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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

G6PD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase
  2. 6-phosphogluconolactonase (PGLS)
  3. 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate dehydrogenase, decarboxylating (PGD)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processCarbohydrate metabolism, Glucose metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Gene namesi
Name:G6PDImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 170G6PD_NInterPro annotationAdd BLAST170
Domaini172 – 463G6PD_CInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0563. Eukaryota.
COG0364. LUCA.
HOVERGENiHBG000856.

Family and domain databases

HAMAPiMF_00966. G6PD. 1 hit.
InterProiView protein in InterPro
IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiView protein in Pfam
PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiView protein in PROSITE
PS00069. G6P_DEHYDROGENASE. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q2VF42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GDLAKKKIYP TIWWLFRDGL LPENTFIVGY ARSRLTVADI RKQSEPFFKA
60 70 80 90 100
TPEEKLKLED FFARNSYVAG QYDDAASYQR LNSHMNALHL GSQANRLFYL
110 120 130 140 150
ALPPTVYEAV TKNIHESCMS QIGWNRIIVE KPFGRDLQSS DRLSNHISSL
160 170 180 190 200
FREDQIYRID HYLGKEMVQN LMVLRFANRI FGPIWNRDNI ACVILTFKEP
210 220 230 240 250
FGTEGRGGYF DEFGIIRDVM QNHLLQMLCL VAMEKPASTN SDDVRDEKVK
260 270 280 290 300
VLKCISEVQA NNVVLGQYVG NPDGEGEATK GYLDDPTVPR GSTTATFAAV
310 320 330 340 350
VLYVENERWD GVPFILRCGK ALNERKAEVR LQFHDVAGDI FHQQCKRNEL
360 370 380 390 400
VIRVQPNEAV YTKMMTKKPG MFFNPEESEL DLTYGNRYKN VKLPDAYERL
410 420 430 440 450
ILDVFCGSQM HFVRSDELRE AWRIFTPLLH QIELEKPKPI PYIYGSRGPT
460 470
EADELMKRVG FQYEGTYKWV NPHKL
Length:475
Mass (Da):54,824
Last modified:January 10, 2006 - v1
Checksum:i08ADCEDEAF05B277
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ173568 Genomic DNA. Translation: ABB90566.1.
DQ173592 Genomic DNA. Translation: ABC25732.1.
DQ173593 Genomic DNA. Translation: ABC25737.1.
DQ173594 Genomic DNA. Translation: ABC25742.1.
DQ173595 Genomic DNA. Translation: ABC25747.1.
DQ173596 Genomic DNA. Translation: ABC25752.1.
DQ173597 Genomic DNA. Translation: ABC25757.1.
DQ173598 Genomic DNA. Translation: ABC25761.1.
DQ173599 Genomic DNA. Translation: ABC25766.1.
DQ173600 Genomic DNA. Translation: ABC25771.1.
DQ173601 Genomic DNA. Translation: ABC25776.1.
DQ173602 Genomic DNA. Translation: ABC25781.1.
DQ173603 Genomic DNA. Translation: ABC25786.1.
DQ173604 Genomic DNA. Translation: ABC25791.1.
DQ173605 Genomic DNA. Translation: ABC25796.1.
DQ173606 Genomic DNA. Translation: ABC25801.1.
DQ173607 Genomic DNA. Translation: ABC25806.1.
DQ173608 Genomic DNA. Translation: ABC25811.1.
DQ173609 Genomic DNA. Translation: ABC25816.1.
DQ173610 Genomic DNA. Translation: ABC25821.1.
DQ173611 Genomic DNA. Translation: ABC25826.1.
UniGeneiHs.461047.
Hs.684904.

Similar proteinsi

Entry informationi

Entry nameiQ2VF42_HUMAN
AccessioniPrimary (citable) accession number: Q2VF42
Entry historyiIntegrated into UniProtKB/TrEMBL: January 10, 2006
Last sequence update: January 10, 2006
Last modified: October 25, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.