Q2V2M9 (FHOD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FH1/FH2 domain-containing protein 3

Alternative name(s):
Formactin-2
Formin homolog overexpressed in spleen 2
Short name=hFHOS2

Gene names

Name:	FHOD3
Synonyms:	FHOS2, KIAA1695

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1422 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Actin-organizing protein that may cause stress fiber formation together with cell elongation By similarity. Isoform 4 may play a role in actin filament polymerization in cardiomyocytes. Ref.2
Subunit structure	Interacts with nestin/NES-based interfilament (IF) By similarity. Interacts with SQSTM1; isoform 4 threonine phosphorylation disrupts SQSTM1-binding. Ref.2
Subcellular location	Cytoplasm › cytoskeleton. Note: Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining By similarity. Ref.2 Isoform 4: Cytoplasm › myofibril › sarcomere › Z line. Note: Threonine phosphorylation in isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes. Ref.2
Tissue specificity	Expressed in the heart, kidney and brain. May be down-regulated in various types of heart diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated cardiomyopathies, as well as ischemic heart disease (at protein level). Ref.1 Ref.2
Domain	The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments By similarity.
Sequence similarities	Belongs to the formin homology family. Contains 1 DAD (diaphanous autoregulatory) domain. Contains 1 FH1 (formin homology 1) domain. Contains 1 FH2 (formin homology 2) domain. Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Sequence caution	The sequence BAB15292.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB15463.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of actin filament polymerization Inferred from electronic annotation. Source: Compara sarcomere organization Inferred from electronic annotation. Source: Compara
Cellular_component	Z disc Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from direct assay. Source: HPA cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell nucleolus Inferred from direct assay. Source: HPA
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SQSTM1	Q13501	6	EBI-6395541,EBI-307104

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q2V2M9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q2V2M9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     400-437: Missing.
     481-481: F → FSRDYLDKREEQRQAREE

Isoform 3 (identifier: Q2V2M9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     481-481: F → FSRDYLDKREEQRQAREE

Note: Prediction based on ESTs. No experimental confirmation available.

Isoform 4 (identifier: Q2V2M9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     399-399: K → KEEEEEEEQP...YHFRSFSSNR
     481-481: F → FSRDYLDKREEQRQAREE
     1282-1283: TD → TDTDEEEEVE

Note: Phosphorylated at Thr-1474 and Thr-1476 by CK2.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1422	1422	FH1/FH2 domain-containing protein 3		PRO_0000283791
Regions
	Domain	18 – 411	394	GBD/FH3
	Domain	827 – 858	32	FH1
	Domain	883 – 1279	397	FH2
	Domain	1359 – 1391	33	DAD
	Coiled coil	448 – 480	33	Potential
	Compositional bias	626 – 635	10	Poly-Ser
	Compositional bias	827 – 872	46	Pro-rich
	Compositional bias	889 – 892	4	Poly-Lys
Natural variations
	Alternative sequence	399	1	K → KEEEEEEEQPITEPSSEEER EDDASCQGKDSKVGAASGQS PTGRDAAPKSSALPAVSNAS SQGKPLLVGTAGGTTWHSGS SGSEATPSALLSPPASAARP SSATPGSLKVSPTIDKLPYV PHSPFHLFSYDFEDSSLSTK EKEAESQKENSSSDSFSLST YSASEPYHFRSFSSNR in isoform 4.		VSP_044682
	Alternative sequence	400 – 437	38	Missing in isoform 2.		VSP_024397
	Alternative sequence	481	1	F → FSRDYLDKREEQRQAREE in isoform 2, isoform 3 and isoform 4.		VSP_024398
	Alternative sequence	1282 – 1283	2	TD → TDTDEEEEVE in isoform 4.		VSP_044683
	Natural variant	475	1	R → W. Corresponds to variant rs9964535 [ dbSNP | Ensembl ].		VAR_055804
Experimental info
	Sequence conflict	71	1	D → G in BAC67014. Ref.1
	Sequence conflict	202	1	K → E in ADL62709. Ref.2
	Sequence conflict	432	1	E → G in ADL62709. Ref.2
	Sequence conflict	435	1	L → W in BAC67014. Ref.1
	Sequence conflict	527	1	S → G in ADL62709. Ref.2
	Sequence conflict	581	1	G → A in ADL62709. Ref.2
	Sequence conflict	647	1	S → P in ADL62709. Ref.2
	Sequence conflict	654	1	L → K in BAC87252. Ref.4
	Sequence conflict	1134	1	V → I in AAH81563. Ref.6
	Sequence conflict	1417	1	T → A in BAB15463. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 13, 2010. Version 2. Checksum: 7CE7A8C0054856BE	FASTA	1,422	158,613
	10 20 30 40 50 60 MATLACRVQF LDDTDPFNST NFPEPSRPPL FTFREDLALG TQLAGVHRLL QAPHKLDDCT 70 80 90 100 110 120 LQLSHNGAYL DLEATLAEQR DELEGFQDDA GRGKKHSIIL RTQLSVRVHA CIEKLYNSSG 130 140 150 160 170 180 RDLRRALFSL KQIFQDDKDL VHEFVVAEGL TCLIKVGAEA DQNYQNYILR ALGQIMLYVD 190 200 210 220 230 240 GMNGVINRNE TIQWLYTLIG SKFRLVVKTA LKLLLVFVEY SESNAPLLIQ AVTAVDTKRG 250 260 270 280 290 300 VKPWSNIMEI LEEKDGVDTE LLVYAMTLVN KTLSGLPDQD TFYDVVDCLE ELGIAAVSQR 310 320 330 340 350 360 HLNKKGTDLD LVEQLNIYEV ALRHEDGDET TEPPPSGCRD RRRASVCSSG GGEHRGLDRR 370 380 390 400 410 420 RSRRHSVQSI KSTLSAPTSP CSQSAPSFKP NQVRDLREKY SNFGNNSYHS SRPSSGSSVP 430 440 450 460 470 480 TTPTSSVSPP QEARLERSSP SGLLTSSFRQ HQESLAAERE RRRQEREERL QRIEREERNK 490 500 510 520 530 540 FRYKYLEQLA AEEHEKELRS RSVSRGRADL SLDLTSPAAP ACLAPLSHSP SSSDSQEALT 550 560 570 580 590 600 VSASSPGTPH HPQASAGDPE PESEAEPEAE AGAGQVADEA GQDIASAHEG AETEVEQALE 610 620 630 640 650 660 QEPEERASLS EKERQNEGVN ERDNCSASSV SSSSSTLERE EKEDKLSRDR TTGLWPAGVQ 670 680 690 700 710 720 DAGVNGQCGD ILTNKRFMLD MLYAHNRKSP DDEEKGDGEA GRTQQEAEAV ASLATRISTL 730 740 750 760 770 780 QANSQTQDES VRRVDVGCLD NRGSVKAFAE KFNSGDLGRG SISPDAEPND KVPETAPVQP 790 800 810 820 830 840 KTESDYIWDQ LMANPRELRI QDMDFTDLGE EDDIDVLDVD LGHREAPGPP PPPPPTFLGL 850 860 870 880 890 900 PPPPPPPLLD SIPPPPVPGN LLVPPPPVFN APQGLGWSQV PRGQPTFTKK KKTIRLFWNE 910 920 930 940 950 960 VRPFDWPCKN NRRCREFLWS KLEPIKVDTS RLEHLFESKS KELSVSKKTA ADGKRQEIIV 970 980 990 1000 1010 1020 LDSKRSNAIN IGLTVLPPPR TIKIAILNFD EYALNKEGIE KILTMIPTDE EKQKIQEAQL 1030 1040 1050 1060 1070 1080 ANPEIPLGSA EQFLLTLSSI SELSARLHLW AFKMDYETTE KEVAEPLLDL KEGIDQLENN 1090 1100 1110 1120 1130 1140 KTLGFILSTL LAIGNFLNGT NAKAFELSYL EKVPEVKDTV HKQSLLHHVC TMVVENFPDS 1150 1160 1170 1180 1190 1200 SDLYSEIGAI TRSAKVDFDQ LQDNLCQMER RCKASWDHLK AIAKHEMKPV LKQRMSEFLK 1210 1220 1230 1240 1250 1260 DCAERIIILK IVHRRIINRF HSFLLFMGHP PYAIREVNIN KFCRIISEFA LEYRTTRERV 1270 1280 1290 1300 1310 1320 LQQKQKRANH RERNKTRGKM ITDSGKFSGS SPAPPSQPQG LSYAEDAAEH ENMKAVLKTS 1330 1340 1350 1360 1370 1380 SPSVEDATPA LGVRTRSRAS RGSTSSWTMG TDDSPNVTDD AADEIMDRIV KSATQVPSQR 1390 1400 1410 1420 VVPRERKRSR ANRKSLRRTL KSGLTPEEAR ALGLVGTSEL QL
	Isoform 2 [UniParc]. Checksum: F2B9F0473D7D3BC6	FASTA	1,401	156,752
	10 20 30 40 50 60 MATLACRVQF LDDTDPFNST NFPEPSRPPL FTFREDLALG TQLAGVHRLL QAPHKLDDCT 70 80 90 100 110 120 LQLSHNGAYL DLEATLAEQR DELEGFQDDA GRGKKHSIIL RTQLSVRVHA CIEKLYNSSG 130 140 150 160 170 180 RDLRRALFSL KQIFQDDKDL VHEFVVAEGL TCLIKVGAEA DQNYQNYILR ALGQIMLYVD 190 200 210 220 230 240 GMNGVINRNE TIQWLYTLIG SKFRLVVKTA LKLLLVFVEY SESNAPLLIQ AVTAVDTKRG 250 260 270 280 290 300 VKPWSNIMEI LEEKDGVDTE LLVYAMTLVN KTLSGLPDQD TFYDVVDCLE ELGIAAVSQR 310 320 330 340 350 360 HLNKKGTDLD LVEQLNIYEV ALRHEDGDET TEPPPSGCRD RRRASVCSSG GGEHRGLDRR 370 380 390 400 410 420 RSRRHSVQSI KSTLSAPTSP CSQSAPSFKP NQVRDLREKS SPSGLLTSSF RQHQESLAAE 430 440 450 460 470 480 RERRRQEREE RLQRIEREER NKFSRDYLDK REEQRQAREE RYKYLEQLAA EEHEKELRSR 490 500 510 520 530 540 SVSRGRADLS LDLTSPAAPA CLAPLSHSPS SSDSQEALTV SASSPGTPHH PQASAGDPEP 550 560 570 580 590 600 ESEAEPEAEA GAGQVADEAG QDIASAHEGA ETEVEQALEQ EPEERASLSE KERQNEGVNE 610 620 630 640 650 660 RDNCSASSVS SSSSTLEREE KEDKLSRDRT TGLWPAGVQD AGVNGQCGDI LTNKRFMLDM 670 680 690 700 710 720 LYAHNRKSPD DEEKGDGEAG RTQQEAEAVA SLATRISTLQ ANSQTQDESV RRVDVGCLDN 730 740 750 760 770 780 RGSVKAFAEK FNSGDLGRGS ISPDAEPNDK VPETAPVQPK TESDYIWDQL MANPRELRIQ 790 800 810 820 830 840 DMDFTDLGEE DDIDVLDVDL GHREAPGPPP PPPPTFLGLP PPPPPPLLDS IPPPPVPGNL 850 860 870 880 890 900 LVPPPPVFNA PQGLGWSQVP RGQPTFTKKK KTIRLFWNEV RPFDWPCKNN RRCREFLWSK 910 920 930 940 950 960 LEPIKVDTSR LEHLFESKSK ELSVSKKTAA DGKRQEIIVL DSKRSNAINI GLTVLPPPRT 970 980 990 1000 1010 1020 IKIAILNFDE YALNKEGIEK ILTMIPTDEE KQKIQEAQLA NPEIPLGSAE QFLLTLSSIS 1030 1040 1050 1060 1070 1080 ELSARLHLWA FKMDYETTEK EVAEPLLDLK EGIDQLENNK TLGFILSTLL AIGNFLNGTN 1090 1100 1110 1120 1130 1140 AKAFELSYLE KVPEVKDTVH KQSLLHHVCT MVVENFPDSS DLYSEIGAIT RSAKVDFDQL 1150 1160 1170 1180 1190 1200 QDNLCQMERR CKASWDHLKA IAKHEMKPVL KQRMSEFLKD CAERIIILKI VHRRIINRFH 1210 1220 1230 1240 1250 1260 SFLLFMGHPP YAIREVNINK FCRIISEFAL EYRTTRERVL QQKQKRANHR ERNKTRGKMI 1270 1280 1290 1300 1310 1320 TDSGKFSGSS PAPPSQPQGL SYAEDAAEHE NMKAVLKTSS PSVEDATPAL GVRTRSRASR 1330 1340 1350 1360 1370 1380 GSTSSWTMGT DDSPNVTDDA ADEIMDRIVK SATQVPSQRV VPRERKRSRA NRKSLRRTLK 1390 1400 SGLTPEEARA LGLVGTSELQ L
	Isoform 3 [UniParc]. Checksum: 72C7122A8348E1A9	FASTA	1,439	160,804
	10 20 30 40 50 60 MATLACRVQF LDDTDPFNST NFPEPSRPPL FTFREDLALG TQLAGVHRLL QAPHKLDDCT 70 80 90 100 110 120 LQLSHNGAYL DLEATLAEQR DELEGFQDDA GRGKKHSIIL RTQLSVRVHA CIEKLYNSSG 130 140 150 160 170 180 RDLRRALFSL KQIFQDDKDL VHEFVVAEGL TCLIKVGAEA DQNYQNYILR ALGQIMLYVD 190 200 210 220 230 240 GMNGVINRNE TIQWLYTLIG SKFRLVVKTA LKLLLVFVEY SESNAPLLIQ AVTAVDTKRG 250 260 270 280 290 300 VKPWSNIMEI LEEKDGVDTE LLVYAMTLVN KTLSGLPDQD TFYDVVDCLE ELGIAAVSQR 310 320 330 340 350 360 HLNKKGTDLD LVEQLNIYEV ALRHEDGDET TEPPPSGCRD RRRASVCSSG GGEHRGLDRR 370 380 390 400 410 420 RSRRHSVQSI KSTLSAPTSP CSQSAPSFKP NQVRDLREKY SNFGNNSYHS SRPSSGSSVP 430 440 450 460 470 480 TTPTSSVSPP QEARLERSSP SGLLTSSFRQ HQESLAAERE RRRQEREERL QRIEREERNK 490 500 510 520 530 540 FSRDYLDKRE EQRQAREERY KYLEQLAAEE HEKELRSRSV SRGRADLSLD LTSPAAPACL 550 560 570 580 590 600 APLSHSPSSS DSQEALTVSA SSPGTPHHPQ ASAGDPEPES EAEPEAEAGA GQVADEAGQD 610 620 630 640 650 660 IASAHEGAET EVEQALEQEP EERASLSEKE RQNEGVNERD NCSASSVSSS SSTLEREEKE 670 680 690 700 710 720 DKLSRDRTTG LWPAGVQDAG VNGQCGDILT NKRFMLDMLY AHNRKSPDDE EKGDGEAGRT 730 740 750 760 770 780 QQEAEAVASL ATRISTLQAN SQTQDESVRR VDVGCLDNRG SVKAFAEKFN SGDLGRGSIS 790 800 810 820 830 840 PDAEPNDKVP ETAPVQPKTE SDYIWDQLMA NPRELRIQDM DFTDLGEEDD IDVLDVDLGH 850 860 870 880 890 900 REAPGPPPPP PPTFLGLPPP PPPPLLDSIP PPPVPGNLLV PPPPVFNAPQ GLGWSQVPRG 910 920 930 940 950 960 QPTFTKKKKT IRLFWNEVRP FDWPCKNNRR CREFLWSKLE PIKVDTSRLE HLFESKSKEL 970 980 990 1000 1010 1020 SVSKKTAADG KRQEIIVLDS KRSNAINIGL TVLPPPRTIK IAILNFDEYA LNKEGIEKIL 1030 1040 1050 1060 1070 1080 TMIPTDEEKQ KIQEAQLANP EIPLGSAEQF LLTLSSISEL SARLHLWAFK MDYETTEKEV 1090 1100 1110 1120 1130 1140 AEPLLDLKEG IDQLENNKTL GFILSTLLAI GNFLNGTNAK AFELSYLEKV PEVKDTVHKQ 1150 1160 1170 1180 1190 1200 SLLHHVCTMV VENFPDSSDL YSEIGAITRS AKVDFDQLQD NLCQMERRCK ASWDHLKAIA 1210 1220 1230 1240 1250 1260 KHEMKPVLKQ RMSEFLKDCA ERIIILKIVH RRIINRFHSF LLFMGHPPYA IREVNINKFC 1270 1280 1290 1300 1310 1320 RIISEFALEY RTTRERVLQQ KQKRANHRER NKTRGKMITD SGKFSGSSPA PPSQPQGLSY 1330 1340 1350 1360 1370 1380 AEDAAEHENM KAVLKTSSPS VEDATPALGV RTRSRASRGS TSSWTMGTDD SPNVTDDAAD 1390 1400 1410 1420 1430 EIMDRIVKSA TQVPSQRVVP RERKRSRANR KSLRRTLKSG LTPEEARALG LVGTSELQL
	Isoform 4 [UniParc]. Checksum: EFCFEA5D7FF75299	FASTA	1,622	180,080
	10 20 30 40 50 60 MATLACRVQF LDDTDPFNST NFPEPSRPPL FTFREDLALG TQLAGVHRLL QAPHKLDDCT 70 80 90 100 110 120 LQLSHNGAYL DLEATLAEQR DELEGFQDDA GRGKKHSIIL RTQLSVRVHA CIEKLYNSSG 130 140 150 160 170 180 RDLRRALFSL KQIFQDDKDL VHEFVVAEGL TCLIKVGAEA DQNYQNYILR ALGQIMLYVD 190 200 210 220 230 240 GMNGVINRNE TIQWLYTLIG SKFRLVVKTA LKLLLVFVEY SESNAPLLIQ AVTAVDTKRG 250 260 270 280 290 300 VKPWSNIMEI LEEKDGVDTE LLVYAMTLVN KTLSGLPDQD TFYDVVDCLE ELGIAAVSQR 310 320 330 340 350 360 HLNKKGTDLD LVEQLNIYEV ALRHEDGDET TEPPPSGCRD RRRASVCSSG GGEHRGLDRR 370 380 390 400 410 420 RSRRHSVQSI KSTLSAPTSP CSQSAPSFKP NQVRDLREKE EEEEEEQPIT EPSSEEERED 430 440 450 460 470 480 DASCQGKDSK VGAASGQSPT GRDAAPKSSA LPAVSNASSQ GKPLLVGTAG GTTWHSGSSG 490 500 510 520 530 540 SEATPSALLS PPASAARPSS ATPGSLKVSP TIDKLPYVPH SPFHLFSYDF EDSSLSTKEK 550 560 570 580 590 600 EAESQKENSS SDSFSLSTYS ASEPYHFRSF SSNRYSNFGN NSYHSSRPSS GSSVPTTPTS 610 620 630 640 650 660 SVSPPQEARL ERSSPSGLLT SSFRQHQESL AAERERRRQE REERLQRIER EERNKFSRDY 670 680 690 700 710 720 LDKREEQRQA REERYKYLEQ LAAEEHEKEL RSRSVSRGRA DLSLDLTSPA APACLAPLSH 730 740 750 760 770 780 SPSSSDSQEA LTVSASSPGT PHHPQASAGD PEPESEAEPE AEAGAGQVAD EAGQDIASAH 790 800 810 820 830 840 EGAETEVEQA LEQEPEERAS LSEKERQNEG VNERDNCSAS SVSSSSSTLE REEKEDKLSR 850 860 870 880 890 900 DRTTGLWPAG VQDAGVNGQC GDILTNKRFM LDMLYAHNRK SPDDEEKGDG EAGRTQQEAE 910 920 930 940 950 960 AVASLATRIS TLQANSQTQD ESVRRVDVGC LDNRGSVKAF AEKFNSGDLG RGSISPDAEP 970 980 990 1000 1010 1020 NDKVPETAPV QPKTESDYIW DQLMANPREL RIQDMDFTDL GEEDDIDVLD VDLGHREAPG 1030 1040 1050 1060 1070 1080 PPPPPPPTFL GLPPPPPPPL LDSIPPPPVP GNLLVPPPPV FNAPQGLGWS QVPRGQPTFT 1090 1100 1110 1120 1130 1140 KKKKTIRLFW NEVRPFDWPC KNNRRCREFL WSKLEPIKVD TSRLEHLFES KSKELSVSKK 1150 1160 1170 1180 1190 1200 TAADGKRQEI IVLDSKRSNA INIGLTVLPP PRTIKIAILN FDEYALNKEG IEKILTMIPT 1210 1220 1230 1240 1250 1260 DEEKQKIQEA QLANPEIPLG SAEQFLLTLS SISELSARLH LWAFKMDYET TEKEVAEPLL 1270 1280 1290 1300 1310 1320 DLKEGIDQLE NNKTLGFILS TLLAIGNFLN GTNAKAFELS YLEKVPEVKD TVHKQSLLHH 1330 1340 1350 1360 1370 1380 VCTMVVENFP DSSDLYSEIG AITRSAKVDF DQLQDNLCQM ERRCKASWDH LKAIAKHEMK 1390 1400 1410 1420 1430 1440 PVLKQRMSEF LKDCAERIII LKIVHRRIIN RFHSFLLFMG HPPYAIREVN INKFCRIISE 1450 1460 1470 1480 1490 1500 FALEYRTTRE RVLQQKQKRA NHRERNKTRG KMITDTDEEE EVESGKFSGS SPAPPSQPQG 1510 1520 1530 1540 1550 1560 LSYAEDAAEH ENMKAVLKTS SPSVEDATPA LGVRTRSRAS RGSTSSWTMG TDDSPNVTDD 1570 1580 1590 1600 1610 1620 AADEIMDRIV KSATQVPSQR VVPRERKRSR ANRKSLRRTL KSGLTPEEAR ALGLVGTSEL QL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament." Kanaya H., Takeya R., Takeuchi K., Watanabe N., Jing N., Sumimoto H. Genes Cells 10:665-678(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance." Iskratsch T., Lange S., Dwyer J., Kho A.L., dos Remedios C., Ehler E. J. Cell Biol. 191:1159-1172(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, INTERACTION WITH SQSTM1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-654 AND 906-1422 (ISOFORM 1). Tissue: Small intestine and Testis.
[5]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-1422 (ISOFORM 2). Tissue: Brain.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 895-1422. Tissue: Brain and PNS.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1009-1422. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB084087 mRNA. Translation: BAC67014.1. HM191478 mRNA. Translation: ADL62709.1. AC023043 Genomic DNA. No translation available. AC055840 Genomic DNA. No translation available. AC090333 Genomic DNA. No translation available. AC131053 Genomic DNA. No translation available. AK025950 mRNA. Translation: BAB15292.1. Different initiation. AK026370 mRNA. Translation: BAB15463.1. Different initiation. AK128053 mRNA. Translation: BAC87252.1. AB051482 mRNA. Translation: BAB21786.1. BC050670 mRNA. Translation: AAH50670.1. BC081563 mRNA. Translation: AAH81563.1. AL834480 mRNA. Translation: CAD39139.1.
IPI	IPI00397675. IPI00843844. IPI00939843.
RefSeq	NP_079411.2. NM_025135.2.
UniGene	Hs.630884.
3D structure databases
ProteinModelPortal	Q2V2M9.
SMR	Q2V2M9. Positions 2-327, 890-1272.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q2V2M9. 3 interactions.
STRING	9606.ENSP00000257209.
PTM databases
PhosphoSite	Q2V2M9.
Polymorphism databases
DMDM	300669639.
Proteomic databases
PaxDb	Q2V2M9.
PRIDE	Q2V2M9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000257209; ENSP00000257209; ENSG00000134775. ENST00000359247; ENSP00000352186; ENSG00000134775. ENST00000445677; ENSP00000411430; ENSG00000134775. ENST00000590592; ENSP00000466937; ENSG00000134775. ENST00000592128; ENSP00000467462; ENSG00000134775.
GeneID	80206.
KEGG	hsa:80206.
UCSC	uc002kzs.1. human. uc002kzt.1. human. uc010dmz.1. human. uc021uiv.1. human.
Organism-specific databases
CTD	80206.
GeneCards	GC18P033877.
H-InvDB	HIX0014410. HIX0174208.
HGNC	HGNC:26178. FHOD3.
HPA	HPA021827. HPA024696.
MIM	609691. gene.
neXtProt	NX_Q2V2M9.
PharmGKB	PA134929910.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG246341.
HOVERGEN	HBG051615.
OMA	PNDKVPE.
Gene expression databases
Bgee	Q2V2M9.
CleanEx	HS_FHOD3.
Genevestigator	Q2V2M9.
Family and domain databases
InterPro	IPR003104. Actin-bd_FH2/DRF_autoreg. IPR016024. ARM-type_fold. IPR014767. Diaphanous_autoregulatory. IPR015425. FH2_actin-bd. IPR014768. GTPase-bd/formin_homology_3. [Graphical view]
Pfam	PF02181. FH2. 1 hit. [Graphical view]
SMART	SM00498. FH2. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF101447. FH2_actin_bd. 1 hit.
PROSITE	PS51231. DAD. 1 hit. PS51444. FH2. 1 hit. PS51232. GBD_FH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FHOD3. human.
GenomeRNAi	80206.
NextBio	35497575.
SOURCE	Search...

Entry information

Entry name

FHOD3_HUMAN

Accession

Primary (citable) accession number: Q2V2M9
Secondary accession number(s): A8MQT4 , E5F5Q0, Q642I2, Q6ZRQ7, Q86TF9, Q8N3A5, Q9C0G8, Q9H604, Q9H6G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	July 13, 2010
Last modified:	May 29, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.