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Q2VF42

- Q2VF42_HUMAN

UniProt

Q2VF42 - Q2VF42_HUMAN

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

G6PD

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
    2. glucose binding Source: Ensembl
    3. NADP binding Source: Ensembl

    GO - Biological processi

    1. glucose 6-phosphate metabolic process Source: Ensembl
    2. pentose-phosphate shunt, oxidative branch Source: Ensembl
    3. regulation of neuron apoptotic process Source: Ensembl
    4. response to ethanol Source: Ensembl
    5. response to food Source: Ensembl
    6. response to organic cyclic compound Source: Ensembl

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolismUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Gene namesi
    Name:G6PDImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. nucleus Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiQ2VF42.

    Expressioni

    Gene expression databases

    ArrayExpressiQ2VF42.
    BgeeiQ2VF42.

    Interactioni

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG000856.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q2VF42-1 [UniParc]FASTAAdd to Basket

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    GDLAKKKIYP TIWWLFRDGL LPENTFIVGY ARSRLTVADI RKQSEPFFKA    50
    TPEEKLKLED FFARNSYVAG QYDDAASYQR LNSHMNALHL GSQANRLFYL 100
    ALPPTVYEAV TKNIHESCMS QIGWNRIIVE KPFGRDLQSS DRLSNHISSL 150
    FREDQIYRID HYLGKEMVQN LMVLRFANRI FGPIWNRDNI ACVILTFKEP 200
    FGTEGRGGYF DEFGIIRDVM QNHLLQMLCL VAMEKPASTN SDDVRDEKVK 250
    VLKCISEVQA NNVVLGQYVG NPDGEGEATK GYLDDPTVPR GSTTATFAAV 300
    VLYVENERWD GVPFILRCGK ALNERKAEVR LQFHDVAGDI FHQQCKRNEL 350
    VIRVQPNEAV YTKMMTKKPG MFFNPEESEL DLTYGNRYKN VKLPDAYERL 400
    ILDVFCGSQM HFVRSDELRE AWRIFTPLLH QIELEKPKPI PYIYGSRGPT 450
    EADELMKRVG FQYEGTYKWV NPHKL 475
    Length:475
    Mass (Da):54,824
    Last modified:January 10, 2006 - v1
    Checksum:i08ADCEDEAF05B277
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ173568 Genomic DNA. Translation: ABB90566.1.
    DQ173592 Genomic DNA. Translation: ABC25732.1.
    DQ173593 Genomic DNA. Translation: ABC25737.1.
    DQ173594 Genomic DNA. Translation: ABC25742.1.
    DQ173595 Genomic DNA. Translation: ABC25747.1.
    DQ173596 Genomic DNA. Translation: ABC25752.1.
    DQ173597 Genomic DNA. Translation: ABC25757.1.
    DQ173598 Genomic DNA. Translation: ABC25761.1.
    DQ173599 Genomic DNA. Translation: ABC25766.1.
    DQ173600 Genomic DNA. Translation: ABC25771.1.
    DQ173601 Genomic DNA. Translation: ABC25776.1.
    DQ173602 Genomic DNA. Translation: ABC25781.1.
    DQ173603 Genomic DNA. Translation: ABC25786.1.
    DQ173604 Genomic DNA. Translation: ABC25791.1.
    DQ173605 Genomic DNA. Translation: ABC25796.1.
    DQ173606 Genomic DNA. Translation: ABC25801.1.
    DQ173607 Genomic DNA. Translation: ABC25806.1.
    DQ173608 Genomic DNA. Translation: ABC25811.1.
    DQ173609 Genomic DNA. Translation: ABC25816.1.
    DQ173610 Genomic DNA. Translation: ABC25821.1.
    DQ173611 Genomic DNA. Translation: ABC25826.1.
    UniGeneiHs.461047.
    Hs.684904.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ173568 Genomic DNA. Translation: ABB90566.1 .
    DQ173592 Genomic DNA. Translation: ABC25732.1 .
    DQ173593 Genomic DNA. Translation: ABC25737.1 .
    DQ173594 Genomic DNA. Translation: ABC25742.1 .
    DQ173595 Genomic DNA. Translation: ABC25747.1 .
    DQ173596 Genomic DNA. Translation: ABC25752.1 .
    DQ173597 Genomic DNA. Translation: ABC25757.1 .
    DQ173598 Genomic DNA. Translation: ABC25761.1 .
    DQ173599 Genomic DNA. Translation: ABC25766.1 .
    DQ173600 Genomic DNA. Translation: ABC25771.1 .
    DQ173601 Genomic DNA. Translation: ABC25776.1 .
    DQ173602 Genomic DNA. Translation: ABC25781.1 .
    DQ173603 Genomic DNA. Translation: ABC25786.1 .
    DQ173604 Genomic DNA. Translation: ABC25791.1 .
    DQ173605 Genomic DNA. Translation: ABC25796.1 .
    DQ173606 Genomic DNA. Translation: ABC25801.1 .
    DQ173607 Genomic DNA. Translation: ABC25806.1 .
    DQ173608 Genomic DNA. Translation: ABC25811.1 .
    DQ173609 Genomic DNA. Translation: ABC25816.1 .
    DQ173610 Genomic DNA. Translation: ABC25821.1 .
    DQ173611 Genomic DNA. Translation: ABC25826.1 .
    UniGenei Hs.461047.
    Hs.684904.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q2VF42.

    Proteomic databases

    PRIDEi Q2VF42.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000856.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Miscellaneous databases

    ChiTaRSi G6PD. human.

    Gene expression databases

    ArrayExpressi Q2VF42.
    Bgeei Q2VF42.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The extent of linkage disequilibrium caused by selection on G6PD in humans."
      Saunders M.A., Slatkin M., Garner C., Hammer M.F., Nachman M.W.
      Genetics 171:1219-1229(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ALB_74_BImported, DKT_331_BImported, GNA_02_BImported, IVC_04_BImported, IVC_18_BImported, IVC_20_BImported, IVC_23_BImported, JK_1029_BImported, JK_1033_BImported, JK_736_BImported, JK_741_BImported, JR_013_BImported, JR_323_BImported, KOH_188_BImported, LD_156_BImported, MKA_21_BImported, MKA_29_BImported, SHO_14_BImported, SHO_30_BImported and SHO_46_BImported.

    Entry informationi

    Entry nameiQ2VF42_HUMAN
    AccessioniPrimary (citable) accession number: Q2VF42
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 10, 2006
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.