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Protein

Probable proline dehydrogenase 2

Gene

Prodh2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Converts proline to delta-1-pyrroline-5-carboxylate.Curated

Catalytic activityi

L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.

Cofactori

FADBy similarity

Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate from L-proline.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable proline dehydrogenase 2 (Prodh2)
  2. Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (Aldh4a1)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Proline metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00261; UER00373.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proline dehydrogenase 2 (EC:1.5.5.2)
Alternative name(s):
Probable proline oxidase 2
Proline oxidase-like protein
Gene namesi
Name:Prodh2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306761. Prodh2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Probable proline dehydrogenase 2PRO_0000308625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei310 – 3101N6-acetyllysineBy similarity
Modified residuei320 – 3201N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2V057.
PRIDEiQ2V057.

PTM databases

iPTMnetiQ2V057.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028392.

Structurei

3D structure databases

ProteinModelPortaliQ2V057.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the proline oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0186. Eukaryota.
COG0506. LUCA.
HOGENOMiHOG000233406.
HOVERGENiHBG108294.
InParanoidiQ2V057.
PhylomeDBiQ2V057.

Family and domain databases

Gene3Di3.20.20.220. 2 hits.
InterProiIPR029041. FAD-linked_oxidoreductase-like.
IPR002872. Proline_DH_dom.
IPR015659. Proline_oxidase.
[Graphical view]
PANTHERiPTHR13914. PTHR13914. 1 hit.
PfamiPF01619. Pro_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51730. SSF51730. 2 hits.

Sequencei

Sequence statusi: Complete.

Q2V057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIWTRLPLYG HSKPSTGGWQ PLRFDGGAFH LKRTAELARA LLVLRLCAWP
60 70 80 90 100
PLVTHGLAFQ AWSQRLLGSR LSGALLRASI YGQFVAGETA EEVRGCVQQL
110 120 130 140 150
QAIGLQPLLA VPTEEEPDSA AKTSEAWYEG NLSAMLHCVD LSRAVADAHG
160 170 180 190 200
PARNSLMQLK VTALTSPRLC KELSAWIQRP RGSSELRPER LAEAMESGRN
210 220 230 240 250
LQLSCLSTEQ NQHLQASLSR LHRVAQHARA QDVRLLVDAE YTFINPALSL
260 270 280 290 300
LVAALAMRLD SSEEEGPWVW NTYQAYLKDT HERLERDAKA AHEAGLAFGV
310 320 330 340 350
KLVRGAYLDK ERSVTQLHGK EDCTQPDYEA TSRSYSRCLE LMLRRVSNHG
360 370 380 390 400
PRCHLMVASH NEESIRQATR RMWELGIPLD GPVCFGQLLG MCDHVSLALG
410 420 430 440 450
QAGYMVYKSI PYGCLEEVIP YLIRRAQENR SVLQGARREQ ALLSQELWRR

LLGRTA
Length:456
Mass (Da):51,002
Last modified:January 24, 2006 - v1
Checksum:i03DA662B133B5857
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222852 mRNA. Translation: AAQ13908.1.
UniGeneiRn.4247.

Genome annotation databases

UCSCiRGD:1306761. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222852 mRNA. Translation: AAQ13908.1.
UniGeneiRn.4247.

3D structure databases

ProteinModelPortaliQ2V057.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028392.

PTM databases

iPTMnetiQ2V057.

Proteomic databases

PaxDbiQ2V057.
PRIDEiQ2V057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1306761. rat.

Organism-specific databases

RGDi1306761. Prodh2.

Phylogenomic databases

eggNOGiKOG0186. Eukaryota.
COG0506. LUCA.
HOGENOMiHOG000233406.
HOVERGENiHBG108294.
InParanoidiQ2V057.
PhylomeDBiQ2V057.

Enzyme and pathway databases

UniPathwayiUPA00261; UER00373.

Miscellaneous databases

PROiQ2V057.

Family and domain databases

Gene3Di3.20.20.220. 2 hits.
InterProiIPR029041. FAD-linked_oxidoreductase-like.
IPR002872. Proline_DH_dom.
IPR015659. Proline_oxidase.
[Graphical view]
PANTHERiPTHR13914. PTHR13914. 1 hit.
PfamiPF01619. Pro_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51730. SSF51730. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Yang Q., Tian Y., Wallner E.I., Kanwar Y.S.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPROD2_RAT
AccessioniPrimary (citable) accession number: Q2V057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 24, 2006
Last modified: January 20, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.