Q2V465 (SCP11_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine carboxypeptidase-like 11
EC=3.4.16.-

Gene names

Name:	SCPL11
Ordered Locus Names:	At2g22970
ORF Names:	F21P24.3, T20K9.19

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable carboxypeptidase By similarity.
Subcellular location	Secreted Potential.
Tissue specificity	Ubiquitous. Ref.4
Sequence similarities	Belongs to the peptidase S10 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Carboxypeptidase Hydrolase Protease
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type carboxypeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q2V465-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q2V465-2)

The sequence of this isoform differs from the canonical sequence as follows:
     314-320: RSIGKWE → VYAINNV
     321-433: Missing.

Note: Derived from EST data. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 433	412	Serine carboxypeptidase-like 11		PRO_0000274625
Sites
	Active site	176	1	By similarity
	Active site	358	1	By similarity
	Active site	411	1	By similarity
Amino acid modifications
	Glycosylation	101	1	N-linked (GlcNAc...) Potential
	Glycosylation	342	1	N-linked (GlcNAc...) Potential
	Glycosylation	374	1	N-linked (GlcNAc...) Potential
	Disulfide bond	80 ↔ 322		By similarity
	Disulfide bond	243 ↔ 257		By similarity
	Disulfide bond	281 ↔ 288		By similarity
Natural variations
	Alternative sequence	314 – 320	7	RSIGKWE → VYAINNV in isoform 2.		VSP_022845
	Alternative sequence	321 – 433	113	Missing in isoform 2.		VSP_022846

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 6, 2007. Version 2. Checksum: 729A21EEC080D6D4	FASTA	433	49,233
	10 20 30 40 50 60 MELTLKLLVL LLFILNHHVG SGSIVKFLPG FEGPLPFELE TGYIGIGEEE EVQLFYYFIK 70 80 90 100 110 120 SERNPKEDPL LLWLSGGPGC SSITGLLFQN GPLALKSEVY NGSVPSLVST TYSWTKTANI 130 140 150 160 170 180 IFLDQPVGAG FSYSRAPLID TPTDTGEVKR IHEFLQKWLS KHPQFSSNHF YAGGDSYSGM 190 200 210 220 230 240 IVPALVQEIS KGNYICCNPP INLKGYVLGN PITHEDDPNY RIPFSHGMAL ISDELYESIR 250 260 270 280 290 300 EACKGNYFNV DPRNTKCLKL VEEFHKCTDK LNEFHILSPD CDTASPDCYL YPFYLISFWA 310 320 330 340 350 360 NDESVRDALH VNKRSIGKWE RCNYLSKPYN KDIKSSVPYH MNNSVSGYRS LIYSGDHDLV 370 380 390 400 410 420 VPFLATQAWI KSLNYSIIDE WRPWMIRDQI TGYTRTYSNK MTFATVKGSG HTAENKPQES 430 FIMFRRWING QPL
	Isoform 2 [UniParc]. Checksum: AEC4FFBF406ABF26	FASTA	320	35,938
	10 20 30 40 50 60 MELTLKLLVL LLFILNHHVG SGSIVKFLPG FEGPLPFELE TGYIGIGEEE EVQLFYYFIK 70 80 90 100 110 120 SERNPKEDPL LLWLSGGPGC SSITGLLFQN GPLALKSEVY NGSVPSLVST TYSWTKTANI 130 140 150 160 170 180 IFLDQPVGAG FSYSRAPLID TPTDTGEVKR IHEFLQKWLS KHPQFSSNHF YAGGDSYSGM 190 200 210 220 230 240 IVPALVQEIS KGNYICCNPP INLKGYVLGN PITHEDDPNY RIPFSHGMAL ISDELYESIR 250 260 270 280 290 300 EACKGNYFNV DPRNTKCLKL VEEFHKCTDK LNEFHILSPD CDTASPDCYL YPFYLISFWA 310 320 NDESVRDALH VNKVYAINNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: cv. Columbia.
[4]	"An expression and bioinformatics analysis of the Arabidopsis serine carboxypeptidase-like gene family." Fraser C.M., Rider L.W., Chapple C. Plant Physiol. 138:1136-1148(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, TISSUE SPECIFICITY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC004401 Genomic DNA. Translation: AAC17814.1. AC004786 Genomic DNA. Translation: AAM15007.1. CP002685 Genomic DNA. Translation: AEC07382.1. CP002685 Genomic DNA. Translation: AEC07383.1. AY039596 mRNA. Translation: AAK62651.1. AY113074 mRNA. Translation: AAM47382.1. BT000747 mRNA. Translation: AAN31888.1.
IPI	IPI00546834. IPI00656619.
PIR	A84619.
RefSeq	NP_001031401.1. NM_001036324.1. NP_179880.1. NM_127862.3.
UniGene	At.12556.
3D structure databases
ProteinModelPortal	Q2V465.
SMR	Q2V465. Positions 25-432.
ModBase	Search...
Protein family/group databases
MEROPS	S10.A08.
Proteomic databases
PaxDb	Q2V465.
PRIDE	Q2V465.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT2G22970.1; AT2G22970.1; AT2G22970.
GeneID	816828.
KEGG	ath:AT2G22970.
Organism-specific databases
TAIR	At2g22970.
Phylogenomic databases
eggNOG	COG2939.
HOGENOM	HOG000198297.
InParanoid	Q2V465.
KO	K16296.
PhylomeDB	Q2V465.
ProtClustDB	CLSN2683870.
Gene expression databases
ArrayExpress	Q2V465.
Genevestigator	Q2V465.
Family and domain databases
InterPro	IPR001563. Peptidase_S10. [Graphical view]
PANTHER	PTHR11802. PTHR11802. 1 hit.
Pfam	PF00450. Peptidase_S10. 1 hit. [Graphical view]
PRINTS	PR00724. CRBOXYPTASEC.
PROSITE	PS00560. CARBOXYPEPT_SER_HIS. False negative. PS00131. CARBOXYPEPT_SER_SER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SCP11_ARATH

Accession

Primary (citable) accession number: Q2V465
Secondary accession number(s): O64807

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program