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Q2VPJ9 (LR75B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat-containing protein 75B
Alternative name(s):
Leucine-rich repeat-containing protein FAM211B
Gene names
Name:LRRC75B
Synonyms:C22orf36, FAM211B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the LRRC75 family.

Contains 2 LRR (leucine-rich) repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainLeucine-rich repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q2VPJ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q2VPJ9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     60-152: DLGLERTLLP...KSSLQKTLLA → AREGAVRPWA...AAECVRVFGV
     153-315: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Leucine-rich repeat-containing protein 75B
PRO_0000254046

Regions

Repeat182 – 19514LRR 1
Repeat207 – 22014LRR 2

Natural variations

Alternative sequence60 – 15293DLGLE…KTLLA → AREGAVRPWAGGQGGSGGLG VWEARGYGLWACIRREARRS WSLARAGGFRGRDRLQHAGS CVGERATAWSEGWVRSADRV EEGAAECVRVFGV in isoform 2.
VSP_021172
Alternative sequence153 – 315163Missing in isoform 2.
VSP_021173
Natural variant1401S → R.
Corresponds to variant rs743370 [ dbSNP | Ensembl ].
VAR_051125

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 10, 2006. Version 1.
Checksum: 099B03832A2DD370

FASTA31534,740
        10         20         30         40         50         60 
MGARLGRRAG PEAGSEAGAA AGCGPAPYER RVRWLREIQS TLRERRPERA RQLLRLLRQD 

        70         80         90        100        110        120 
LGLERTLLPD ILYRDVAFLN PVDPISHDLL VNLARDLQCP KKDYELWKSS DKICRQLIYH 

       130        140        150        160        170        180 
LTPHSKQQQG SSLRQRKTQS CLKSSLQKTL LAGETVDLSG IPLSTQDVQH ITRYLSSHGA 

       190        200        210        220        230        240 
VLAVLDLSFT GLSDELLHLL LPSLWALPRL TQLLLNGNRL TRATARKLTD AIKDTTKFPA 

       250        260        270        280        290        300 
LAWVDLGNNV DVASLPQPLL VGLRRRLSQR TSLPTIYEGL DLEPEGSAAG ATTPASTWDS 

       310 
TAAGLGPEPQ ACCAR 

« Hide

Isoform 2 [UniParc].

Checksum: 5450D9C35B799B30
Show »

FASTA15216,640

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Small intestine.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK097054 mRNA. Translation: BAC04937.1.
BC032388 mRNA. Translation: AAH32388.1.
BC108684 mRNA. Translation: AAI08685.1.
CCDSCCDS42991.1. [Q2VPJ9-1]
RefSeqNP_997527.2. NM_207644.2. [Q2VPJ9-1]
UniGeneHs.113314.

3D structure databases

ProteinModelPortalQ2VPJ9.
SMRQ2VPJ9. Positions 142-275.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM118573588.

Proteomic databases

PaxDbQ2VPJ9.
PRIDEQ2VPJ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318753; ENSP00000320520; ENSG00000178026. [Q2VPJ9-1]
GeneID388886.
KEGGhsa:388886.
UCSCuc003aaq.2. human. [Q2VPJ9-1]

Organism-specific databases

CTD388886.
GeneCardsGC22M024983.
HGNCHGNC:33155. LRRC75B.
HPAHPA002540.
neXtProtNX_Q2VPJ9.
PharmGKBPA162378982.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43518.
HOGENOMHOG000111942.
HOVERGENHBG066484.
InParanoidQ2VPJ9.
OMALQCPKKD.
OrthoDBEOG747PJW.
PhylomeDBQ2VPJ9.
TreeFamTF332831.

Gene expression databases

ArrayExpressQ2VPJ9.
BgeeQ2VPJ9.
CleanExHS_C22orf36.
GenevestigatorQ2VPJ9.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi388886.
NextBio102414.
PROQ2VPJ9.

Entry information

Entry nameLR75B_HUMAN
AccessionPrimary (citable) accession number: Q2VPJ9
Secondary accession number(s): Q8N0S9, Q8N8B1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 10, 2006
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM