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Q2VF42

- Q2VF42_HUMAN

UniProt

Q2VF42 - Q2VF42_HUMAN

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
G6PD
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. NADP binding Source: Ensembl
  2. glucose binding Source: Ensembl
  3. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glucose 6-phosphate metabolic process Source: Ensembl
  2. pentose-phosphate shunt, oxidative branch Source: Ensembl
  3. regulation of neuron apoptotic process Source: Ensembl
  4. response to ethanol Source: Ensembl
  5. response to food Source: Ensembl
  6. response to organic cyclic compound Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Gene namesi
Name:G6PDImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ2VF42.

Expressioni

Gene expression databases

ArrayExpressiQ2VF42.
BgeeiQ2VF42.

Interactioni

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000856.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q2VF42-1 [UniParc]FASTAAdd to Basket

« Hide

GDLAKKKIYP TIWWLFRDGL LPENTFIVGY ARSRLTVADI RKQSEPFFKA    50
TPEEKLKLED FFARNSYVAG QYDDAASYQR LNSHMNALHL GSQANRLFYL 100
ALPPTVYEAV TKNIHESCMS QIGWNRIIVE KPFGRDLQSS DRLSNHISSL 150
FREDQIYRID HYLGKEMVQN LMVLRFANRI FGPIWNRDNI ACVILTFKEP 200
FGTEGRGGYF DEFGIIRDVM QNHLLQMLCL VAMEKPASTN SDDVRDEKVK 250
VLKCISEVQA NNVVLGQYVG NPDGEGEATK GYLDDPTVPR GSTTATFAAV 300
VLYVENERWD GVPFILRCGK ALNERKAEVR LQFHDVAGDI FHQQCKRNEL 350
VIRVQPNEAV YTKMMTKKPG MFFNPEESEL DLTYGNRYKN VKLPDAYERL 400
ILDVFCGSQM HFVRSDELRE AWRIFTPLLH QIELEKPKPI PYIYGSRGPT 450
EADELMKRVG FQYEGTYKWV NPHKL 475
Length:475
Mass (Da):54,824
Last modified:January 10, 2006 - v1
Checksum:i08ADCEDEAF05B277
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ173568 Genomic DNA. Translation: ABB90566.1.
DQ173592 Genomic DNA. Translation: ABC25732.1.
DQ173593 Genomic DNA. Translation: ABC25737.1.
DQ173594 Genomic DNA. Translation: ABC25742.1.
DQ173595 Genomic DNA. Translation: ABC25747.1.
DQ173596 Genomic DNA. Translation: ABC25752.1.
DQ173597 Genomic DNA. Translation: ABC25757.1.
DQ173598 Genomic DNA. Translation: ABC25761.1.
DQ173599 Genomic DNA. Translation: ABC25766.1.
DQ173600 Genomic DNA. Translation: ABC25771.1.
DQ173601 Genomic DNA. Translation: ABC25776.1.
DQ173602 Genomic DNA. Translation: ABC25781.1.
DQ173603 Genomic DNA. Translation: ABC25786.1.
DQ173604 Genomic DNA. Translation: ABC25791.1.
DQ173605 Genomic DNA. Translation: ABC25796.1.
DQ173606 Genomic DNA. Translation: ABC25801.1.
DQ173607 Genomic DNA. Translation: ABC25806.1.
DQ173608 Genomic DNA. Translation: ABC25811.1.
DQ173609 Genomic DNA. Translation: ABC25816.1.
DQ173610 Genomic DNA. Translation: ABC25821.1.
DQ173611 Genomic DNA. Translation: ABC25826.1.
UniGeneiHs.461047.
Hs.684904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ173568 Genomic DNA. Translation: ABB90566.1 .
DQ173592 Genomic DNA. Translation: ABC25732.1 .
DQ173593 Genomic DNA. Translation: ABC25737.1 .
DQ173594 Genomic DNA. Translation: ABC25742.1 .
DQ173595 Genomic DNA. Translation: ABC25747.1 .
DQ173596 Genomic DNA. Translation: ABC25752.1 .
DQ173597 Genomic DNA. Translation: ABC25757.1 .
DQ173598 Genomic DNA. Translation: ABC25761.1 .
DQ173599 Genomic DNA. Translation: ABC25766.1 .
DQ173600 Genomic DNA. Translation: ABC25771.1 .
DQ173601 Genomic DNA. Translation: ABC25776.1 .
DQ173602 Genomic DNA. Translation: ABC25781.1 .
DQ173603 Genomic DNA. Translation: ABC25786.1 .
DQ173604 Genomic DNA. Translation: ABC25791.1 .
DQ173605 Genomic DNA. Translation: ABC25796.1 .
DQ173606 Genomic DNA. Translation: ABC25801.1 .
DQ173607 Genomic DNA. Translation: ABC25806.1 .
DQ173608 Genomic DNA. Translation: ABC25811.1 .
DQ173609 Genomic DNA. Translation: ABC25816.1 .
DQ173610 Genomic DNA. Translation: ABC25821.1 .
DQ173611 Genomic DNA. Translation: ABC25826.1 .
UniGenei Hs.461047.
Hs.684904.

3D structure databases

ModBasei Search...

Chemistry

BindingDBi Q2VF42.

Proteomic databases

PRIDEi Q2VF42.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000856.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Miscellaneous databases

ChiTaRSi G6PD. human.

Gene expression databases

ArrayExpressi Q2VF42.
Bgeei Q2VF42.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The extent of linkage disequilibrium caused by selection on G6PD in humans."
    Saunders M.A., Slatkin M., Garner C., Hammer M.F., Nachman M.W.
    Genetics 171:1219-1229(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ALB_74_BImported, DKT_331_BImported, GNA_02_BImported, IVC_04_BImported, IVC_18_BImported, IVC_20_BImported, IVC_23_BImported, JK_1029_BImported, JK_1033_BImported, JK_736_BImported, JK_741_BImported, JR_013_BImported, JR_323_BImported, KOH_188_BImported, LD_156_BImported, MKA_21_BImported, MKA_29_BImported, SHO_14_BImported, SHO_30_BImported and SHO_46_BImported.

Entry informationi

Entry nameiQ2VF42_HUMAN
AccessioniPrimary (citable) accession number: Q2VF42
Entry historyi
Integrated into UniProtKB/TrEMBL: January 10, 2006
Last sequence update: January 10, 2006
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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