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Protein

Leucine-rich repeat-containing protein 75B

Gene

LRRC75B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 75B
Alternative name(s):
Leucine-rich repeat-containing protein FAM211B
Gene namesi
Name:LRRC75B
Synonyms:C22orf36, FAM211B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000178026.12.
HGNCiHGNC:33155. LRRC75B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178026.
PharmGKBiPA162378982.

Polymorphism and mutation databases

BioMutaiFAM211B.
DMDMi118573588.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002540461 – 315Leucine-rich repeat-containing protein 75BAdd BLAST315

Proteomic databases

PaxDbiQ2VPJ9.
PRIDEiQ2VPJ9.

PTM databases

PhosphoSitePlusiQ2VPJ9.

Expressioni

Gene expression databases

BgeeiENSG00000178026.
CleanExiHS_C22orf36.
ExpressionAtlasiQ2VPJ9. baseline and differential.
GenevisibleiQ2VPJ9. HS.

Organism-specific databases

HPAiHPA002540.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320520.

Structurei

3D structure databases

ProteinModelPortaliQ2VPJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati182 – 195LRR 1Add BLAST14
Repeati207 – 220LRR 2Add BLAST14

Sequence similaritiesi

Belongs to the LRRC75 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IIWD. Eukaryota.
ENOG410Z0F1. LUCA.
GeneTreeiENSGT00390000004841.
HOGENOMiHOG000111942.
HOVERGENiHBG066484.
InParanoidiQ2VPJ9.
OMAiIYEYTEG.
OrthoDBiEOG091G0JK8.
PhylomeDBiQ2VPJ9.
TreeFamiTF332831.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. LRR_dom_sf.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2VPJ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGARLGRRAG PEAGSEAGAA AGCGPAPYER RVRWLREIQS TLRERRPERA
60 70 80 90 100
RQLLRLLRQD LGLERTLLPD ILYRDVAFLN PVDPISHDLL VNLARDLQCP
110 120 130 140 150
KKDYELWKSS DKICRQLIYH LTPHSKQQQG SSLRQRKTQS CLKSSLQKTL
160 170 180 190 200
LAGETVDLSG IPLSTQDVQH ITRYLSSHGA VLAVLDLSFT GLSDELLHLL
210 220 230 240 250
LPSLWALPRL TQLLLNGNRL TRATARKLTD AIKDTTKFPA LAWVDLGNNV
260 270 280 290 300
DVASLPQPLL VGLRRRLSQR TSLPTIYEGL DLEPEGSAAG ATTPASTWDS
310
TAAGLGPEPQ ACCAR
Length:315
Mass (Da):34,740
Last modified:January 10, 2006 - v1
Checksum:i099B03832A2DD370
GO
Isoform 2 (identifier: Q2VPJ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-152: DLGLERTLLP...KSSLQKTLLA → AREGAVRPWA...AAECVRVFGV
     153-315: Missing.

Note: No experimental confirmation available.
Show »
Length:152
Mass (Da):16,640
Checksum:i5450D9C35B799B30
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051125140S → R. Corresponds to variant dbSNP:rs743370Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02117260 – 152DLGLE…KTLLA → AREGAVRPWAGGQGGSGGLG VWEARGYGLWACIRREARRS WSLARAGGFRGRDRLQHAGS CVGERATAWSEGWVRSADRV EEGAAECVRVFGV in isoform 2. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_021173153 – 315Missing in isoform 2. 1 PublicationAdd BLAST163

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097054 mRNA. Translation: BAC04937.1.
BC032388 mRNA. Translation: AAH32388.1.
BC108684 mRNA. Translation: AAI08685.1.
CCDSiCCDS42991.1. [Q2VPJ9-1]
RefSeqiNP_997527.2. NM_207644.2. [Q2VPJ9-1]
UniGeneiHs.113314.

Genome annotation databases

EnsembliENST00000318753; ENSP00000320520; ENSG00000178026. [Q2VPJ9-1]
GeneIDi388886.
KEGGihsa:388886.
UCSCiuc003aaq.3. human. [Q2VPJ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLR75B_HUMAN
AccessioniPrimary (citable) accession number: Q2VPJ9
Secondary accession number(s): Q8N0S9, Q8N8B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 10, 2006
Last modified: November 22, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families