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Protein

Mitochondrial glycine transporter

Gene

AO090009000436

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:AO090009000436
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 52Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei79 – 105Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei139 – 164Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei192 – 215Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei238 – 264Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei293 – 311Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789281 – 327Mitochondrial glycine transporterAdd BLAST327

Structurei

3D structure databases

ProteinModelPortaliQ2UU67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 104Solcar 1UniRule annotationAdd BLAST84
Repeati136 – 217Solcar 2UniRule annotationAdd BLAST82
Repeati234 – 318Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000006978
KOiK15118
OMAiTVYEQMM
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q2UU67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSAVYAVP QVKKTSATTT SKTTFHFAAG LCSGLSSAIL LQPADLLKTR
60 70 80 90 100
VQQSQNAALL PTIKSIISSP NGIRGLWRGT LPSALRTGFG SALYFTSLNA
110 120 130 140 150
LRQGLAHTGV PVALSSASAN GKGVASSSAL PKLSNSANLA TGAAARVAAG
160 170 180 190 200
FVMMPVTVLK VRYESSYYAY GSLYSAGRDI LRTEGVRGLF AGFGATAARD
210 220 230 240 250
APYAGLYVLF YEQLKRRFAS LADSGTGDQS LKSSSSSINF VSGALAAGLA
260 270 280 290 300
TAITNPFDAV KTRLQLMPNK YGNMMRAVKL MVHEDGVRSL LGGLGLRITR
310 320
KALSSALAWT VYEELILRAE KHWATRD
Length:327
Mass (Da):34,455
Last modified:January 24, 2006 - v1
Checksum:i6A2497B0E013A362
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007150 Genomic DNA Translation: BAE54898.1
RefSeqiXP_001816900.1, XM_001816848.2

Genome annotation databases

EnsemblFungiiBAE54898; BAE54898; AO090009000436
GeneIDi5988830
KEGGiaor:AO090009000436

Similar proteinsi

Entry informationi

Entry nameiS2538_ASPOR
AccessioniPrimary (citable) accession number: Q2UU67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: January 24, 2006
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health