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Q2VPJ9

- LR75B_HUMAN

UniProt

Q2VPJ9 - LR75B_HUMAN

Protein

Leucine-rich repeat-containing protein 75B

Gene

LRRC75B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (10 Jan 2006)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeat-containing protein 75B
    Alternative name(s):
    Leucine-rich repeat-containing protein FAM211B
    Gene namesi
    Name:LRRC75B
    Synonyms:C22orf36, FAM211B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:33155. LRRC75B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162378982.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Leucine-rich repeat-containing protein 75BPRO_0000254046Add
    BLAST

    Proteomic databases

    PaxDbiQ2VPJ9.
    PRIDEiQ2VPJ9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ2VPJ9.
    BgeeiQ2VPJ9.
    CleanExiHS_C22orf36.
    GenevestigatoriQ2VPJ9.

    Organism-specific databases

    HPAiHPA002540.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2VPJ9.
    SMRiQ2VPJ9. Positions 142-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati182 – 19514LRR 1Add
    BLAST
    Repeati207 – 22014LRR 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the LRRC75 family.Curated
    Contains 2 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG43518.
    HOGENOMiHOG000111942.
    HOVERGENiHBG066484.
    InParanoidiQ2VPJ9.
    OMAiLQCPKKD.
    OrthoDBiEOG747PJW.
    PhylomeDBiQ2VPJ9.
    TreeFamiTF332831.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q2VPJ9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MGARLGRRAG PEAGSEAGAA AGCGPAPYER RVRWLREIQS TLRERRPERA    50
    RQLLRLLRQD LGLERTLLPD ILYRDVAFLN PVDPISHDLL VNLARDLQCP 100
    KKDYELWKSS DKICRQLIYH LTPHSKQQQG SSLRQRKTQS CLKSSLQKTL 150
    LAGETVDLSG IPLSTQDVQH ITRYLSSHGA VLAVLDLSFT GLSDELLHLL 200
    LPSLWALPRL TQLLLNGNRL TRATARKLTD AIKDTTKFPA LAWVDLGNNV 250
    DVASLPQPLL VGLRRRLSQR TSLPTIYEGL DLEPEGSAAG ATTPASTWDS 300
    TAAGLGPEPQ ACCAR 315
    Length:315
    Mass (Da):34,740
    Last modified:January 10, 2006 - v1
    Checksum:i099B03832A2DD370
    GO
    Isoform 2 (identifier: Q2VPJ9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         60-152: DLGLERTLLP...KSSLQKTLLA → AREGAVRPWA...AAECVRVFGV
         153-315: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:152
    Mass (Da):16,640
    Checksum:i5450D9C35B799B30
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti140 – 1401S → R.
    Corresponds to variant rs743370 [ dbSNP | Ensembl ].
    VAR_051125

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei60 – 15293DLGLE…KTLLA → AREGAVRPWAGGQGGSGGLG VWEARGYGLWACIRREARRS WSLARAGGFRGRDRLQHAGS CVGERATAWSEGWVRSADRV EEGAAECVRVFGV in isoform 2. 1 PublicationVSP_021172Add
    BLAST
    Alternative sequencei153 – 315163Missing in isoform 2. 1 PublicationVSP_021173Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK097054 mRNA. Translation: BAC04937.1.
    BC032388 mRNA. Translation: AAH32388.1.
    BC108684 mRNA. Translation: AAI08685.1.
    CCDSiCCDS42991.1. [Q2VPJ9-1]
    RefSeqiNP_997527.2. NM_207644.2. [Q2VPJ9-1]
    UniGeneiHs.113314.

    Genome annotation databases

    EnsembliENST00000318753; ENSP00000320520; ENSG00000178026. [Q2VPJ9-1]
    GeneIDi388886.
    KEGGihsa:388886.
    UCSCiuc003aaq.2. human. [Q2VPJ9-1]

    Polymorphism databases

    DMDMi118573588.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK097054 mRNA. Translation: BAC04937.1 .
    BC032388 mRNA. Translation: AAH32388.1 .
    BC108684 mRNA. Translation: AAI08685.1 .
    CCDSi CCDS42991.1. [Q2VPJ9-1 ]
    RefSeqi NP_997527.2. NM_207644.2. [Q2VPJ9-1 ]
    UniGenei Hs.113314.

    3D structure databases

    ProteinModelPortali Q2VPJ9.
    SMRi Q2VPJ9. Positions 142-275.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 118573588.

    Proteomic databases

    PaxDbi Q2VPJ9.
    PRIDEi Q2VPJ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318753 ; ENSP00000320520 ; ENSG00000178026 . [Q2VPJ9-1 ]
    GeneIDi 388886.
    KEGGi hsa:388886.
    UCSCi uc003aaq.2. human. [Q2VPJ9-1 ]

    Organism-specific databases

    CTDi 388886.
    GeneCardsi GC22M024983.
    HGNCi HGNC:33155. LRRC75B.
    HPAi HPA002540.
    neXtProti NX_Q2VPJ9.
    PharmGKBi PA162378982.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43518.
    HOGENOMi HOG000111942.
    HOVERGENi HBG066484.
    InParanoidi Q2VPJ9.
    OMAi LQCPKKD.
    OrthoDBi EOG747PJW.
    PhylomeDBi Q2VPJ9.
    TreeFami TF332831.

    Miscellaneous databases

    GenomeRNAii 388886.
    NextBioi 102414.
    PROi Q2VPJ9.

    Gene expression databases

    ArrayExpressi Q2VPJ9.
    Bgeei Q2VPJ9.
    CleanExi HS_C22orf36.
    Genevestigatori Q2VPJ9.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Small intestine.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Uterus.

    Entry informationi

    Entry nameiLR75B_HUMAN
    AccessioniPrimary (citable) accession number: Q2VPJ9
    Secondary accession number(s): Q8N0S9, Q8N8B1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3