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Q2UUG8 (CREB_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable ubiquitin carboxyl-terminal hydrolase creB

EC=3.4.19.12
Alternative name(s):
Carbon catabolite repression protein B
Deubiquitinating enzyme creB
Ubiquitin thioesterase creB
Ubiquitin-hydrolyzing enzyme creB
Ubiquitin-specific-processing protease creB
Gene names
Name:creB
ORF Names:AO090009000320
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length754 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with creA, creC and qutD By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence caution

The sequence BAE54797.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 754754Probable ubiquitin carboxyl-terminal hydrolase creB
PRO_0000395682

Regions

Domain54 – 467414USP
Coiled coil580 – 62950 Potential
Compositional bias675 – 6806Poly-Ser

Sites

Active site631Nucleophile By similarity
Active site4181Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2UUG8 [UniParc].

Last modified July 13, 2010. Version 2.
Checksum: 5C2FE319F4111992

FASTA75484,965
        10         20         30         40         50         60 
MGSFLRSLRR DGPPTPSVGA TPAKKEPPVP PVTPLEKMLQ DMGAIREDGS DKFFGMENYG 

        70         80         90        100        110        120 
NTCYCNSILQ CLYYSVPFRE AVVNYPTRTP IESLEAALAN TLRYQNFAAN LEAEALAEKQ 

       130        140        150        160        170        180 
KAANAQRPGA PPNQPQKPED KDSPEYKKKM ALQTLPLLET KNNATSYGMS ESLFTSLKDL 

       190        200        210        220        230        240 
FESVVASQSR IGIIRPQHFL DVLRREHEMF RTAMHQDAHE FLNLLLNEVV ANVEAEASKQ 

       250        260        270        280        290        300 
PEPERSLPPA ESADSTELSG SSGSKTPNTT RWVHELFEGT LTSETQCLTC EKVSQRDEVF 

       310        320        330        340        350        360 
LDLSVDLEQH SSVTSCLRKF SAEEMLCERN KFHCDNCGGL QEAEKRMKIK RLPRILALHL 

       370        380        390        400        410        420 
KRFKYTEDLQ RLQKLFHRVV YPYHLRLFNT TDDAEDPDRL YELYAVVVHI GGGPYHGHYV 

       430        440        450        460        470        480 
AIIKTQDRGW LLFDDEMVEP VDKNYVRNFF GDRPGLACAY VLFYQETTLE AVMKEQEQEN 

       490        500        510        520        530        540 
MDLNTSVADI NDSTLKQNGY PLSPGLAHVH SASQIPSPSE PARFSNLQRA PTAPPLFPHP 

       550        560        570        580        590        600 
EHADSESSPA DPSTTASATP PVPPIPDIHS LPLSPKKSDS HFKKERAKEE KERKANEKEK 

       610        620        630        640        650        660 
EKQRRRDQEA RIREQRREDA EIRAALEASK ASKAEEDRRH SPDDTKKSSH GLSRLKRGSK 

       670        680        690        700        710        720 
SFSHRLGKDK ENRVSSSSHS ATPIAEHPPS RNGASESQQQ LPNGQSPGSH GLHTRHTGLD 

       730        740        750 
EERDTLKDPK HDRSGHHGKW RSFSLKKKSF SILS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP007150 Genomic DNA. Translation: BAE54797.1. Sequence problems.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5062.CADAORAP00003720.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG5533.
HOGENOMHOG000192482.
OrthoDBEOG7TF7JV.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCREB_ASPOR
AccessionPrimary (citable) accession number: Q2UUG8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: February 19, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries