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Q2VLC6 (ACDH_BURCE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Name:bphG
Encoded onPlasmid pIJB1
OrganismBurkholderia cepacia (Pseudomonas cepacia)
Taxonomic identifier292 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387629

Regions

Nucleotide binding12 – 154NAD By similarity
Nucleotide binding163 – 1719NAD By similarity

Sites

Active site1321Acyl-thioester intermediate By similarity
Binding site2911NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2VLC6 [UniParc].

Last modified January 10, 2006. Version 1.
Checksum: C48710A78F13FC9E

FASTA31333,040
        10         20         30         40         50         60 
MARKLKAAII GSGNIGTDLM IKILRHGQNI EMGAMVGIDP ASDGLARAAR MGVATTHEGV 

        70         80         90        100        110        120 
EGLTRLDVFK DIDFVFDATS AGAHVKNDAF LRTLKPGIRM IDLTPAAIGP YCIPVVNGED 

       130        140        150        160        170        180 
HLDALNVNMV TCGGQATIPM VAAVSRVAKV HYGEIVASIS SKSAGPGTRA NIDEFTETTS 

       190        200        210        220        230        240 
KAIEVVGGAA KGKAIIVLNP AEPPLIMRDT VYTLSDFASE DAIAESVERM AADVQAYVPG 

       250        260        270        280        290        300 
YRLKQKVQFD RIEASHPINI PGVGPRMSGL KTSIFLEVEG AAHYLPAYAG NLDIMTSAGL 

       310 
RTAEHMATRM LAA 

« Hide

References

[1]Sebastianelli A., Bruce I.J.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 2a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ065837 Genomic DNA. Translation: AAZ08174.1.

3D structure databases

ProteinModelPortalQ2VLC6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_BURCE
AccessionPrimary (citable) accession number: Q2VLC6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: January 10, 2006
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families