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Protein

Hydroxyproline dehydrogenase

Gene

Prodh2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.By similarity

Catalytic activityi

L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.By similarity
trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol.By similarity

Cofactori

FADBy similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processProline metabolism
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyproline dehydrogenaseBy similarity (EC:1.5.5.-By similarity)
Short name:
HYPDHBy similarity
Alternative name(s):
Probable proline dehydrogenase 2By similarity (EC:1.5.5.2By similarity)
Probable proline oxidase 2
Proline oxidase-like protein
Gene namesi
Name:Prodh2Imported
Synonyms:HypdhBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306761. Prodh2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003086251 – 456Hydroxyproline dehydrogenaseAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei310N6-acetyllysineBy similarity1
Modified residuei320N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2V057.
PRIDEiQ2V057.

PTM databases

iPTMnetiQ2V057.
PhosphoSitePlusiQ2V057.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028392.

Structurei

3D structure databases

ProteinModelPortaliQ2V057.
SMRiQ2V057.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the proline oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0186. Eukaryota.
COG0506. LUCA.
HOGENOMiHOG000233406.
HOVERGENiHBG108294.
InParanoidiQ2V057.
PhylomeDBiQ2V057.

Family and domain databases

Gene3Di3.20.20.220. 1 hit.
InterProiView protein in InterPro
IPR029041. FAD-linked_oxidoreductase-like.
IPR002872. Proline_DH_dom.
IPR015659. Proline_oxidase.
PANTHERiPTHR13914. PTHR13914. 1 hit.
PfamiView protein in Pfam
PF01619. Pro_dh. 1 hit.
SUPFAMiSSF51730. SSF51730. 2 hits.

Sequencei

Sequence statusi: Complete.

Q2V057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIWTRLPLYG HSKPSTGGWQ PLRFDGGAFH LKRTAELARA LLVLRLCAWP
60 70 80 90 100
PLVTHGLAFQ AWSQRLLGSR LSGALLRASI YGQFVAGETA EEVRGCVQQL
110 120 130 140 150
QAIGLQPLLA VPTEEEPDSA AKTSEAWYEG NLSAMLHCVD LSRAVADAHG
160 170 180 190 200
PARNSLMQLK VTALTSPRLC KELSAWIQRP RGSSELRPER LAEAMESGRN
210 220 230 240 250
LQLSCLSTEQ NQHLQASLSR LHRVAQHARA QDVRLLVDAE YTFINPALSL
260 270 280 290 300
LVAALAMRLD SSEEEGPWVW NTYQAYLKDT HERLERDAKA AHEAGLAFGV
310 320 330 340 350
KLVRGAYLDK ERSVTQLHGK EDCTQPDYEA TSRSYSRCLE LMLRRVSNHG
360 370 380 390 400
PRCHLMVASH NEESIRQATR RMWELGIPLD GPVCFGQLLG MCDHVSLALG
410 420 430 440 450
QAGYMVYKSI PYGCLEEVIP YLIRRAQENR SVLQGARREQ ALLSQELWRR

LLGRTA
Length:456
Mass (Da):51,002
Last modified:January 24, 2006 - v1
Checksum:i03DA662B133B5857
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222852 mRNA. Translation: AAQ13908.1.
UniGeneiRn.4247.

Genome annotation databases

UCSCiRGD:1306761. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222852 mRNA. Translation: AAQ13908.1.
UniGeneiRn.4247.

3D structure databases

ProteinModelPortaliQ2V057.
SMRiQ2V057.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028392.

PTM databases

iPTMnetiQ2V057.
PhosphoSitePlusiQ2V057.

Proteomic databases

PaxDbiQ2V057.
PRIDEiQ2V057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1306761. rat.

Organism-specific databases

RGDi1306761. Prodh2.

Phylogenomic databases

eggNOGiKOG0186. Eukaryota.
COG0506. LUCA.
HOGENOMiHOG000233406.
HOVERGENiHBG108294.
InParanoidiQ2V057.
PhylomeDBiQ2V057.

Miscellaneous databases

PROiPR:Q2V057.

Family and domain databases

Gene3Di3.20.20.220. 1 hit.
InterProiView protein in InterPro
IPR029041. FAD-linked_oxidoreductase-like.
IPR002872. Proline_DH_dom.
IPR015659. Proline_oxidase.
PANTHERiPTHR13914. PTHR13914. 1 hit.
PfamiView protein in Pfam
PF01619. Pro_dh. 1 hit.
SUPFAMiSSF51730. SSF51730. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiHYPDH_RAT
AccessioniPrimary (citable) accession number: Q2V057
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 24, 2006
Last modified: June 7, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.