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Q2UTX5

- BGLE_ASPOR

UniProt

Q2UTX5 - BGLE_ASPOR

Protein

Probable beta-glucosidase E

Gene

bglE

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 2 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei438 – 4381By similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00696.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-glucosidase E (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase E
    Cellobiase E
    Gentiobiase E
    Gene namesi
    Name:bglE
    ORF Names:AO090009000554
    OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
    Taxonomic identifieri510516 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006564: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10481048Probable beta-glucosidase EPRO_0000394873Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi578 – 5781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi895 – 8951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi991 – 9911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5062.CADAORAP00003913.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2UTX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 150150CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 1048877ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei151 – 17121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000031215.
    KOiK05349.
    OrthoDBiEOG7HMS8F.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProiIPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR30620. PTHR30620. 1 hit.
    PfamiPF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view]
    PRINTSiPR00133. GLHYDRLASE3.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q2UTX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPPPFRDAP SSAKSSQRYT PLHESIPEEL NDKQYSSDAD SLPLSDPSDG     50
    EDDSEIRLRR VDRNGTRSNQ ATAYVPVVRK SGDVEAYFDS IAEAELELLS 100
    ASRQYDGVDD DDDDSDGYGV GVKRGQRQGL LKRTHDGRTG WRTVYYSKYW 150
    WRALIGVVVV LVLLVLVFLG LARSKQVGDE LDYSMIPAES WFPSPRGGAL 200
    KEWAADYQKA ALLVGNMTLI EKVNITTGTG WQMGLCVGNT GPAESVHFPS 250
    LCLQDGPMGI RYADHISAFP PGLTTGATWN RDLIRERGIA MGLEARLKGV 300
    NVLLGPSMGP LGMMPAGGRN WEAFGSDPVL QGVAAAETIK GIQSNGVMAT 350
    AKHFVMNEQE HFRQPFEWGI PTALSSNVGD RALHEVFAWP FAESIRADVA 400
    SVMCAYQMVN NSHACENSKL LNGILKDELG FQGFVQSDWL AQRSGINSAL 450
    GGLDMSMPGD GLHWADGKSL WGSELTRAVL NTSIPMERLN DMVTRIVAAW 500
    YHLGQDQWER PPPDGEGGPN FSSWTDDQTG WWQQASVEAG DQDGGWGIVN 550
    KYVDAGAGHG DIARKVAAEG IVLVKNNNNT LPLSRSPPSP YRIGIYGDDA 600
    GPALGPNACP DRGCSQGTLA SGWGSGTVEF PFLVSPLEAL QGAWETEVEI 650
    TPYLQNMVMP VSVQDKDLCL VFANANSGEG YIHAGGIHGD RNDLFLQKGG 700
    DTLIQAVANN CAGPTVVVVH AVGPVVVESW IDLPGVDAVL FAHLPGQESG 750
    NALVDVLFGD VDASGRLPYT VGKSLEDYGP GAQVLYENNA PVPQVDFLDA 800
    LYIDYRYFDK FNITPRYEFG FGLSYTSFEL SKLYIKSMQW KSRLPKSRPQ 850
    DQVSPPEYDT RPPVNENVLF PEGFHALSKY VYSYLPSLDG TAAANYTEYP 900
    DGYDLPRQPS EAGGDLGGNP SLYEEMAKVQ VQVANTGARA GQTVVQAYVS 950
    FPSDVVEEGD LVEVPVDEKG ETVTFVPSKE QVEFPDRVLR NFTKIALEPG 1000
    EKKTVEMTLS RKDLSYWSAR QQNWVMPDGD FQIWVGQSSR DLPLHGKY 1048
    Length:1,048
    Mass (Da):114,456
    Last modified:June 15, 2010 - v2
    Checksum:iC11B8431841623DE
    GO

    Sequence cautioni

    The sequence BAE54990.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007150 Genomic DNA. Translation: BAE54990.1. Sequence problems.
    RefSeqiXP_001816992.2. XM_001816940.2.

    Genome annotation databases

    GeneIDi5988922.
    KEGGiaor:AOR_1_914184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007150 Genomic DNA. Translation: BAE54990.1 . Sequence problems.
    RefSeqi XP_001816992.2. XM_001816940.2.

    3D structure databases

    ProteinModelPortali Q2UTX5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5062.CADAORAP00003913.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5988922.
    KEGGi aor:AOR_1_914184.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000031215.
    KOi K05349.
    OrthoDBi EOG7HMS8F.

    Enzyme and pathway databases

    UniPathwayi UPA00696 .

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProi IPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR30620. PTHR30620. 1 hit.
    Pfami PF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00133. GLHYDRLASE3.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of Aspergillus oryzae."
      Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
      , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
      Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 42149 / RIB 40.

    Entry informationi

    Entry nameiBGLE_ASPOR
    AccessioniPrimary (citable) accession number: Q2UTX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 46 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3