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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

G6PD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
  2. glucose binding Source: Ensembl
  3. NADP binding Source: InterPro

GO - Biological processi

  1. glucose metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt, oxidative branch Source: Ensembl
  3. regulation of neuron apoptotic process Source: Ensembl
  4. response to ethanol Source: Ensembl
  5. response to food Source: Ensembl
  6. response to organic cyclic compound Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Gene namesi
Name:G6PDImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ2VF42.

Expressioni

Gene expression databases

BgeeiQ2VF42.
ExpressionAtlasiQ2VF42. baseline and differential.

Interactioni

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG000856.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q2VF42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GDLAKKKIYP TIWWLFRDGL LPENTFIVGY ARSRLTVADI RKQSEPFFKA
60 70 80 90 100
TPEEKLKLED FFARNSYVAG QYDDAASYQR LNSHMNALHL GSQANRLFYL
110 120 130 140 150
ALPPTVYEAV TKNIHESCMS QIGWNRIIVE KPFGRDLQSS DRLSNHISSL
160 170 180 190 200
FREDQIYRID HYLGKEMVQN LMVLRFANRI FGPIWNRDNI ACVILTFKEP
210 220 230 240 250
FGTEGRGGYF DEFGIIRDVM QNHLLQMLCL VAMEKPASTN SDDVRDEKVK
260 270 280 290 300
VLKCISEVQA NNVVLGQYVG NPDGEGEATK GYLDDPTVPR GSTTATFAAV
310 320 330 340 350
VLYVENERWD GVPFILRCGK ALNERKAEVR LQFHDVAGDI FHQQCKRNEL
360 370 380 390 400
VIRVQPNEAV YTKMMTKKPG MFFNPEESEL DLTYGNRYKN VKLPDAYERL
410 420 430 440 450
ILDVFCGSQM HFVRSDELRE AWRIFTPLLH QIELEKPKPI PYIYGSRGPT
460 470
EADELMKRVG FQYEGTYKWV NPHKL
Length:475
Mass (Da):54,824
Last modified:January 10, 2006 - v1
Checksum:i08ADCEDEAF05B277
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ173568 Genomic DNA. Translation: ABB90566.1.
DQ173592 Genomic DNA. Translation: ABC25732.1.
DQ173593 Genomic DNA. Translation: ABC25737.1.
DQ173594 Genomic DNA. Translation: ABC25742.1.
DQ173595 Genomic DNA. Translation: ABC25747.1.
DQ173596 Genomic DNA. Translation: ABC25752.1.
DQ173597 Genomic DNA. Translation: ABC25757.1.
DQ173598 Genomic DNA. Translation: ABC25761.1.
DQ173599 Genomic DNA. Translation: ABC25766.1.
DQ173600 Genomic DNA. Translation: ABC25771.1.
DQ173601 Genomic DNA. Translation: ABC25776.1.
DQ173602 Genomic DNA. Translation: ABC25781.1.
DQ173603 Genomic DNA. Translation: ABC25786.1.
DQ173604 Genomic DNA. Translation: ABC25791.1.
DQ173605 Genomic DNA. Translation: ABC25796.1.
DQ173606 Genomic DNA. Translation: ABC25801.1.
DQ173607 Genomic DNA. Translation: ABC25806.1.
DQ173608 Genomic DNA. Translation: ABC25811.1.
DQ173609 Genomic DNA. Translation: ABC25816.1.
DQ173610 Genomic DNA. Translation: ABC25821.1.
DQ173611 Genomic DNA. Translation: ABC25826.1.
UniGeneiHs.461047.
Hs.684904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ173568 Genomic DNA. Translation: ABB90566.1.
DQ173592 Genomic DNA. Translation: ABC25732.1.
DQ173593 Genomic DNA. Translation: ABC25737.1.
DQ173594 Genomic DNA. Translation: ABC25742.1.
DQ173595 Genomic DNA. Translation: ABC25747.1.
DQ173596 Genomic DNA. Translation: ABC25752.1.
DQ173597 Genomic DNA. Translation: ABC25757.1.
DQ173598 Genomic DNA. Translation: ABC25761.1.
DQ173599 Genomic DNA. Translation: ABC25766.1.
DQ173600 Genomic DNA. Translation: ABC25771.1.
DQ173601 Genomic DNA. Translation: ABC25776.1.
DQ173602 Genomic DNA. Translation: ABC25781.1.
DQ173603 Genomic DNA. Translation: ABC25786.1.
DQ173604 Genomic DNA. Translation: ABC25791.1.
DQ173605 Genomic DNA. Translation: ABC25796.1.
DQ173606 Genomic DNA. Translation: ABC25801.1.
DQ173607 Genomic DNA. Translation: ABC25806.1.
DQ173608 Genomic DNA. Translation: ABC25811.1.
DQ173609 Genomic DNA. Translation: ABC25816.1.
DQ173610 Genomic DNA. Translation: ABC25821.1.
DQ173611 Genomic DNA. Translation: ABC25826.1.
UniGeneiHs.461047.
Hs.684904.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ2VF42.

Proteomic databases

PRIDEiQ2VF42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000856.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Miscellaneous databases

ChiTaRSiG6PD. human.

Gene expression databases

BgeeiQ2VF42.
ExpressionAtlasiQ2VF42. baseline and differential.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The extent of linkage disequilibrium caused by selection on G6PD in humans."
    Saunders M.A., Slatkin M., Garner C., Hammer M.F., Nachman M.W.
    Genetics 171:1219-1229(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ALB_74_BImported, DKT_331_BImported, GNA_02_BImported, IVC_04_BImported, IVC_18_BImported, IVC_20_BImported, IVC_23_BImported, JK_1029_BImported, JK_1033_BImported, JK_736_BImported, JK_741_BImported, JR_013_BImported, JR_323_BImported, KOH_188_BImported, LD_156_BImported, MKA_21_BImported, MKA_29_BImported, SHO_14_BImported, SHO_30_BImported and SHO_46_BImported.

Entry informationi

Entry nameiQ2VF42_HUMAN
AccessioniPrimary (citable) accession number: Q2VF42
Entry historyi
Integrated into UniProtKB/TrEMBL: January 10, 2006
Last sequence update: January 10, 2006
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.