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Q2UY11

- COSA1_MOUSE

UniProt

Q2UY11 - COSA1_MOUSE

Protein

Collagen alpha-1(XXVIII) chain

Gene

Col28a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    May act as a cell-binding protein.

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(XXVIII) chain
    Gene namesi
    Name:Col28a1
    Synonyms:Col28
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2685312. Col28a1.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrixbasement membrane 1 Publication

    GO - Cellular componenti

    1. basement membrane Source: MGI
    2. collagen trimer Source: UniProtKB-KW

    Keywords - Cellular componenti

    Basement membrane, Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 11411121Collagen alpha-1(XXVIII) chainPRO_5000074665Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi1088 ↔ 1138PROSITE-ProRule annotation
    Disulfide bondi1097 ↔ 1121PROSITE-ProRule annotation
    Disulfide bondi1113 ↔ 1134PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ2UY11.

    PTM databases

    PhosphoSiteiQ2UY11.

    Expressioni

    Tissue specificityi

    Expressed in skin, intestine, sternum, brain and kidney. Lower expression is also observed in heart, lung, sciatic nerve, dorsal root ganglia, peripheral nerves and calvaria of newborn mice and in intestine and brain of adult mice. Found in basement membrane surrounding a particular subset of Schwann cells in adult sciatic nerve.1 Publication

    Developmental stagei

    Major expression in dorsal root ganglia and peripheral nerves, with small amounts in connective tissues like calvaria and skin.1 Publication

    Gene expression databases

    BgeeiQ2UY11.
    CleanExiMM_COL28A1.
    GenevestigatoriQ2UY11.

    Interactioni

    Subunit structurei

    Trimer or homomer. Secreted into as a 135 kDa monomer under reducing conditions and as a homotrimer under non-reducing conditions.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ2UY11.
    SMRiQ2UY11. Positions 46-232, 791-1028, 1094-1139.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 227180VWFA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini243 – 30058Collagen-like 1Add
    BLAST
    Domaini301 – 35858Collagen-like 2Add
    BLAST
    Domaini501 – 54444Collagen-like 3Add
    BLAST
    Domaini545 – 58844Collagen-like 4Add
    BLAST
    Domaini733 – 76937Collagen-like 5Add
    BLAST
    Domaini798 – 976179VWFA 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1088 – 113851BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the VWA-containing collagen family.Curated
    Contains 1 BPTI/Kunitz inhibitor domain.PROSITE-ProRule annotation
    Contains 5 collagen-like domains.Curated
    Contains 2 VWFA domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG236064.
    GeneTreeiENSGT00730000110647.
    HOGENOMiHOG000085654.
    HOVERGENiHBG104822.
    InParanoidiQ2UY11.
    OMAiQAANDMF.
    OrthoDBiEOG7NSB1W.
    PhylomeDBiQ2UY11.
    TreeFamiTF331207.

    Family and domain databases

    Gene3Di3.40.50.410. 2 hits.
    4.10.410.10. 1 hit.
    InterProiIPR008160. Collagen.
    IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF01391. Collagen. 3 hits.
    PF00014. Kunitz_BPTI. 1 hit.
    PF00092. VWA. 2 hits.
    [Graphical view]
    SMARTiSM00131. KU. 1 hit.
    SM00327. VWA. 2 hits.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 2 hits.
    SSF57362. SSF57362. 1 hit.
    PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
    PS50279. BPTI_KUNITZ_2. 1 hit.
    PS50234. VWFA. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q2UY11-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRRRDVAFCL LLLPAFMTQA VYGQRKKGPK PNTLARKNDF QDAICFIDVV     50
    FILDSSESSK IVLFDNQKDF VDSLSEKIFQ LTPGRSLKYD IKLAALQFSS 100
    SVQIDPPLSS WKDLRTFKQR VKSLNLIGQG TFSYYAISNA TRLLKREGRK 150
    DGVKVALLMT DGIDHPKSPD VQSISEDARI LGISFITVGL STVVNEAKLR 200
    LISGDPSNEP VLLLSDPTLV DRIQERLGVL FERKCEHKIC ECEKGEPGDP 250
    GPPGTHGNPG IKGERGPKGN PGDAQKGETG ERGPVGIPGY KGDKGERGEC 300
    GKPGMKGDKG PEGPYGPKGP RGIQGIGGPP GDPGPKGFQG NKGEPGPPGP 350
    YGPPGAPGIG QQGVKGERGQ EGRMGAPGPI GIGEPGQPGP RGPEGAPGER 400
    GLPGEGFPGP KGEKGSEGPI GPQGLQGLSI KGDKGDLGPV GPQGPAGIPG 450
    IGSQGEQGIQ GPSGPPGPQG PPGQGSPGPK GEVGQMGPTG PRGPMGIGVQ 500
    GPKGEPGTVG LPGQPGVPGE DGASGKKGEA GLPGTRGPEG MPGKGQPGPK 550
    GDEGKKGSKG NQGQRGFPGP EGPKGEPGVM GPFGMPGASI PGPSGPKGDR 600
    GGPGMPGLKG EPGLPVRGPK GAQGPRGPVG APGLKGDGYP GVAGPRGLPG 650
    PPGPMGLRGV GDTGAKGEPG VRGPPGPSGP RGIGTQGPKG DTGQKGLPGP 700
    PGPPGYGSQG IKGEQGPQGF PGSKGTVGLG LPGQKGEHGD RGDVGRKGEK 750
    GETGEPGSPG KQGLQGPKGD LGLTKEEIIK LIIEICGCGP KCKETPLELV 800
    FVIDSSESVG PENFQIIQSF VKTLADRVAL DLGTARIGII NYSHKVEKVA 850
    SLKQFSSKDD FKLVVDNMQY LGEGTYTATA LQAANDMFKE ARPGVKKVAL 900
    VITDGQTDSR DKKKLADVVK DANDSNVEIF VIGVVKKDDP NFEIFHKEMN 950
    LIATDAEHVY QFDDFFTLQD TLKQKLSKKI CEDFDSYLIQ VFGSPSFQPE 1000
    FGVSEREVSV STPKPAKEMS KSFNVSRGQN EETESYVLTE AGILAIPTPP 1050
    EATNTLEPLL SSREGVETRT PNPNLLQSEK SLYKDPRCEE ALKPGECGDY 1100
    VVRWYYDKQV NSCARFWFSG CNGSGNRFHS EKECRETCIK Q 1141
    Length:1,141
    Mass (Da):118,749
    Last modified:January 24, 2006 - v1
    Checksum:iA2C43C4BB7913272
    GO
    Isoform 2 (identifier: Q2UY11-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         667-699: GEPGVRGPPGPSGPRGIGTQGPKGDTGQKGLPG → VRFLKEAKILVFKKVLIDDFGKCVLFLSGTQEE
         700-1141: Missing.

    Show »
    Length:699
    Mass (Da):71,075
    Checksum:i35385C4AE8FC3DC6
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei667 – 69933GEPGV…KGLPG → VRFLKEAKILVFKKVLIDDF GKCVLFLSGTQEE in isoform 2. 1 PublicationVSP_031095Add
    BLAST
    Alternative sequencei700 – 1141442Missing in isoform 2. 1 PublicationVSP_031096Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ890449 mRNA. Translation: CAI67593.1.
    AJ890450 mRNA. Translation: CAI67594.1.
    CCDSiCCDS39424.1. [Q2UY11-1]
    RefSeqiNP_001032954.1. NM_001037865.1. [Q2UY11-1]
    XP_006505094.1. XM_006505031.1. [Q2UY11-1]
    XP_006505095.1. XM_006505032.1. [Q2UY11-1]
    UniGeneiMm.297404.

    Genome annotation databases

    EnsembliENSMUST00000115537; ENSMUSP00000111199; ENSMUSG00000068794. [Q2UY11-1]
    GeneIDi213945.
    KEGGimmu:213945.
    UCSCiuc009axi.1. mouse. [Q2UY11-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ890449 mRNA. Translation: CAI67593.1 .
    AJ890450 mRNA. Translation: CAI67594.1 .
    CCDSi CCDS39424.1. [Q2UY11-1 ]
    RefSeqi NP_001032954.1. NM_001037865.1. [Q2UY11-1 ]
    XP_006505094.1. XM_006505031.1. [Q2UY11-1 ]
    XP_006505095.1. XM_006505032.1. [Q2UY11-1 ]
    UniGenei Mm.297404.

    3D structure databases

    ProteinModelPortali Q2UY11.
    SMRi Q2UY11. Positions 46-232, 791-1028, 1094-1139.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q2UY11.

    Proteomic databases

    PRIDEi Q2UY11.

    Protocols and materials databases

    DNASUi 213945.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000115537 ; ENSMUSP00000111199 ; ENSMUSG00000068794 . [Q2UY11-1 ]
    GeneIDi 213945.
    KEGGi mmu:213945.
    UCSCi uc009axi.1. mouse. [Q2UY11-1 ]

    Organism-specific databases

    CTDi 340267.
    MGIi MGI:2685312. Col28a1.

    Phylogenomic databases

    eggNOGi NOG236064.
    GeneTreei ENSGT00730000110647.
    HOGENOMi HOG000085654.
    HOVERGENi HBG104822.
    InParanoidi Q2UY11.
    OMAi QAANDMF.
    OrthoDBi EOG7NSB1W.
    PhylomeDBi Q2UY11.
    TreeFami TF331207.

    Enzyme and pathway databases

    Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.

    Miscellaneous databases

    NextBioi 374132.
    PROi Q2UY11.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q2UY11.
    CleanExi MM_COL28A1.
    Genevestigatori Q2UY11.

    Family and domain databases

    Gene3Di 3.40.50.410. 2 hits.
    4.10.410.10. 1 hit.
    InterProi IPR008160. Collagen.
    IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF01391. Collagen. 3 hits.
    PF00014. Kunitz_BPTI. 1 hit.
    PF00092. VWA. 2 hits.
    [Graphical view ]
    SMARTi SM00131. KU. 1 hit.
    SM00327. VWA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 2 hits.
    SSF57362. SSF57362. 1 hit.
    PROSITEi PS00280. BPTI_KUNITZ_1. 1 hit.
    PS50279. BPTI_KUNITZ_2. 1 hit.
    PS50234. VWFA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain."
      Veit G., Kobbe B., Keene D.R., Paulsson M., Koch M., Wagener R.
      J. Biol. Chem. 281:3494-3504(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBUNITS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: C57BL/6J.
      Tissue: Brain and Limb.

    Entry informationi

    Entry nameiCOSA1_MOUSE
    AccessioniPrimary (citable) accession number: Q2UY11
    Secondary accession number(s): Q2UY10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3