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Protein

AP-5 complex subunit beta-1

Gene

AP5B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.1 Publication

GO - Biological processi

  • endosomal transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-5 complex subunit beta-1
Alternative name(s):
Adaptor-related protein complex 5 beta subunit
Short name:
Beta5
Gene namesi
Name:AP5B1
ORF Names:PP1030
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25104. AP5B1.

Subcellular locationi

GO - Cellular componenti

  • AP-type membrane coat adaptor complex Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiAP5B1.
DMDMi374095511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878AP-5 complex subunit beta-1PRO_0000405404Add
BLAST

Proteomic databases

EPDiQ2VPB7.
MaxQBiQ2VPB7.
PaxDbiQ2VPB7.
PeptideAtlasiQ2VPB7.
PRIDEiQ2VPB7.

PTM databases

iPTMnetiQ2VPB7.
PhosphoSiteiQ2VPB7.

Expressioni

Gene expression databases

BgeeiENSG00000254470.
GenevisibleiQ2VPB7. HS.

Organism-specific databases

HPAiHPA065739.
HPA067880.

Interactioni

Subunit structurei

Probably part of the adaptor protein complex 5 (AP-5), a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts with ZFYVE26 and SPG11.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CAMK2BQ135543EBI-5917279,EBI-1058722
NIF3L1Q9GZT83EBI-5917279,EBI-740897

Protein-protein interaction databases

BioGridi124791. 11 interactions.
DIPiDIP-60181N.
IntActiQ2VPB7. 4 interactions.
STRINGi9606.ENSP00000454303.

Structurei

3D structure databases

ProteinModelPortaliQ2VPB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi78 – 422345Leu-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IHX1. Eukaryota.
ENOG410YCX3. LUCA.
GeneTreeiENSGT00530000064721.
HOVERGENiHBG054671.
InParanoidiQ2VPB7.
KOiK19022.
OMAiLESCKPG.
OrthoDBiEOG091G03S9.
TreeFamiTF332158.

Sequencei

Sequence statusi: Complete.

Q2VPB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLSRDAWA QRLGAFRASP SAFMAGPEGE DLGRDLLSDL RSEKLSEQTK
60 70 80 90 100
VSLLALSMEY PAQLWPDASA AEVAATSLLD TLVLLPPRPS ALRRPLLLAA
110 120 130 140 150
TTALAAGGAL GPTSGASCRL LPLLLGLAAG SDLGRGFVPA SEQRPLQATA
160 170 180 190 200
CECLRELESC KPGLLGGSLG LLRGLLGQEG PVQPLSLLLA LALRNTLVLQ
210 220 230 240 250
SRVGAGLGGL LTDKVSPTGG GPWDWTLVEE GDGRLQPQAP SWPAAEEGEG
260 270 280 290 300
ERSLTAREHS PEEARELRAA VIQLLDTSYL LTPVAQAQLL WLLGWALRGL
310 320 330 340 350
QGQPPALFKP QLVRLLGTAQ LTLLHAMLAL KAAFGEALFT AQDEALLLRR
360 370 380 390 400
LTLAAQHPAL PPPTHLFYLH CVLSFPENWP LGPEGEEAAP LLLGPQLCRG
410 420 430 440 450
LLPSLLHDPM ALLARLHLLC LLCAEEEEEE KGQLPSPRHY LEELLAGLRQ
460 470 480 490 500
RAALDGGPRA LATLCFQASY LVACCLAGQP TVLTPLIHGL AQLYQARPML
510 520 530 540 550
APHFVDLLDQ VDSELREPLK VVLRQVVVSR PGRDEALCWH LQMLAKVADG
560 570 580 590 600
DAQSATLNFL QAAAAHCTNW DLQQGLLRVC RALLRAGVRG GLVDLLQVLA
610 620 630 640 650
RQLEDPDGRD HARLYYILLA HLAAPKLGVA LGPSLAAPAL ASSLVAENQG
660 670 680 690 700
FVAALMVQEA PALVRLSLGS HRVKGPLPVL KLQPEALEPI YSLELRFRVE
710 720 730 740 750
GQLYAPLEAV HVPCLCPGRP ARPLLLPLQP RCPAPARLDV HALYTTSTGL
760 770 780 790 800
TCHAHLPPLF VNFADLFLPF PQPPEGAGLG FFEELWDSCL PEGAESRVWC
810 820 830 840 850
PLGPQGLEGL VSRHLEPFVV VAQPPTSYCV AIHLPPDSKL LLRLEAALAD
860 870
GVPVALRTDD WAVLPLAGDY LRGLAAAV
Length:878
Mass (Da):93,949
Last modified:January 25, 2012 - v4
Checksum:iB1E8A2BBFE45872B
GO

Sequence cautioni

The sequence AAG22468 differs from that shown.Sequencing errors.Curated
The sequence AAI09110 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI09111 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI26906 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI28057 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW74438 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti529 – 5291S → P in CAD38944 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ313135 mRNA. Translation: AFA36464.1.
AP001266 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74438.1. Sequence problems.
BC004895 mRNA. Translation: AAH04895.2.
BC109109 mRNA. Translation: AAI09110.2. Different initiation.
BC109110 mRNA. Translation: AAI09111.2. Different initiation.
BC126905 mRNA. Translation: AAI26906.1. Different initiation.
BC128056 mRNA. Translation: AAI28057.1. Different initiation.
AL834269 mRNA. Translation: CAD38944.1.
AF193040 mRNA. Translation: AAG22468.1. Sequence problems.
CCDSiCCDS58146.1.
RefSeqiNP_612377.4. NM_138368.4.
UniGeneiHs.591957.

Genome annotation databases

EnsembliENST00000532090; ENSP00000454303; ENSG00000254470.
GeneIDi91056.
KEGGihsa:91056.
UCSCiuc031qbm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ313135 mRNA. Translation: AFA36464.1.
AP001266 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74438.1. Sequence problems.
BC004895 mRNA. Translation: AAH04895.2.
BC109109 mRNA. Translation: AAI09110.2. Different initiation.
BC109110 mRNA. Translation: AAI09111.2. Different initiation.
BC126905 mRNA. Translation: AAI26906.1. Different initiation.
BC128056 mRNA. Translation: AAI28057.1. Different initiation.
AL834269 mRNA. Translation: CAD38944.1.
AF193040 mRNA. Translation: AAG22468.1. Sequence problems.
CCDSiCCDS58146.1.
RefSeqiNP_612377.4. NM_138368.4.
UniGeneiHs.591957.

3D structure databases

ProteinModelPortaliQ2VPB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124791. 11 interactions.
DIPiDIP-60181N.
IntActiQ2VPB7. 4 interactions.
STRINGi9606.ENSP00000454303.

PTM databases

iPTMnetiQ2VPB7.
PhosphoSiteiQ2VPB7.

Polymorphism and mutation databases

BioMutaiAP5B1.
DMDMi374095511.

Proteomic databases

EPDiQ2VPB7.
MaxQBiQ2VPB7.
PaxDbiQ2VPB7.
PeptideAtlasiQ2VPB7.
PRIDEiQ2VPB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532090; ENSP00000454303; ENSG00000254470.
GeneIDi91056.
KEGGihsa:91056.
UCSCiuc031qbm.2. human.

Organism-specific databases

CTDi91056.
GeneCardsiAP5B1.
HGNCiHGNC:25104. AP5B1.
HPAiHPA065739.
HPA067880.
MIMi614367. gene.
neXtProtiNX_Q2VPB7.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHX1. Eukaryota.
ENOG410YCX3. LUCA.
GeneTreeiENSGT00530000064721.
HOVERGENiHBG054671.
InParanoidiQ2VPB7.
KOiK19022.
OMAiLESCKPG.
OrthoDBiEOG091G03S9.
TreeFamiTF332158.

Miscellaneous databases

GenomeRNAii91056.
PROiQ2VPB7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000254470.
GenevisibleiQ2VPB7. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiAP5B1_HUMAN
AccessioniPrimary (citable) accession number: Q2VPB7
Secondary accession number(s): A1L0S6
, H6WUK2, Q0D2Q2, Q8N3J7, Q8WYH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 25, 2012
Last modified: September 7, 2016
This is version 75 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.