Q2VPA4 (CR1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Complement component receptor 1-like protein

Alternative name(s):
Complement C4b-binding protein CR-1-like protein

Gene names

Name:

CR1L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	569 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3). Ref.3
Subcellular location	Cytoplasm. Membrane. Secreted. Note: Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant. Ref.3
Tissue specificity	Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue. Ref.3
Sequence similarities	Belongs to the receptors of complement activation (RCA) family. Contains 8 Sushi (CCP/SCR) domains.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Sushi
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q2VPA4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q2VPA4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     444-444: H → F
     445-569: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q2VPA4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     444-444: H → F
     445-569: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Potential
	Chain	33 – 569	537	Complement component receptor 1-like protein		PRO_0000317776
Regions
	Domain	33 – 93	61	Sushi 1
	Domain	94 – 155	62	Sushi 2
	Domain	156 – 226	71	Sushi 3
	Domain	228 – 287	60	Sushi 4
	Domain	287 – 347	61	Sushi 5
	Domain	348 – 410	63	Sushi 6
	Domain	411 – 472	62	Sushi 7
	Domain	473 – 543	71	Sushi 8
Amino acid modifications
	Glycosylation	48	1	N-linked (GlcNAc...) Potential
	Disulfide bond	35 ↔ 78		By similarity
	Disulfide bond	65 ↔ 91		By similarity
	Disulfide bond	96 ↔ 137		By similarity
	Disulfide bond	123 ↔ 153		By similarity
	Disulfide bond	158 ↔ 207		By similarity
	Disulfide bond	187 ↔ 224		By similarity
	Disulfide bond	230 ↔ 272		By similarity
	Disulfide bond	258 ↔ 285		By similarity
	Disulfide bond	289 ↔ 332		By similarity
	Disulfide bond	318 ↔ 345		By similarity
	Disulfide bond	350 ↔ 392		By similarity
	Disulfide bond	378 ↔ 408		By similarity
	Disulfide bond	413 ↔ 454		By similarity
	Disulfide bond	440 ↔ 470		By similarity
	Disulfide bond	504 ↔ 541		By similarity
Natural variations
	Alternative sequence	1 – 263	263	Missing in isoform 2.		VSP_031151
	Alternative sequence	444	1	H → F in isoform 2 and isoform 3.		VSP_031152
	Alternative sequence	445 – 569	125	Missing in isoform 2 and isoform 3.		VSP_031153
	Natural variant	116	1	R → G. Corresponds to variant rs2296158 [ dbSNP | Ensembl ].		VAR_038677
	Natural variant	139	1	I → V. Corresponds to variant rs3085 [ dbSNP | Ensembl ].		VAR_038678
	Natural variant	402	1	N → D. Ref.2 Corresponds to variant rs12729569 [ dbSNP | Ensembl ].		VAR_038679
	Natural variant	455	1	I → V. Ref.2 Corresponds to variant rs6683902 [ dbSNP | Ensembl ].		VAR_038680
	Natural variant	491	1	L → P. Corresponds to variant rs2796257 [ dbSNP | Ensembl ].		VAR_038681

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: D49F7517E1347A5D	FASTA	569	62,714
	10 20 30 40 50 60 MAPPVRLERP FPSRRFPGLL LAALVLLLSS FSDQCNVPEW LPFARPTNLT DDFEFPIGTY 70 80 90 100 110 120 LNYECRPGYS GRPFSIICLK NSVWTSAKDK CKRKSCRNPP DPVNGMAHVI KDIQFRSQIK 130 140 150 160 170 180 YSCPKGYRLI GSSSATCIIS GNTVIWDNKT PVCDRIICGL PPTIANGDFT SISREYFHYG 190 200 210 220 230 240 SVVTYHCNLG SRGKKVFELV GEPSIYCTSK DDQVGIWSGP APQCIIPNKC TPPNVENGIL 250 260 270 280 290 300 VSDNRSLFSL NEVVEFRCQP GFGMKGPSHV KCQALNKWEP ELPSCSRVCQ PPPDVLHAER 310 320 330 340 350 360 TQRDKDNFSP GQEVFYSCEP GYDLRGSTYL HCTPQGDWSP AAPRCEVKSC DDFLGQLPNG 370 380 390 400 410 420 HVLFPLNLQL GAKVDFVCDE GFQLKGSSAS YCVLAGMESL WNSSVPVCER KSCETPPVPV 430 440 450 460 470 480 NGMVHVITDI HVGSRINYSC TTGHRLIGHS SAECILSGNT AHWSMKPPIC QQIFCPNPPA 490 500 510 520 530 540 ILNGRHTGTP LGDIPYGKEV SYTCDPHPDR GMTFNLIGES TIRRTSEPHG NGVWSSPAPR 550 560 CELPVGAGSH DALIVGKFYE VFAEEFCHL
	Isoform 2 [UniParc]. Checksum: CFC9CC2E28455ED5	FASTA	181	19,907
	10 20 30 40 50 60 MKGPSHVKCQ ALNKWEPELP SCSRVCQPPP DVLHAERTQR DKDNFSPGQE VFYSCEPGYD 70 80 90 100 110 120 LRGSTYLHCT PQGDWSPAAP RCEVKSCDDF LGQLPNGHVL FPLNLQLGAK VDFVCDEGFQ 130 140 150 160 170 180 LKGSSASYCV LAGMESLWNS SVPVCERKSC ETPPVPVNGM VHVITDIHVG SRINYSCTTG F
	Isoform 3 [UniParc]. Checksum: 8F4AAEFF760F21F3	FASTA	444	49,143
	10 20 30 40 50 60 MAPPVRLERP FPSRRFPGLL LAALVLLLSS FSDQCNVPEW LPFARPTNLT DDFEFPIGTY 70 80 90 100 110 120 LNYECRPGYS GRPFSIICLK NSVWTSAKDK CKRKSCRNPP DPVNGMAHVI KDIQFRSQIK 130 140 150 160 170 180 YSCPKGYRLI GSSSATCIIS GNTVIWDNKT PVCDRIICGL PPTIANGDFT SISREYFHYG 190 200 210 220 230 240 SVVTYHCNLG SRGKKVFELV GEPSIYCTSK DDQVGIWSGP APQCIIPNKC TPPNVENGIL 250 260 270 280 290 300 VSDNRSLFSL NEVVEFRCQP GFGMKGPSHV KCQALNKWEP ELPSCSRVCQ PPPDVLHAER 310 320 330 340 350 360 TQRDKDNFSP GQEVFYSCEP GYDLRGSTYL HCTPQGDWSP AAPRCEVKSC DDFLGQLPNG 370 380 390 400 410 420 HVLFPLNLQL GAKVDFVCDE GFQLKGSSAS YCVLAGMESL WNSSVPVCER KSCETPPVPV 430 440 NGMVHVITDI HVGSRINYSC TTGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-526 (ISOFORM 1), VARIANTS ASP-402 AND VAL-455.
[3]	"A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue." Logar C.M., Chen W., Schmitt H., Yu C.Y., Birmingham D.J. Mol. Immunol. 40:831-840(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-569 (ISOFORM 3), TISSUE SPECIFICITY, INTERACTION WITH IC4, SUBCELLULAR LOCATION. Tissue: Bone marrow.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL137789 Genomic DNA. No translation available. AL365178 Genomic DNA. No translation available. BC109190 mRNA. Translation: AAI09191.1. BC109191 mRNA. Translation: AAI09192.1. AY114160 mRNA. Translation: AAM47024.1.
IPI	IPI00472110. IPI00885197. IPI00965735.
RefSeq	NP_783641.1. NM_175710.1.
UniGene	Hs.628568. Hs.655194.
3D structure databases
HSSP	HSSP built from PDB template 2A55 based on UniProtKB P04003.
ProteinModelPortal	Q2VPA4.
SMR	Q2VPA4. Positions 34-563.
ModBase	Search...
PTM databases
PhosphoSite	Q2VPA4.
Polymorphism databases
DMDM	296439386.
Proteomic databases
PaxDb	Q2VPA4.
PRIDE	Q2VPA4.
Protocols and materials databases
DNASU	1379.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000294997; ENSP00000434864; ENSG00000197721. ENST00000508064; ENSP00000421736; ENSG00000197721.
GeneID	1379.
KEGG	hsa:1379.
UCSC	uc001hga.4. human.
Organism-specific databases
CTD	1379.
GeneCards	GC01P207820.
H-InvDB	HIX0200033.
HGNC	HGNC:2335. CR1L.
HPA	HPA049348.
MIM	605886. gene.
neXtProt	NX_Q2VPA4.
PharmGKB	PA26856.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000111977.
HOVERGEN	HBG081346.
InParanoid	Q2VPA4.
OMA	TPVCDRI.
OrthoDB	EOG4DFPMK.
Gene expression databases
Bgee	Q2VPA4.
CleanEx	HS_CR1L.
Genevestigator	Q2VPA4.
Family and domain databases
InterPro	IPR000436. Sushi_SCR_CCP. [Graphical view]
Pfam	PF00084. Sushi. 8 hits. [Graphical view]
SMART	SM00032. CCP. 8 hits. [Graphical view]
SUPFAM	SSF57535. Complement_control_module. 8 hits.
PROSITE	PS50923. SUSHI. 8 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1379.
NextBio	5597.
SOURCE	Search...

Entry information

Entry name

CR1L_HUMAN

Accession

Primary (citable) accession number: Q2VPA4
Secondary accession number(s): Q32MC9, Q8NEU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 62 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.