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Protein

Helicase POLQ-like

Gene

Helq

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent ATPase and 5' to 3' DNA helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi318 – 325ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase POLQ-like (EC:3.6.4.12)
Alternative name(s):
Mus308-like helicase
POLQ-like helicase
Gene namesi
Name:Helq
Synonyms:Hel308
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2176740. Helq.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290611 – 1069Helicase POLQ-likeAdd BLAST1069

Proteomic databases

MaxQBiQ2VPA6.
PaxDbiQ2VPA6.
PRIDEiQ2VPA6.

PTM databases

iPTMnetiQ2VPA6.
PhosphoSitePlusiQ2VPA6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035266.
ExpressionAtlasiQ2VPA6. baseline and differential.
GenevisibleiQ2VPA6. MM.

Interactioni

Subunit structurei

Hexamer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041599.

Structurei

3D structure databases

ProteinModelPortaliQ2VPA6.
SMRiQ2VPA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini305 – 477Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST173
Domaini525 – 717Helicase C-terminalPROSITE-ProRule annotationAdd BLAST193

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi422 – 425DEAH box4

Sequence similaritiesi

Belongs to the helicase family. SKI2 subfamily.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0950. Eukaryota.
COG1204. LUCA.
GeneTreeiENSGT00640000091272.
HOGENOMiHOG000110747.
InParanoidiQ2VPA6.
KOiK19178.
OMAiFNSNERG.
OrthoDBiEOG091G021D.
PhylomeDBiQ2VPA6.
TreeFamiTF105018.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2VPA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDGCPRIRR RVSVRKRNRG NLENLRASPT PAELQPAEDT EDEAAAGSRR
60 70 80 90 100
RKTGSPEHAQ ENDSEEDMFG DYDSFTESSF LAHVDDLEQR YMQLPECGDR
110 120 130 140 150
DADSGTKDLC SAGLKNNLRV TTVINLTDPE TSEHGQKQSH LDVPAEPEPG
160 170 180 190 200
SDLSFDVPSS QILYFENPQN SPEALGDPCT KKTNGDPQKS SHEELVSSHT
210 220 230 240 250
EQPEPNNDFS NVRAASESSR RKSLKDHLKS TMAGNARAQT PAFPRSKHLR
260 270 280 290 300
EALLSEEISV AKKAIESPSD DLGPFYSLPS KVRDLYVQLK GIKKLYDWQH
310 320 330 340 350
TCLTLRSVQE RKNLIYSLPT SGGKTLVAEI LMLQELLCRQ KDVLMILPYV
360 370 380 390 400
AIVQEKISSL SSFGIELGFF VEEYAGSKGR FPPIKRREKK SLYIATIEKA
410 420 430 440 450
HSLVNALIET SRLSTLGLVV VDELHMIGEG SRGAILEMTL AKVLYTSKTT
460 470 480 490 500
QIIGMSATLN NVEDLQAFLK AEYYTSQFRP VELKEFLKVN DTIYEVDSQA
510 520 530 540 550
ADGMTFSRLL SYKYSEALKK MDPDRLVALV TEVIPNYSCL VFCPSKKNCE
560 570 580 590 600
NVAEMLCKFL SKDYLNHREK EKCEVIKSLR NIGNGKVCPV LKRTVPFGIA
610 620 630 640 650
YHHSGLTSEE RKLLEEAYST GVLCLLTCTS TLAAGVNLPA RRVILRAPYV
660 670 680 690 700
ANTFLKRNQY KQMVGRAGRA GIDTAGESIL LLQEKDKQQV LELISGPLET
710 720 730 740 750
CCSHLVEEFT KGIQALFLSL IGLKIAASLG DIYQFMSGTF FGVQQKILLK
760 770 780 790 800
EKSLWEITVD ALEHLTEKGL LQKDSCGDNE GLECHFRITK LGQASFKGAI
810 820 830 840 850
DLAYCDTLYR DLKKGLEGLV LESLLHLIYL TTPYDLAAQS EPDWMVYFKQ
860 870 880 890 900
FGQLSPTEQN VAALLGVSES FIGKKAAGQA VRKKVDKNVV NRLYLSFVLY
910 920 930 940 950
SLLKETNVWS VSEKFNLPRG YIQNLLMGAA SFSSCVLHFC EELEEFWVYK
960 970 980 990 1000
ALLVELTKKL TYCVKAELIP LMEVTGVLEG RAKQLYNAGY RSIMHLANAN
1010 1020 1030 1040 1050
PEVLVKTIDH LSRRQARQIV SSAKMLLHEK AEALQGEAEE LLRLPADLPG
1060
LGGPSSERAG SHAGDVTLS
Length:1,069
Mass (Da):119,098
Last modified:October 31, 2006 - v2
Checksum:i69E56935E9F65BCB
GO
Isoform 2 (identifier: Q2VPA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     884-979: Missing.

Show »
Length:973
Mass (Da):108,019
Checksum:i6D247D4E7D1D92DC
GO
Isoform 3 (identifier: Q2VPA6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     725-766: Missing.
     851-866: FGQLSPTEQNVAALLG → VTEQVSWAETSLDFVT
     867-1069: Missing.

Show »
Length:824
Mass (Da):92,053
Checksum:i996BBCC1DA6B4FCA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti428G → C in AAI09170 (PubMed:15489334).Curated1
Sequence conflicti440L → Q in AAL85275 (PubMed:11751861).Curated1
Sequence conflicti533V → A in AAL85275 (PubMed:11751861).Curated1
Sequence conflicti647A → S in AAH82601 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032949725 – 766Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_032950851 – 866FGQLS…AALLG → VTEQVSWAETSLDFVT in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_032951867 – 1069Missing in isoform 3. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_032952884 – 979Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082601 mRNA. Translation: AAH82601.1.
BC109169 mRNA. Translation: AAI09170.1.
BC109170 mRNA. Translation: AAI09171.2.
AK052427 mRNA. Translation: BAC34984.1.
AF436846 mRNA. Translation: AAL85275.1.
CCDSiCCDS39184.1. [Q2VPA6-1]
RefSeqiNP_001074576.1. NM_001081107.1. [Q2VPA6-1]
UniGeneiMm.21469.

Genome annotation databases

EnsembliENSMUST00000044684; ENSMUSP00000041599; ENSMUSG00000035266. [Q2VPA6-1]
GeneIDi191578.
KEGGimmu:191578.
UCSCiuc008yhz.1. mouse. [Q2VPA6-1]
uc012dzs.1. mouse. [Q2VPA6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082601 mRNA. Translation: AAH82601.1.
BC109169 mRNA. Translation: AAI09170.1.
BC109170 mRNA. Translation: AAI09171.2.
AK052427 mRNA. Translation: BAC34984.1.
AF436846 mRNA. Translation: AAL85275.1.
CCDSiCCDS39184.1. [Q2VPA6-1]
RefSeqiNP_001074576.1. NM_001081107.1. [Q2VPA6-1]
UniGeneiMm.21469.

3D structure databases

ProteinModelPortaliQ2VPA6.
SMRiQ2VPA6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041599.

PTM databases

iPTMnetiQ2VPA6.
PhosphoSitePlusiQ2VPA6.

Proteomic databases

MaxQBiQ2VPA6.
PaxDbiQ2VPA6.
PRIDEiQ2VPA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044684; ENSMUSP00000041599; ENSMUSG00000035266. [Q2VPA6-1]
GeneIDi191578.
KEGGimmu:191578.
UCSCiuc008yhz.1. mouse. [Q2VPA6-1]
uc012dzs.1. mouse. [Q2VPA6-2]

Organism-specific databases

CTDi113510.
MGIiMGI:2176740. Helq.

Phylogenomic databases

eggNOGiKOG0950. Eukaryota.
COG1204. LUCA.
GeneTreeiENSGT00640000091272.
HOGENOMiHOG000110747.
InParanoidiQ2VPA6.
KOiK19178.
OMAiFNSNERG.
OrthoDBiEOG091G021D.
PhylomeDBiQ2VPA6.
TreeFamiTF105018.

Miscellaneous databases

ChiTaRSiHelq. mouse.
PROiQ2VPA6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035266.
ExpressionAtlasiQ2VPA6. baseline and differential.
GenevisibleiQ2VPA6. MM.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHELQ_MOUSE
AccessioniPrimary (citable) accession number: Q2VPA6
Secondary accession number(s): Q2VPA7
, Q640L4, Q8BWI5, Q8R4K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 31, 2006
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.