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Protein

Chromosome-associated kinesin KIF4B

Gene

KIF4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi88 – 958ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  • microtubule-based movement Source: GO_Central
  • mitotic cytokinesis Source: UniProtKB
  • mitotic spindle midzone assembly Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-437239. Recycling pathway of L1.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome-associated kinesin KIF4B
Alternative name(s):
Chromokinesin-B
Gene namesi
Name:KIF4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6322. KIF4B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30106.

Polymorphism and mutation databases

BioMutaiKIF4B.
DMDMi158564279.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12341234Chromosome-associated kinesin KIF4BPRO_0000301666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei394 – 3941PhosphoserineBy similarity
Modified residuei799 – 7991PhosphothreonineBy similarity
Modified residuei801 – 8011PhosphoserineBy similarity
Modified residuei951 – 9511PhosphoserineBy similarity
Modified residuei1001 – 10011PhosphoserineBy similarity
Modified residuei1013 – 10131PhosphoserineBy similarity
Modified residuei1017 – 10171PhosphoserineBy similarity
Modified residuei1028 – 10281PhosphoserineBy similarity
Modified residuei1183 – 11831PhosphothreonineBy similarity
Modified residuei1188 – 11881PhosphoserineBy similarity
Modified residuei1227 – 12271PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ2VIQ3.
MaxQBiQ2VIQ3.
PaxDbiQ2VIQ3.
PRIDEiQ2VIQ3.

PTM databases

iPTMnetiQ2VIQ3.
PhosphoSiteiQ2VIQ3.

Expressioni

Tissue specificityi

Specifically expressed in testis.1 Publication

Gene expression databases

BgeeiQ2VIQ3.
CleanExiHS_KIF4B.

Organism-specific databases

HPAiHPA034745.
HPA034746.

Interactioni

Protein-protein interaction databases

BioGridi130168. 2 interactions.
IntActiQ2VIQ3. 1 interaction.
STRINGi9606.ENSP00000387875.

Structurei

3D structure databases

ProteinModelPortaliQ2VIQ3.
SMRiQ2VIQ3. Positions 5-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 336328Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni663 – 1234572Interaction with PRC1By similarityAdd
BLAST
Regioni1000 – 1234235GlobularBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili350 – 999650Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi793 – 7986Nuclear localization signalBy similarity

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0244. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129683.
HOGENOMiHOG000048108.
HOVERGENiHBG052256.
InParanoidiQ2VIQ3.
KOiK10395.
OMAiKERRIRC.
OrthoDBiEOG7P8P9J.
PhylomeDBiQ2VIQ3.
TreeFamiTF105224.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM01114. CXC. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2VIQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEEVKGIPV RVALRCRPLV PKEISEGCQM CLSFVPGETQ VVVGTDKSFT
60 70 80 90 100
YDFVFDPCTE QEEVFNKAVA PLIKGIFKGY NATVLAYGQT GSGKTYSMGG
110 120 130 140 150
AYTAEQENEP TVGIIPRVIQ LLFKEIDKKS DFEFTLKVSY LEIYNEEILD
160 170 180 190 200
LLCPSREKAQ INIREDPKEG IKIVGLTEKT VLVALDTVSC LEQGNNSRTV
210 220 230 240 250
ASTAMNSQSS RSHAIFTISI EQRKKSDKNC SFRSKLHLVD LAGSERQKKT
260 270 280 290 300
KAEGDRLKEG ININRGLLCL GNVISALGDD KKGSFVPYRD SKLTRLLQDS
310 320 330 340 350
LGGNSHTLMI ACVSPADSNL EETLSTLRYA DRARKIKNKP IVNIDPHTAE
360 370 380 390 400
LNHLKQQVQQ LQVLLLQAHG GTLPGSINAE PSENLQSLME KNQSLVEENE
410 420 430 440 450
KLSRCLSKAA GQTAQMLERI ILTEQVNEKL NAKLEELRQH VACKLDLQKL
460 470 480 490 500
VETLEDQELK ENVEIICNLQ QLITQLSDET VACTAAAIDT AVEEEAQVET
510 520 530 540 550
SPETSRSSDA FTTQHALHQA QMSKEVVELN NALALKEALV RKMTQNDNQL
560 570 580 590 600
QPIQFQYQDN IKNLELEVIN LQKEKEELVR ELQTAKKNVN QAKLSEHRHK
610 620 630 640 650
LLQELEGQIA DLKKKLNEQS KLLKLKESTE RTVSKLNQEI WMMKNQRVQL
660 670 680 690 700
MRQMKEDAEK FRQWKQKKDK EVIQLKERDR KRQYELLKLE RNFQKQSSVL
710 720 730 740 750
RRKTEEAAAA NKRLKDALQK QREVTDKRKE TQSHGKEGIA ARVRNWLGNE
760 770 780 790 800
IEVMVSTEEA KRHLNDLLED RKILAQDVVQ LKEKKESREN PPPKLRKCTF
810 820 830 840 850
SLSEVHGQVL ESEDCITKQI ESLETEMELR SAQIADLQQK LLDAESEDRP
860 870 880 890 900
KQCWENIATI LEAKCALKYL IGELVSSKIH VTKLENSLRQ SKASCADMQK
910 920 930 940 950
MLFEEQNHFS EIETELQAEL VRMEQQHQEK VLYLVSQLQE SQMAEKQLEK
960 970 980 990 1000
SASEKEQQLV STLQCQDEEL EKMREVCEQN QQLLQENEII KQKLILLQVA
1010 1020 1030 1040 1050
SRQKHLPNDT LLSPDSSFEY IPPKPKPSRV KEKFLEQSMD IEDLKYCSEH
1060 1070 1080 1090 1100
SVNEHEDGDG DGDSDEGDDE EWKPTKLVKV SRKNIQGCSC KGWCGNKQCG
1110 1120 1130 1140 1150
CRKQKSDCGV DCSCDPTKCR NRQQGKDSLG TVEQTQDSEG SFKLEDPTEV
1160 1170 1180 1190 1200
TPGLSFFNPV CATPNSKILK EMCDMEQVLS KKTAPAPSPF DLPESKHGAT
1210 1220 1230
EYQQNKPPGK KKKRALASNT SFFSGCSPIE EEAH
Length:1,234
Mass (Da):140,035
Last modified:September 11, 2007 - v2
Checksum:i13B1A8ADC95A735B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281K → Q in AF241316 (PubMed:10978527).Curated
Sequence conflicti220 – 2201I → L in AF241316 (PubMed:10978527).Curated
Sequence conflicti223 – 2231R → G in AF241316 (PubMed:10978527).Curated
Sequence conflicti230 – 2301C → S in AF241316 (PubMed:10978527).Curated
Sequence conflicti441 – 4411V → A in AF241316 (PubMed:10978527).Curated
Sequence conflicti589 – 5891V → A in AF241316 (PubMed:10978527).Curated
Sequence conflicti599 – 5991H → R in AF241316 (PubMed:10978527).Curated
Sequence conflicti641 – 6411W → R in AF241316 (PubMed:10978527).Curated
Sequence conflicti668 – 6681K → R in AF241316 (PubMed:10978527).Curated
Sequence conflicti698 – 6981S → N in AF241316 (PubMed:10978527).Curated
Sequence conflicti725 – 7251T → A in AF241316 (PubMed:10978527).Curated
Sequence conflicti734 – 7396HGKEGI → RGMEGT in AF241316 (PubMed:10978527).Curated
Sequence conflicti755 – 7551V → I in ABB92415 (PubMed:16201836).Curated
Sequence conflicti957 – 9571Q → P in AF241316 (PubMed:10978527).Curated
Sequence conflicti1029 – 10291R → H in ABB92415 (PubMed:16201836).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti494 – 4941E → Q.
Corresponds to variant rs17116709 [ dbSNP | Ensembl ].
VAR_049695
Natural varianti580 – 5801R → L.1 Publication
Corresponds to variant rs6580126 [ dbSNP | Ensembl ].
VAR_049696
Natural varianti680 – 6801R → H.1 Publication
Corresponds to variant rs17116710 [ dbSNP | Ensembl ].
VAR_049697
Natural varianti684 – 6841Y → C.
Corresponds to variant rs10056252 [ dbSNP | Ensembl ].
VAR_061281

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241316 Genomic DNA. No translation available.
DQ120629 Genomic DNA. Translation: ABB92415.1.
CCDSiCCDS47324.1.
RefSeqiNP_001092763.1. NM_001099293.1.
UniGeneiHs.567824.

Genome annotation databases

EnsembliENST00000435029; ENSP00000387875; ENSG00000226650.
GeneIDi285643.
KEGGihsa:285643.
UCSCiuc010jih.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241316 Genomic DNA. No translation available.
DQ120629 Genomic DNA. Translation: ABB92415.1.
CCDSiCCDS47324.1.
RefSeqiNP_001092763.1. NM_001099293.1.
UniGeneiHs.567824.

3D structure databases

ProteinModelPortaliQ2VIQ3.
SMRiQ2VIQ3. Positions 5-343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130168. 2 interactions.
IntActiQ2VIQ3. 1 interaction.
STRINGi9606.ENSP00000387875.

PTM databases

iPTMnetiQ2VIQ3.
PhosphoSiteiQ2VIQ3.

Polymorphism and mutation databases

BioMutaiKIF4B.
DMDMi158564279.

Proteomic databases

EPDiQ2VIQ3.
MaxQBiQ2VIQ3.
PaxDbiQ2VIQ3.
PRIDEiQ2VIQ3.

Protocols and materials databases

DNASUi285643.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435029; ENSP00000387875; ENSG00000226650.
GeneIDi285643.
KEGGihsa:285643.
UCSCiuc010jih.2. human.

Organism-specific databases

CTDi285643.
GeneCardsiKIF4B.
H-InvDBHIX0032631.
HGNCiHGNC:6322. KIF4B.
HPAiHPA034745.
HPA034746.
MIMi609184. gene.
neXtProtiNX_Q2VIQ3.
PharmGKBiPA30106.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0244. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129683.
HOGENOMiHOG000048108.
HOVERGENiHBG052256.
InParanoidiQ2VIQ3.
KOiK10395.
OMAiKERRIRC.
OrthoDBiEOG7P8P9J.
PhylomeDBiQ2VIQ3.
TreeFamiTF105224.

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-437239. Recycling pathway of L1.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Miscellaneous databases

GenomeRNAii285643.
PROiQ2VIQ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ2VIQ3.
CleanExiHS_KIF4B.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM01114. CXC. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein."
    Oh S.J., Hahn H., Torrey T.A., Shin H., Choi W., Lee Y.M., Morse H.C. III, Kim W.
    Biochim. Biophys. Acta 1493:219-224(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Emergence of young human genes after a burst of retroposition in primates."
    Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.
    PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1185, TISSUE SPECIFICITY, VARIANTS LEU-580 AND HIS-680.

Entry informationi

Entry nameiKIF4B_HUMAN
AccessioniPrimary (citable) accession number: Q2VIQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 8, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.