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Q2VPA4

- CR1L_HUMAN

UniProt

Q2VPA4 - CR1L_HUMAN

Protein

Complement component receptor 1-like protein

Gene

CR1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complement component receptor 1-like protein
    Alternative name(s):
    Complement C4b-binding protein CR-1-like protein
    Gene namesi
    Name:CR1L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:2335. CR1L.

    Subcellular locationi

    Cytoplasm 1 Publication. Membrane 1 Publication. Secreted 1 Publication
    Note: Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-SubCell
    4. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26856.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 569537Complement component receptor 1-like proteinPRO_0000317776Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi35 ↔ 78PROSITE-ProRule annotation
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi65 ↔ 91PROSITE-ProRule annotation
    Disulfide bondi96 ↔ 137PROSITE-ProRule annotation
    Disulfide bondi123 ↔ 153PROSITE-ProRule annotation
    Disulfide bondi158 ↔ 207PROSITE-ProRule annotation
    Disulfide bondi187 ↔ 224PROSITE-ProRule annotation
    Disulfide bondi230 ↔ 272PROSITE-ProRule annotation
    Disulfide bondi258 ↔ 285PROSITE-ProRule annotation
    Disulfide bondi289 ↔ 332PROSITE-ProRule annotation
    Disulfide bondi318 ↔ 345PROSITE-ProRule annotation
    Disulfide bondi350 ↔ 392PROSITE-ProRule annotation
    Disulfide bondi378 ↔ 408PROSITE-ProRule annotation
    Disulfide bondi413 ↔ 454PROSITE-ProRule annotation
    Disulfide bondi440 ↔ 470PROSITE-ProRule annotation
    Disulfide bondi504 ↔ 541PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ2VPA4.
    PRIDEiQ2VPA4.

    PTM databases

    PhosphoSiteiQ2VPA4.

    Expressioni

    Tissue specificityi

    Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue.1 Publication

    Gene expression databases

    BgeeiQ2VPA4.
    CleanExiHS_CR1L.
    GenevestigatoriQ2VPA4.

    Organism-specific databases

    HPAiHPA049348.

    Interactioni

    Subunit structurei

    Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3).1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ2VPA4.
    SMRiQ2VPA4. Positions 34-563.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 9361Sushi 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini94 – 15562Sushi 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini156 – 22671Sushi 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini228 – 28760Sushi 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini287 – 34761Sushi 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini348 – 41063Sushi 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini411 – 47262Sushi 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini473 – 54371Sushi 8PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 8 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Sushi

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000111977.
    HOVERGENiHBG081346.
    InParanoidiQ2VPA4.
    OMAiHVGSRIN.
    OrthoDBiEOG7FV3PV.
    PhylomeDBiQ2VPA4.
    TreeFamiTF334137.

    Family and domain databases

    InterProiIPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PfamiPF00084. Sushi. 8 hits.
    [Graphical view]
    SMARTiSM00032. CCP. 8 hits.
    [Graphical view]
    SUPFAMiSSF57535. SSF57535. 8 hits.
    PROSITEiPS50923. SUSHI. 8 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q2VPA4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPPVRLERP FPSRRFPGLL LAALVLLLSS FSDQCNVPEW LPFARPTNLT    50
    DDFEFPIGTY LNYECRPGYS GRPFSIICLK NSVWTSAKDK CKRKSCRNPP 100
    DPVNGMAHVI KDIQFRSQIK YSCPKGYRLI GSSSATCIIS GNTVIWDNKT 150
    PVCDRIICGL PPTIANGDFT SISREYFHYG SVVTYHCNLG SRGKKVFELV 200
    GEPSIYCTSK DDQVGIWSGP APQCIIPNKC TPPNVENGIL VSDNRSLFSL 250
    NEVVEFRCQP GFGMKGPSHV KCQALNKWEP ELPSCSRVCQ PPPDVLHAER 300
    TQRDKDNFSP GQEVFYSCEP GYDLRGSTYL HCTPQGDWSP AAPRCEVKSC 350
    DDFLGQLPNG HVLFPLNLQL GAKVDFVCDE GFQLKGSSAS YCVLAGMESL 400
    WNSSVPVCER KSCETPPVPV NGMVHVITDI HVGSRINYSC TTGHRLIGHS 450
    SAECILSGNT AHWSMKPPIC QQIFCPNPPA ILNGRHTGTP LGDIPYGKEV 500
    SYTCDPHPDR GMTFNLIGES TIRRTSEPHG NGVWSSPAPR CELPVGAGSH 550
    DALIVGKFYE VFAEEFCHL 569
    Length:569
    Mass (Da):62,714
    Last modified:May 18, 2010 - v3
    Checksum:iD49F7517E1347A5D
    GO
    Isoform 2 (identifier: Q2VPA4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-263: Missing.
         444-444: H → F
         445-569: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:181
    Mass (Da):19,907
    Checksum:iCFC9CC2E28455ED5
    GO
    Isoform 3 (identifier: Q2VPA4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         444-444: H → F
         445-569: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:444
    Mass (Da):49,143
    Checksum:i8F4AAEFF760F21F3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti116 – 1161R → G.
    Corresponds to variant rs2296158 [ dbSNP | Ensembl ].
    VAR_038677
    Natural varianti139 – 1391I → V.
    Corresponds to variant rs3085 [ dbSNP | Ensembl ].
    VAR_038678
    Natural varianti402 – 4021N → D.1 Publication
    Corresponds to variant rs12729569 [ dbSNP | Ensembl ].
    VAR_038679
    Natural varianti455 – 4551I → V.1 Publication
    Corresponds to variant rs6683902 [ dbSNP | Ensembl ].
    VAR_038680
    Natural varianti491 – 4911L → P.
    Corresponds to variant rs2796257 [ dbSNP | Ensembl ].
    VAR_038681

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 263263Missing in isoform 2. 1 PublicationVSP_031151Add
    BLAST
    Alternative sequencei444 – 4441H → F in isoform 2 and isoform 3. 2 PublicationsVSP_031152
    Alternative sequencei445 – 569125Missing in isoform 2 and isoform 3. 2 PublicationsVSP_031153Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL137789 Genomic DNA. No translation available.
    AL365178 Genomic DNA. No translation available.
    BC109190 mRNA. Translation: AAI09191.1.
    BC109191 mRNA. Translation: AAI09192.1.
    AY114160 mRNA. Translation: AAM47024.1.
    CCDSiCCDS44310.1. [Q2VPA4-1]
    RefSeqiNP_783641.1. NM_175710.1. [Q2VPA4-1]
    UniGeneiHs.628568.
    Hs.655194.

    Genome annotation databases

    EnsembliENST00000294997; ENSP00000434864; ENSG00000197721.
    ENST00000508064; ENSP00000421736; ENSG00000197721. [Q2VPA4-1]
    GeneIDi1379.
    KEGGihsa:1379.
    UCSCiuc001hga.4. human. [Q2VPA4-1]

    Polymorphism databases

    DMDMi296439386.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL137789 Genomic DNA. No translation available.
    AL365178 Genomic DNA. No translation available.
    BC109190 mRNA. Translation: AAI09191.1 .
    BC109191 mRNA. Translation: AAI09192.1 .
    AY114160 mRNA. Translation: AAM47024.1 .
    CCDSi CCDS44310.1. [Q2VPA4-1 ]
    RefSeqi NP_783641.1. NM_175710.1. [Q2VPA4-1 ]
    UniGenei Hs.628568.
    Hs.655194.

    3D structure databases

    ProteinModelPortali Q2VPA4.
    SMRi Q2VPA4. Positions 34-563.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q2VPA4.

    Polymorphism databases

    DMDMi 296439386.

    Proteomic databases

    PaxDbi Q2VPA4.
    PRIDEi Q2VPA4.

    Protocols and materials databases

    DNASUi 1379.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294997 ; ENSP00000434864 ; ENSG00000197721 .
    ENST00000508064 ; ENSP00000421736 ; ENSG00000197721 . [Q2VPA4-1 ]
    GeneIDi 1379.
    KEGGi hsa:1379.
    UCSCi uc001hga.4. human. [Q2VPA4-1 ]

    Organism-specific databases

    CTDi 1379.
    GeneCardsi GC01P207820.
    H-InvDB HIX0200033.
    HGNCi HGNC:2335. CR1L.
    HPAi HPA049348.
    MIMi 605886. gene.
    neXtProti NX_Q2VPA4.
    PharmGKBi PA26856.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000111977.
    HOVERGENi HBG081346.
    InParanoidi Q2VPA4.
    OMAi HVGSRIN.
    OrthoDBi EOG7FV3PV.
    PhylomeDBi Q2VPA4.
    TreeFami TF334137.

    Miscellaneous databases

    GenomeRNAii 1379.
    NextBioi 5597.
    PROi Q2VPA4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q2VPA4.
    CleanExi HS_CR1L.
    Genevestigatori Q2VPA4.

    Family and domain databases

    InterProi IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    Pfami PF00084. Sushi. 8 hits.
    [Graphical view ]
    SMARTi SM00032. CCP. 8 hits.
    [Graphical view ]
    SUPFAMi SSF57535. SSF57535. 8 hits.
    PROSITEi PS50923. SUSHI. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-526 (ISOFORM 1), VARIANTS ASP-402 AND VAL-455.
    3. "A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue."
      Logar C.M., Chen W., Schmitt H., Yu C.Y., Birmingham D.J.
      Mol. Immunol. 40:831-840(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-569 (ISOFORM 3), TISSUE SPECIFICITY, INTERACTION WITH IC4, SUBCELLULAR LOCATION.
      Tissue: Bone marrow.

    Entry informationi

    Entry nameiCR1L_HUMAN
    AccessioniPrimary (citable) accession number: Q2VPA4
    Secondary accession number(s): Q32MC9, Q8NEU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 75 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3