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Protein

Complement component receptor 1-like protein

Gene

CR1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component receptor 1-like protein
Alternative name(s):
Complement C4b-binding protein CR-1-like protein
Gene namesi
Name:CR1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:2335. CR1L.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Membrane 1 Publication
  • Secreted 1 Publication

  • Note: Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular region Source: UniProtKB-SubCell
  • membrane Source: UniProtKB-SubCell
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26856.

Polymorphism and mutation databases

BioMutaiCR1L.
DMDMi296439386.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 569537Complement component receptor 1-like proteinPRO_0000317776Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 78PROSITE-ProRule annotation
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi65 ↔ 91PROSITE-ProRule annotation
Disulfide bondi96 ↔ 137PROSITE-ProRule annotation
Disulfide bondi123 ↔ 153PROSITE-ProRule annotation
Disulfide bondi158 ↔ 207PROSITE-ProRule annotation
Disulfide bondi187 ↔ 224PROSITE-ProRule annotation
Disulfide bondi230 ↔ 272PROSITE-ProRule annotation
Disulfide bondi258 ↔ 285PROSITE-ProRule annotation
Disulfide bondi289 ↔ 332PROSITE-ProRule annotation
Disulfide bondi318 ↔ 345PROSITE-ProRule annotation
Disulfide bondi350 ↔ 392PROSITE-ProRule annotation
Disulfide bondi378 ↔ 408PROSITE-ProRule annotation
Disulfide bondi413 ↔ 454PROSITE-ProRule annotation
Disulfide bondi440 ↔ 470PROSITE-ProRule annotation
Disulfide bondi504 ↔ 541PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ2VPA4.
PRIDEiQ2VPA4.

PTM databases

PhosphoSiteiQ2VPA4.

Expressioni

Tissue specificityi

Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue.1 Publication

Gene expression databases

BgeeiQ2VPA4.
CleanExiHS_CR1L.
GenevestigatoriQ2VPA4.

Organism-specific databases

HPAiHPA049348.

Interactioni

Subunit structurei

Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3).1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ2VPA4.
SMRiQ2VPA4. Positions 34-563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 9361Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini94 – 15562Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini156 – 22671Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini228 – 28760Sushi 4PROSITE-ProRule annotationAdd
BLAST
Domaini287 – 34761Sushi 5PROSITE-ProRule annotationAdd
BLAST
Domaini348 – 41063Sushi 6PROSITE-ProRule annotationAdd
BLAST
Domaini411 – 47262Sushi 7PROSITE-ProRule annotationAdd
BLAST
Domaini473 – 54371Sushi 8PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000111977.
HOVERGENiHBG081346.
InParanoidiQ2VPA4.
OMAiHVGSRIN.
OrthoDBiEOG7FV3PV.
PhylomeDBiQ2VPA4.
TreeFamiTF334137.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 8 hits.
[Graphical view]
SMARTiSM00032. CCP. 8 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 8 hits.
PROSITEiPS50923. SUSHI. 8 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2VPA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPVRLERP FPSRRFPGLL LAALVLLLSS FSDQCNVPEW LPFARPTNLT
60 70 80 90 100
DDFEFPIGTY LNYECRPGYS GRPFSIICLK NSVWTSAKDK CKRKSCRNPP
110 120 130 140 150
DPVNGMAHVI KDIQFRSQIK YSCPKGYRLI GSSSATCIIS GNTVIWDNKT
160 170 180 190 200
PVCDRIICGL PPTIANGDFT SISREYFHYG SVVTYHCNLG SRGKKVFELV
210 220 230 240 250
GEPSIYCTSK DDQVGIWSGP APQCIIPNKC TPPNVENGIL VSDNRSLFSL
260 270 280 290 300
NEVVEFRCQP GFGMKGPSHV KCQALNKWEP ELPSCSRVCQ PPPDVLHAER
310 320 330 340 350
TQRDKDNFSP GQEVFYSCEP GYDLRGSTYL HCTPQGDWSP AAPRCEVKSC
360 370 380 390 400
DDFLGQLPNG HVLFPLNLQL GAKVDFVCDE GFQLKGSSAS YCVLAGMESL
410 420 430 440 450
WNSSVPVCER KSCETPPVPV NGMVHVITDI HVGSRINYSC TTGHRLIGHS
460 470 480 490 500
SAECILSGNT AHWSMKPPIC QQIFCPNPPA ILNGRHTGTP LGDIPYGKEV
510 520 530 540 550
SYTCDPHPDR GMTFNLIGES TIRRTSEPHG NGVWSSPAPR CELPVGAGSH
560
DALIVGKFYE VFAEEFCHL
Length:569
Mass (Da):62,714
Last modified:May 18, 2010 - v3
Checksum:iD49F7517E1347A5D
GO
Isoform 2 (identifier: Q2VPA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     444-444: H → F
     445-569: Missing.

Note: No experimental confirmation available.

Show »
Length:181
Mass (Da):19,907
Checksum:iCFC9CC2E28455ED5
GO
Isoform 3 (identifier: Q2VPA4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-444: H → F
     445-569: Missing.

Note: No experimental confirmation available.

Show »
Length:444
Mass (Da):49,143
Checksum:i8F4AAEFF760F21F3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti116 – 1161R → G.
Corresponds to variant rs2296158 [ dbSNP | Ensembl ].
VAR_038677
Natural varianti139 – 1391I → V.
Corresponds to variant rs3085 [ dbSNP | Ensembl ].
VAR_038678
Natural varianti402 – 4021N → D.1 Publication
Corresponds to variant rs12729569 [ dbSNP | Ensembl ].
VAR_038679
Natural varianti455 – 4551I → V.1 Publication
Corresponds to variant rs6683902 [ dbSNP | Ensembl ].
VAR_038680
Natural varianti491 – 4911L → P.
Corresponds to variant rs2796257 [ dbSNP | Ensembl ].
VAR_038681

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 263263Missing in isoform 2. 1 PublicationVSP_031151Add
BLAST
Alternative sequencei444 – 4441H → F in isoform 2 and isoform 3. 2 PublicationsVSP_031152
Alternative sequencei445 – 569125Missing in isoform 2 and isoform 3. 2 PublicationsVSP_031153Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137789 Genomic DNA. No translation available.
AL365178 Genomic DNA. No translation available.
BC109190 mRNA. Translation: AAI09191.1.
BC109191 mRNA. Translation: AAI09192.1.
AY114160 mRNA. Translation: AAM47024.1.
CCDSiCCDS44310.1. [Q2VPA4-1]
RefSeqiNP_783641.1. NM_175710.1. [Q2VPA4-1]
UniGeneiHs.628568.
Hs.655194.

Genome annotation databases

EnsembliENST00000508064; ENSP00000421736; ENSG00000197721. [Q2VPA4-1]
GeneIDi1379.
KEGGihsa:1379.
UCSCiuc001hga.4. human. [Q2VPA4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137789 Genomic DNA. No translation available.
AL365178 Genomic DNA. No translation available.
BC109190 mRNA. Translation: AAI09191.1.
BC109191 mRNA. Translation: AAI09192.1.
AY114160 mRNA. Translation: AAM47024.1.
CCDSiCCDS44310.1. [Q2VPA4-1]
RefSeqiNP_783641.1. NM_175710.1. [Q2VPA4-1]
UniGeneiHs.628568.
Hs.655194.

3D structure databases

ProteinModelPortaliQ2VPA4.
SMRiQ2VPA4. Positions 34-563.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ2VPA4.

Polymorphism and mutation databases

BioMutaiCR1L.
DMDMi296439386.

Proteomic databases

PaxDbiQ2VPA4.
PRIDEiQ2VPA4.

Protocols and materials databases

DNASUi1379.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000508064; ENSP00000421736; ENSG00000197721. [Q2VPA4-1]
GeneIDi1379.
KEGGihsa:1379.
UCSCiuc001hga.4. human. [Q2VPA4-1]

Organism-specific databases

CTDi1379.
GeneCardsiGC01P207826.
H-InvDBHIX0200033.
HGNCiHGNC:2335. CR1L.
HPAiHPA049348.
MIMi605886. gene.
neXtProtiNX_Q2VPA4.
PharmGKBiPA26856.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000111977.
HOVERGENiHBG081346.
InParanoidiQ2VPA4.
OMAiHVGSRIN.
OrthoDBiEOG7FV3PV.
PhylomeDBiQ2VPA4.
TreeFamiTF334137.

Miscellaneous databases

GenomeRNAii1379.
NextBioi5597.
PROiQ2VPA4.
SOURCEiSearch...

Gene expression databases

BgeeiQ2VPA4.
CleanExiHS_CR1L.
GenevestigatoriQ2VPA4.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 8 hits.
[Graphical view]
SMARTiSM00032. CCP. 8 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 8 hits.
PROSITEiPS50923. SUSHI. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-526 (ISOFORM 1), VARIANTS ASP-402 AND VAL-455.
  3. "A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue."
    Logar C.M., Chen W., Schmitt H., Yu C.Y., Birmingham D.J.
    Mol. Immunol. 40:831-840(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-569 (ISOFORM 3), TISSUE SPECIFICITY, INTERACTION WITH IC4, SUBCELLULAR LOCATION.
    Tissue: Bone marrow.

Entry informationi

Entry nameiCR1L_HUMAN
AccessioniPrimary (citable) accession number: Q2VPA4
Secondary accession number(s): Q32MC9, Q8NEU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: May 27, 2015
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.