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Protein

Zinc finger transcription factor YY1

Gene

YY1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri79 – 103C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri108 – 132C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri138 – 162C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri168 – 193C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri230 – 255C2H2-type 5PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • abscisic acid-activated signaling pathway Source: UniProtKB-KW
  • defense response Source: UniProtKB-KW
  • negative regulation of abscisic acid-activated signaling pathway Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: TAIR
  • positive regulation of transcription, DNA-templated Source: TAIR
  • regulation of defense response to fungus Source: UniProtKB
  • regulation of response to salt stress Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • response to abscisic acid Source: UniProtKB
  • response to absence of light Source: UniProtKB
  • response to light stimulus Source: UniProtKB
  • response to osmotic stress Source: UniProtKB
  • response to salt stress Source: UniProtKB
  • response to water deprivation Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processAbscisic acid signaling pathway, Plant defense, Stress response, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger transcription factor YY11 Publication
Alternative name(s):
Protein YIN YANG 11 Publication
Short name:
AtYY11 Publication
Gene namesi
Name:YY11 Publication
Ordered Locus Names:At4g06634Imported
ORF Names:F8H12Curated
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G06634.
TAIRilocus:1005716361. AT4G06634.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Deregulated expression of glutaredoxins GRX480, GRXS13 and thioredoxin TRX-h5 leading to enhanced susceptibility to fungal infection (e.g. B.cinerea) (PubMed:24451981). Increased sensitivity to abscisic acid (ABA), drought, and salt (NaCl) stress. Reduced induction of ABR1, but reduced repression of RD29A, RD29B, and COR15A in response to abiotic stresses (PubMed:26961720).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003059421 – 387Zinc finger transcription factor YY1Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2V3L3.

PTM databases

iPTMnetiQ2V3L3.

Expressioni

Tissue specificityi

Mostly expressed in flowers, to a lower extent in seedlings, stems and leaves, and, at low levels, in roots and senescent leaves.1 Publication

Developmental stagei

Rapidly induced following seed germination, especially in tender cotyledons.1 Publication

Inductioni

Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light.1 Publication

Gene expression databases

ExpressionAtlasiQ2V3L3. baseline and differential.

Interactioni

Subunit structurei

Interacts with MED18 to suppress disease susceptibility via the repression of genes glutaredoxins GRX480, GRXS13 and thioredoxin TRX-h5.1 Publication

Protein-protein interaction databases

BioGridi11401. 2 interactors.
STRINGi3702.AT4G06634.1.

Structurei

3D structure databases

ProteinModelPortaliQ2V3L3.
SMRiQ2V3L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 290MED18-binding1 PublicationAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili339 – 367Sequence analysisAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi319 – 326Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi341 – 386Glu-richPROSITE-ProRule annotationAdd BLAST46

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri79 – 103C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri108 – 132C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri138 – 162C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri168 – 193C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri230 – 255C2H2-type 5PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000241156.
InParanoidiQ2V3L3.
OMAiLHFKTQH.
OrthoDBiEOG09360F4W.
PhylomeDBiQ2V3L3.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 5 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2V3L3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDHQNYQYQN PFERRPILKS KAPAVKWIKE WVPQDIVATG GKCHLHKWVT
60 70 80 90 100
EDTFSRLKEK EKEPDVPEPE PEPTTEILFL CSYDGCGKTF FDVSALRKHS
110 120 130 140 150
HIHGERQYVC DQEGCGKKFL DSSKLKRHYL IHTGERNYIC TYEGCGKAFS
160 170 180 190 200
LDFNLRSHMK THSQENYHIC PYSGCVKRYA HEYKLKNHVA AYHEKNGGGE
210 220 230 240 250
TPKYTPPAEK VLRTVKTPAT VCGPSSDRPY ACPYEGCEKA YIHEYKLKLH
260 270 280 290 300
LKREHPGHLQ EENADTPTLN KHNGNDRNEI DDGSDQDVYR KHASNGKGQT
310 320 330 340 350
HKQQSRAKPN MRTPPAKVGK KGSTSSPAKA RIAKKPWQAK ETFEEVEREE
360 370 380
EEDSEETEED RDNVEDGWRF GENNEDDDDD EETEYED
Note: Derived from EST data. No experimental confirmation available.
Length:387
Mass (Da):44,703
Last modified:January 10, 2006 - v1
Checksum:i070C11CC3A1A97E3
GO
Isoform 2 (identifier: Q2V3L3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     39-50: TGGKCHLHKWVT → MLNCIIVLLLLP

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:349
Mass (Da):40,084
Checksum:i8E2BAD9E3896FE94
GO

Sequence cautioni

The sequence BAB83613 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0283871 – 38Missing in isoform 2. CuratedAdd BLAST38
Alternative sequenceiVSP_02838839 – 50TGGKC…HKWVT → MLNCIIVLLLLP in isoform 2. CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073162 Genomic DNA. Translation: BAB83613.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE82553.1.
CP002687 Genomic DNA. Translation: AEE82554.1.
RefSeqiNP_001031589.1. NM_001036512.2. [Q2V3L3-2]
NP_849323.1. NM_178992.4. [Q2V3L3-1]
UniGeneiAt.47264.

Genome annotation databases

EnsemblPlantsiAT4G06634.1; AT4G06634.1; AT4G06634. [Q2V3L3-1]
GeneIDi826093.
GrameneiAT4G06634.1; AT4G06634.1; AT4G06634. [Q2V3L3-1]
KEGGiath:AT4G06634.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiYY1_ARATH
AccessioniPrimary (citable) accession number: Q2V3L3
Secondary accession number(s): Q27GJ7, Q8W3M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 10, 2006
Last modified: July 5, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names