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Protein

Probable alpha-fucosidase A

Gene

afcA

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Alpha-fucosidase involved in degradation of fucosylated xyloglucans. Hydrolyzes alpha-1,2-linked fucose (By similarity).By similarity

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

GO - Molecular functioni

  1. alpha-L-fucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha-fucosidase A (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase A
Gene namesi
Name:afcA
ORF Names:AO090005000382
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564 Componenti: Chromosome 1

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 723708Probable alpha-fucosidase APRO_0000394703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi595 – 5951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00002350.

Structurei

3D structure databases

ProteinModelPortaliQ2USL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 95 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG04067.
HOGENOMiHOG000235039.
OrthoDBiEOG77HDP8.

Family and domain databases

Gene3Di2.70.98.50. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR027414. GH_fam_N_dom.
[Graphical view]
PfamiPF14498. Glyco_hyd_65N_2. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2USL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLVLLGMS SLATANSLWS SKAASWDTTN EAYTLGNGKL GVMPFGEPGA
60 70 80 90 100
EKLNLNHDEL WEGGPFEVNG YRGGNPNSSM TEILSEVRDE IWKKGTGNDS
110 120 130 140 150
RLHGDTDGYG SFHSLANLTI AIDGIDKVSD YTRSLDLGTG IHTTTYSTGK
160 170 180 190 200
GKYTTDVYCS YPAQVCIYKL NSTATLSKVT IYFDQLVEES SLWNATCDSD
210 220 230 240 250
FARLRGVTQE GPPRGMTYDT IARSSIPGRC DSSTGKLAIN ARNSSSLTIV
260 270 280 290 300
IGAGTDFDGT KGTAATDYTF KGEDPAEYVE KITSSALSQS ESKLRTEHIE
310 320 330 340 350
DYSGLMSAFT LDLPDTQDST GTELSTLITN YNANKTDGDP YLEKLLFDYG
360 370 380 390 400
RHLFISSSRA NSLPPNLQGV WSPTKNAAWS GDYHANINLQ MNLWGAEATG
410 420 430 440 450
LGELTVAVFN YMEQNWMPRG AETAELLYGG AGWVTHDEMN IFGHTGSLVV
460 470 480 490 500
NPCTSPEQGP TTFGCTHWQQ LIHQVYENAI QGAEIAGETD STLLKDIKDQ
510 520 530 540 550
LPRLDKGLHI GTWGQIKEWK LPDSYDYEKE GNEHRHLSHL VGWYPGWSLS
560 570 580 590 600
SYFNGYNNAT IQSAVNTSLI SRGVGLYTNA GWEKVWRSAC WARLNNTEKA
610 620 630 640 650
HYELRLTIDQ NIGQSGLSLY SGGDTPSGAF QIDANFGYLG AVLSMLVVDM
660 670 680 690 700
PLDSTHSEDD VRTVVLGPAI PAAWAGGSVK GLRLRGGGSV DFSWDSEGLV
710 720
DKASATGVSS NVRIVNVEGT VLV
Length:723
Mass (Da):78,538
Last modified:June 15, 2010 - v2
Checksum:i8F22F67C3367E604
GO

Sequence cautioni

The sequence BAE55452.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007151 Genomic DNA. Translation: BAE55452.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007151 Genomic DNA. Translation: BAE55452.1. Sequence problems.

3D structure databases

ProteinModelPortaliQ2USL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5062.CADAORAP00002350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG04067.
HOGENOMiHOG000235039.
OrthoDBiEOG77HDP8.

Family and domain databases

Gene3Di2.70.98.50. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR027414. GH_fam_N_dom.
[Graphical view]
PfamiPF14498. Glyco_hyd_65N_2. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiAFCA_ASPOR
AccessioniPrimary (citable) accession number: Q2USL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 1, 2015
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.