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Protein

Dixin

Gene

Dixdc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Dixin
Alternative name(s):
Coiled-coil protein DIX1
Short name:
Coiled-coil-DIX1
DIX domain-containing protein 1
Gene namesi
Name:Dixdc1
Synonyms:Ccd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1309902 Dixdc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002872251 – 674DixinAdd BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191PhosphoserineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei565PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine and serine residues.By similarity
Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ2VUH7
PRIDEiQ2VUH7

PTM databases

iPTMnetiQ2VUH7
PhosphoSitePlusiQ2VUH7

Expressioni

Gene expression databases

BgeeiENSRNOG00000010260
ExpressionAtlasiQ2VUH7 baseline and differential
GenevisibleiQ2VUH7 RN

Interactioni

Subunit structurei

May bind filamentous actin. Interacts with the complex composed of DVL2 and Rac. Interacts with AXIN1; competes with MAP3K1. Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1. Directly interacts (via DIX domain) with DVL2 (via DIX domain). Interacts with gamma-tubulin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037500

Structurei

3D structure databases

ProteinModelPortaliQ2VUH7
SMRiQ2VUH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 132Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST108
Domaini575 – 655DIXPROSITE-ProRule annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni132 – 305Actin-bindingBy similarityAdd BLAST174

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili282 – 469Sequence analysisAdd BLAST188

Domaini

The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4.By similarity
The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through MAP3K1. Mediates interaction with DVL2; this interaction is required for activation of Wnt signaling (By similarity).By similarity

Sequence similaritiesi

Belongs to the DIXDC1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFNC Eukaryota
ENOG410XPPR LUCA
GeneTreeiENSGT00390000013552
HOGENOMiHOG000112219
HOVERGENiHBG107812
InParanoidiQ2VUH7
PhylomeDBiQ2VUH7

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10878 PTHR10878, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00778 DIX, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00021 DAX, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS50841 DIX, 1 hit

Sequencei

Sequence statusi: Complete.

Q2VUH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSATLDET VELRAGEEPS DASLGQQLQA YVAWVNAQLK KRPSVKPVQD
60 70 80 90 100
LRQDLRDGVI LAYLIEIVAG EKLSGVQLSP SNQQEMKSNV ERVLQFVASK
110 120 130 140 150
NIRMHQTSAK DIVEGNLKSI MRLVLALAAH FKPGSSRTVS QGRDSRTSVQ
160 170 180 190 200
SHQPHCATAV AQGAAAALAD VCHDVSRSGR DVFRYRQRNA SVDEEIENPY
210 220 230 240 250
WSVRALVQQY EGQQRSPSES SCSSLTSPSP IHSAKSESII TQSEEKADFV
260 270 280 290 300
IIPSEGIENR TDETGSPLSR DWRPGSPGTY LEATWEEQLL EQQEHLEKEM
310 320 330 340 350
EEAKKMISGL QALLLNGSLP EDEQERPVAL CEPGVNPEEQ LIIIRSRLDQ
360 370 380 390 400
SMEENQDLKK ELLKCKQEAR NLQGIKDALQ QRLTQQDTSV LQLKQELLRA
410 420 430 440 450
NMDKDELHNQ NVDLQRKLDE RNRLLGEYKK DLGQKDRLLQ QQQAKLEDAL
460 470 480 490 500
RKLSDASYQQ VDLERELEQK DVLLAHRVKG DTDESSDLQL VRDALRSLRN
510 520 530 540 550
SFSGHDPQHH TIDSLEQGIS SLIERLHVIE TQKKQERKVR GRSPRNQASS
560 570 580 590 600
EYRASWPPNS TLPHSQSSPA VSNTCTKVLY FTDRSLTPFM VNIPKRLGEV
610 620 630 640 650
TLKDFKAAID REGSHRYHFK ALDPEFGTVK EEVFHDDDAI PGWEGKIVAW
660 670
ERGLTPEDTE KFLTRAAKKK LLQV
Length:674
Mass (Da):76,141
Last modified:January 10, 2006 - v1
Checksum:iFB92F592DAB9D571
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY770507 mRNA Translation: AAX76925.1
RefSeqiNP_001032743.1, NM_001037654.1
UniGeneiRn.8331

Genome annotation databases

EnsembliENSRNOT00000039045; ENSRNOP00000037500; ENSRNOG00000010260
GeneIDi363062
KEGGirno:363062
UCSCiRGD:1309902 rat

Similar proteinsi

Entry informationi

Entry nameiDIXC1_RAT
AccessioniPrimary (citable) accession number: Q2VUH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: January 10, 2006
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health