ID   CR1L_HUMAN              Reviewed;         569 AA.
AC   Q2VPA4; Q32MC9; Q8NEU7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   24-JAN-2024, entry version 136.
DE   RecName: Full=Complement component receptor 1-like protein;
DE   AltName: Full=Complement C4b-binding protein CR-1-like protein;
DE   Flags: Precursor;
GN   Name=CR1L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 1-526 (ISOFORM 1), AND VARIANTS ASP-402 AND VAL-455.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 57-569 (ISOFORM 3), TISSUE SPECIFICITY,
RP   INTERACTION WITH IC4, AND SUBCELLULAR LOCATION.
RC   TISSUE=Bone marrow;
RX   PubMed=14687939; DOI=10.1016/j.molimm.2003.09.010;
RA   Logar C.M., Chen W., Schmitt H., Yu C.Y., Birmingham D.J.;
RT   "A human CR1-like transcript containing sequence for a binding protein for
RT   iC4 is expressed in hematopoietic and fetal lymphoid tissue.";
RL   Mol. Immunol. 40:831-840(2004).
CC   -!- SUBUNIT: Interacts with iC4 (methylamine-treated C4) but not for iC3
CC       (methylamine-treated C3). {ECO:0000269|PubMed:14687939}.
CC   -!- INTERACTION:
CC       Q2VPA4; Q8NEL9-2: DDHD1; NbExp=3; IntAct=EBI-12330477, EBI-11062258;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14687939}. Membrane
CC       {ECO:0000269|PubMed:14687939}. Secreted {ECO:0000269|PubMed:14687939}.
CC       Note=Predominantly found in association with the membrane fraction, but
CC       also located in the cytoplasm and in the supernatant.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q2VPA4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q2VPA4-2; Sequence=VSP_031151, VSP_031152, VSP_031153;
CC       Name=3;
CC         IsoId=Q2VPA4-3; Sequence=VSP_031152, VSP_031153;
CC   -!- TISSUE SPECIFICITY: Expressed in fetal liver and to a lesser extent in
CC       fetal spleen and thymus. Expression appears to be limited to
CC       hematopoietic and fetal lymphoid tissue. {ECO:0000269|PubMed:14687939}.
CC   -!- SIMILARITY: Belongs to the receptors of complement activation (RCA)
CC       family. {ECO:0000305}.
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DR   EMBL; AL137789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL365178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC109190; AAI09191.1; -; mRNA.
DR   EMBL; BC109191; AAI09192.1; -; mRNA.
DR   EMBL; AY114160; AAM47024.1; -; mRNA.
DR   CCDS; CCDS44310.1; -. [Q2VPA4-1]
DR   RefSeq; NP_783641.1; NM_175710.1. [Q2VPA4-1]
DR   AlphaFoldDB; Q2VPA4; -.
DR   SMR; Q2VPA4; -.
DR   BioGRID; 107770; 12.
DR   IntAct; Q2VPA4; 1.
DR   STRING; 9606.ENSP00000421736; -.
DR   GlyCosmos; Q2VPA4; 1 site, No reported glycans.
DR   GlyGen; Q2VPA4; 1 site.
DR   iPTMnet; Q2VPA4; -.
DR   PhosphoSitePlus; Q2VPA4; -.
DR   BioMuta; CR1L; -.
DR   DMDM; 296439386; -.
DR   EPD; Q2VPA4; -.
DR   jPOST; Q2VPA4; -.
DR   MassIVE; Q2VPA4; -.
DR   PaxDb; 9606-ENSP00000421736; -.
DR   PeptideAtlas; Q2VPA4; -.
DR   Antibodypedia; 53872; 58 antibodies from 11 providers.
DR   DNASU; 1379; -.
DR   Ensembl; ENST00000508064.7; ENSP00000421736.2; ENSG00000197721.17. [Q2VPA4-1]
DR   GeneID; 1379; -.
DR   KEGG; hsa:1379; -.
DR   MANE-Select; ENST00000508064.7; ENSP00000421736.2; NM_175710.2; NP_783641.1.
DR   UCSC; uc001hga.5; human. [Q2VPA4-1]
DR   AGR; HGNC:2335; -.
DR   CTD; 1379; -.
DR   DisGeNET; 1379; -.
DR   GeneCards; CR1L; -.
DR   HGNC; HGNC:2335; CR1L.
DR   HPA; ENSG00000197721; Tissue enriched (bone).
DR   MIM; 605886; gene.
DR   neXtProt; NX_Q2VPA4; -.
DR   OpenTargets; ENSG00000197721; -.
DR   PharmGKB; PA26856; -.
DR   VEuPathDB; HostDB:ENSG00000197721; -.
DR   eggNOG; KOG4297; Eukaryota.
DR   GeneTree; ENSGT00940000164130; -.
DR   InParanoid; Q2VPA4; -.
DR   OMA; QQIFCPN; -.
DR   OrthoDB; 5395408at2759; -.
DR   PhylomeDB; Q2VPA4; -.
DR   TreeFam; TF334137; -.
DR   PathwayCommons; Q2VPA4; -.
DR   SignaLink; Q2VPA4; -.
DR   BioGRID-ORCS; 1379; 58 hits in 1140 CRISPR screens.
DR   ChiTaRS; CR1L; human.
DR   GenomeRNAi; 1379; -.
DR   Pharos; Q2VPA4; Tdark.
DR   PRO; PR:Q2VPA4; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q2VPA4; Protein.
DR   Bgee; ENSG00000197721; Expressed in bone marrow and 103 other cell types or tissues.
DR   ExpressionAtlas; Q2VPA4; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IDA:MGI.
DR   GO; GO:0045959; P:negative regulation of complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0030449; P:regulation of complement activation; IDA:MGI.
DR   GO; GO:1903659; P:regulation of complement-dependent cytotoxicity; IDA:MGI.
DR   GO; GO:0002456; P:T cell mediated immunity; IBA:GO_Central.
DR   CDD; cd00033; CCP; 8.
DR   Gene3D; 2.10.70.10; Complement Module, domain 1; 8.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR19325:SF545; COMPLEMENT RECEPTOR TYPE 1; 1.
DR   Pfam; PF00084; Sushi; 8.
DR   SMART; SM00032; CCP; 8.
DR   SUPFAM; SSF57535; Complement control module/SCR domain; 8.
DR   PROSITE; PS50923; SUSHI; 8.
DR   Genevisible; Q2VPA4; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasm; Disulfide bond; Glycoprotein; Membrane;
KW   Reference proteome; Repeat; Secreted; Signal; Sushi.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..569
FT                   /note="Complement component receptor 1-like protein"
FT                   /id="PRO_0000317776"
FT   DOMAIN          33..93
FT                   /note="Sushi 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          94..155
FT                   /note="Sushi 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          156..226
FT                   /note="Sushi 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          228..287
FT                   /note="Sushi 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          287..347
FT                   /note="Sushi 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          348..410
FT                   /note="Sushi 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          411..472
FT                   /note="Sushi 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          473..543
FT                   /note="Sushi 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   CARBOHYD        48
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        35..78
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        65..91
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        96..137
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        123..153
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        158..207
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        187..224
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        230..272
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        258..285
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        289..332
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        318..345
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        350..392
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        378..408
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        413..454
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        440..470
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        504..541
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   VAR_SEQ         1..263
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031151"
FT   VAR_SEQ         444
FT                   /note="H -> F (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14687939,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031152"
FT   VAR_SEQ         445..569
FT                   /note="Missing (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14687939,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031153"
FT   VARIANT         116
FT                   /note="R -> G (in dbSNP:rs2296158)"
FT                   /id="VAR_038677"
FT   VARIANT         139
FT                   /note="I -> V (in dbSNP:rs3085)"
FT                   /id="VAR_038678"
FT   VARIANT         402
FT                   /note="N -> D (in dbSNP:rs12729569)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_038679"
FT   VARIANT         455
FT                   /note="I -> V (in dbSNP:rs6683902)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_038680"
FT   VARIANT         491
FT                   /note="L -> P (in dbSNP:rs2796257)"
FT                   /id="VAR_038681"
SQ   SEQUENCE   569 AA;  62714 MW;  D49F7517E1347A5D CRC64;
     MAPPVRLERP FPSRRFPGLL LAALVLLLSS FSDQCNVPEW LPFARPTNLT DDFEFPIGTY
     LNYECRPGYS GRPFSIICLK NSVWTSAKDK CKRKSCRNPP DPVNGMAHVI KDIQFRSQIK
     YSCPKGYRLI GSSSATCIIS GNTVIWDNKT PVCDRIICGL PPTIANGDFT SISREYFHYG
     SVVTYHCNLG SRGKKVFELV GEPSIYCTSK DDQVGIWSGP APQCIIPNKC TPPNVENGIL
     VSDNRSLFSL NEVVEFRCQP GFGMKGPSHV KCQALNKWEP ELPSCSRVCQ PPPDVLHAER
     TQRDKDNFSP GQEVFYSCEP GYDLRGSTYL HCTPQGDWSP AAPRCEVKSC DDFLGQLPNG
     HVLFPLNLQL GAKVDFVCDE GFQLKGSSAS YCVLAGMESL WNSSVPVCER KSCETPPVPV
     NGMVHVITDI HVGSRINYSC TTGHRLIGHS SAECILSGNT AHWSMKPPIC QQIFCPNPPA
     ILNGRHTGTP LGDIPYGKEV SYTCDPHPDR GMTFNLIGES TIRRTSEPHG NGVWSSPAPR
     CELPVGAGSH DALIVGKFYE VFAEEFCHL
//