ID   LR75B_HUMAN             Reviewed;         315 AA.
AC   Q2VPJ9; Q8N0S9; Q8N8B1;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   24-JAN-2024, entry version 121.
DE   RecName: Full=Leucine-rich repeat-containing protein 75B {ECO:0000305};
DE   AltName: Full=Leucine-rich repeat-containing protein FAM211B;
GN   Name=LRRC75B {ECO:0000312|HGNC:HGNC:33155};
GN   Synonyms=C22orf36, FAM211B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Small intestine;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May suppress myogenic differentiation by modulating MYOG
CC       expression and Erk1/2 signaling. {ECO:0000250|UniProtKB:Q7TPD7}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q2VPJ9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q2VPJ9-2; Sequence=VSP_021172, VSP_021173;
CC   -!- SIMILARITY: Belongs to the LRRC75 family. {ECO:0000305}.
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DR   EMBL; AK097054; BAC04937.1; -; mRNA.
DR   EMBL; BC032388; AAH32388.1; -; mRNA.
DR   EMBL; BC108684; AAI08685.1; -; mRNA.
DR   CCDS; CCDS42991.1; -. [Q2VPJ9-1]
DR   RefSeq; NP_997527.2; NM_207644.2. [Q2VPJ9-1]
DR   AlphaFoldDB; Q2VPJ9; -.
DR   SMR; Q2VPJ9; -.
DR   BioGRID; 132882; 2.
DR   STRING; 9606.ENSP00000320520; -.
DR   GlyGen; Q2VPJ9; 1 site, 1 O-linked glycan (1 site).
DR   PhosphoSitePlus; Q2VPJ9; -.
DR   BioMuta; LRRC75B; -.
DR   DMDM; 118573588; -.
DR   MassIVE; Q2VPJ9; -.
DR   PaxDb; 9606-ENSP00000320520; -.
DR   PeptideAtlas; Q2VPJ9; -.
DR   Antibodypedia; 265; 76 antibodies from 13 providers.
DR   DNASU; 388886; -.
DR   Ensembl; ENST00000318753.13; ENSP00000320520.8; ENSG00000178026.13. [Q2VPJ9-1]
DR   GeneID; 388886; -.
DR   KEGG; hsa:388886; -.
DR   MANE-Select; ENST00000318753.13; ENSP00000320520.8; NM_207644.3; NP_997527.2.
DR   UCSC; uc003aaq.3; human. [Q2VPJ9-1]
DR   AGR; HGNC:33155; -.
DR   CTD; 388886; -.
DR   DisGeNET; 388886; -.
DR   GeneCards; LRRC75B; -.
DR   HGNC; HGNC:33155; LRRC75B.
DR   HPA; ENSG00000178026; Tissue enhanced (brain).
DR   neXtProt; NX_Q2VPJ9; -.
DR   OpenTargets; ENSG00000178026; -.
DR   PharmGKB; PA162378982; -.
DR   VEuPathDB; HostDB:ENSG00000178026; -.
DR   eggNOG; ENOG502QRJY; Eukaryota.
DR   GeneTree; ENSGT00940000162815; -.
DR   HOGENOM; CLU_050536_2_0_1; -.
DR   InParanoid; Q2VPJ9; -.
DR   OMA; SEPQACC; -.
DR   OrthoDB; 2910309at2759; -.
DR   PhylomeDB; Q2VPJ9; -.
DR   TreeFam; TF332831; -.
DR   PathwayCommons; Q2VPJ9; -.
DR   BioGRID-ORCS; 388886; 16 hits in 1148 CRISPR screens.
DR   GenomeRNAi; 388886; -.
DR   Pharos; Q2VPJ9; Tdark.
DR   PRO; PR:Q2VPJ9; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; Q2VPJ9; Protein.
DR   Bgee; ENSG00000178026; Expressed in kidney epithelium and 157 other cell types or tissues.
DR   ExpressionAtlas; Q2VPJ9; baseline and differential.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR39654; -; 1.
DR   PANTHER; PTHR39654:SF5; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 75B; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   Genevisible; Q2VPJ9; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..315
FT                   /note="Leucine-rich repeat-containing protein 75B"
FT                   /id="PRO_0000254046"
FT   REPEAT          182..195
FT                   /note="LRR 1"
FT   REPEAT          207..220
FT                   /note="LRR 2"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          284..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         60..152
FT                   /note="DLGLERTLLPDILYRDVAFLNPVDPISHDLLVNLARDLQCPKKDYELWKSSD
FT                   KICRQLIYHLTPHSKQQQGSSLRQRKTQSCLKSSLQKTLLA -> AREGAVRPWAGGQG
FT                   GSGGLGVWEARGYGLWACIRREARRSWSLARAGGFRGRDRLQHAGSCVGERATAWSEGW
FT                   VRSADRVEEGAAECVRVFGV (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_021172"
FT   VAR_SEQ         153..315
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_021173"
FT   VARIANT         140
FT                   /note="S -> R (in dbSNP:rs743370)"
FT                   /id="VAR_051125"
SQ   SEQUENCE   315 AA;  34740 MW;  099B03832A2DD370 CRC64;
     MGARLGRRAG PEAGSEAGAA AGCGPAPYER RVRWLREIQS TLRERRPERA RQLLRLLRQD
     LGLERTLLPD ILYRDVAFLN PVDPISHDLL VNLARDLQCP KKDYELWKSS DKICRQLIYH
     LTPHSKQQQG SSLRQRKTQS CLKSSLQKTL LAGETVDLSG IPLSTQDVQH ITRYLSSHGA
     VLAVLDLSFT GLSDELLHLL LPSLWALPRL TQLLLNGNRL TRATARKLTD AIKDTTKFPA
     LAWVDLGNNV DVASLPQPLL VGLRRRLSQR TSLPTIYEGL DLEPEGSAAG ATTPASTWDS
     TAAGLGPEPQ ACCAR
//