Q2VPJ9 (F211B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-rich repeat-containing protein FAM211B

Gene names

Name:	FAM211B
Synonyms:	C22orf36

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM211 family. Contains 2 LRR (leucine-rich) repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q2VPJ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q2VPJ9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     60-152: DLGLERTLLP...KSSLQKTLLA → AREGAVRPWA...AAECVRVFGV
     153-315: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Leucine-rich repeat-containing protein FAM211B		PRO_0000254046
Regions
	Repeat	182 – 195	14	LRR 1
	Repeat	207 – 220	14	LRR 2
Natural variations
	Alternative sequence	60 – 152	93	DLGLE…KTLLA → AREGAVRPWAGGQGGSGGLG VWEARGYGLWACIRREARRS WSLARAGGFRGRDRLQHAGS CVGERATAWSEGWVRSADRV EEGAAECVRVFGV in isoform 2.		VSP_021172
	Alternative sequence	153 – 315	163	Missing in isoform 2.		VSP_021173
	Natural variant	140	1	S → R. Corresponds to variant rs743370 [ dbSNP | Ensembl ].		VAR_051125

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2006. Version 1. Checksum: 099B03832A2DD370	FASTA	315	34,740
	10 20 30 40 50 60 MGARLGRRAG PEAGSEAGAA AGCGPAPYER RVRWLREIQS TLRERRPERA RQLLRLLRQD 70 80 90 100 110 120 LGLERTLLPD ILYRDVAFLN PVDPISHDLL VNLARDLQCP KKDYELWKSS DKICRQLIYH 130 140 150 160 170 180 LTPHSKQQQG SSLRQRKTQS CLKSSLQKTL LAGETVDLSG IPLSTQDVQH ITRYLSSHGA 190 200 210 220 230 240 VLAVLDLSFT GLSDELLHLL LPSLWALPRL TQLLLNGNRL TRATARKLTD AIKDTTKFPA 250 260 270 280 290 300 LAWVDLGNNV DVASLPQPLL VGLRRRLSQR TSLPTIYEGL DLEPEGSAAG ATTPASTWDS 310 TAAGLGPEPQ ACCAR
	Isoform 2 [UniParc]. Checksum: 5450D9C35B799B30	FASTA	152	16,640
	10 20 30 40 50 60 MGARLGRRAG PEAGSEAGAA AGCGPAPYER RVRWLREIQS TLRERRPERA RQLLRLLRQA 70 80 90 100 110 120 REGAVRPWAG GQGGSGGLGV WEARGYGLWA CIRREARRSW SLARAGGFRG RDRLQHAGSC 130 140 150 VGERATAWSE GWVRSADRVE EGAAECVRVF GV

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Small intestine.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK097054 mRNA. Translation: BAC04937.1. BC032388 mRNA. Translation: AAH32388.1. BC108684 mRNA. Translation: AAI08685.1.
IPI	IPI00384730. IPI00746581.
RefSeq	NP_997527.2. NM_207644.2.
UniGene	Hs.113314.
3D structure databases
ProteinModelPortal	Q2VPJ9.
ModBase	Search...
Polymorphism databases
DMDM	118573588.
Proteomic databases
PaxDb	Q2VPJ9.
PRIDE	Q2VPJ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318753; ENSP00000320520; ENSG00000178026.
GeneID	388886.
KEGG	hsa:388886.
UCSC	uc003aaq.2. human.
Organism-specific databases
CTD	388886.
GeneCards	GC22M024982.
HGNC	HGNC:33155. FAM211B.
HPA	HPA002540.
neXtProt	NX_Q2VPJ9.
PharmGKB	PA162378982.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43518.
HOGENOM	HOG000111942.
HOVERGEN	HBG066484.
InParanoid	Q2VPJ9.
OMA	TDILYRN.
OrthoDB	EOG4TF0MB.
Gene expression databases
ArrayExpress	Q2VPJ9.
Bgee	Q2VPJ9.
CleanEx	HS_C22orf36.
Genevestigator	Q2VPJ9.
GermOnline	ENSG00000178026. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	388886.
NextBio	102414.

Entry information

Entry name

F211B_HUMAN

Accession

Primary (citable) accession number: Q2VPJ9
Secondary accession number(s): Q8N0S9, Q8N8B1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.