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Q2UY11

- COSA1_MOUSE

UniProt

Q2UY11 - COSA1_MOUSE

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Protein

Collagen alpha-1(XXVIII) chain

Gene
Col28a1, Col28
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as a cell-binding protein.

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXVIII) chain
Gene namesi
Name:Col28a1
Synonyms:Col28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2685312. Col28a1.

Subcellular locationi

Secretedextracellular spaceextracellular matrixbasement membrane 1 Publication

GO - Cellular componenti

  1. basement membrane Source: MGI
  2. collagen trimer Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 11411121Collagen alpha-1(XXVIII) chainPRO_5000074665Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi1088 ↔ 1138 By similarity
Disulfide bondi1097 ↔ 1121 By similarity
Disulfide bondi1113 ↔ 1134 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ2UY11.

PTM databases

PhosphoSiteiQ2UY11.

Expressioni

Tissue specificityi

Expressed in skin, intestine, sternum, brain and kidney. Lower expression is also observed in heart, lung, sciatic nerve, dorsal root ganglia, peripheral nerves and calvaria of newborn mice and in intestine and brain of adult mice. Found in basement membrane surrounding a particular subset of Schwann cells in adult sciatic nerve.1 Publication

Developmental stagei

Major expression in dorsal root ganglia and peripheral nerves, with small amounts in connective tissues like calvaria and skin.1 Publication

Gene expression databases

BgeeiQ2UY11.
CleanExiMM_COL28A1.
GenevestigatoriQ2UY11.

Interactioni

Subunit structurei

Trimer or homomer. Secreted into as a 135 kDa monomer under reducing conditions and as a homotrimer under non-reducing conditions.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ2UY11.
SMRiQ2UY11. Positions 46-232, 791-1028, 1094-1139.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 227180VWFA 1Add
BLAST
Domaini243 – 30058Collagen-like 1Add
BLAST
Domaini301 – 35858Collagen-like 2Add
BLAST
Domaini501 – 54444Collagen-like 3Add
BLAST
Domaini545 – 58844Collagen-like 4Add
BLAST
Domaini733 – 76937Collagen-like 5Add
BLAST
Domaini798 – 976179VWFA 2Add
BLAST
Domaini1088 – 113851BPTI/Kunitz inhibitorAdd
BLAST

Sequence similaritiesi

Contains 2 VWFA domains.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG236064.
GeneTreeiENSGT00730000110647.
HOGENOMiHOG000085654.
HOVERGENiHBG104822.
InParanoidiQ2UY11.
OMAiQAANDMF.
OrthoDBiEOG7NSB1W.
PhylomeDBiQ2UY11.
TreeFamiTF331207.

Family and domain databases

Gene3Di3.40.50.410. 2 hits.
4.10.410.10. 1 hit.
InterProiIPR008160. Collagen.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 3 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00131. KU. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
SSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2UY11-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRRRDVAFCL LLLPAFMTQA VYGQRKKGPK PNTLARKNDF QDAICFIDVV     50
FILDSSESSK IVLFDNQKDF VDSLSEKIFQ LTPGRSLKYD IKLAALQFSS 100
SVQIDPPLSS WKDLRTFKQR VKSLNLIGQG TFSYYAISNA TRLLKREGRK 150
DGVKVALLMT DGIDHPKSPD VQSISEDARI LGISFITVGL STVVNEAKLR 200
LISGDPSNEP VLLLSDPTLV DRIQERLGVL FERKCEHKIC ECEKGEPGDP 250
GPPGTHGNPG IKGERGPKGN PGDAQKGETG ERGPVGIPGY KGDKGERGEC 300
GKPGMKGDKG PEGPYGPKGP RGIQGIGGPP GDPGPKGFQG NKGEPGPPGP 350
YGPPGAPGIG QQGVKGERGQ EGRMGAPGPI GIGEPGQPGP RGPEGAPGER 400
GLPGEGFPGP KGEKGSEGPI GPQGLQGLSI KGDKGDLGPV GPQGPAGIPG 450
IGSQGEQGIQ GPSGPPGPQG PPGQGSPGPK GEVGQMGPTG PRGPMGIGVQ 500
GPKGEPGTVG LPGQPGVPGE DGASGKKGEA GLPGTRGPEG MPGKGQPGPK 550
GDEGKKGSKG NQGQRGFPGP EGPKGEPGVM GPFGMPGASI PGPSGPKGDR 600
GGPGMPGLKG EPGLPVRGPK GAQGPRGPVG APGLKGDGYP GVAGPRGLPG 650
PPGPMGLRGV GDTGAKGEPG VRGPPGPSGP RGIGTQGPKG DTGQKGLPGP 700
PGPPGYGSQG IKGEQGPQGF PGSKGTVGLG LPGQKGEHGD RGDVGRKGEK 750
GETGEPGSPG KQGLQGPKGD LGLTKEEIIK LIIEICGCGP KCKETPLELV 800
FVIDSSESVG PENFQIIQSF VKTLADRVAL DLGTARIGII NYSHKVEKVA 850
SLKQFSSKDD FKLVVDNMQY LGEGTYTATA LQAANDMFKE ARPGVKKVAL 900
VITDGQTDSR DKKKLADVVK DANDSNVEIF VIGVVKKDDP NFEIFHKEMN 950
LIATDAEHVY QFDDFFTLQD TLKQKLSKKI CEDFDSYLIQ VFGSPSFQPE 1000
FGVSEREVSV STPKPAKEMS KSFNVSRGQN EETESYVLTE AGILAIPTPP 1050
EATNTLEPLL SSREGVETRT PNPNLLQSEK SLYKDPRCEE ALKPGECGDY 1100
VVRWYYDKQV NSCARFWFSG CNGSGNRFHS EKECRETCIK Q 1141
Length:1,141
Mass (Da):118,749
Last modified:January 24, 2006 - v1
Checksum:iA2C43C4BB7913272
GO
Isoform 2 (identifier: Q2UY11-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-699: GEPGVRGPPGPSGPRGIGTQGPKGDTGQKGLPG → VRFLKEAKILVFKKVLIDDFGKCVLFLSGTQEE
     700-1141: Missing.

Show »
Length:699
Mass (Da):71,075
Checksum:i35385C4AE8FC3DC6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei667 – 69933GEPGV…KGLPG → VRFLKEAKILVFKKVLIDDF GKCVLFLSGTQEE in isoform 2. VSP_031095Add
BLAST
Alternative sequencei700 – 1141442Missing in isoform 2. VSP_031096Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ890449 mRNA. Translation: CAI67593.1.
AJ890450 mRNA. Translation: CAI67594.1.
CCDSiCCDS39424.1. [Q2UY11-1]
RefSeqiNP_001032954.1. NM_001037865.1. [Q2UY11-1]
XP_006505094.1. XM_006505031.1. [Q2UY11-1]
XP_006505095.1. XM_006505032.1. [Q2UY11-1]
UniGeneiMm.297404.

Genome annotation databases

EnsembliENSMUST00000115537; ENSMUSP00000111199; ENSMUSG00000068794. [Q2UY11-1]
GeneIDi213945.
KEGGimmu:213945.
UCSCiuc009axi.1. mouse. [Q2UY11-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ890449 mRNA. Translation: CAI67593.1 .
AJ890450 mRNA. Translation: CAI67594.1 .
CCDSi CCDS39424.1. [Q2UY11-1 ]
RefSeqi NP_001032954.1. NM_001037865.1. [Q2UY11-1 ]
XP_006505094.1. XM_006505031.1. [Q2UY11-1 ]
XP_006505095.1. XM_006505032.1. [Q2UY11-1 ]
UniGenei Mm.297404.

3D structure databases

ProteinModelPortali Q2UY11.
SMRi Q2UY11. Positions 46-232, 791-1028, 1094-1139.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q2UY11.

Proteomic databases

PRIDEi Q2UY11.

Protocols and materials databases

DNASUi 213945.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000115537 ; ENSMUSP00000111199 ; ENSMUSG00000068794 . [Q2UY11-1 ]
GeneIDi 213945.
KEGGi mmu:213945.
UCSCi uc009axi.1. mouse. [Q2UY11-1 ]

Organism-specific databases

CTDi 340267.
MGIi MGI:2685312. Col28a1.

Phylogenomic databases

eggNOGi NOG236064.
GeneTreei ENSGT00730000110647.
HOGENOMi HOG000085654.
HOVERGENi HBG104822.
InParanoidi Q2UY11.
OMAi QAANDMF.
OrthoDBi EOG7NSB1W.
PhylomeDBi Q2UY11.
TreeFami TF331207.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

NextBioi 374132.
PROi Q2UY11.
SOURCEi Search...

Gene expression databases

Bgeei Q2UY11.
CleanExi MM_COL28A1.
Genevestigatori Q2UY11.

Family and domain databases

Gene3Di 3.40.50.410. 2 hits.
4.10.410.10. 1 hit.
InterProi IPR008160. Collagen.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01391. Collagen. 3 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view ]
SMARTi SM00131. KU. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 2 hits.
SSF57362. SSF57362. 1 hit.
PROSITEi PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain."
    Veit G., Kobbe B., Keene D.R., Paulsson M., Koch M., Wagener R.
    J. Biol. Chem. 281:3494-3504(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBUNITS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: C57BL/6J.
    Tissue: Brain and Limb.

Entry informationi

Entry nameiCOSA1_MOUSE
AccessioniPrimary (citable) accession number: Q2UY11
Secondary accession number(s): Q2UY10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi