Q2VIQ3 (KIF4B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosome-associated kinesin KIF4B

Alternative name(s):
Chromokinesin-B

Gene names

Name:

KIF4B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1234 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization By similarity.
Subcellular location	Nucleus matrix By similarity. Cytoplasm › cytoskeleton Probable.
Tissue specificity	Specifically expressed in testis. Ref.3
Sequence similarities	Belongs to the kinesin-like protein family. Chromokinesin subfamily. Contains 1 kinesin-motor domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule Nucleus
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	axon guidance Traceable author statement. Source: Reactome blood coagulation Traceable author statement. Source: Reactome microtubule-based movement Traceable author statement. Source: Reactome
Cellular component	cytosol Traceable author statement. Source: Reactome microtubule Inferred from electronic annotation. Source: UniProtKB-KW nuclear matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1234	1234	Chromosome-associated kinesin KIF4B		PRO_0000301666
Regions
	Domain	1 – 349	349	Kinesin-motor
	Nucleotide binding	88 – 95	8	ATP By similarity
	Region	663 – 1234	572	Interaction with PRC1 By similarity
	Region	1000 – 1234	235	Globular By similarity
	Coiled coil	350 – 999	650	Potential
	Motif	793 – 798	6	Nuclear localization signal By similarity
Amino acid modifications
	Modified residue	1038	1	Phosphoserine Ref.4 Ref.5
	Modified residue	1227	1	Phosphoserine Ref.4
Natural variations
	Natural variant	494	1	E → Q. Corresponds to variant rs17116709 [ dbSNP | Ensembl ].		VAR_049695
	Natural variant	580	1	R → L. Ref.3 Corresponds to variant rs6580126 [ dbSNP | Ensembl ].		VAR_049696
	Natural variant	680	1	R → H. Ref.3 Corresponds to variant rs17116710 [ dbSNP | Ensembl ].		VAR_049697
	Natural variant	684	1	Y → C. Corresponds to variant rs10056252 [ dbSNP | Ensembl ].		VAR_061281
Experimental info
	Sequence conflict	128	1	K → Q in AF241316. Ref.1
	Sequence conflict	220	1	I → L in AF241316. Ref.1
	Sequence conflict	223	1	R → G in AF241316. Ref.1
	Sequence conflict	230	1	C → S in AF241316. Ref.1
	Sequence conflict	441	1	V → A in AF241316. Ref.1
	Sequence conflict	589	1	V → A in AF241316. Ref.1
	Sequence conflict	599	1	H → R in AF241316. Ref.1
	Sequence conflict	641	1	W → R in AF241316. Ref.1
	Sequence conflict	668	1	K → R in AF241316. Ref.1
	Sequence conflict	698	1	S → N in AF241316. Ref.1
	Sequence conflict	725	1	T → A in AF241316. Ref.1
	Sequence conflict	734 – 739	6	HGKEGI → RGMEGT in AF241316. Ref.1
	Sequence conflict	755	1	V → I in ABB92415. Ref.3
	Sequence conflict	957	1	Q → P in AF241316. Ref.1
	Sequence conflict	1029	1	R → H in ABB92415. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q2VIQ3 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: 13B1A8ADC95A735B	FASTA	1,234	140,035
	10 20 30 40 50 60 MKEEVKGIPV RVALRCRPLV PKEISEGCQM CLSFVPGETQ VVVGTDKSFT YDFVFDPCTE 70 80 90 100 110 120 QEEVFNKAVA PLIKGIFKGY NATVLAYGQT GSGKTYSMGG AYTAEQENEP TVGIIPRVIQ 130 140 150 160 170 180 LLFKEIDKKS DFEFTLKVSY LEIYNEEILD LLCPSREKAQ INIREDPKEG IKIVGLTEKT 190 200 210 220 230 240 VLVALDTVSC LEQGNNSRTV ASTAMNSQSS RSHAIFTISI EQRKKSDKNC SFRSKLHLVD 250 260 270 280 290 300 LAGSERQKKT KAEGDRLKEG ININRGLLCL GNVISALGDD KKGSFVPYRD SKLTRLLQDS 310 320 330 340 350 360 LGGNSHTLMI ACVSPADSNL EETLSTLRYA DRARKIKNKP IVNIDPHTAE LNHLKQQVQQ 370 380 390 400 410 420 LQVLLLQAHG GTLPGSINAE PSENLQSLME KNQSLVEENE KLSRCLSKAA GQTAQMLERI 430 440 450 460 470 480 ILTEQVNEKL NAKLEELRQH VACKLDLQKL VETLEDQELK ENVEIICNLQ QLITQLSDET 490 500 510 520 530 540 VACTAAAIDT AVEEEAQVET SPETSRSSDA FTTQHALHQA QMSKEVVELN NALALKEALV 550 560 570 580 590 600 RKMTQNDNQL QPIQFQYQDN IKNLELEVIN LQKEKEELVR ELQTAKKNVN QAKLSEHRHK 610 620 630 640 650 660 LLQELEGQIA DLKKKLNEQS KLLKLKESTE RTVSKLNQEI WMMKNQRVQL MRQMKEDAEK 670 680 690 700 710 720 FRQWKQKKDK EVIQLKERDR KRQYELLKLE RNFQKQSSVL RRKTEEAAAA NKRLKDALQK 730 740 750 760 770 780 QREVTDKRKE TQSHGKEGIA ARVRNWLGNE IEVMVSTEEA KRHLNDLLED RKILAQDVVQ 790 800 810 820 830 840 LKEKKESREN PPPKLRKCTF SLSEVHGQVL ESEDCITKQI ESLETEMELR SAQIADLQQK 850 860 870 880 890 900 LLDAESEDRP KQCWENIATI LEAKCALKYL IGELVSSKIH VTKLENSLRQ SKASCADMQK 910 920 930 940 950 960 MLFEEQNHFS EIETELQAEL VRMEQQHQEK VLYLVSQLQE SQMAEKQLEK SASEKEQQLV 970 980 990 1000 1010 1020 STLQCQDEEL EKMREVCEQN QQLLQENEII KQKLILLQVA SRQKHLPNDT LLSPDSSFEY 1030 1040 1050 1060 1070 1080 IPPKPKPSRV KEKFLEQSMD IEDLKYCSEH SVNEHEDGDG DGDSDEGDDE EWKPTKLVKV 1090 1100 1110 1120 1130 1140 SRKNIQGCSC KGWCGNKQCG CRKQKSDCGV DCSCDPTKCR NRQQGKDSLG TVEQTQDSEG 1150 1160 1170 1180 1190 1200 SFKLEDPTEV TPGLSFFNPV CATPNSKILK EMCDMEQVLS KKTAPAPSPF DLPESKHGAT 1210 1220 1230 EYQQNKPPGK KKKRALASNT SFFSGCSPIE EEAH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein." Oh S.J., Hahn H., Torrey T.A., Shin H., Choi W., Lee Y.M., Morse H.C. III, Kim W. Biochim. Biophys. Acta 1493:219-224(2000) [PubMed: 10978527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Emergence of young human genes after a burst of retroposition in primates." Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H. PLoS Biol. 3:E357-E357(2005) [PubMed: 16201836] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1185, TISSUE SPECIFICITY, VARIANTS LEU-580 AND HIS-680.
[4]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1038 AND SER-1227, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1038, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF241316 Genomic DNA. No translation available. DQ120629 Genomic DNA. Translation: ABB92415.1.
IPI	IPI00175193.
RefSeq	NP_001092763.1. NM_001099293.1.
UniGene	Hs.567824.
3D structure databases
HSSP	HSSP built from PDB template 1F9T based on UniProtKB P17119.
ProteinModelPortal	Q2VIQ3.
SMR	Q2VIQ3. Positions 7-363.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2VIQ3.
PTM databases
PhosphoSite	Q2VIQ3.
Polymorphism databases
DMDM	158564279.
Proteomic databases
PRIDE	Q2VIQ3.
Protocols and materials databases
DNASU	285643.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000435029; ENSP00000387875; ENSG00000226650.
GeneID	285643.
KEGG	hsa:285643.
UCSC	uc010jih.1. human.
Organism-specific databases
CTD	285643.
GeneCards	GC05P154393.
HGNC	HGNC:6322. KIF4B.
HPA	HPA034745. HPA034746.
MIM	609184. gene.
neXtProt	NX_Q2VIQ3.
PharmGKB	PA30106.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5059.
GeneTree	ENSGT00650000092919.
HOGENOM	HOG000048108.
HOVERGEN	HBG052256.
InParanoid	Q2VIQ3.
KO	K10395.
OMA	TVRVHEV.
OrthoDB	EOG40S0DV.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology. REACT_604. Hemostasis.
Gene expression databases
Bgee	Q2VIQ3.
CleanEx	HS_KIF4B.
Genevestigator	Q2VIQ3.
Family and domain databases
Gene3D	G3DSA:3.40.850.10. kinesin_motor. 1 hit.
InterPro	IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. [Graphical view]
Pfam	PF00225. Kinesin. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. [Graphical view]
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	95679.
SOURCE	Search...

Entry information

Entry name

KIF4B_HUMAN

Accession

Primary (citable) accession number: Q2VIQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	May 16, 2012
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.