 400
EGIPSPKMSW LKNGRKIHSN GRIKMYNSKL VINQIIPEDD AIYQCMAENS
410 420 430 440 450
QGSILSRARL TVVMSEDRPS APYNVHAETM SSSAILLAWE RPLYNSDKVI
460 470 480 490 500
AYSVHYMKAE GLNNEEYQVV IGNDTTHYII DDLEPASNYT FYIVAYMPMG
510 520 530 540 550
ASQMSDHVTQ NTLEDVPLRP PEISLTSRSP TDILISWLPI PAKYRRGQVV
560 570 580 590 600
LYRLSFRLST ENSIQVLELP GTTHEYLLEG LKPDSVYLVR ITAATRVGLG
610 620 630 640 650
ESSVWTSHRT PKATSVKAPK SPELHLEPLN CTTISVRWQQ DVEDTAAIQG
660 670 680 690 700
YKLYYKEEGQ QENGPIFLDT KDLLYTLSGL DPRRKYHVRL LAYNNIDDGY
710 720 730 740 750
QADQTVSTPG CVSVRDRMVP PPPPPHHLYA KANTSSSIFL HWRRPAFTAA
760 770 780 790 800
QIINYTIRCN PVGLQNASLV LYLQTSETHM LVQGLEPNTK YEFAVRLHVD
810 820 830 840 850
QLSSPWSPVV YHSTLPEAPA GPPVGVKVTL IEDDTALVSW KPPDGPETVV
860 870 880 890 900
TRYTILYASR KAWIAGEWQV LHREGAITMA LLENLVAGNV YIVKISASNE
910 920 930 940 950
VGEGPFSNSV ELAVLPKETS ESNQRPKRLD SADAKVYSGY YHLDQKSMTG
960 970 980 990 1000
IAVGVGIALT CILICVLILI YRSKARKSSA SKTAQNGTQQ LPRTSASLAS
1010 1020 1030 1040 1050
GNEVGKNLEG AVGNEESLMP MIMPNSFIDA KGGTDLIINS YGPIIKNNSK
1060 1070 1080 1090 1100
KKWFFFQDSK KIQVEQPQRR FTPAVCFYQP GTTVLISDED SPSSPGQTTS
1110 1120 1130 1140 1150
FSRPFGVAAD TEHSANSEGS HETGDSGRFS HESNDEIHLS SVISTTPPNL
Length:1,150
Mass (Da):127,076
Last modified:January 10, 2006 - v1
Checksum:iF64CBA30C0F1EC89
GO

Sequence cautioni

The sequence BAC05355.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti236 – 2361T → A.
Corresponds to variant rs16976466 [ dbSNP | Ensembl ].
VAR_049916
Natural varianti826 – 8261V → L.
Corresponds to variant rs10518816 [ dbSNP | Ensembl ].
VAR_049917
Natural varianti1062 – 10621I → L.1 Publication
Corresponds to variant rs1438914 [ dbSNP | Ensembl ].
VAR_038467

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY630258 mRNA. Translation: AAU05741.1.
AK098622 mRNA. Translation: BAC05355.1. Different initiation.
CCDSiCCDS42040.1.
RefSeqiNP_776175.2. NM_173814.5.
UniGeneiHs.130957.

Genome annotation databases

EnsembliENST00000389286; ENSP00000373937; ENSG00000166450.
GeneIDi283659.
KEGGihsa:283659.
UCSCiuc002adg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY630258 mRNA. Translation: AAU05741.1.
AK098622 mRNA. Translation: BAC05355.1. Different initiation.
CCDSiCCDS42040.1.
RefSeqiNP_776175.2. NM_173814.5.
UniGeneiHs.130957.

3D structure databases

ProteinModelPortaliQ2VWP7.
SMRiQ2VWP7. Positions 37-612, 617-912.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129634. 2 interactions.
STRINGi9606.ENSP00000373937.

PTM databases

iPTMnetiQ2VWP7.
PhosphoSiteiQ2VWP7.

Polymorphism and mutation databases

BioMutaiPRTG.
DMDMi121946850.

Proteomic databases

PaxDbiQ2VWP7.
PRIDEiQ2VWP7.

Protocols and materials databases

DNASUi283659.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389286; ENSP00000373937; ENSG00000166450.
GeneIDi283659.
KEGGihsa:283659.
UCSCiuc002adg.4. human.

Organism-specific databases

CTDi283659.
GeneCardsiPRTG.
HGNCiHGNC:26373. PRTG.
HPAiHPA032138.
MIMi613261. gene.
neXtProtiNX_Q2VWP7.
PharmGKBiPA142671124.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4221. Eukaryota.
ENOG410Z913. LUCA.
GeneTreeiENSGT00840000129688.
HOGENOMiHOG000113009.
HOVERGENiHBG101283.
InParanoidiQ2VWP7.
OMAiVWCFSEL.
OrthoDBiEOG776SP5.
PhylomeDBiQ2VWP7.
TreeFamiTF321506.

Miscellaneous databases

GenomeRNAii283659.
PROiQ2VWP7.
SOURCEiSearch...

Gene expression databases

BgeeiQ2VWP7.
CleanExiHS_PRTG.
ExpressionAtlasiQ2VWP7. baseline and differential.
GenevisibleiQ2VWP7. HS.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033011. Protogenin.
[Graphical view]
PANTHERiPTHR10489:SF661. PTHR10489:SF661. 1 hit.
PfamiPF00041. fn3. 5 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Shen-Dan is a novel receptor for embryonic stem cells and developing neurons."
    Wong Y.-H., Chang C., Chen P.-H., Yu J.-Y., Wang Y.-C., Lee C.-M., Lin W.-J., Tsai T.-F., Wang A.-G., Fann M.-J.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 603-1150, VARIANT LEU-1062.
    Tissue: TestisImported.

Entry informationi

Entry nameiPRTG_HUMAN
AccessioniPrimary (citable) accession number: Q2VWP7
Secondary accession number(s): Q8N7D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 10, 2006
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.