Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dixin

Gene

Dixdc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cerebellar cortex development Source: RGD
  • positive regulation of axonogenesis Source: RGD
  • positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  • positive regulation of JNK cascade Source: RGD
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dixin
Alternative name(s):
Coiled-coil protein DIX1
Short name:
Coiled-coil-DIX1
DIX domain-containing protein 1
Gene namesi
Name:Dixdc1
Synonyms:Ccd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1309902. Dixdc1.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • cytoplasm Source: RGD
  • cytosol Source: UniProtKB
  • focal adhesion Source: UniProtKB-SubCell
  • neuronal cell body Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 674674DixinPRO_0000287225Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei191 – 1911PhosphoserineBy similarity
Modified residuei236 – 2361PhosphoserineBy similarity
Modified residuei565 – 5651PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine and serine residues.By similarity
Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ2VUH7.
PRIDEiQ2VUH7.

PTM databases

PhosphoSiteiQ2VUH7.

Expressioni

Gene expression databases

ExpressionAtlasiQ2VUH7. baseline and differential.
GenevisibleiQ2VUH7. RN.

Interactioni

Subunit structurei

May bind filamentous actin. Interacts with the complex composed of DVL2 and Rac. Interacts with AXIN1; competes with MAP3K1. Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1. Directly interacts (via DIX domain) with DVL2 (via DIX domain). Interacts with gamma-tubulin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037500.

Structurei

3D structure databases

ProteinModelPortaliQ2VUH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 132108CHPROSITE-ProRule annotationAdd
BLAST
Domaini575 – 65581DIXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 305174Actin-bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili282 – 469188Sequence analysisAdd
BLAST

Domaini

The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4.By similarity
The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through MAP3K1. Mediates interaction with DVL2; this interaction is required for activation of Wnt signaling (By similarity).By similarity

Sequence similaritiesi

Belongs to the DIXDC1 family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 DIX domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFNC. Eukaryota.
ENOG410XPPR. LUCA.
GeneTreeiENSGT00390000013552.
HOGENOMiHOG000112219.
HOVERGENiHBG107812.
InParanoidiQ2VUH7.
OMAiETSWEEQ.
OrthoDBiEOG7X0VGJ.
PhylomeDBiQ2VUH7.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 2 hits.
PfamiPF00307. CH. 1 hit.
PF00778. DIX. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00021. DAX. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS50841. DIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2VUH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSATLDET VELRAGEEPS DASLGQQLQA YVAWVNAQLK KRPSVKPVQD
60 70 80 90 100
LRQDLRDGVI LAYLIEIVAG EKLSGVQLSP SNQQEMKSNV ERVLQFVASK
110 120 130 140 150
NIRMHQTSAK DIVEGNLKSI MRLVLALAAH FKPGSSRTVS QGRDSRTSVQ
160 170 180 190 200
SHQPHCATAV AQGAAAALAD VCHDVSRSGR DVFRYRQRNA SVDEEIENPY
210 220 230 240 250
WSVRALVQQY EGQQRSPSES SCSSLTSPSP IHSAKSESII TQSEEKADFV
260 270 280 290 300
IIPSEGIENR TDETGSPLSR DWRPGSPGTY LEATWEEQLL EQQEHLEKEM
310 320 330 340 350
EEAKKMISGL QALLLNGSLP EDEQERPVAL CEPGVNPEEQ LIIIRSRLDQ
360 370 380 390 400
SMEENQDLKK ELLKCKQEAR NLQGIKDALQ QRLTQQDTSV LQLKQELLRA
410 420 430 440 450
NMDKDELHNQ NVDLQRKLDE RNRLLGEYKK DLGQKDRLLQ QQQAKLEDAL
460 470 480 490 500
RKLSDASYQQ VDLERELEQK DVLLAHRVKG DTDESSDLQL VRDALRSLRN
510 520 530 540 550
SFSGHDPQHH TIDSLEQGIS SLIERLHVIE TQKKQERKVR GRSPRNQASS
560 570 580 590 600
EYRASWPPNS TLPHSQSSPA VSNTCTKVLY FTDRSLTPFM VNIPKRLGEV
610 620 630 640 650
TLKDFKAAID REGSHRYHFK ALDPEFGTVK EEVFHDDDAI PGWEGKIVAW
660 670
ERGLTPEDTE KFLTRAAKKK LLQV
Length:674
Mass (Da):76,141
Last modified:January 10, 2006 - v1
Checksum:iFB92F592DAB9D571
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY770507 mRNA. Translation: AAX76925.1.
RefSeqiNP_001032743.1. NM_001037654.1.
UniGeneiRn.8331.

Genome annotation databases

EnsembliENSRNOT00000039045; ENSRNOP00000037500; ENSRNOG00000010260.
GeneIDi363062.
KEGGirno:363062.
UCSCiRGD:1309902. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY770507 mRNA. Translation: AAX76925.1.
RefSeqiNP_001032743.1. NM_001037654.1.
UniGeneiRn.8331.

3D structure databases

ProteinModelPortaliQ2VUH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037500.

PTM databases

PhosphoSiteiQ2VUH7.

Proteomic databases

PaxDbiQ2VUH7.
PRIDEiQ2VUH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000039045; ENSRNOP00000037500; ENSRNOG00000010260.
GeneIDi363062.
KEGGirno:363062.
UCSCiRGD:1309902. rat.

Organism-specific databases

CTDi85458.
RGDi1309902. Dixdc1.

Phylogenomic databases

eggNOGiENOG410IFNC. Eukaryota.
ENOG410XPPR. LUCA.
GeneTreeiENSGT00390000013552.
HOGENOMiHOG000112219.
HOVERGENiHBG107812.
InParanoidiQ2VUH7.
OMAiETSWEEQ.
OrthoDBiEOG7X0VGJ.
PhylomeDBiQ2VUH7.

Miscellaneous databases

NextBioi682294.
PROiQ2VUH7.

Gene expression databases

ExpressionAtlasiQ2VUH7. baseline and differential.
GenevisibleiQ2VUH7. RN.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 2 hits.
PfamiPF00307. CH. 1 hit.
PF00778. DIX. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00021. DAX. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS50841. DIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of wnt pathway protein dixin."
    Zhou G., Wang X., Qian C., Liu W.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiDIXC1_RAT
AccessioniPrimary (citable) accession number: Q2VUH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: January 10, 2006
Last modified: May 11, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.