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Q2VPJ9

- LR75B_HUMAN

UniProt

Q2VPJ9 - LR75B_HUMAN

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Protein

Leucine-rich repeat-containing protein 75B

Gene
LRRC75B, C22orf36, FAM211B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 75B
Alternative name(s):
Leucine-rich repeat-containing protein FAM211B
Gene namesi
Name:LRRC75B
Synonyms:C22orf36, FAM211B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:33155. LRRC75B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Leucine-rich repeat-containing protein 75BPRO_0000254046Add
BLAST

Proteomic databases

PaxDbiQ2VPJ9.
PRIDEiQ2VPJ9.

Expressioni

Gene expression databases

ArrayExpressiQ2VPJ9.
BgeeiQ2VPJ9.
CleanExiHS_C22orf36.
GenevestigatoriQ2VPJ9.

Organism-specific databases

HPAiHPA002540.

Structurei

3D structure databases

ProteinModelPortaliQ2VPJ9.
SMRiQ2VPJ9. Positions 142-275.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati182 – 19514LRR 1Add
BLAST
Repeati207 – 22014LRR 2Add
BLAST

Sequence similaritiesi

Belongs to the LRRC75 family.

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG43518.
HOGENOMiHOG000111942.
HOVERGENiHBG066484.
InParanoidiQ2VPJ9.
OMAiLQCPKKD.
OrthoDBiEOG747PJW.
PhylomeDBiQ2VPJ9.
TreeFamiTF332831.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2VPJ9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGARLGRRAG PEAGSEAGAA AGCGPAPYER RVRWLREIQS TLRERRPERA    50
RQLLRLLRQD LGLERTLLPD ILYRDVAFLN PVDPISHDLL VNLARDLQCP 100
KKDYELWKSS DKICRQLIYH LTPHSKQQQG SSLRQRKTQS CLKSSLQKTL 150
LAGETVDLSG IPLSTQDVQH ITRYLSSHGA VLAVLDLSFT GLSDELLHLL 200
LPSLWALPRL TQLLLNGNRL TRATARKLTD AIKDTTKFPA LAWVDLGNNV 250
DVASLPQPLL VGLRRRLSQR TSLPTIYEGL DLEPEGSAAG ATTPASTWDS 300
TAAGLGPEPQ ACCAR 315
Length:315
Mass (Da):34,740
Last modified:January 10, 2006 - v1
Checksum:i099B03832A2DD370
GO
Isoform 2 (identifier: Q2VPJ9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-152: DLGLERTLLP...KSSLQKTLLA → AREGAVRPWA...AAECVRVFGV
     153-315: Missing.

Note: No experimental confirmation available.

Show »
Length:152
Mass (Da):16,640
Checksum:i5450D9C35B799B30
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401S → R.
Corresponds to variant rs743370 [ dbSNP | Ensembl ].
VAR_051125

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei60 – 15293DLGLE…KTLLA → AREGAVRPWAGGQGGSGGLG VWEARGYGLWACIRREARRS WSLARAGGFRGRDRLQHAGS CVGERATAWSEGWVRSADRV EEGAAECVRVFGV in isoform 2. VSP_021172Add
BLAST
Alternative sequencei153 – 315163Missing in isoform 2. VSP_021173Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK097054 mRNA. Translation: BAC04937.1.
BC032388 mRNA. Translation: AAH32388.1.
BC108684 mRNA. Translation: AAI08685.1.
CCDSiCCDS42991.1. [Q2VPJ9-1]
RefSeqiNP_997527.2. NM_207644.2. [Q2VPJ9-1]
UniGeneiHs.113314.

Genome annotation databases

EnsembliENST00000318753; ENSP00000320520; ENSG00000178026. [Q2VPJ9-1]
GeneIDi388886.
KEGGihsa:388886.
UCSCiuc003aaq.2. human. [Q2VPJ9-1]

Polymorphism databases

DMDMi118573588.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK097054 mRNA. Translation: BAC04937.1 .
BC032388 mRNA. Translation: AAH32388.1 .
BC108684 mRNA. Translation: AAI08685.1 .
CCDSi CCDS42991.1. [Q2VPJ9-1 ]
RefSeqi NP_997527.2. NM_207644.2. [Q2VPJ9-1 ]
UniGenei Hs.113314.

3D structure databases

ProteinModelPortali Q2VPJ9.
SMRi Q2VPJ9. Positions 142-275.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 118573588.

Proteomic databases

PaxDbi Q2VPJ9.
PRIDEi Q2VPJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318753 ; ENSP00000320520 ; ENSG00000178026 . [Q2VPJ9-1 ]
GeneIDi 388886.
KEGGi hsa:388886.
UCSCi uc003aaq.2. human. [Q2VPJ9-1 ]

Organism-specific databases

CTDi 388886.
GeneCardsi GC22M024983.
HGNCi HGNC:33155. LRRC75B.
HPAi HPA002540.
neXtProti NX_Q2VPJ9.
PharmGKBi PA162378982.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43518.
HOGENOMi HOG000111942.
HOVERGENi HBG066484.
InParanoidi Q2VPJ9.
OMAi LQCPKKD.
OrthoDBi EOG747PJW.
PhylomeDBi Q2VPJ9.
TreeFami TF332831.

Miscellaneous databases

GenomeRNAii 388886.
NextBioi 102414.
PROi Q2VPJ9.

Gene expression databases

ArrayExpressi Q2VPJ9.
Bgeei Q2VPJ9.
CleanExi HS_C22orf36.
Genevestigatori Q2VPJ9.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Uterus.

Entry informationi

Entry nameiLR75B_HUMAN
AccessioniPrimary (citable) accession number: Q2VPJ9
Secondary accession number(s): Q8N0S9, Q8N8B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 10, 2006
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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