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Q2UUG8

- CREB_ASPOR

UniProt

Q2UUG8 - CREB_ASPOR

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Protein

Probable ubiquitin carboxyl-terminal hydrolase creB

Gene
creB, AO090009000320
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Nucleophile By similarity
Active sitei418 – 4181Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. carbon catabolite repression of transcription Source: UniProtKB
  2. ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase creB (EC:3.4.19.12)
Alternative name(s):
Carbon catabolite repression protein B
Deubiquitinating enzyme creB
Ubiquitin thioesterase creB
Ubiquitin-hydrolyzing enzyme creB
Ubiquitin-specific-processing protease creB
Gene namesi
Name:creB
ORF Names:AO090009000320
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Probable ubiquitin carboxyl-terminal hydrolase creBPRO_0000395682Add
BLAST

Interactioni

Subunit structurei

Interacts with creA, creC and qutD By similarity.

Protein-protein interaction databases

STRINGi5062.CADAORAP00003720.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 467414USPAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili580 – 62950 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi675 – 6806Poly-Ser

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000192482.
OrthoDBiEOG7TF7JV.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2UUG8-1 [UniParc]FASTAAdd to Basket

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MGSFLRSLRR DGPPTPSVGA TPAKKEPPVP PVTPLEKMLQ DMGAIREDGS    50
DKFFGMENYG NTCYCNSILQ CLYYSVPFRE AVVNYPTRTP IESLEAALAN 100
TLRYQNFAAN LEAEALAEKQ KAANAQRPGA PPNQPQKPED KDSPEYKKKM 150
ALQTLPLLET KNNATSYGMS ESLFTSLKDL FESVVASQSR IGIIRPQHFL 200
DVLRREHEMF RTAMHQDAHE FLNLLLNEVV ANVEAEASKQ PEPERSLPPA 250
ESADSTELSG SSGSKTPNTT RWVHELFEGT LTSETQCLTC EKVSQRDEVF 300
LDLSVDLEQH SSVTSCLRKF SAEEMLCERN KFHCDNCGGL QEAEKRMKIK 350
RLPRILALHL KRFKYTEDLQ RLQKLFHRVV YPYHLRLFNT TDDAEDPDRL 400
YELYAVVVHI GGGPYHGHYV AIIKTQDRGW LLFDDEMVEP VDKNYVRNFF 450
GDRPGLACAY VLFYQETTLE AVMKEQEQEN MDLNTSVADI NDSTLKQNGY 500
PLSPGLAHVH SASQIPSPSE PARFSNLQRA PTAPPLFPHP EHADSESSPA 550
DPSTTASATP PVPPIPDIHS LPLSPKKSDS HFKKERAKEE KERKANEKEK 600
EKQRRRDQEA RIREQRREDA EIRAALEASK ASKAEEDRRH SPDDTKKSSH 650
GLSRLKRGSK SFSHRLGKDK ENRVSSSSHS ATPIAEHPPS RNGASESQQQ 700
LPNGQSPGSH GLHTRHTGLD EERDTLKDPK HDRSGHHGKW RSFSLKKKSF 750
SILS 754
Length:754
Mass (Da):84,965
Last modified:July 13, 2010 - v2
Checksum:i5C2FE319F4111992
GO

Sequence cautioni

The sequence BAE54797.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007150 Genomic DNA. Translation: BAE54797.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007150 Genomic DNA. Translation: BAE54797.1 . Sequence problems.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00003720.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000192482.
OrthoDBi EOG7TF7JV.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiCREB_ASPOR
AccessioniPrimary (citable) accession number: Q2UUG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: February 19, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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