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Q2UY09

- COSA1_HUMAN

UniProt

Q2UY09 - COSA1_HUMAN

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Protein

Collagen alpha-1(XXVIII) chain

Gene

COL28A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a cell-binding protein.

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. extracellular matrix organization Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.

Protein family/group databases

MEROPSiI02.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXVIII) chain
Gene namesi
Name:COL28A1
Synonyms:COL28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:22442. COL28A1.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: UniProtKB-KW
  2. collagen trimer Source: UniProtKB-KW
  3. endoplasmic reticulum lumen Source: Reactome
  4. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485437.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 11251102Collagen alpha-1(XXVIII) chainPRO_5000074667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi1072 ↔ 1122PROSITE-ProRule annotation
Disulfide bondi1081 ↔ 1105PROSITE-ProRule annotation
Disulfide bondi1097 ↔ 1118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ2UY09.
PRIDEiQ2UY09.

PTM databases

PhosphoSiteiQ2UY09.

Expressioni

Gene expression databases

BgeeiQ2UY09.
CleanExiHS_COL28A1.
ExpressionAtlasiQ2UY09. baseline and differential.
GenevestigatoriQ2UY09.

Organism-specific databases

HPAiHPA060468.

Interactioni

Subunit structurei

Trimer or homomer. Secreted into as a 135 kDa monomer under reducing conditions and as a homotrimer under non-reducing conditions (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000382356.

Structurei

3D structure databases

ProteinModelPortaliQ2UY09.
SMRiQ2UY09. Positions 795-977, 1079-1122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 227180VWFA 1PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 27432Collagen-like 1Add
BLAST
Domaini301 – 36060Collagen-like 2Add
BLAST
Domaini383 – 40523Collagen-like 3Add
BLAST
Domaini501 – 54444Collagen-like 4Add
BLAST
Domaini545 – 58339Collagen-like 5Add
BLAST
Domaini730 – 76940Collagen-like 6Add
BLAST
Domaini798 – 980183VWFA 2PROSITE-ProRule annotationAdd
BLAST
Domaini1072 – 112251BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the VWA-containing collagen family.Curated
Contains 1 BPTI/Kunitz inhibitor domain.PROSITE-ProRule annotation
Contains 6 collagen-like domains.Curated
Contains 2 VWFA domains.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG236064.
GeneTreeiENSGT00760000119051.
HOVERGENiHBG104822.
InParanoidiQ2UY09.
OMAiQAANDMF.
OrthoDBiEOG7NSB1W.
PhylomeDBiQ2UY09.
TreeFamiTF331207.

Family and domain databases

Gene3Di3.40.50.410. 2 hits.
4.10.410.10. 1 hit.
InterProiIPR008160. Collagen.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 5 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00131. KU. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
SSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2UY09-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWNRYFVFYL LLLSAFTSQT VSGQRKKGPK SNLLARKSDV QGSICFIDIV
60 70 80 90 100
FIVDSSESSK IALFDKQKDF VDSLSDKIFQ LTPGRSLEYD IKLAALQFSS
110 120 130 140 150
SVQIDPPFSS WKDLQTFKQK VKSMNLIGQG TFSYYAISNA TRLLKREGRK
160 170 180 190 200
DGVKVVLLMT DGIDHPKNPD VQSISEDARI SGISFITIAL STVVNEAKLR
210 220 230 240 250
LISGDSSSEP TLLLSDPTLV DKIQDRLDIL FEKKCERKIC ECEKGDPGDP
260 270 280 290 300
GPPGTHGNPG IKGERGPKGN PGNAQKGEAG ERGPGGIPGY KGDKGERGEC
310 320 330 340 350
GKPGIKGDKG SPGPYGPKGP RGIQGITGPP GDPGPKGFQG NKGEPGPPGP
360 370 380 390 400
YGSPGAPGIG QQGIKGERGQ EGRPGAPGPI GVGEPGQPGP RGPEGVPGER
410 420 430 440 450
GLPGEGFPGP KGEKGSEGPT GPQGLQGLSI KGEKGDIGPV GPQGPMGIPG
460 470 480 490 500
IGSQGEQGIQ GPIGPPGPQG PAGQGLPGSK GEVGQMGPTG PRGPVGIGVQ
510 520 530 540 550
GPKGEPGSIG LPGQPGVPGE DGAAGKKGEA GLPGARGPEG PPGKGQPGPK
560 570 580 590 600
GDEGKKGSKG NQGQRGLPGP EGPKGEPGIM GPFGMPGTSI PGPPGPKGDR
610 620 630 640 650
GGPGIPGFKG EPGLSIRGPK GVQGPRGPVG APGLKGDGYP GVPGPRGLPG
660 670 680 690 700
PPGPMGLRGV GDTGAKGEPG VRGPPGPSGP RGVGTQGPKG DTGQKGLPGP
710 720 730 740 750
PGPPGYGSQG IKGEQGPQGF PGPKGTMGHG LPGQKGEHGE RGDVGKKGDK
760 770 780 790 800
GEIGEPGSPG KQGLQGPKGD LGLTKEEIIK LITEICGCGP KCKETPLELV
810 820 830 840 850
FVIDSSESVG PENFQIIKNF VKTMADRVAL DLATARIGII NYSHKVEKVA
860 870 880 890 900
NLKQFSSKDD FKLAVDNMQY LGEGTYTATA LQAANDMFED ARPGVKKVAL
910 920 930 940 950
VITDGQTDSR DKEKLTEVVK NASDTNVEIF VIGVVKKNDP NFEIFHKEMN
960 970 980 990 1000
LIATDPEHVY QFDDFFTLQD TLKQKLFQKI CEDFDSYLVQ IFGSSSPQPG
1010 1020 1030 1040 1050
FGMSGEELSE STPEPQKEIS ESLSVTRDQD EDDKAPEPTW ADDLPATTSS
1060 1070 1080 1090 1100
EATTTPRPLL STPVDGAEDP RCLEALKPGN CGEYVVRWYY DKQVNSCARF
1110 1120
WFSGCNGSGN RFNSEKECQE TCIQG
Length:1,125
Mass (Da):116,657
Last modified:February 5, 2008 - v2
Checksum:i0969733A0D1095F2
GO
Isoform 2 (identifier: Q2UY09-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-713: GEPGVRGPPG...PGYGSQGIKG → TLNTSHGLED...IPASGTRQDG
     714-1125: Missing.

Show »
Length:713
Mass (Da):72,210
Checksum:iA1EF4CE194D7C78A
GO
Isoform 3 (identifier: Q2UY09-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-334: GERGECGKPG...GITGPPGDPG → QYSREDREVE...SLTHHGTCSH
     335-1125: Missing.

Show »
Length:334
Mass (Da):36,755
Checksum:i4CA00ED002DB706A
GO

Sequence cautioni

The sequence EAL24305.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAL24306.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAL24307.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti189 – 1891A → G.2 Publications
Corresponds to variant rs7804532 [ dbSNP | Ensembl ].
VAR_038566
Natural varianti239 – 2391I → V.
Corresponds to variant rs10486180 [ dbSNP | Ensembl ].
VAR_038567
Natural varianti327 – 3271T → S.
Corresponds to variant rs10486176 [ dbSNP | Ensembl ].
VAR_038568
Natural varianti433 – 4331E → D.
Corresponds to variant rs6952195 [ dbSNP | Ensembl ].
VAR_038569
Natural varianti437 – 4371I → M.
Corresponds to variant rs55745506 [ dbSNP | Ensembl ].
VAR_061117
Natural varianti472 – 4721A → P.
Corresponds to variant rs17167927 [ dbSNP | Ensembl ].
VAR_038570
Natural varianti741 – 7411R → Q.
Corresponds to variant rs17167102 [ dbSNP | Ensembl ].
VAR_038571

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei295 – 33440GERGE…PGDPG → QYSREDREVEHNNEKYVACL LPSPALLQQSSLTHHGTCSH in isoform 3. 1 PublicationVSP_031091Add
BLAST
Alternative sequencei335 – 1125791Missing in isoform 3. 1 PublicationVSP_031092Add
BLAST
Alternative sequencei667 – 71347GEPGV…QGIKG → TLNTSHGLEDPSCPDCSFCH FSLAADIQPKWPALLQLIPA SGTRQDG in isoform 2. 1 PublicationVSP_031093Add
BLAST
Alternative sequencei714 – 1125412Missing in isoform 2. 1 PublicationVSP_031094Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ890451 mRNA. Translation: CAI67595.1.
AJ890452 mRNA. Translation: CAI67596.1.
AJ890453 mRNA. Translation: CAI67597.1.
AC004982 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24305.1. Sequence problems.
CH236948 Genomic DNA. Translation: EAL24306.1. Sequence problems.
CH236948 Genomic DNA. Translation: EAL24307.1. Sequence problems.
BC136892 mRNA. Translation: AAI36893.1.
CCDSiCCDS43553.1. [Q2UY09-1]
RefSeqiNP_001032852.2. NM_001037763.2. [Q2UY09-1]
UniGeneiHs.491104.

Genome annotation databases

EnsembliENST00000399429; ENSP00000382356; ENSG00000215018. [Q2UY09-1]
ENST00000435823; ENSP00000410557; ENSG00000215018.
ENST00000444268; ENSP00000408401; ENSG00000215018.
GeneIDi340267.
KEGGihsa:340267.
UCSCiuc003src.1. human. [Q2UY09-1]

Polymorphism databases

DMDMi167009138.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ890451 mRNA. Translation: CAI67595.1 .
AJ890452 mRNA. Translation: CAI67596.1 .
AJ890453 mRNA. Translation: CAI67597.1 .
AC004982 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24305.1 . Sequence problems.
CH236948 Genomic DNA. Translation: EAL24306.1 . Sequence problems.
CH236948 Genomic DNA. Translation: EAL24307.1 . Sequence problems.
BC136892 mRNA. Translation: AAI36893.1 .
CCDSi CCDS43553.1. [Q2UY09-1 ]
RefSeqi NP_001032852.2. NM_001037763.2. [Q2UY09-1 ]
UniGenei Hs.491104.

3D structure databases

ProteinModelPortali Q2UY09.
SMRi Q2UY09. Positions 795-977, 1079-1122.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000382356.

Chemistry

ChEMBLi CHEMBL2364188.

Protein family/group databases

MEROPSi I02.974.

PTM databases

PhosphoSitei Q2UY09.

Polymorphism databases

DMDMi 167009138.

Proteomic databases

PaxDbi Q2UY09.
PRIDEi Q2UY09.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000399429 ; ENSP00000382356 ; ENSG00000215018 . [Q2UY09-1 ]
ENST00000435823 ; ENSP00000410557 ; ENSG00000215018 .
ENST00000444268 ; ENSP00000408401 ; ENSG00000215018 .
GeneIDi 340267.
KEGGi hsa:340267.
UCSCi uc003src.1. human. [Q2UY09-1 ]

Organism-specific databases

CTDi 340267.
GeneCardsi GC07M007364.
H-InvDB HIX0034009.
HGNCi HGNC:22442. COL28A1.
HPAi HPA060468.
MIMi 609996. gene.
neXtProti NX_Q2UY09.
PharmGKBi PA143485437.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236064.
GeneTreei ENSGT00760000119051.
HOVERGENi HBG104822.
InParanoidi Q2UY09.
OMAi QAANDMF.
OrthoDBi EOG7NSB1W.
PhylomeDBi Q2UY09.
TreeFami TF331207.

Enzyme and pathway databases

Reactomei REACT_121139. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

GeneWikii COL28A1.
GenomeRNAii 340267.
NextBioi 97768.
PROi Q2UY09.
SOURCEi Search...

Gene expression databases

Bgeei Q2UY09.
CleanExi HS_COL28A1.
ExpressionAtlasi Q2UY09. baseline and differential.
Genevestigatori Q2UY09.

Family and domain databases

Gene3Di 3.40.50.410. 2 hits.
4.10.410.10. 1 hit.
InterProi IPR008160. Collagen.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01391. Collagen. 5 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view ]
SMARTi SM00131. KU. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 2 hits.
SSF57362. SSF57362. 1 hit.
PROSITEi PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain."
    Veit G., Kobbe B., Keene D.R., Paulsson M., Koch M., Wagener R.
    J. Biol. Chem. 281:3494-3504(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Endometrial adenocarcinoma, Germ cell and Lung.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-189.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-189.

Entry informationi

Entry nameiCOSA1_HUMAN
AccessioniPrimary (citable) accession number: Q2UY09
Secondary accession number(s): A4D101
, A4D106, A4D107, A8MVR2, B9EGX9, Q2UY07, Q2UY08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3