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Protein

Eukaryotic translation initiation factor 6

Gene

tif6

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:tif6
ORF Names:AO090009000659
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleusnucleolus UniRule annotation

  • Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Eukaryotic translation initiation factor 6PRO_0000402106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741Phosphoserine; by CK1UniRule annotation
Modified residuei175 – 1751Phosphoserine; by CK1UniRule annotation

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2UTN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230605.
KOiK03264.
OrthoDBiEOG092C4BDP.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2UTN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRAQFENS NEVGVFARLT NSYAVVAIGA SENFYSVFEA ELQDVIPICH
60 70 80 90 100
ATIAGTRIVG RLTAGNRKGL LVPTTTTDQE LQHLRNTLPD SVKIQRIEER
110 120 130 140 150
LSALGNVICC NDHVALIHPD LERETEEIIA DVLGVEVFRQ TIADNVLTGS
160 170 180 190 200
YMALSNQGGI VHPKTSIRDQ DELSSLLQVP LVAGSVNRGS AVVGAGMVVN
210 220 230 240
DWLAVTGLDT TATELSVIES VFRLGEMGPR GVGMGSTNKE SIVESFY
Length:247
Mass (Da):26,568
Last modified:November 30, 2010 - v2
Checksum:iA86EC4CC4764508F
GO

Sequence cautioni

The sequence BAE55078 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007150 Genomic DNA. Translation: BAE55078.1. Sequence problems.
RefSeqiXP_001817080.2. XM_001817028.2.

Genome annotation databases

GeneIDi5989010.
KEGGiaor:AOR_1_1108184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007150 Genomic DNA. Translation: BAE55078.1. Sequence problems.
RefSeqiXP_001817080.2. XM_001817028.2.

3D structure databases

ProteinModelPortaliQ2UTN7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5989010.
KEGGiaor:AOR_1_1108184.

Phylogenomic databases

HOGENOMiHOG000230605.
KOiK03264.
OrthoDBiEOG092C4BDP.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIF6_ASPOR
AccessioniPrimary (citable) accession number: Q2UTN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: September 7, 2016
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.