Reviewed, UniProtKB/Swiss-Prot Q2V057 (PROD2_RAT)

Names and origin

Protein names

Recommended name:
    Probable proline dehydrogenase 2
    EC=1.5.99.8
Alternative name(s):
    Probable proline oxidase 2
    Proline oxidase-like protein

Gene names

Name:

Prodh2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts proline to delta-1-pyrroline-5-carboxylate Probable.
Catalytic activity	L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Sequence similarities	Belongs to the proline oxidase family.

Ontologies

Keywords
Biological process	Proline metabolism
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glutamate biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	proline dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Probable proline dehydrogenase 2		PRO_0000308625

Sequences

	Sequence		Length	Mass (Da)
	Q2V057-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 03DA662B133B5857	FASTA	456	51,002
	10 20 30 40 50 60 MIWTRLPLYG HSKPSTGGWQ PLRFDGGAFH LKRTAELARA LLVLRLCAWP PLVTHGLAFQ 70 80 90 100 110 120 AWSQRLLGSR LSGALLRASI YGQFVAGETA EEVRGCVQQL QAIGLQPLLA VPTEEEPDSA 130 140 150 160 170 180 AKTSEAWYEG NLSAMLHCVD LSRAVADAHG PARNSLMQLK VTALTSPRLC KELSAWIQRP 190 200 210 220 230 240 RGSSELRPER LAEAMESGRN LQLSCLSTEQ NQHLQASLSR LHRVAQHARA QDVRLLVDAE 250 260 270 280 290 300 YTFINPALSL LVAALAMRLD SSEEEGPWVW NTYQAYLKDT HERLERDAKA AHEAGLAFGV 310 320 330 340 350 360 KLVRGAYLDK ERSVTQLHGK EDCTQPDYEA TSRSYSRCLE LMLRRVSNHG PRCHLMVASH 370 380 390 400 410 420 NEESIRQATR RMWELGIPLD GPVCFGQLLG MCDHVSLALG QAGYMVYKSI PYGCLEEVIP 430 440 450 YLIRRAQENR SVLQGARREQ ALLSQELWRR LLGRTA

References

[1]	Yang Q., Tian Y., Wallner E.I., Kanwar Y.S. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222852 mRNA. Translation: AAQ13908.1.
IPI	IPI00205107.
UniGene	Rn.4247
3D structure databases
SMR	Q2V057. Positions 79-429.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000028392; ENSRNOP00000028392; ENSRNOG00000020900; Rattus norvegicus. [Genome view]
Organism-specific databases
RGD	1306761. Prodh2.
Phylogenomic databases
eggNOG	maNOG08806.
HOVERGEN	Q2V057.
InParanoid	Q2V057.
Enzyme and pathway databases
BRENDA	1.5.99.8. 248.
Gene expression databases
ArrayExpress	Q2V057.
Genevestigator	Q2V057.
Family and domain databases
InterPro	IPR002872. Proline_DH. IPR015659. Proline_oxidase. [Graphical view]
PANTHER	PTHR13914. Proline_oxidase. 1 hit.
Pfam	PF01619. Pro_dh. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROD2_RAT

Accession

Primary (citable) accession number: Q2V057

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	January 24, 2006
Last modified:	January 19, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)