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Q2VPA4 (CR1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complement component receptor 1-like protein
Alternative name(s):
Complement C4b-binding protein CR-1-like protein
Gene names
Name:CR1L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length569 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3). Ref.3

Subcellular location

Cytoplasm. Membrane. Secreted. Note: Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant. Ref.3

Tissue specificity

Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue. Ref.3

Sequence similarities

Belongs to the receptors of complement activation (RCA) family.

Contains 8 Sushi (CCP/SCR) domains.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
Sushi
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

receptor complex

Inferred from direct assay PubMed 23382219. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q2VPA4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q2VPA4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     444-444: H → F
     445-569: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q2VPA4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     444-444: H → F
     445-569: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 569537Complement component receptor 1-like protein
PRO_0000317776

Regions

Domain33 – 9361Sushi 1
Domain94 – 15562Sushi 2
Domain156 – 22671Sushi 3
Domain228 – 28760Sushi 4
Domain287 – 34761Sushi 5
Domain348 – 41063Sushi 6
Domain411 – 47262Sushi 7
Domain473 – 54371Sushi 8

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Disulfide bond35 ↔ 78 By similarity
Disulfide bond65 ↔ 91 By similarity
Disulfide bond96 ↔ 137 By similarity
Disulfide bond123 ↔ 153 By similarity
Disulfide bond158 ↔ 207 By similarity
Disulfide bond187 ↔ 224 By similarity
Disulfide bond230 ↔ 272 By similarity
Disulfide bond258 ↔ 285 By similarity
Disulfide bond289 ↔ 332 By similarity
Disulfide bond318 ↔ 345 By similarity
Disulfide bond350 ↔ 392 By similarity
Disulfide bond378 ↔ 408 By similarity
Disulfide bond413 ↔ 454 By similarity
Disulfide bond440 ↔ 470 By similarity
Disulfide bond504 ↔ 541 By similarity

Natural variations

Alternative sequence1 – 263263Missing in isoform 2.
VSP_031151
Alternative sequence4441H → F in isoform 2 and isoform 3.
VSP_031152
Alternative sequence445 – 569125Missing in isoform 2 and isoform 3.
VSP_031153
Natural variant1161R → G.
Corresponds to variant rs2296158 [ dbSNP | Ensembl ].
VAR_038677
Natural variant1391I → V.
Corresponds to variant rs3085 [ dbSNP | Ensembl ].
VAR_038678
Natural variant4021N → D. Ref.2
Corresponds to variant rs12729569 [ dbSNP | Ensembl ].
VAR_038679
Natural variant4551I → V. Ref.2
Corresponds to variant rs6683902 [ dbSNP | Ensembl ].
VAR_038680
Natural variant4911L → P.
Corresponds to variant rs2796257 [ dbSNP | Ensembl ].
VAR_038681

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: D49F7517E1347A5D

FASTA56962,714
        10         20         30         40         50         60 
MAPPVRLERP FPSRRFPGLL LAALVLLLSS FSDQCNVPEW LPFARPTNLT DDFEFPIGTY 

        70         80         90        100        110        120 
LNYECRPGYS GRPFSIICLK NSVWTSAKDK CKRKSCRNPP DPVNGMAHVI KDIQFRSQIK 

       130        140        150        160        170        180 
YSCPKGYRLI GSSSATCIIS GNTVIWDNKT PVCDRIICGL PPTIANGDFT SISREYFHYG 

       190        200        210        220        230        240 
SVVTYHCNLG SRGKKVFELV GEPSIYCTSK DDQVGIWSGP APQCIIPNKC TPPNVENGIL 

       250        260        270        280        290        300 
VSDNRSLFSL NEVVEFRCQP GFGMKGPSHV KCQALNKWEP ELPSCSRVCQ PPPDVLHAER 

       310        320        330        340        350        360 
TQRDKDNFSP GQEVFYSCEP GYDLRGSTYL HCTPQGDWSP AAPRCEVKSC DDFLGQLPNG 

       370        380        390        400        410        420 
HVLFPLNLQL GAKVDFVCDE GFQLKGSSAS YCVLAGMESL WNSSVPVCER KSCETPPVPV 

       430        440        450        460        470        480 
NGMVHVITDI HVGSRINYSC TTGHRLIGHS SAECILSGNT AHWSMKPPIC QQIFCPNPPA 

       490        500        510        520        530        540 
ILNGRHTGTP LGDIPYGKEV SYTCDPHPDR GMTFNLIGES TIRRTSEPHG NGVWSSPAPR 

       550        560 
CELPVGAGSH DALIVGKFYE VFAEEFCHL 

« Hide

Isoform 2 [UniParc].

Checksum: CFC9CC2E28455ED5
Show »

FASTA18119,907
Isoform 3 [UniParc].

Checksum: 8F4AAEFF760F21F3
Show »

FASTA44449,143

References

« Hide 'large scale' references
[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-526 (ISOFORM 1), VARIANTS ASP-402 AND VAL-455.
[3]"A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue."
Logar C.M., Chen W., Schmitt H., Yu C.Y., Birmingham D.J.
Mol. Immunol. 40:831-840(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-569 (ISOFORM 3), TISSUE SPECIFICITY, INTERACTION WITH IC4, SUBCELLULAR LOCATION.
Tissue: Bone marrow.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL137789 Genomic DNA. No translation available.
AL365178 Genomic DNA. No translation available.
BC109190 mRNA. Translation: AAI09191.1.
BC109191 mRNA. Translation: AAI09192.1.
AY114160 mRNA. Translation: AAM47024.1.
CCDSCCDS44310.1. [Q2VPA4-1]
RefSeqNP_783641.1. NM_175710.1. [Q2VPA4-1]
UniGeneHs.628568.
Hs.655194.

3D structure databases

ProteinModelPortalQ2VPA4.
SMRQ2VPA4. Positions 34-563.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ2VPA4.

Polymorphism databases

DMDM296439386.

Proteomic databases

PaxDbQ2VPA4.
PRIDEQ2VPA4.

Protocols and materials databases

DNASU1379.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294997; ENSP00000434864; ENSG00000197721.
ENST00000508064; ENSP00000421736; ENSG00000197721. [Q2VPA4-1]
GeneID1379.
KEGGhsa:1379.
UCSCuc001hga.4. human. [Q2VPA4-1]

Organism-specific databases

CTD1379.
GeneCardsGC01P207820.
H-InvDBHIX0200033.
HGNCHGNC:2335. CR1L.
HPAHPA049348.
MIM605886. gene.
neXtProtNX_Q2VPA4.
PharmGKBPA26856.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000111977.
HOVERGENHBG081346.
InParanoidQ2VPA4.
OMAHVGSRIN.
OrthoDBEOG7FV3PV.
PhylomeDBQ2VPA4.
TreeFamTF334137.

Gene expression databases

BgeeQ2VPA4.
CleanExHS_CR1L.
GenevestigatorQ2VPA4.

Family and domain databases

InterProIPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamPF00084. Sushi. 8 hits.
[Graphical view]
SMARTSM00032. CCP. 8 hits.
[Graphical view]
SUPFAMSSF57535. SSF57535. 8 hits.
PROSITEPS50923. SUSHI. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi1379.
NextBio5597.
PROQ2VPA4.
SOURCESearch...

Entry information

Entry nameCR1L_HUMAN
AccessionPrimary (citable) accession number: Q2VPA4
Secondary accession number(s): Q32MC9, Q8NEU7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM