Q2V6T4 (Q2V6T4_LEIBR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Mannose-6-phosphate isomerase RuleBase RU000611
EC=5.3.1.8 RuleBase RU000611

Gene names

Name:	MPI EMBL ABU25178.1
Synonyms:	mpi EMBL ABY50483.1, PMI EMBL CAM42970.1
ORF Names:	LBRM_32_1750 EMBL CAM42970.1

Organism

Leishmania braziliensis EMBL ABB91670.1

Taxonomic identifier

5660 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania › Leishmania braziliensis species complex

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannose 6-phosphate = D-fructose 6-phosphate. RuleBase RU000611
Cofactor	Binds 1 zinc ion per subunit By similarity. RuleBase RU000611
Sequence similarities	Belongs to the mannose-6-phosphate isomerase type 1 family. RuleBase RU004189

Ontologies

Keywords
Ligand	Zinc RuleBase RU000611
Molecular function	Isomerase RuleBase RU000611 EMBL ABB91670.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2V6T4 [UniParc]. Last modified January 10, 2006. Version 1. Checksum: 25A4B6CD6199D19D	FASTA	428	47,177
	10 20 30 40 50 60 MSALIKLDAS YQDYAWGKNA ASSFVAKMKG LTEDQSGKMY AELWVGTHPS CPSKVANGSA 70 80 90 100 110 120 QLLEDFLKDP ENKKRYFSAA HQSTSFRDTV PYLLKILSIR TALSIQAHPC KKLAEELHAA 130 140 150 160 170 180 QPDKYKDPNH KPELICALTP FEALCCFRPL KEIIAYLKRI PQLAALVAAD TVLGSYMMAP 190 200 210 220 230 240 QSALPAADSD AERQSLKSLM TNLYAAPEDT VTKELRLHLR HIEEKGAQCA EDTLFVRIYK 250 260 270 280 290 300 QYPDDVGCWM VYFLNYVQMV PGEALFLSDS EPHAYISGDG VEIMACSDNV VRAGLTPKWK 310 320 330 340 350 360 DVPTLVSMLK YSTTGLASAR FEKNCSEDAA QWQVQCYQPP AQFPDFCLYR MQYDHTSGSG 370 380 390 400 410 420 TTSVTLPTIG LGFCLEGSAR VNGTVVCAGD CFAVPYGKVT CQAEERKALV FVASTNDLSG TCPNSLRE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Typing of four genetic loci discriminates among closely related species of New World Leishmania." Tsukayama P., Lucas C., Bacon D.J. Int. J. Parasitol. 39:355-362(2009) [PubMed: 18817779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: MHOM/PE/88/BAA2072 EMBL ABU25178.1.
[2]	"Comparative genomic analysis of three Leishmania species that cause diverse human disease." Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A., Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A., Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T., Hance Z. , Jagels K., Moule S., Ormond D., Rutter S., Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M. Nat. Genet. 39:839-847(2007) [PubMed: 17572675] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MHOM/BR/75/M2904.
[3]	"Development of a genetic assay to distinguish between Leishmania (Viannia) species based on isoenzyme differences." Zhang W.-W., Miranda-Verastegui C., Matlashewski G. Clin. Infect. Dis. 0:0-0(2006) Cited for: NUCLEOTIDE SEQUENCE. Strain: MHOM/BR/91/2195 EMBL ABB91670.1.
[4]	"Genetic evidence of sexual recombination in new world Leishmania populations from the sequence analysis of three isoenzyme markers." Tsukayama P., Bacon D.J. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: MHOM/PE/93/LEH0022 EMBL ABY50504.1, MHOM/PE/93/LEH1642 EMBL ABY50485.1 and MHOM/PE/94/LEH1829 EMBL ABY50483.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ288169 Genomic DNA. Translation: ABB91670.1. EU053117 Genomic DNA. Translation: ABU25178.1. EU327893 Genomic DNA. Translation: ABY50483.1. EU327895 Genomic DNA. Translation: ABY50485.1. EU327892 Genomic DNA. Translation: ABY50504.1. FR799007 Genomic DNA. Translation: CAM42970.1.
RefSeq	XP_001567530.1. XM_001567480.1.
3D structure databases
ProteinModelPortal	Q2V6T4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5418456.
KEGG	lbz:LbrM32_V2.1750.
Organism-specific databases
EuPathDB	EupathDB:LbrM.32.1750.
Phylogenomic databases
HOGENOM	HBG590632.
OMA	KVISARI.
PhylomeDB	Q2V6T4.
ProtClustDB	CLSZ2437568.
Family and domain databases
InterPro	IPR011051. Cupin_RmlC_type. IPR001250. Man6P_Isoase-1. IPR016305. Mannose-6-P_Isomerase. IPR018050. Pmannose_isomerase-type1_CS. IPR014710. RmlC-like_jellyroll. [Graphical view]
Gene3D	G3DSA:2.60.120.10. RmlC-like_jellyroll. 2 hits.
KO	K01809.
PANTHER	PTHR10309. PTHR10309. 1 hit.
Pfam	PF01238. PMI_typeI. 1 hit. [Graphical view]
PIRSF	PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTS	PR00714. MAN6PISMRASE.
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMs	TIGR00218. ManA. 1 hit.
PROSITE	PS00965. PMI_I_1. 1 hit. PS00966. PMI_I_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2V6T4_LEIBR

Accession

Primary (citable) accession number: Q2V6T4

Entry history

Integrated into UniProtKB/TrEMBL:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)