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Protein

Eukaryotic translation initiation factor 6

Gene

tif6

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:tif6
ORF Names:AO090009000659
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004021061 – 247Eukaryotic translation initiation factor 6Add BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174Phosphoserine; by CK1UniRule annotation1
Modified residuei175Phosphoserine; by CK1UniRule annotation1

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2UTN7
SMRiQ2UTN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230605
OrthoDBiEOG092C4BDP

Family and domain databases

CDDicd00527 IF6, 1 hit
HAMAPiMF_00032 eIF_6, 1 hit
InterProiView protein in InterPro
IPR002769 eIF6
PANTHERiPTHR10784 PTHR10784, 1 hit
PfamiView protein in Pfam
PF01912 eIF-6, 1 hit
PIRSFiPIRSF006413 IF-6, 1 hit
SMARTiView protein in SMART
SM00654 eIF6, 1 hit
TIGRFAMsiTIGR00323 eIF-6, 1 hit

Sequencei

Sequence statusi: Complete.

Q2UTN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRAQFENS NEVGVFARLT NSYAVVAIGA SENFYSVFEA ELQDVIPICH
60 70 80 90 100
ATIAGTRIVG RLTAGNRKGL LVPTTTTDQE LQHLRNTLPD SVKIQRIEER
110 120 130 140 150
LSALGNVICC NDHVALIHPD LERETEEIIA DVLGVEVFRQ TIADNVLTGS
160 170 180 190 200
YMALSNQGGI VHPKTSIRDQ DELSSLLQVP LVAGSVNRGS AVVGAGMVVN
210 220 230 240
DWLAVTGLDT TATELSVIES VFRLGEMGPR GVGMGSTNKE SIVESFY
Length:247
Mass (Da):26,568
Last modified:November 30, 2010 - v2
Checksum:iA86EC4CC4764508F
GO

Sequence cautioni

The sequence BAE55078 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007150 Genomic DNA Translation: BAE55078.1 Sequence problems.
RefSeqiXP_001817080.2, XM_001817028.2

Genome annotation databases

EnsemblFungiiBAE55078; BAE55078; AO090009000659

Similar proteinsi

Entry informationi

Entry nameiIF6_ASPOR
AccessioniPrimary (citable) accession number: Q2UTN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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